Improvement in insulin sensitivity without concomitant changes in body composition and cardiovascular risk markers following fixed administration of a very low growth hormone (GH) dose in adults with severe GH deficiency

2005 ◽  
Vol 63 (4) ◽  
pp. 428-436 ◽  
Author(s):  
Kevin C. J. Yuen ◽  
Jan Frystyk ◽  
Deborah K. White ◽  
Th. B. Twickler ◽  
Hans P. F. Koppeschaar ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Body Composition ◽  
Cardiovascular Risk ◽  
Insulin Sensitivity ◽  
Gh Deficiency ◽  
Risk Markers

scholarly journals The Decreased Growth Hormone Response to Growth Hormone Releasing Hormone in Obesity Is Associated to Cardiometabolic Risk Factors

2010 ◽  
Vol 2010 ◽  
pp. 1-8 ◽  
Author(s):  
Fernando Cordido ◽  
Jesús Garcia-Buela ◽  
Susana Sangiao-Alvarellos ◽  
Teresa Martinez ◽  
Ovidio Vidal
Keyword(s):  
Insulin Resistance ◽  
Growth Hormone ◽  
Cardiovascular Risk ◽  
Ldl Cholesterol ◽  
Premenopausal Women ◽  
Fasting Insulin ◽  
Risk Markers ◽  
Obese Women ◽  
Gh Secretion ◽  
The Metabolic Syndrome

The aim of the present study was to evaluate the relationship between GHRH-induced GH secretion in obese premenopausal women and cardiovascular risk markers or insulin resistance. Premenopausal obese women, aged 35–52 years, were studied. GH secretion, IGF-I, serum cardiovascular risk markers, insulin, leptin, mid-waist and hip circumference, total body fat, and truncal fat were measured. Subjects were classified as meeting the criteria for GH deficiency (GHD) when peak GH after stimulation with GHRH was≤3 μg/L. Mean total and LDL cholesterol, fasting insulin, and HOMA-IR were all higher, in subjects who would have been classified as GH-deficient compared with GH-sufficient. Peak GH secretion after stimulation was inversely associated with fasting insulin (R=−0.650,P=.012), HOMA-IR (R=−0.846,P=.001), total cholesterol (R=−0.532,P=.034), and LDL cholesterol (R=−0.692,P=.006) and positively associated with HDL cholesterol (R=0.561,P=.037). These data strongly suggest a role for insulin resistance in the decreased GH secretion of obesity and that the blunted GH secretion of central obesity could be the pituitary expression of the metabolic syndrome.

scholarly journals Effects of GH on Body Composition and Cardiovascular Risk Markers in Young Men With Abdominal Obesity

2013 ◽  
Vol 98 (9) ◽  
pp. 3864-3872 ◽  
Author(s):  
Miriam A. Bredella ◽  
Anu V. Gerweck ◽  
Eleanor Lin ◽  
Melissa G. Landa ◽  
Martin Torriani ◽  
...  
Keyword(s):  
Body Composition ◽  
Cardiovascular Risk ◽  
Abdominal Obesity ◽  
Young Men ◽  
Risk Markers

scholarly journals Long-Term Effect of Growth Hormone (GH) Treatment on Body Composition in Children with GH Deficiency

1999 ◽  
Vol 46 (Suppl) ◽  
pp. S35-S38 ◽  
Author(s):  
RYUICHI KUROMARU ◽  
HITOSHI KOHNO ◽  
NAMI UEYAMA ◽  
HASSAN MOHAMED SALAMA HASSAN ◽  
SUNAO HONDA ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Body Composition ◽  
Gh Deficiency ◽  
Term Effect ◽  
Gh Treatment ◽  
Long Term Effect

scholarly journals Acute Effect of Pegvisomant on Cardiovascular Risk Markers in Healthy Men: Implications for the Pathogenesis of Atherosclerosis in GH Deficiency

2001 ◽  
Vol 86 (11) ◽  
pp. 5165-5171 ◽  
Author(s):  
A. F. Muller ◽  
F. W. G. Leebeek ◽  
J. A. M. J. L. Janssen ◽  
S. W. J. Lamberts ◽  
L. Hofland ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Gh Deficiency ◽  
Acute Effect ◽  
Risk Markers ◽  
Healthy Men
Sign in / Sign up

Export Citation Format

Share Document