Serotype and antimicrobial susceptibility patterns of isolates of Streptococcus pneumoniae causing invasive disease in The Gambia 1996–2003

2006 ◽  
Vol 11 (7) ◽  
pp. 1128-1135 ◽  
Author(s):  
Richard A. Adegbola ◽  
Philip C. Hill ◽  
Ousman Secka ◽  
Usman N. Ikumapayi ◽  
George Lahai ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Antimicrobial Susceptibility ◽  
Invasive Disease ◽  
The Gambia ◽  
Susceptibility Patterns

Comparison of antimicrobial resistance patterns in Streptococcus pneumoniae from respiratory and blood cultures in Canadian hospitals from 2007–16

2019 ◽  
Vol 74 (Supplement_4) ◽  
pp. iv39-iv47 ◽  
Author(s):  
Alyssa R Golden ◽  
Melanie R Baxter ◽  
Ross J Davidson ◽  
Irene Martin ◽  
Walter Demczuk ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Antimicrobial Susceptibility ◽  
Invasive Disease ◽  
Non Invasive ◽  
Microdilution Method ◽  
Broth Microdilution Method ◽  
Resistance Patterns ◽  
Specific Factors ◽  
Susceptibility Patterns ◽  
Respiratory Specimens

Abstract Objectives To compare the epidemiology and antimicrobial susceptibility patterns of Streptococcus pneumoniae collected from respiratory and blood culture samples in Canada between 2007 and 2016. Methods S. pneumoniae strains were obtained from Canadian hospitals as part of the ongoing national surveillance study, CANWARD. Isolates were serotyped using the Quellung method. Antimicrobial susceptibility testing was performed using the CLSI broth microdilution method. MDR and XDR were defined as resistance to three or more and five or more classes of antimicrobials, respectively. Results Of the 2581 S. pneumoniae isolates collected, 1685 (65.3%) and 896 (34.7%) were obtained from respiratory and blood samples, respectively. Respiratory isolates demonstrated lower rates of antimicrobial susceptibility than blood isolates to penicillin, ceftriaxone, clarithromycin, clindamycin, doxycycline and trimethoprim/sulfamethoxazole (P ≤ 0.03). From 2007 to 2016, invasive isolates demonstrated trends towards increasing penicillin susceptibility and decreasing clarithromycin susceptibility. MDR was significantly higher in respiratory S. pneumoniae compared with blood (9.1% versus 4.5%, P < 0.0001). Serotypes 11A, 16F, 19F, 23A/B/F, 34, 35B and non-typeable strains were more commonly isolated from respiratory specimens, while 4, 5, 7F, 8, 12F, 14 and 19A were more commonly invasive serotypes. Numerous serotypes, including 3 and 22F, were isolated frequently from both specimen sources. Conclusions S. pneumoniae from respiratory samples demonstrated lower antimicrobial susceptibilities and higher MDR in a greater diversity of serotypes than isolates obtained from blood. Many serotypes were associated with one specific specimen source, while others were associated with both; genetic characterization is necessary to elucidate the specific factors influencing the ability of these serotypes to commonly cause both invasive and non-invasive disease.

scholarly journals Ten-year surveillance of invasive Streptococcus pneumoniae isolates in central Turkey prior to the introduction of a conjugate vaccine

2010 ◽  
Vol 4 (09) ◽  
pp. 560-565 ◽  
Author(s):  
Duygu Percin ◽  
Yasemin Ay Altintop ◽  
Bulent Sumerkan
Keyword(s):  
Streptococcus Pneumoniae ◽  
Conjugate Vaccine ◽  
Antimicrobial Susceptibility ◽  
Rank Order ◽  
Age Group ◽  
Immunization Program ◽  
Conjugate Vaccines ◽  
Microbiological Methods ◽  
Central Turkey ◽  
Susceptibility Patterns

Introduction: The aim of this study was to characterize the serotypes and antimicrobial susceptibility patterns of invasive Streptococcus pneumoniae isolates in central Turkey. Methodology: A total of 332 invasive S. pneumoniae isolates were identified, serotyped and tested for antimicrobial susceptibility by routine microbiological methods. Results: The most common serogroups/serotypes were 1, 19, 3, 18, 6, 14, and 7 in rank order. Serogroup/serotype coverage of the 23-valent polysaccharide vaccine, and the 7-, 10-, and 13-valent conjugate vaccines were 96%, 44%, 78.6%, 96.4%, respectively. Overall, 20 (6%) of the isolates were resistant to penicillin, 1 (0.3%) to cefotaxime, 20 (6%) to erythromycin, 13 (4%) to cloramphenicol, and 120 (36%) to trimethoprim-sulfamethoxasole. Among cerebrospinal fluid (CSF) isolates, 20 (18.5%) were resistant to penicillin (26.3% and 11.5%, respectively, of child and adult meningitis cases; p≥0.05). Conclusions: Although the seven-valent conjugate vaccine is expected to protect less than half of children younger than three years of age, of the incorporation of this vaccine into the routine immunization program of Turkey is advised to continue. However, the 13-valent conjugate vaccine, including serotypes 1, 3, 5, and 7, has the most potential prevent the highest burden of invasive pneumococcal diseases in this age group.

scholarly journals Antimicrobial susceptibility patterns of multi-drug resistant Streptococcus pneumoniae at general hospital in Japan

2015 ◽  
Vol 48 (2) ◽  
pp. S65-S66 ◽  
Author(s):  
Masaaki Minami ◽  
Ryoko Sakakibara ◽  
Taichi Imura ◽  
Hideo Morita ◽  
Naoto Kanemaki ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
General Hospital ◽  
Antimicrobial Susceptibility ◽  
Drug Resistant ◽  
Susceptibility Patterns

scholarly journals Serotype Distribution and Antimicrobial Resistance of Streptococcus pneumoniae Isolates from Pediatric Patients in Singapore

2000 ◽  
Vol 44 (8) ◽  
pp. 2193-2196 ◽  
Author(s):  
Shirlena Wee-Ling Soh ◽  
Chit Laa Poh ◽  
Raymond V. Tzer Pin Lin
Keyword(s):  
Multidrug Resistance ◽  
Streptococcus Pneumoniae ◽  
Antimicrobial Resistance ◽  
Antimicrobial Susceptibility ◽  
Pediatric Patients ◽  
Pediatric Hospital ◽  
Serotype Distribution ◽  
Large Numbers ◽  
Susceptibility Patterns

ABSTRACT One hundred eighty Streptococcus pneumoniae strains isolated from children at a pediatric hospital in Singapore from 1997 to 1999 were serotyped and their antimicrobial susceptibility patterns were determined. Sixty-three percent of the isolates were resistant to penicillin. Significantly large numbers of the strains investigated were resistant to trimethoprim-sulfamethoxazole (87.8%), tetracycline (71.7%), erythromycin (67.8%), and chloramphenicol (40%). Penicillin and multidrug resistance was mostly associated with the frequently isolated S. pneumoniae isolates of serotypes (serotypes 19F, 23F, 6B, and 14). Isolates of serotype 19F, the serotype most commonly encountered in Singapore (41.1%), had the highest prevalence of penicillin (78.4%) and multidrug resistance (94.6%). Most of the invasive S. pneumoniae isolates (8 of 17; 47.1%) were of serotype 14.

Antimicrobial susceptibility patterns of Streptococcus pneumoniae in Mexico

2004 ◽  
Vol 49 (1) ◽  
pp. 53-58 ◽  
Author(s):  
Francisco Quiñones-Falconi ◽  
Juan José Calva ◽  
Yolanda López-Vidal ◽  
Miriam Galicia-Velazco ◽  
María Elena Jiménez-Martinez ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Antimicrobial Susceptibility ◽  
Susceptibility Patterns
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