Bioavailability of single and multiple doses of a new oral formulation of 5-ASA in patients with inflammatory bowel disease and healthy volunteers

Background: Inflammatory bowel disease (IBD) is associated with delay in gastric emptying, increase in ghrelin, and decrease in leptin. The aim was to investigate the correlation between gastroduodenal (GD) symptoms, gastric emptying, and serum levels of active ghrelin and leptin in IBD. Twenty-seven IBD patients and 26 healthy volunteers were asked to complete the Porto Alegre Dyspeptic Symptoms Questionnaire. A gastric emptying test for solids was performed using a C13 octanoic acid breath test. During this test, serum samples were collected for measuring active ghrelin and leptin concentrations by radioimmunoassay. Summary: Patients with IBD demonstrated delayed gastric emptying compared with healthy volunteers. In patients with GD symptoms, the delay in gastric emptying was more pronounced, and there were significant correlations of satiety and vomiting with gastric emptying. Basal leptin, but not active ghrelin, increased in patients with GD symptoms compared with patients without these symptoms. There were negative correlations between basal active ghrelin with total Porto Alegre score and epigastric pain in IBD patients with GD symptoms. Key Messages: In IBD, satiety and vomiting were associated with delay in gastric emptying. Conversely, epigastric pain had a negative correlation with active ghrelin. Our results suggest that different pathophysiological mechanisms contribute to GD symptoms in IBD.

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Serum S100A8/A9 as a Potentially Sensitive Biomarker for Inflammatory Bowel Disease

Laboratory Medicine ◽

10.1093/labmed/lmz003 ◽

2019 ◽

Vol 50 (4) ◽

pp. 370-380 ◽

Cited By ~ 3

Author(s):

Kohki Okada ◽

Makoto Okabe ◽

Yuto Kimura ◽

Hiroshi Itoh ◽

Masaki Ikemoto

Keyword(s):

Ulcerative Colitis ◽

Inflammatory Bowel Disease ◽

Serum Level ◽

Correlation Analysis ◽

Healthy Volunteers ◽

Clinical Significance ◽

Inflammatory Cytokines ◽

Bowel Disease ◽

Inflammatory Bowel ◽

Inflammatory Proteins

Abstract Background The clinical significance of human S100A8/A9 (h-S100A8/A9) in patients with inflammatory bowel disease (IBD) is poorly understood. Objective To clarify whether serum S100A8/A9 is a sensitive biomarker for IBD. Methods Serum specimens from outpatients with IBD (n = 101) and healthy volunteers (HVs) (n = 101) were used in this study. Enzyme-linked immunosorbent assays for h-S100A8/A9 and inflammatory cytokines were performed using these specimens. Further, correlation analysis was performed to investigate the significance of h-S100A8/A9 fluctuation in patients with IBD. Results The average of serum h-S100A8/A9 concentration in outpatients with IBD was significantly higher than that in HVs. The concentration of h-S100A8/A9 in patients with IBD was barely correlated with that of CRP and inflammatory cytokines. Despite that finding, the serum level of h-S100A8/A9 in patients with ulcerative colitis (UC) was correlated with the severity of IBD, compared with other inflammatory proteins. Conclusion Serum h-S100A8/A9 is superior to CRP as a sensitive biomarker for IBD.

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