Quality assessment of corn snacks enriched with soybean ferritin among young healthy people and patient with Crohn’s disease: the effect of extrusion conditions

2021 ◽  
Author(s):  
Krystyna Szymandera‐Buszka ◽  
Magdalena Zielińska‐Dawidziak ◽  
Agnieszka Makowska ◽  
Małgorzata Majcher ◽  
Anna Jędrusek‐Golińska ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Quality Assessment ◽  
Healthy People ◽  
Corn Snacks

scholarly journals The role of enteroclysis and roentgen anatomy of jejunum and ileumin Crohn's disease

2005 ◽  
Vol 58 (9-10) ◽  
pp. 437-443
Author(s):  
Dragan Krivokuca ◽  
Djordjije Saranovic ◽  
Milivoje Vukovic ◽  
Laslo Puskas ◽  
Gordana Stankovic ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Gastrointestinal Symptom ◽  
Morphological Changes ◽  
Healthy People ◽  
Control Group ◽  
Study Group ◽  
Double Contrast ◽  
Mucosal Folds

Introduction The aims of this research were: I) to establish the value ofen-teroclysis in detection of morphological changes of jejunum and ileum in cases with suspected Crohn's disease and 2) to establish types of morphological changes of jejunum and ileum in patients with Crohn's disease. Material and methods The study compared two groups of people who voluntarily accepted to be examined: a control group and a study group. The control group included 11 healthy people, without gastrointestinal symptom. The study group included 16 patients with Crohn's disease. Single and double-contrast enteroclysis were performed in both groups. Afterwards, we defined parameters which were compared in these groups. Conclusions We concluded that according to statistics there are significantly lower values of the width of the jejunal and Heal lumen and the number of mucosa/folds (per I cm) of the jejunal and Heal wall in the examined group in contrast to the control group. Also, according to statistics there are significantly higher values of the width of the jejunal and ileal wall and the thickness of mucosal folds of the jejunum and ileum in the study group in contrast to the control group.

Evidence Quality Assessment for Use of Capsule Endoscopy (CE) in Suspected Small Bowel Crohn's Disease (CD)

2009 ◽  
Vol 69 (5) ◽  
pp. AB316
Author(s):  
Ian M. Gralnek ◽  
Jonathan A. Leighton ◽  
Michael J. Lacey ◽  
Julie W. Doberne ◽  
Randel E. Richner ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Small Bowel ◽  
Crohn's Disease ◽  
Quality Assessment ◽  
Capsule Endoscopy ◽  
Evidence Quality

scholarly journals The Crohn’s Disease and Proinflammatory Cytokines

2021 ◽  
Author(s):  
Ahmed Al Qteishat ◽  
Kiril Kirov ◽  
Dmitry O. Bokov
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Proinflammatory Cytokines ◽  
Activity Index ◽  
Systemic Reaction ◽  
The Body ◽  
Healthy People ◽  
Control Group ◽  
Tnf Α ◽  
Ifn Γ

Abstract The aim of the study was to examine the profile of the main proinflammatory cytokines in the serum of patients with Crohn's disease and establish their association with the severity and activity of the disease. A total of 61 patients (29 women (47.5%), 32 men (52.5%) aged from 18 to 40 years (mean age (30.42 ± 2.51) years) with the verified diagnosis of Crohn's disease in the active phase were examined. The control group consisted of 30 virtually healthy people (VHP) of corresponding age. Crohn's disease is characterized by reliable (p<0.05) increase of pro-inflammatory cytokines in blood compared to virtually healthy people: TNF-α – by 4.45 times (p<0.05), IL-1α – by 5.08 times (p<0.05), IL-6 – by 2.16 times (p<0.05), IL-8 – by 2.04 times (p<0.05), and IFN-γ – by 5.30 times (p<0.05), which can be due to the development of the active inflammatory process in the intestine and the systemic reaction of the body. The degree of increase in TNF-α and IFN-γ content, as well as the presence of direct correlations between the Best activity index and the content of these cytokines in the blood of the examined patients, confirm their leading role in the cascade of immune-inflammatory reactions during Crohn's disease.

Strategies to Distinguish Perianal Fistulas Related to Crohn’s Disease From Cryptoglandular Disease: Systematic Review With Meta-Analysis

2021 ◽  
Author(s):  
Kevin Chin Koon Siw ◽  
Jake Engel ◽  
Samantha Visva ◽  
Ranjeeta Mallick ◽  
Ailsa Hart ◽  
...  
Keyword(s):  
Systematic Review ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Diagnostic Accuracy ◽  
Quality Assessment ◽  
Fixed Effects ◽  
Meta Analysis ◽  
Pelvic Mri ◽  
Perianal Fistulas ◽  
Imaging Characteristics

Abstract Background Management of perianal fistulas differs based on fistula type. We aimed to assess the ability of diagnostic strategies to differentiate between Crohn’s disease (CD) and cryptoglandular disease (CGD) in patients with perianal fistulas. Methods We performed a diagnostic accuracy systematic review and meta-analysis. A systematic search of electronic databases was performed from inception through February 2021 for studies assessing a diagnostic test’s ability to distinguish fistula types. We calculated weighted summary estimates with 95% confidence intervals for sensitivity and specificity by bivariate analysis, using fixed effects models when data were available from 2 or more studies. The Quality Assessment of Diagnostic Accuracy Studies tool was used to assess study quality. Results Twenty-one studies were identified and included clinical symptoms (2 studies; n=154), magnetic resonance imaging (MRI) characteristics (3 studies; n=296), ultrasound characteristics (7 studies; n=1003), video capsule endoscopy (2 studies; n=44), fecal calprotectin (1 study; n=56), and various biomarkers (8 studies; n=440). MRI and ultrasound characteristics had the most robust data. Rectal inflammation, multiple-branched fistula tracts, and abscesses on pelvic MRI and the Crohn’s ultrasound fistula sign, fistula debris, and bifurcated fistulas on pelvic ultrasonography had high specificity (range, 80%-95% vs 89%-96%) but poor sensitivity (range, 17%-37% vs 31%-63%), respectively. Fourteen of 21 studies had risk of bias on at least 1 of the Quality Assessment of Diagnostic Accuracy Studies domains. Conclusions Limited high-quality evidence suggest that imaging characteristics may help discriminate CD from CGD in patients with perianal fistulas. Larger, prospective studies are needed to confirm these findings and to evaluate if combining multiple diagnostic tests can improve diagnostic sensitivity.

scholarly journals Mechanisms and effectiveness of prebiotics in modifying the gastrointestinal microbiota for the management of digestive disorders

2013 ◽  
Vol 72 (3) ◽  
pp. 288-298 ◽  
Author(s):  
Kevin Whelan
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Enteral Nutrition ◽  
Human Subjects ◽  
Healthy People ◽  
Cell Phenotype ◽  
Gastrointestinal Microbiota ◽  
Healthy Human ◽  
Healthy Human Subjects ◽  
Digestive Disorders

The gastrointestinal microbiota is a complex ecosystem with each human individual hosting at least 160 different bacterial strains. Our understanding of its role is rapidly expanding as a result of the molecular microbiological techniques that can accurately characterise its composition and ‘omics’ technologies that measure its metabolic activity. Since 1995, extensive research has investigated the prebiotic concept, which describes how supplementation of some non-digestible oligosaccharides can stimulate the growth and/or activity of specific genera including bifidobacteria. However, the vast majority of studies are in healthy human subjects, with few undertaken in patients with disorders relevant to clinical nutrition. Marked alterations of the luminal microbiota have been demonstrated in patients with digestive disorders, highlighting mechanisms through which they might be involved in their pathogenesis, including higher clostridia in patients who develop diarrhoea during enteral nutrition and the influence of bifidobacteria on intestinal dendritic cell phenotype in Crohn's disease. The impact of prebiotics on the intestinal microbiota of healthy people has not been consistently replicated in patients with digestive disorders. For example, a number of studies show that inulin/oligofructose do not increase bifidobacteria in enteral nutrition and Crohn's disease. Indeed, in Crohn's disease and irritable bowel syndrome there is evidence that some prebiotics in high doses worsen functional symptoms. Unlike healthy human subjects, patients experience a number of issues that may alter their gastrointestinal microbiota (disease, antibiotics and inflammation) and the use of microbiota modifying therapies, such as prebiotics, do not always elicit the same effects in patients as they do in healthy people.

scholarly journals Serum agglutinins toEubacteriumandPeptostreptococcusspecies in Crohn's and other diseases

1981 ◽  
Vol 87 (1) ◽  
pp. 13-24 ◽  
Author(s):  
F. Wensinck ◽  
J. P. van de Merwe
Keyword(s):  
Ulcerative Colitis ◽  
Crohn’S Disease ◽  
Ankylosing Spondylitis ◽  
Discriminant Analysis ◽  
Crohn's Disease ◽  
Healthy Subjects ◽  
Healthy People ◽  
A Posteriori ◽  
Granulomatous Diseases ◽  
Peptostreptococcus Productus

SummarySera from patients suffering from Crohn's and other diseases and from healthy subjects were tested for agglutinins to anaerobic, gram-positive coccoid rods belonging to species ofEubacteriumandPeptostreptococcus. Four strains labelledEubacterium contortum(two strains),Eubacterium rectaleandPeptostreptococcus productuswere agglutinated by a higher percentage of sera from patients with Crohn's disease than from healthy subjects and from patients with liver and intestinal diseases (including ulcerative colitis), ankylosing spondylitis, granulomatous diseases, diseases of immunity and malignancies.The agglutinins were of the IgG and IgM classes and strain-specific; the titres were low.The results obtained with sera from patients with Crohn's disease and healthy people were subjected to discriminant analysis to estimate the probability, based on the combined results with the four strains, that a patient suffers from Crohn's disease. When sera giving ana posterioriprobability ≥ 0·95 (aprioriprobability = 0·5) were considered positive, the test with four strains had a sensitivity of 54% and a, specificity of nearly 100%. The results with sera submitted for diagnosis showed that positive reactions in patients with a diagnosis apparently incompatible with Crohn's disease were within acceptable limits.

On-table endoscopy to define strictures and resection margins: experience from 178 operations for Crohn's disease using intraoperative endoscopy

2001 ◽  
Vol 3 (Supplement 2) ◽  
pp. 58-62
Author(s):  
G. Olaison ◽  
P. Andersson ◽  
P. Myrelid ◽  
K. Smedh ◽  
J. Soderholm ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Resection Margins ◽  
Intraoperative Endoscopy

The natural history of Crohn's disease: prevalence in Europe and the cancer risk

2001 ◽  
Vol 3 (Supplement 2) ◽  
pp. 51-53
Author(s):  
M.D. Hellier
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Natural History ◽  
Cancer Risk ◽  
Disease Prevalence ◽  
History Of

Granulomatous perivasculitis in Crohn's disease

1981 ◽  
Vol 117 (10) ◽  
pp. 674-675 ◽  
Author(s):  
W. Burgdorf
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease

MRI imaging of the effects of infliximab in perianal fistulizing Crohn's disease

2001 ◽  
Vol 120 (5) ◽  
pp. A68-A68
Author(s):  
G VANASSCHE ◽  
D VANBECKEVOORT ◽  
D BIELEN ◽  
G COREMANS ◽  
I AERDEN ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Mri Imaging
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