Rewiring the yeast cell wall integrity (CWI) pathway through a synthetic positive feedback circuit unveils a novel role for the MAPKKK Ssk2 in CWI pathway activation

FEBS Journal ◽  
2020 ◽  
Vol 287 (22) ◽  
pp. 4881-4901 ◽  
Author(s):  
Elena Jiménez‐Gutiérrez ◽  
Estíbaliz Alegría‐Carrasco ◽  
Esmeralda Alonso‐Rodríguez ◽  
Teresa Fernández‐Acero ◽  
María Molina ◽  
...  
Keyword(s):  
Cell Wall ◽  
Yeast Cell ◽  
Positive Feedback ◽  
Cell Wall Integrity ◽  
Yeast Cell Wall ◽  
Feedback Circuit ◽  
Pathway Activation ◽  
Positive Feedback Circuit

scholarly journals Transcription factors of M-phase cyclin CLB2 in the yeast cell wall integrity checkpoint

2009 ◽  
Vol 84 (4) ◽  
pp. 269-276 ◽  
Author(s):  
Mizuho Sekiya ◽  
Satoru Nogami ◽  
Yoshikazu Ohya
Keyword(s):  
Cell Wall ◽  
Transcription Factors ◽  
Yeast Cell ◽  
Cell Wall Integrity ◽  
Yeast Cell Wall ◽  
M Phase

scholarly journals Yeast cell wall integrity sensors form specific plasma membrane microdomains important for signalling

2016 ◽  
Vol 18 (9) ◽  
pp. 1251-1267 ◽  
Author(s):  
Christian Kock ◽  
Henning Arlt ◽  
Christian Ungermann ◽  
Jürgen J. Heinisch
Keyword(s):  
Cell Wall ◽  
Plasma Membrane ◽  
Yeast Cell ◽  
Cell Wall Integrity ◽  
Yeast Cell Wall ◽  
Membrane Microdomains ◽  
Plasma Membrane Microdomains

Activation of the yeast cell wall integrity MAPK pathway by zymolyase depends on protease and glucanase activities and requires the mucin-like protein Hkr1 but not Msb2

FEBS Letters ◽  
2013 ◽  
Vol 587 (22) ◽  
pp. 3675-3680 ◽  
Author(s):  
José M. Rodríguez-Peña ◽  
Sonia Díez-Muñiz ◽  
Clara Bermejo ◽  
César Nombela ◽  
Javier Arroyo
Keyword(s):  
Cell Wall ◽  
Yeast Cell ◽  
Mapk Pathway ◽  
Cell Wall Integrity ◽  
Yeast Cell Wall

scholarly journals Up against the Wall: Is Yeast Cell Wall Integrity Ensured by Mechanosensing in Plasma Membrane Microdomains?

2014 ◽  
Vol 81 (3) ◽  
pp. 806-811 ◽  
Author(s):  
Christian Kock ◽  
Yves F. Dufrêne ◽  
Jürgen J. Heinisch
Keyword(s):  
Cell Wall ◽  
Plasma Membrane ◽  
Yeast Cell ◽  
Antifungal Drugs ◽  
Cell Wall Integrity ◽  
Yeast Cell Wall ◽  
Membrane Microdomains ◽  
Wall Structure ◽  
Fungal Cell ◽  
Membrane Spanning

ABSTRACTYeast cell wall integrity (CWI) signaling serves as a model of the regulation of fungal cell wall synthesis and provides the basis for the development of antifungal drugs. A set of five membrane-spanning sensors (Wsc1 to Wsc3, Mid2, and Mtl1) detect cell surface stress and commence the signaling pathway upon perturbations of either the cell wall structure or the plasma membrane. We here summarize the latest advances in the structure/function relationship primarily of the Wsc1 sensor and critically review the evidence that it acts as a mechanosensor. The relevance and physiological significance of the information obtained for the function of the other CWI sensors, as well as expected future developments, are discussed.

A block of endocytosis of the yeast cell wall integrity sensors Wsc1 and Wsc2 results in reduced fitness in vivo

2010 ◽  
Vol 284 (3) ◽  
pp. 217-229 ◽  
Author(s):  
Sabrina Wilk ◽  
Janina Wittland ◽  
Andreas Thywissen ◽  
Hans-Peter Schmitz ◽  
Jürgen J. Heinisch
Keyword(s):  
Cell Wall ◽  
Yeast Cell ◽  
Cell Wall Integrity ◽  
Yeast Cell Wall

scholarly journals An Analog-sensitive Version of the Protein Kinase Slt2 Allows Identification of Novel Targets of the Yeast Cell Wall Integrity Pathway

2016 ◽  
Vol 291 (11) ◽  
pp. 5461-5472 ◽  
Author(s):  
Esmeralda Alonso-Rodríguez ◽  
Pablo Fernández-Piñar ◽  
Almudena Sacristán-Reviriego ◽  
María Molina ◽  
Humberto Martín
Keyword(s):  
Cell Wall ◽  
Protein Kinase ◽  
Yeast Cell ◽  
Cell Wall Integrity ◽  
Yeast Cell Wall ◽  
Cell Wall Integrity Pathway ◽  
Novel Targets

scholarly journals Regulation of LRG1 expression by RNA‐binding protein Puf5 in the budding yeast cell wall integrity pathway

2018 ◽  
Vol 23 (12) ◽  
pp. 988-997 ◽  
Author(s):  
Nguyen Thi Minh Viet ◽  
Duong Long Duy ◽  
Kazuhiro Saito ◽  
Kaoru Irie ◽  
Yasuyuki Suda ◽  
...  
Keyword(s):  
Cell Wall ◽  
Yeast Cell ◽  
Rna Binding ◽  
Budding Yeast ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Cell Wall Integrity ◽  
Yeast Cell Wall ◽  
Cell Wall Integrity Pathway

scholarly journals SMA-based Extraction of the Yeast Cell Wall Integrity Sensor Mid2 from Native Membranes of Saccharomyces cerevisiae – Electron Microscopy Study

2019 ◽  
Vol 25 (S2) ◽  
pp. 1338-1339
Author(s):  
Natalia Voskoboynikova ◽  
Maria Karlova ◽  
Rainer Kurre ◽  
Juergen Heinisch ◽  
Heinz-Juergen Steinhoff ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Saccharomyces Cerevisiae ◽  
Cell Wall ◽  
Yeast Cell ◽  
Microscopy Study ◽  
Electron Microscopy Study ◽  
Cell Wall Integrity ◽  
Yeast Cell Wall
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