Genetic variations in the genes encoding receptor activator nuclear factor κ B (RANK), receptor activator nuclear factor κ B ligand (RANKL) and osteoprotegerin (OPG) in patients with psoriasis and psoriatic arthritis: A case-control study

2010 ◽  
Vol 38 (6) ◽  
pp. 519-523 ◽  
Author(s):  
Gunter ASSMANN ◽  
Claudia PFOEHLER ◽  
Pierre SIMON ◽  
Michael PFREUNDSCHUH ◽  
Wolfgang TILGEN ◽  
...  
Keyword(s):  
Psoriatic Arthritis ◽  
Case Control Study ◽  
Case Control ◽  
Genetic Variations ◽  
Nuclear Factor ◽  
Receptor Activator ◽  
Genes Encoding ◽  
Nuclear Factor Κ B ◽  
Control Study

scholarly journals Relation of therapies for ankylosing spondylitis and psoriatic arthritis to risk of myocardial infarction: a nested case control study

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Rachael Stovall ◽  
Christine Peloquin ◽  
David Felson ◽  
Tuhina Neogi ◽  
Maureen Dubreuil
Keyword(s):  
Myocardial Infarction ◽  
Psoriatic Arthritis ◽  
Ankylosing Spondylitis ◽  
Case Control Study ◽  
Tumor Necrosis Factor Inhibitor ◽  
The United States ◽  
Case Control ◽  
Geographical Regions ◽  
Nested Case Control ◽  
Control Study

Abstract Background Risk of myocardial infarction (MI) is elevated in ankylosing spondylitis and psoriatic arthritis (AS/PsA) compared to the general population. We evaluated the risk of MI related to the use of tumor necrosis factor inhibitor (TNFi) and other therapies in AS/PsA. Methods We conducted a nested case-control study using 1994–2018 data from OptumLabs® Data Warehouse, which includes de-identified medical and pharmacy claims, laboratory results, and enrollment records for commercial and Medicare Advantage enrollees. The database contains longitudinal health information on enrollees and patients, representing a diverse mixture of ages, ethnicities and geographical regions across the United States. Assessing AS/PsA separately, MI cases were matched to 4 controls by sex, age, diagnosis year and insurance type. We evaluated treatment within 6 months prior to MI including NSAIDs (AS referent), disease-modifying anti-rheumatic drug (DMARDs; PsA referent) and TNFi alone or in combinations. We evaluated the relation of treatment categories to MI risk using conditional logistical regression adjusting for confounders. Results Among 26,648 AS subjects, there were 237 MI cases and 894 matched controls. Among 43,734 PsA subjects, there were 404 cases and 1596 controls. In AS, relative to NSAID use, the adjusted odds ratio (aOR) for MI among TNFi only users was 0.85 (95% CI 0.39–1.85) and for DMARD only users was 1.04 (95% CI 0.65–1.68). In PsA, relative to DMARD use, the aOR among TNFi only was 1.09 (95% CI 0.74–1.60). Combination therapies also had no effect. Conclusions Among AS/PsA, no combination of therapies appeared to be protective or harmful with regards to MI. Future studies should capture more AS and PsA patients and include longer term follow up to further investigate this question.

scholarly journals Subclinical atherosclerosis in patients with psoriatic arthritis: a case-control study. Preliminary data

Reumatismo ◽  
2011 ◽  
Vol 61 (4) ◽  
Author(s):  
C. Contessa ◽  
R. Ramonda ◽  
A. Lo Nigro ◽  
V. Modesti ◽  
M. Lorenzin ◽  
...  
Keyword(s):  
Psoriatic Arthritis ◽  
Preliminary Data ◽  
Case Control Study ◽  
Subclinical Atherosclerosis ◽  
Case Control ◽  
Control Study

scholarly journals Histamine-1 Receptors Expression in Primary Pterygium Tissue is Higher than Normal Conjunctival Tissue

2019 ◽  
Vol 12 (3) ◽  
pp. 1441-1448
Author(s):  
Putu Yuliawati ◽  
Cynthia Dewi M ◽  
A A A Sukartini Djelantik ◽  
Putu Budhiastra ◽  
N K Niti Susila
Keyword(s):  
Cell Proliferation ◽  
Observational Study ◽  
Case Control Study ◽  
Case Control ◽  
Eye Disease ◽  
Nuclear Factor ◽  
Study Approach ◽  
Final Score ◽  
Control Study ◽  
Primary Pterygium

Pterygium is an eye disease with multifactorial etiopathogenesis. Molecular factors such as cell proliferation and inflammatory mediators are associated with increased calcium mobilization and activation of nuclear factor kβ mediated by histamine-1 receptors (H1R). This study aims to determine whether the expression of H1R primary pterygium tissue is higher than normal conjunctival tissue and the expression of H1R based on pterygium grades. This study was an analytic observational study with a case-control study approach at Sanglah General Hospital, Bali Mandara Eye Hospital, and Mangusada Hospital. The study was conducted from November 2017 to April 2018. The pterygium and conjunctival tissues obtained from 28 subjects in the same eye and examined for H1R expression by immunohistochemistry. The results of this study obtained 64.3% of women with a mean age of 54.2 ± 7.8 years. There was no difference in mean H1R expression between pterygium grades in the final score (P = 0.759). There was a mean difference of H1R between primary pterygium (42.50) and normal conjunctival tissue (14.50) with P <0.001. Only tissue types affected the expression of H1R in the final score (B = 4.893; 95% CI 4.363-5.423; P <0.001). It was concluded that the expression of H1R primary pterygium tissue was higher in primary pterygium than normal conjunctival tissue.

scholarly journals Epigenetic role of the nuclear factor NF-Y on ID gene family in endometrial tissues of women with endometriosis: a case control study

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Shirin Amirteimouri ◽  
Manan Ashini ◽  
Fariba Ramazanali ◽  
Reza Aflatoonian ◽  
Parvaneh Afsharian ◽  
...  
Keyword(s):  
Gene Family ◽  
Case Control Study ◽  
Case Control ◽  
Nuclear Factor ◽  
Control Study

scholarly journals Prediabetes Is Associated withHNF-4αP2 Promoter Polymorphism rs1884613: A Case-Control Study in Han Chinese Population and an Updated Meta-Analysis

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Changyi Wang ◽  
Sihan Chen ◽  
Tao Zhang ◽  
Zhongwei Chen ◽  
Shengyuan Liu ◽  
...  
Keyword(s):  
Chinese Population ◽  
Case Control Study ◽  
Meta Analysis ◽  
Promoter Polymorphism ◽  
Case Control ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
P2 Promoter ◽  
Control Study

Background. Controversy remains for the association between hepatocyte nuclear factor4α(HNF-4α) P2 promoter polymorphism rs1884613 and type 2 diabetes (T2D). There was no association test of this polymorphism with prediabetes and T2D in the Chinese population. Moreover, an updated meta-analysis in various ethnic groups is needed to establish the contribution of rs1884613 to T2D risk.Methods. Using the Sequenom MassARRAY platform approach, we genotyped rs1884613 ofHNF-4αin the P2 promoter region among 490 T2D patients, 471 individuals with prediabetes, and 575 healthy controls. All the individuals were recruited from 16 community health service centers in Nanshan district in Shenzhen province. Using STATA 11.0 software, meta-analysis was performed to summarize the overall contribution of rs1884613 to T2D risk.Results. Polymorphism rs1884613 was associated with genetic susceptibility to prediabetes in the whole samples (OR = 1.40, 95% CI = 1.16–1.68,P=0.0001) and the female subgrouped samples (OR = 1.48, 95% CI = 1.14–1.92,P=0.003) after adjusting for age and body mass index (BMI). In contrast, there was no association of rs1884613 with T2D in the whole samples and male in our case-control study and meta-analysis.Conclusions. Our results suggest that rs1884613 contributes to susceptibility to prediabetes, whereas this polymorphism may not play an important role in the development of T2D.

Genetic variations in LTA gene and PDCD1 gene and intrauterine infection of hepatitis B virus: a case–control study in China

Amino Acids ◽  
2018 ◽  
Vol 50 (7) ◽  
pp. 877-883 ◽  
Author(s):  
Tingting Liu ◽  
Zhihua Wan ◽  
Songxu Peng ◽  
Yanni Wang ◽  
Hongyan Chen ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Case Control Study ◽  
Intrauterine Infection ◽  
Case Control ◽  
Genetic Variations ◽  
B Virus ◽  
Control Study
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