Deformable liposomes as enhancer of caffeine penetration through human skin in a Franz diffusion cell test

2020 ◽  
Author(s):  
E. Abd ◽  
J. Gomes ◽  
C. C. Sales ◽  
S. Yousef ◽  
F. Forouz ◽  
...  
Keyword(s):  
Human Skin ◽  
Diffusion Cell ◽  
Franz Diffusion Cell ◽  
Cell Test

ASSESSMENT OF PERMEABILITY BEHAVIOR OF BERBERINE CHLORIDE ACROSS GOAT INTESTINAL MEMBRANE IN PRESENCE OF NATURAL BIOPOTENTIATOR CURCUMIN

INDIAN DRUGS ◽  
2021 ◽  
Vol 58 (4) ◽  
pp. 23-27
Author(s):  
Sarika Narade ◽  
Yogesh Pore ◽  
◽  
Keyword(s):  
Efflux Pump ◽  
Diffusion Cell ◽  
Apparent Permeability ◽  
Franz Diffusion Cell ◽  
Permeability Characteristics ◽  
Berberine Chloride ◽  
Intestinal Membrane ◽  
Permeability Studies ◽  
Cell Data ◽  
Intestinal Efflux

The present study investigates the influence of co-administration of different concentrations (2, 6, and 10 mg) of curcumin on goat intestinal permeability of berberine chloride (BBC) using Franz diffusion cell. Data obtained in triplicate from permeability studies were used to calculate percentage cumulative drug release (% CDR), apparent permeability (Papp), flux (J) and enhancement ratio (ER). Co-administration of 6 mg concentration of curcumin with BBC was found to be optimum to enhance the permeability of BBC up to 23.92 ± 0.78 % CDR, over control (8.49 ± 1.45 % CDR). At the optimized concentration of curcumin, permeability characteristics were improved significantly compared to control. The present study reveals the beneficial effect of co-administration of curcumin (6 mg) to promote membrane permeability of BBC which would be expected to improve its bioavailability, thereby therapeutic efficacy. The effect could be attributed to curcumin-mediated inhibition of intestinal efflux pump P-gp, acting as an absorption barrier for BBC.

Negligible penetration of incidental amounts of alpha-hydroxy acid from rinse-off personal care products in human skin using an in vitro static diffusion cell model

2011 ◽  
Vol 25 (8) ◽  
pp. 2041-2047 ◽  
Author(s):  
M. Okuda ◽  
D.A. Donahue ◽  
L.E. Kaufman ◽  
J. Avalos ◽  
F.A. Simion ◽  
...  
Keyword(s):  
Human Skin ◽  
Hydroxy Acid ◽  
Cell Model ◽  
Personal Care Products ◽  
Diffusion Cell ◽  
Personal Care

Comparative Effects of Span 20 and Span 40 on Liposomes Release Properties

2017 ◽  
Vol 13 (12) ◽  
Author(s):  
Radoslava N. Pravilović ◽  
Bojana D. Balanč ◽  
Kata T. Trifković ◽  
Verica B. Đorđević ◽  
Nevenka M. Bošković-Vragolović ◽  
...  
Keyword(s):  
Mass Transfer ◽  
Natural Antioxidants ◽  
Polyphenolic Compounds ◽  
Diffusion Cell ◽  
Transfer Resistance ◽  
Franz Diffusion Cell ◽  
Model Substance ◽  
Different Types ◽  
Liposome Size ◽  
The Common

AbstractLiposomes are known as convenient carriers for a broad range of actives. The release rate of actives can be adjusted/controlled by the addition of different surfactants. The aim of this study was to compare the effects of two surfactants, Span 20 and Span 40, on liposomes release properties. In particular, the study shows how the membrane modification affects the mass transfer resistances and liposome size compared with the common liposomes. The aqueous extract of thyme was used as a model substance. It is a valuable source of natural antioxidants – polyphenols. The diffusion of polyphenols from native thyme extract (un-encapsulated) and from different types of liposomes was conducted using Franz diffusion cell. The results were approximated with Fick’s second law and they implied that liposomes modified with Span 20 provided the slowest release of polyphenolic compounds due to the highest value of mass transfer resistance (2.523 × 106s/m).

Effect of pectins on the mass transfer kinetics of monosaccharides, amino acids, and a corn oil-in-water emulsion in a Franz diffusion cell

2016 ◽  
Vol 209 ◽  
pp. 144-153 ◽  
Author(s):  
Mauricio Espinal-Ruiz ◽  
Luz-Patricia Restrepo-Sánchez ◽  
Carlos-Eduardo Narváez-Cuenca
Keyword(s):  
Amino Acids ◽  
Mass Transfer ◽  
Corn Oil ◽  
Diffusion Cell ◽  
Water Emulsion ◽  
Franz Diffusion Cell ◽  
Oil In Water ◽  
Mass Transfer Kinetics ◽  
Oil In Water Emulsion ◽  
Kinetics Of

Chloride-binding isotherms from the diffusion cell test

1998 ◽  
Vol 28 (7) ◽  
pp. 939-945 ◽  
Author(s):  
G.K. Glass ◽  
G.M. Stevenson ◽  
N.R. Buenfeld
Keyword(s):  
Chloride Binding ◽  
Diffusion Cell ◽  
Binding Isotherms ◽  
Cell Test

A measurement of the unstirred aqueous boundary layer in a Franz diffusion cell

2011 ◽  
Vol 17 (6) ◽  
pp. 705-711 ◽  
Author(s):  
Matthew Alexander Miller ◽  
Gerald Kasting
Keyword(s):  
Boundary Layer ◽  
Diffusion Cell ◽  
Franz Diffusion Cell ◽  
Aqueous Boundary Layer

scholarly journals On-line automated evaluation of lipid nanoparticles transdermal permeation using Franz diffusion cell and low-pressure chromatography

Talanta ◽  
2016 ◽  
Vol 146 ◽  
pp. 369-374 ◽  
Author(s):  
Ana Catarina Alves ◽  
Inês I. Ramos ◽  
Cláudia Nunes ◽  
Luís M. Magalhães ◽  
Hana Sklenářová ◽  
...  
Keyword(s):  
Low Pressure ◽  
Lipid Nanoparticles ◽  
Diffusion Cell ◽  
Franz Diffusion Cell ◽  
Transdermal Permeation ◽  
Automated Evaluation ◽  
On Line

scholarly journals The influence of membrane composition on the release of polyphenols from liposomes

2015 ◽  
Vol 69 (4) ◽  
pp. 347-353 ◽  
Author(s):  
Radoslava Pravilovic ◽  
Vesna Radunovic ◽  
Nevenka Boskovic-Vragolovic ◽  
Branko Bugarski ◽  
Rada Pjanovic
Keyword(s):  
Tween 20 ◽  
Diffusion Resistance ◽  
Diffusion Cell ◽  
Membrane Composition ◽  
Membrane Modification ◽  
Liposome Membrane ◽  
Franz Diffusion Cell ◽  
Therapeutic Properties ◽  
Tween 60 ◽  
Tea Extract

Polyphenols are compound which are widely studied because of their antioxidative and potential therapeutic properties. Systems for the controlled release of drugs offer a number of benefits comparing with traditional forms of medicines and because of that these systems are widely researched. The objective of this paper is to investigate the possibility of using liposomes as carriers of polyphenols and influence the membrane composition on the release rate of encapsulated polyphenols. Experiments show how the membrane modification affects the mass transfer comparing to a conventional liposomes. Liposomes were modified with surfactants Tween 20 and Tween 60, and thyme tea extract was used as a source of polyphenols. The diffusion of polyphenols from thyme extract, dispersion of conventional liposomes and liposomes modified with Tween 20 and Tween 60 was studied using Franz diffusion cell. From the experimental data diffusion coefficients were determined for each of the systems, as well as the corresponding diffusion resistances. From the obtained results it can be concluded that the encapsulation of polyphenols in liposomes significantly slows diffusion, and with membrane modification can be achieved further slowing. The diffusion resistance of the liposome membrane modified with Tween 20 and Tween 60 is about 5 times higher compared to the diffusion of unencapsulated polyphenols from the thyme extract.

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