Immunoglobulin production against Staphylococcal adhesin and polyclonal immunoglobulin activation induced by superantigen

Nephrology ◽  
2004 ◽  
Vol 9 (s2) ◽  
pp. A63-A63
Author(s):  
Yoshio SHIMIZU ◽  
Akio KOYAMA
Keyword(s):  
Immunoglobulin Production ◽  
Polyclonal Immunoglobulin

scholarly journals Cell Population Data and Serum Polyclonal Immunoglobulin Free Light Chains in the Assessment of COVID-19 Severity

Viruses ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1381
Author(s):  
Milena Małecka-Giełdowska ◽  
Maria Fołta ◽  
Agnieszka Wiśniewska ◽  
Emilia Czyżewska ◽  
Olga Ciepiela
Keyword(s):  
Nucleic Acid ◽  
Serum Concentration ◽  
Odds Ratio ◽  
Healthcare Quality ◽  
Reference Value ◽  
Population Data ◽  
Light Chains ◽  
Nucleic Acid Content ◽  
Free Light Chains ◽  
Polyclonal Immunoglobulin

Distinguishing between severe and nonsevere COVID-19 to ensure adequate healthcare quality and efficiency is a challenge for the healthcare system. The aim of this study was to assess the usefulness of CBC parameters together with analysis of FLC serum concentration in risk stratification of COVID-19. Materials and methods: CBC was analyzed in 735 COVID ICU, COVID non-ICU, and non-COVID ICU cases. FLC concentration was analyzed in 133 of them. Results: COVID ICU had neutrophils and lymphocytes with the greatest size, granularity, and nucleic acid content. Significant differences in concentrations of κ and λ FLCs were shown between COVID ICU and COVID non-ICU. However, no difference was found in the κ/λ ratio between these groups, and the ratio stayed within the reference value, which indicates the presence of polyclonal FLCs. FLC κ measurement has significant power to distinguish between severe COVID-19 and nonsevere COVID-19 (AUC = 0.7669), with a sensitivity of 86.67% and specificity of 93.33%. The κ coefficients’ odds ratio of 3.0401 was estimated. Conclusion: It can be concluded that the results obtained from the measure of free light immunoglobulin concentration in serum are useful in distinguishing between severe and nonsevere COVID-19.

855 In vitro immunoglobulin production in patients with partial IgA deficiency (pIgAd)

1996 ◽  
Vol 97 (1) ◽  
pp. 396-396
Author(s):  
R RABY ◽  
K BARSNESS ◽  
S HUTCHINSON ◽  
W VALENSKI ◽  
R TROUY ◽  
...  
Keyword(s):  
Iga Deficiency ◽  
Immunoglobulin Production

scholarly journals A BAFF-R mutation associated with non-Hodgkin lymphoma alters TRAF recruitment and reveals new insights into BAFF-R signaling

2010 ◽  
Vol 207 (12) ◽  
pp. 2569-2579 ◽  
Author(s):  
Joanne M. Hildebrand ◽  
Zhenghua Luo ◽  
Michelle K. Manske ◽  
Tammy Price-Troska ◽  
Steven C. Ziesmer ◽  
...  
Keyword(s):  
B Cell ◽  
Hodgkin Lymphoma ◽  
Novel Mutation ◽  
B Cell Development ◽  
Signaling Cascades ◽  
Binding Motif ◽  
Wild Type ◽  
Immunoglobulin Production ◽  
Gene Encoding ◽  
Non Hodgkin Lymphoma

The cytokine B cell activating factor (BAFF) and its receptor, BAFF receptor (BAFF-R), modulate signaling cascades critical for B cell development and survival. We identified a novel mutation in TNFRSF13C, the gene encoding human BAFF-R, that is present in both tumor and germline tissue from a subset of patients with non-Hodgkin lymphoma. This mutation encodes a His159Tyr substitution in the cytoplasmic tail of BAFF-R adjacent to the TRAF3 binding motif. Signaling through this mutant BAFF-R results in increased NF-κB1 and NF-κB2 activity and increased immunoglobulin production compared with the wild-type (WT) BAFF-R. This correlates with increased TRAF2, TRAF3, and TRAF6 recruitment to His159Tyr BAFF-R. In addition, we document a requirement for TRAF6 in WT BAFF-R signaling. Together, these data identify a novel lymphoma-associated mutation in human BAFF-R that results in NF-κB activation and reveals TRAF6 as a necessary component of normal BAFF-R signaling.

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