Pathophysiology of NSAID-induced gastroduodenal damage: epidemiology and mechanisms of action of therapeutic agents

2007 ◽  
Vol 5 ◽  
pp. 91-98 ◽  
Author(s):  
K. J. IVEY
Keyword(s):  
Therapeutic Agents ◽  
Mechanisms Of Action ◽  
Gastroduodenal Damage

Autophagy Modulators and Neuroinflammation

2020 ◽  
Vol 27 (6) ◽  
pp. 955-982 ◽  
Author(s):  
Kyoung Sang Cho ◽  
Jang Ho Lee ◽  
Jeiwon Cho ◽  
Guang-Ho Cha ◽  
Gyun Jee Song
Keyword(s):  
Neurodegenerative Disorders ◽  
Neurological Disorders ◽  
Mammalian Cells ◽  
Critical Role ◽  
Therapeutic Agents ◽  
Mechanisms Of Action ◽  
Scientific Interest ◽  
Therapeutic Tools ◽  
Underlying Mechanisms

Background: Neuroinflammation plays a critical role in the development and progression of various neurological disorders. Therefore, various studies have focused on the development of neuroinflammation inhibitors as potential therapeutic tools. Recently, the involvement of autophagy in the regulation of neuroinflammation has drawn substantial scientific interest, and a growing number of studies support the role of impaired autophagy in the pathogenesis of common neurodegenerative disorders. Objective: The purpose of this article is to review recent research on the role of autophagy in controlling neuroinflammation. We focus on studies employing both mammalian cells and animal models to evaluate the ability of different autophagic modulators to regulate neuroinflammation. Methods: We have mostly reviewed recent studies reporting anti-neuroinflammatory properties of autophagy. We also briefly discussed a few studies showing that autophagy modulators activate neuroinflammation in certain conditions. Results: Recent studies report neuroprotective as well as anti-neuroinflammatory effects of autophagic modulators. We discuss the possible underlying mechanisms of action of these drugs and their potential limitations as therapeutic agents against neurological disorders. Conclusion: Autophagy activators are promising compounds for the treatment of neurological disorders involving neuroinflammation.

Potential mechanisms of action of convalescent plasma in COVID-19

Diagnosis ◽  
2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Massimo Franchini ◽  
Claudia Glingani ◽  
Giancarlo Maria Liumbruno
Keyword(s):  
Therapeutic Agents ◽  
Mechanisms Of Action ◽  
Narrative Review ◽  
Hypercoagulable State ◽  
Human History ◽  
Catastrophic Events ◽  
Immune Mechanisms ◽  
Anti Inflammatory

Abstract The COVID-19 pandemic will be remembered as one of the worst catastrophic events in human history. Unfortunately, no universally recognized effective therapeutic agents are currently available for the treatment of severe SARS-CoV-2 infection. In this context, the use of convalescent plasma from recovered COVID-19 patients has gained increasing interest thanks to the initially positive clinical reports. A number of mechanisms of action have been proposed for convalescent plasma, including direct neutralization and suppression of viremia, anti-inflammatory and immunomodulation effects and mitigation of the COVID-19-associated hypercoagulable state. These immune and non-immune mechanisms will be critically discussed in this narrative review.

scholarly journals Activity of Anti-Microbial Peptides (AMPs) against Leishmania and Other Parasites: An Overview

Biomolecules ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 984
Author(s):  
Rima El-Dirany ◽  
Hawraa Shahrour ◽  
Zeinab Dirany ◽  
Fadi Abdel-Sater ◽  
Gustavo Gonzalez-Gaitano ◽  
...  
Keyword(s):  
Innate Immune System ◽  
Therapeutic Agents ◽  
Mechanisms Of Action ◽  
Innate Immune ◽  
Biologically Active ◽  
Neglected Tropical Disease ◽  
Parasitic Diseases ◽  
Promising Alternative ◽  
Parasitic Effect ◽  
Anti Fungal

Anti-microbial peptides (AMPs), small biologically active molecules, produced by different organisms through their innate immune system, have become a considerable subject of interest in the request of novel therapeutics. Most of these peptides are cationic-amphipathic, exhibiting two main mechanisms of action, direct lysis and by modulating the immunity. The most commonly reported activity of AMPs is their anti-bacterial effects, although other effects, such as anti-fungal, anti-viral, and anti-parasitic, as well as anti-tumor mechanisms of action have also been described. Their anti-parasitic effect against leishmaniasis has been studied. Leishmaniasis is a neglected tropical disease. Currently among parasitic diseases, it is the second most threating illness after malaria. Clinical treatments, mainly antimonial derivatives, are related to drug resistance and some undesirable effects. Therefore, the development of new therapeutic agents has become a priority, and AMPs constitute a promising alternative. In this work, we describe the principal families of AMPs (melittin, cecropin, cathelicidin, defensin, magainin, temporin, dermaseptin, eumenitin, and histatin) exhibiting a potential anti-leishmanial activity, as well as their effectiveness against other microorganisms.

scholarly journals Antidiabetic Effects of Resveratrol: The Way Forward in Its Clinical Utility

2016 ◽  
Vol 2016 ◽  
pp. 1-14 ◽  
Author(s):  
Omolola R. Oyenihi ◽  
Ayodeji B. Oyenihi ◽  
Anne A. Adeyanju ◽  
Oluwafemi O. Oguntibeju
Keyword(s):  
Diabetes Mellitus ◽  
Clinical Utility ◽  
Therapeutic Agent ◽  
Molecular Targets ◽  
Therapeutic Agents ◽  
Mechanisms Of Action ◽  
Antidiabetic Drug ◽  
Near Future ◽  
Antidiabetic Effects ◽  
The Way

Despite recent advances in the understanding and management ofdiabetes mellitus, the prevalence of the disease is increasing unabatedly with resulting disabling and life-reducing consequences to the global human population. The limitations and side effects associated with current antidiabetic therapies have necessitated the search for novel therapeutic agents. Due to the multipathogenicity ofdiabetes mellitus,plant-derived compounds with proven multiple pharmacological actions have been postulated to “hold the key” in the search for an affordable, efficacious, and safer therapeutic agent in the treatment of the disease and associated complications. Resveratrol, a phytoalexin present in few plant species, has demonstrated beneficial antidiabetic effects in animals and humans through diverse mechanisms and multiple molecular targets. However, despite the enthusiasm and widespread successes achieved with the use of resveratrol in animal models ofdiabetes mellitus, there are extremely limited clinical data to confirm the antidiabetic qualities of resveratrol. This review presents an update on the mechanisms of action and protection of resveratrol indiabetes mellitus, highlights challenges in its clinical utility, and suggests the way forward in translating the promising preclinical data to a possible antidiabetic drug in the near future.

scholarly journals Mechanisms of action and adverse effects of the major therapeutic agents in trial for COVID-19 therapeutics: review of literature

2020 ◽  
Author(s):  
Emeka Ogiji ◽  
Obumneme Ezeanosike ◽  
Casimir Ofor ◽  
Edak Ezeanosike ◽  
Charles Maduba ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Therapeutic Agents ◽  
Mechanisms Of Action ◽  
Review Of Literature

scholarly journals Rationale of Immunotherapy in Hepatocellular Carcinoma and Its Potential Biomarkers

Cancers ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 1926 ◽  
Author(s):  
David Tai ◽  
Su Pin Choo ◽  
Valerie Chew
Keyword(s):  
Hepatocellular Carcinoma ◽  
Response Rate ◽  
Single Agent ◽  
Predictive Biomarkers ◽  
Therapeutic Agents ◽  
Immune Checkpoint Blockade ◽  
Mechanisms Of Action ◽  
Common Type ◽  
Combination Therapies ◽  
Treatment Benefit

Hepatocellular carcinoma (HCC), the most common type of liver cancer, is derived mostly from a background of chronic inflammation. Multiple immunotherapeutic strategies have been evaluated in HCC, with some degree of success, particularly with immune checkpoint blockade (ICB). Despite the initial enthusiasm, treatment benefit is only appreciated in a modest proportion of patients (response rate to single agent ~20%). Therapy-induced immune-related adverse events (irAEs) and economic impact are pertinent considerations with ICB. It is imperative that a deeper understanding of its mechanisms of action either as monotherapy or in combination with other therapeutic agents is needed. We herein discuss the latest developments in the immunotherapeutic approaches for HCC, the potential predictive biomarkers and the rationale for combination therapies. We also outline promising future immunotherapeutic strategies for HCC patients.

Phyto-anti-estrogens are potential selective modifiers of biological reactions in breast cancer

2016 ◽  
Vol 21 (4) ◽  
pp. 212-219 ◽  
Author(s):  
Juliya A. Borisova ◽  
G. B Smirnova ◽  
I. Zh Shubina ◽  
Z. S Shprakh ◽  
E. M Treshchalina
Keyword(s):  
Breast Cancer ◽  
Proliferative Activity ◽  
Estrogen Therapy ◽  
Therapeutic Agents ◽  
Mechanisms Of Action ◽  
Present Knowledge ◽  
Estrogen Action ◽  
In Vivo Models ◽  
Positive Breast Cancer

The review analyzes up-to-date information about specific characteristics of anti-estrogen therapeutic agents with different mechanisms of action with regard to present knowledge of endocrine therapy for estrogen-positive breast cancer (ER+ BC). The paper presents some agents for anti-estrogen therapy of breast cancer - aromatase inhibitors and selective modifiers of biological reactions (SMBR) and their mechanisms of anti-proliferative action. The authors describe significant therapeutic and side effects as well as different options for anti-estrogen combinations. Special emphasis is made on national herbal estrogens/anti-estrogens that have no toxicity associated with the well-known SMBRs. The review presents the structure and characteristics of a perspective phyto-anti-estrogen sekoizolaricirezinol (SEKO), which demonstrated significant anti-proliferative activity with no pro-estrogen action in the in vivo models of ER+ BC.

scholarly journals Targeting Melanoma with Cancer-Killing Viruses

2017 ◽  
Vol 11 (1) ◽  
pp. 28-47 ◽  
Author(s):  
Tiantian Zhang ◽  
Yogesh R. Suryawanshi ◽  
Helene M. Woyczesczyk ◽  
Karim Essani
Keyword(s):  
Immune Responses ◽  
Therapeutic Agents ◽  
Mechanisms Of Action ◽  
Oncolytic Viruses ◽  
Significant Morbidity ◽  
Cellular Mechanisms ◽  
Tumor Reduction ◽  
Oncolytic Activity ◽  
Modified Forms ◽  
Novel Therapeutic

Melanoma is the deadliest skin cancer with ever-increasing incidence. Despite the development in diagnostics and therapies, metastatic melanoma is still associated with significant morbidity and mortality. Oncolytic viruses (OVs) represent a class of novel therapeutic agents for cancer by possessing two closely related properties for tumor reduction: virus-induced lysis of tumor cells and induction of host anti-tumor immune responses. A variety of viruses, either in “natural” or in genetically modified forms, have exhibited a remarkable therapeutic efficacy in regressing melanoma in experimental and/or clinical studies. This review provides a comprehensive summary of the molecular and cellular mechanisms of action of these viruses, which involve manipulating and targeting the abnormalities of melanoma, and can be categorized as enhancing viral tropism, targeting the tumor microenvironment and increasing the innate and adaptive antitumor responses. Additionally, this review describes the “biomarkers” and deregulated pathways of melanoma that are responsible for melanoma initiation, progression and metastasis. Advances in understanding these abnormalities of melanoma have resulted in effective targeted and immuno-therapies, and could potentially be applied for engineering OVs with enhanced oncolytic activity in future.

scholarly journals Clinical Delivery of Therapeutic Agents Based on Metals

1997 ◽  
Vol 4 (3) ◽  
pp. 133-135
Author(s):  
John Fox
Keyword(s):  
Clinical Practice ◽  
Therapeutic Agents ◽  
Mechanisms Of Action ◽  
The Body ◽  
Toxic Effects ◽  
Metal Chemistry

Metals have been used in clinical practice for hundreds of years and for a variety of indications. Although potent agents whose activity may be adapted by manipulation of their chemistry and that of associated ligands, their use has been limited by toxic effects. There is now a burgeoning series of delivery technologies available which may be adapted to the administration of metal based drugs. Together with greater understanding of metal chemistry and their mechanisms of action in disease processes, there is an opportunity to increase the use of metals in medicine by targeting their action more effectively to the therapeutic site and/or protecting the body from toxic effects.

Traditional uses, biological activities, and phytochemicals of Lecaniodiscus cupanioides: a review

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Olusesan Ojo ◽  
Derek T. Ndinteh
Keyword(s):  
Skin Infection ◽  
Biological Activities ◽  
Therapeutic Agents ◽  
Mechanisms Of Action ◽  
Active Components ◽  
Active Constituents ◽  
Medicinal Tree ◽  
Drug Candidates ◽  
Solid Foundation ◽  
Ethnomedicinal Uses

Abstract Medicinal plants are indispensable source of therapeutic agents, and have proved to be “warehouse” of lead drug candidates. Lecaniodiscus cupanioides Planch. ex Benth is a medicinal tree plant that is extensively distributed in both Asia and Africa. The species has many ethnomedicinal uses in the treatment of fever, cough, typhoid, wound, skin infection, measles, jaundice, diabetes, sexual dysfunction, cancer, bone fracture, and as galactogogues. In the recent decades, the extracts and phytochemicals of L. cupanioides have been investigated to possess antibacterial, anticancer, aphrodisiac, antifungal, cytotoxic, antidiabetic, antiprotozoal, antioxidant, antidiarrhoeal, analgesic and ameliorative properties. However, triterpenoids which have been linked to its anticancer and antifungal actions, are the only isolated active constituents identified from the species despite the results of the phytochemical screenings and reported biological activities. Moreover, the mechanisms of action of the extracts and active components are yet to be fully elucidated. This paper provides a general review on the ethnomedicinal, phytochemicals, and biological activities of L. cupanioides, and lays a solid foundation for future investigations on the plant.

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