The alpha-3 polypeptide chain of laminin 5: insight into wound healing responses from the study of genodermatoses

2005 ◽  
Vol 30 (4) ◽  
pp. 398-404 ◽  
Author(s):  
K. J. Hamill ◽  
W. H. I. McLean
2021 ◽  
Author(s):  
Laxmi Parwani ◽  
Mansi Shrivastava ◽  
Jaspreet Singh

The wound care market is rapidly expanding due to the development of innumerable dressings that exhibit specific healing requirements for different wound types. The use of biomaterials as suitable wound dressing material is highly advantageous due to their biocompatibility, biodegradability, and non-toxicity. Cyanobacteria have been widely explored for their potential applications in wound healing, as they are the rich source of bioactive compounds with antibacterial, antitumor, antiviral, antioxidant, and antifungal activities. In recent years this group of organisms has been widely studied due to their immense potential in biomedical applications. Although their different bioactivities can support wound healing in different ways, very few forms have proven utility as a wound-healing agent. This chapter gives an insight into the potential of cyanobacteria in wound healing. Different bioactive compounds present in variable forms of cyanobacteria and their associated activities were reported to support tissue regeneration and wound healing acceleration. As the demand for cost-effective, bioactive wound care products is ever increasing, these organisms have immense potential to be utilized for the development of bioactive wound dressings. Hence, various bioactive compounds of cyanobacteria, their associated activities, and roles in wound healing have been briefly reviewed in this chapter.


2008 ◽  
Vol 24 (1-2) ◽  
pp. 127-132 ◽  
Author(s):  
S. Georgescu ◽  
M. Manea ◽  
A. Dinischiotu ◽  
C. Tesio ◽  
M. Costache

Junctional Epidermolysis Bullosa (JEB) is an inherited disease which causes skin lesions in newborn foals and results in large areas of skin loss. The mutation responsible for the disease is a cytosine insertion in the LAMC2 gene, which results in absent expression of the laminin ?2 polypeptide chain of laminin 5. JEB is inherited as an autosomal recessive trait (Spirito et al. 2002, Milenkovic et al. 2003, Spirito et al. 2002). Our objective was to develop an easy and efficient method for correctly identifying the normal homozygous and heterozygous carrier horses for the JEB trait. We analyzed a population of Romanian Draft Horses using a set of primers which amplify a fragment from the LAMC2 gene possibly containing the insertion. The number of allele peaks depends on whether the horse tested is a heterozygote (carrier) or homozygote (normal or JEB affected). Results suggest that the genetic test will be useful in identifying horses which are heterozygous for the JEB trait and foals with JEB.


2020 ◽  
Vol 26 (38) ◽  
pp. 4894-4908 ◽  
Author(s):  
Ameya Sharma ◽  
Vivek Puri ◽  
Pradeep Kumar ◽  
Inderbir Singh

Background: Any sort of wound injury leads to skin integrity and further leads to wound formation. Millions of deaths are reported every year, which contributes to an economical hamper world widely, this accounts for 10% of death rate that insight into various diseases. Current Methodology: Rapid wound healing plays an important role in effective health care. Wound healing is a multi-factorial physiological process, which helps in the growth of new tissue to render the body with the imperative barrier from the external environment. The complexity of this phenomenon makes it prone to several abnormalities. Wound healing, as a normal biological inherent process occurs in the body, which is reaped through four highly defined programmed phases, such as hemostasis, inflammation, proliferation, and remodeling and these phases occur in the proper progression. An overview, types, and classification of wounds along with the stages of wound healing and various factors affecting wound healing have been discussed systematically. Various biopolymers are reported for developing nanofibers and microfibers in wound healing, which can be used as a therapeutic drug delivery for wound healing applications. Biopolymers are relevant for biomedical purposes owing to biodegradability, biocompatibility, and non- toxicity. Biopolymers such as polysaccharides, proteins and various gums are used for wound healing applications. Patents and future perspectives have been given in the concluding part of the manuscript. Overall, applications of biopolymers in the development of fibers and their applications in wound healing are gaining interest in researchers to develop modified biopolymers and tunable delivery systems for effective management and care of different types of wounds.


Biomaterials ◽  
2010 ◽  
Vol 31 (17) ◽  
pp. 4725-4730 ◽  
Author(s):  
Seung-Ki Min ◽  
Sang-Chul Lee ◽  
Seong-Doo Hong ◽  
Chong-Pyoung Chung ◽  
Won Ho Park ◽  
...  
Keyword(s):  

2015 ◽  
Vol 2015 ◽  
pp. 1-18 ◽  
Author(s):  
M. Jannathul Firdhouse ◽  
P. Lalitha

Silver nanoparticles possess unique properties which find myriad applications such as antimicrobial, anticancer, larvicidal, catalytic, and wound healing activities. Biogenic syntheses of silver nanoparticles using plants and their pharmacological and other potential applications are gaining momentum owing to its assured rewards. This critical review is aimed at providing an insight into the phytomediated synthesis of silver nanoparticles, its significant applications in various fields, and characterization techniques involved.


Author(s):  
Bei Ho Pan ◽  
Qiang Zhang ◽  
Chun Hei Lam ◽  
Ho Yin Yuen ◽  
Shifeng Kuang ◽  
...  
Keyword(s):  

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