Brain state‐dependent high‐frequency activity as a biomarker for abnormal neocortical networks in an epileptic spasms animal model

SUMMARYBouts of high frequency activity known as sharp wave ripples (SPW-Rs) facilitate communication between the hippocampus and neocortex. However, the paths and mechanisms by which SPW-Rs broadcast their content are not well understood. Due to its anatomical positioning, the granular retrosplenial cortex (gRSC) may be a bridge for this hippocampo-cortical dialogue. Using silicon probe recordings in awake, head-fixed mice, we show the existence of SPW-R analogues in gRSC and demonstrate their coupling to hippocampal SPW-Rs. gRSC neurons reliably distinguished different subclasses of hippocampal SPW-Rs according to ensemble activity patterns in CA1. We demonstrate that this coupling is brain state-dependent, and delineate a topographically-organized anatomical pathway via VGlut2-expressing, bursty neurons in the subiculum. Optogenetic stimulation or inhibition of bursty subicular cells induced or reduced responses in superficial gRSC, respectively. These results identify a specific path and underlying mechanisms by which the hippocampus can convey neuronal content to the neocortex during SPW-Rs.

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Brain state-dependent recruitment of high-frequency oscillations in the human hippocampus

Cortex ◽

10.1016/j.cortex.2017.06.002 ◽

2017 ◽

Vol 94 ◽

pp. 87-99 ◽

Cited By ~ 10

Author(s):

Pablo Billeke ◽

Tomas Ossandon ◽

Marcelo Stockle ◽

Marcela Perrone-Bertolotti ◽

Philippe Kahane ◽

...

Keyword(s):

High Frequency ◽

Brain State ◽

High Frequency Oscillations ◽

Human Hippocampus ◽

State Dependent

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Novel approach to modeling high-frequency activity data to assess therapeutic effects of analgesics in chronic pain conditions

Scientific Reports ◽

10.1038/s41598-021-87304-w ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Zekun Xu ◽

Eric Laber ◽

Ana-Maria Staicu ◽

B. Duncan X. Lascelles

Keyword(s):

High Frequency ◽

Activity Patterns ◽

Treatment Strategies ◽

Therapeutic Effects ◽

Activity Levels ◽

Activity Data ◽

Novel Approach ◽

High Frequency Activity ◽

Using Data ◽

Chronic Pain Conditions

AbstractOsteoarthritis (OA) is a chronic condition often associated with pain, affecting approximately fourteen percent of the population, and increasing in prevalence. A globally aging population have made treating OA-associated pain as well as maintaining mobility and activity a public health priority. OA affects all mammals, and the use of spontaneous animal models is one promising approach for improving translational pain research and the development of effective treatment strategies. Accelerometers are a common tool for collecting high-frequency activity data on animals to study the effects of treatment on pain related activity patterns. There has recently been increasing interest in their use to understand treatment effects in human pain conditions. However, activity patterns vary widely across subjects; furthermore, the effects of treatment may manifest in higher or lower activity counts or in subtler ways like changes in the frequency of certain types of activities. We use a zero inflated Poisson hidden semi-Markov model to characterize activity patterns and subsequently derive estimators of the treatment effect in terms of changes in activity levels or frequency of activity type. We demonstrate the application of our model, and its advance over traditional analysis methods, using data from a naturally occurring feline OA-associated pain model.

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Alpha and broadband high‐frequency activity track task dynamics and predict performance in controlled decision‐making

Psychophysiology ◽

10.1111/psyp.13901 ◽

2021 ◽

Author(s):

Saskia Haegens ◽

Yagna J. Pathak ◽

Elliot H. Smith ◽

Charles B. Mikell ◽

Garrett P. Banks ◽

...

Keyword(s):

Decision Making ◽

High Frequency ◽

High Frequency Activity

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High-Frequency Oscillatory Ventilation Combined with Volume Guarantee in a Neonatal Animal Model of Respiratory Distress Syndrome

Critical Care Research and Practice ◽

10.1155/2013/593915 ◽

2013 ◽

Vol 2013 ◽

pp. 1-6 ◽

Cited By ~ 3

Author(s):

Manuel Sánchez Luna ◽

Martín Santos González ◽

Francisco Tendillo Cortijo

Keyword(s):

Animal Model ◽

High Frequency ◽

Distress Syndrome ◽

Lung Surfactant ◽

High Frequency Oscillatory Ventilation ◽

Constant Frequency ◽

Oscillatory Ventilation ◽

Before And After ◽

Lung Condition ◽

High Frequency Oscillatory

Objective. To assess volume guarantee (VG) ventilation combined with high-frequency oscillatory ventilation (HFOV) strategy on PaCO2regulation in an experimental model of neonatal distress syndrome.Methods. Six 2-day-old piglets weighing kg were used for this interventional experimental study. Animals were ventilated during physiologic lung conditions and after depletion of lung surfactant by bronchoalveolar lavage (BAL). The effect of HFOV combined with VG on PaCO2was evaluated at different high-frequency expired tidal volume (VThf) at constant frequency () and mean airway pressure (mPaw). Fluctuations of the pressure (ΔPhf) around the mPaw and PaCO2were analyzed before and after lung surfactant depletion.Results. PaCO2levels were inversely proportional to VThf. In the physiological lung condition, an increase in VThf caused a significant decrease in PaCO2and an increase in ΔPhf. After BAL, PaCO2did not change as compared with pre-BAL situation as the VThf remained constant by the ventilator.Conclusions. In this animal model, using HFOV combined with VG, changes in the VThf settings induced significant modifications in PaCO2. After changing the lung condition by depletion of surfactant, PaCO2remained unchanged, as the VThf setting was maintained constant by modifications in the ΔPhf done by the ventilator.

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