scholarly journals The importance of polyreactive antibodies in protection against pneumococcal infection

Immunology ◽  
2021 ◽  
Vol 162 (4) ◽  
pp. 339-340
Author(s):  
Simon Milling
Keyword(s):  
Pneumococcal Infection ◽  
Polyreactive Antibodies

RESULTS OF VACCINATION AGAINST PNEUMOCOCCAL INFECTION IN CHILDREN WITH RECURRENT BRONCHITIS

2017 ◽  
Vol 96 (4) ◽  
pp. 146-150
Author(s):  
O. I. Golubtsova ◽  
◽  
N. P. Andreeva ◽  
M. P. Kostinov ◽  
A. M. Kostinov ◽  
...  
Keyword(s):  
Pneumococcal Infection

scholarly journals Antimicrobial resistance profile and multidrug resistance patterns of Streptococcus pneumoniae isolates from patients suspected of pneumococcal infections in Ethiopia

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Bekele Sharew ◽  
Feleke Moges ◽  
Gizachew Yismaw ◽  
Wondwossen Abebe ◽  
Surafal Fentaw ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Streptococcus Pneumoniae ◽  
Antimicrobial Resistance ◽  
Addis Ababa ◽  
Pneumococcal Infection ◽  
Test Method ◽  
Resistance Testing ◽  
Global Public Health ◽  
Pneumococcal Infections ◽  
Resistance Patterns

Abstract Background Antimicrobial-resistant strains of Streptococcus pneumoniae have become one of the greatest challenges to global public health today and inappropriate use of antibiotics and high level of antibiotic use is probably the main factor driving the emergence of resistance worldwide. The aim of this study is, therefore, to assess the antimicrobial resistance profiles and multidrug resistance patterns of S. pneumoniae isolates from patients suspected of pneumococcal infections in Ethiopia. Methods A hospital-based prospective study was conducted from January 2018 to December 2019 at Addis Ababa city and Amhara National Region State Referral Hospitals. Antimicrobial resistance tests were performed from isolates of S. pneumoniae that were collected from pediatric and adult patients. Samples (cerebrospinal fluid, blood, sputum, eye discharge, ear discharge, and pleural and peritoneal fluids) from all collection sites were initially cultured on 5% sheep blood agar plates and incubated overnight at 37 °C in a 5% CO2 atmosphere. Streptococcus pneumoniae was identified and confirmed by typical colony morphology, alpha-hemolysis, Gram staining, optochin susceptibility, and bile solubility test. Drug resistance testing was performed using the E-test method according to recommendations of the Clinical and Laboratory Standards Institute. Results Of the 57 isolates, 17.5% were fully resistant to penicillin. The corresponding value for both cefotaxime and ceftriaxone was 1.8%. Resistance rates to erythromycin, clindamycin, tetracycline, chloramphenicol and trimethoprim-sulfamethoxazole were 59.6%, 17.5%, 38.6%, 17.5 and 24.6%, respectively. Multidrug resistance (MDR) was seen in 33.3% isolates. The most common pattern was co-resistance to penicillin, erythromycin, clindamycin, and tetracycline. Conclusions Most S. pneumoniae isolates were susceptible to ceftriaxone and cefotaxime. Penicillin has been used as a drug of choice for treating S. pneumoniae infection. However, antimicrobial resistance including multidrug resistance was observed to several commonly used antibiotics including penicillin. Hence, it is important to periodically monitor the antimicrobial resistance patterns to select empirical treatments for better management of pneumococcal infection.

Importance of Phosphoinositide 3-Kinase γ in the Host Defense against Pneumococcal Infection

2007 ◽  
Vol 175 (9) ◽  
pp. 958-966 ◽  
Author(s):  
Ulrich A. Maus ◽  
Myriam Backi ◽  
Christine Winter ◽  
Mrigank Srivastava ◽  
Matthias K. Schwarz ◽  
...  
Keyword(s):  
Host Defense ◽  
Pneumococcal Infection ◽  
Phosphoinositide 3 Kinase

scholarly journals Streptococcus pneumoniae Serotype-2 Childhood Meningitis in Bangladesh: A Newly Recognized Pneumococcal Infection Threat

PLoS ONE ◽  
2012 ◽  
Vol 7 (3) ◽  
pp. e32134 ◽  
Author(s):  
Samir K. Saha ◽  
Hassan M. Al Emran ◽  
Belal Hossain ◽  
Gary L. Darmstadt ◽  
Senjuti Saha ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Pneumococcal Infection

scholarly journals Complement Activation by C-Reactive Protein Is Critical for Protection of Mice Against Pneumococcal Infection

2020 ◽  
Vol 11 ◽  
Author(s):  
Sanjay K. Singh ◽  
Donald N. Ngwa ◽  
Alok Agrawal
Keyword(s):  
Complement Activation ◽  
Pneumococcal Infection ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals The Respiratory Commensal Bacterium Dolosigranulum pigrum 040417 Improves the Innate Immune Response to Streptococcus pneumoniae

2021 ◽  
Vol 9 (6) ◽  
pp. 1324
Author(s):  
Fernanda Raya Tonetti ◽  
Mikado Tomokiyo ◽  
Ramiro Ortiz Moyano ◽  
Sandra Quilodrán-Vega ◽  
Hikari Yamamuro ◽  
...  
Keyword(s):  
Immune Response ◽  
Streptococcus Pneumoniae ◽  
Innate Immune Response ◽  
Pneumococcal Infection ◽  
Innate Immune ◽  
Nasal Administration ◽  
Commensal Bacterium ◽  
Beneficial Effects ◽  
Immunological Mechanisms ◽  
Immunomodulatory Properties

Previously, we demonstrated that the nasal administration of Dolosigranulum pigrum 040417 differentially modulated the respiratory innate immune response triggered by the activation of Toll-like receptor 2 in infant mice. In this work, we aimed to evaluate the beneficial effects of D. pigrum 040417 in the context of Streptococcus pneumoniae infection and characterize the role of alveolar macrophages (AMs) in the immunomodulatory properties of this respiratory commensal bacterium. The nasal administration of D. pigrum 040417 to infant mice significantly increased their resistance to pneumococcal infection, differentially modulated respiratory cytokines production, and reduced lung injuries. These effects were associated to the ability of the 040417 strain to modulate AMs function. Depletion of AMs significantly reduced the capacity of the 040417 strain to improve both the reduction of pathogen loads and the protection against lung tissue damage. We also demonstrated that the immunomodulatory properties of D. pigrum are strain-specific, as D. pigrum 030918 was not able to modulate respiratory immunity or to increase the resistance of mice to an S. pneumoniae infection. These findings enhanced our knowledge regarding the immunological mechanisms involved in modulation of respiratory immunity induced by beneficial respiratory commensal bacteria and suggested that particular strains could be used as next-generation probiotics.

Prevention of Pneumococcal Infection With Vaccines

JAMA ◽  
2012 ◽  
Vol 307 (8) ◽  
Author(s):  
Eugene D. Shapiro
Keyword(s):  
Pneumococcal Infection
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