scholarly journals Review: Serum and urine biomarkers of kidney disease: A pathophysiological perspective

Nephrology ◽  
2010 ◽  
Vol 15 (6) ◽  
pp. 609-616 ◽  
Author(s):  
GREG H TESCH
Keyword(s):  
Kidney Disease ◽  
Urine Biomarkers ◽  
Serum And Urine

scholarly journals Association between serum and urine biomarkers and lumbar spine individual radiographic features: the Johnston County Osteoarthritis Project

2012 ◽  
Vol 20 (11) ◽  
pp. 1286-1293 ◽  
Author(s):  
A.P. Goode ◽  
S.W. Marshall ◽  
V.B. Kraus ◽  
J.B. Renner ◽  
T. Stürmer ◽  
...  
Keyword(s):  
Lumbar Spine ◽  
Radiographic Features ◽  
Urine Biomarkers ◽  
Serum And Urine

scholarly journals Associations of Urine Biomarkers with Kidney Function Decline in HIV-Infected and Uninfected Men

2019 ◽  
Vol 50 (5) ◽  
pp. 401-410 ◽  
Author(s):  
Simon B. Ascher ◽  
Rebecca Scherzer ◽  
Michelle M. Estrella ◽  
Michael G. Shlipak ◽  
Derek K. Ng ◽  
...  
Keyword(s):  
Risk Factors ◽  
Kidney Disease ◽  
Kidney Function ◽  
Disease Risk ◽  
Kidney Injury ◽  
Procollagen Type ◽  
Urine Albumin ◽  
Urine Biomarkers ◽  
Increased Risk ◽  
Egfr Decline

Background: HIV-infected (HIV+) persons are at increased risk of chronic kidney disease, but serum creatinine does not detect early losses in kidney function. We hypothesized that urine biomarkers of kidney damage would be associated with subsequent changes in kidney function in a contemporary cohort of HIV+ and HIV-uninfected (HIV–) men. Methods: In the Multicenter AIDS Cohort Study, we measured baseline urine concentrations of 5 biomarkers from 2009 to 2011 in 860 HIV+ and 337 HIV– men: albumin, alpha-1-microglobulin (α1m), interleukin-18 (IL-18), kidney injury molecule-1 (KIM-1), and procollagen type III N-terminal propeptide (PIIINP). We evaluated associations of urine biomarker concentrations with annual changes in estimated glomerular filtration rate (eGFR) using multivariable linear mixed models adjusted for demographics, traditional kidney disease risk factors, HIV-related risk factors, and baseline eGFR. Results: Over a median follow-up of 4.8 years, the average annual eGFR decline was 1.42 mL/min/1.73 m2/year in HIV+ men and 1.22 mL/min/1.73 m2/year in HIV– men. Among HIV+ men, the highest vs. lowest tertiles of albumin (–1.78 mL/min/1.73 m2/year, 95% CI –3.47 to –0.09) and α1m (–2.43 mL/min/1.73 m2/year, 95% CI –4.14 to –0.73) were each associated with faster annual eGFR declines after multivariable adjustment. Among HIV– men, the highest vs. lowest tertile of α1m (–2.49 mL/min/1.73 m2/year, 95% CI –4.48 to –0.50) was independently associated with faster annual eGFR decline. Urine IL-18, KIM-1, and PIIINP showed no independent associations with eGFR decline, regardless of HIV serostatus. Conclusions: Among HIV+ men, higher urine albumin and α1m are associated with subsequent declines in kidney function, independent of eGFR.

Blood and urine biomarkers in chronic kidney disease: An update

2019 ◽  
Vol 495 ◽  
pp. 239-250 ◽  
Author(s):  
Mohammad Zulkarnain Bidin ◽  
Anim Md Shah ◽  
J. Stanslas ◽  
Christopher Lim Thiam Seong
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Urine Biomarkers

scholarly journals Primary Membranous Glomerulonephritis: The Role of Serum and Urine Biomarkers in Patient Management

Biomedicines ◽  
2019 ◽  
Vol 7 (4) ◽  
pp. 86 ◽  
Author(s):  
Maifata ◽  
Hod ◽  
Zakaria ◽  
Abd Ghani
Keyword(s):  
Membranous Glomerulonephritis ◽  
Invasive Procedure ◽  
Treatment Decision ◽  
Retinol Binding Protein ◽  
Non Invasive ◽  
Urine Biomarkers ◽  
Phospholipase A2 Receptor ◽  
Beta 2 Microglobulin ◽  
Serum And Urine

The detection of phospholipase A2 receptor (PLA2R) and thrombospondin domain containing 7A THSD7A among primary membranous glomerulonephritis (MGN) patients transformed the diagnosis, treatment monitoring, and prognosis. Anti-PLA2R can be detected in 70–90% of primary MGN patients while anti-THSD7A in 2–3% of anti-PLA2R negative primary MGN patients depending on the technique used. Serum and urine samples are less invasive and non-invasive, respectively, and thus can detect the presence of anti-PLA2R and anti-THSD7A with higher sensitivity and specificity, which is significant in patient monitoring and prognosis. It is better than exposing patients to a frequent biopsy, which is an invasive procedure. Different techniques of detection of PLA2R and THSD7A in patients’ urine and sera were reviewed to provide newer and alternative techniques. We proposed the use of biomarkers (PLA2R and THSD7A) in the diagnosis, treatment decision, and follow-up of patients with primary MGN. In addition, other prognostic renal biomarkers like retinol binding protein (RBP) and beta-2 microglobulin were reviewed to detect the progression of renal damage for early intervention.

Diurnal variation of serum and urine biomarkers in patients with radiographic knee osteoarthritis

2006 ◽  
Vol 54 (8) ◽  
pp. 2496-2504 ◽  
Author(s):  
S. Y. Kong ◽  
T. V. Stabler ◽  
L. G. Criscione ◽  
A. L. Elliott ◽  
J. M. Jordan ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Diurnal Variation ◽  
Urine Biomarkers ◽  
Radiographic Knee Osteoarthritis ◽  
Serum And Urine

scholarly journals Markers of Glomerular and Tubular Damage in the Early Stage of Kidney Disease in Type 2 Diabetic Patients

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Agnieszka Żyłka ◽  
Paulina Dumnicka ◽  
Beata Kuśnierz-Cabala ◽  
Agnieszka Gala-Błądzińska ◽  
Piotr Ceranowicz ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Cystatin C ◽  
Tubular Damage ◽  
Creatinine Ratio ◽  
Urine Ngal ◽  
Early Assessment ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Serum And Urine

Diabetic kidney disease develops in half of genetically predisposed patients with type 2 diabetes (T2DM). Early diagnosis of kidney damage and nephroprotective treatment are the ways of preventing the disease progression. Our aim was to evaluate selected laboratory markers of glomerular and tubular damage in T2DM patients with early stages of chronic kidney disease (G1/G2, A1/A2) for their associations with A2 albuminuria and early decline in the estimated glomerular filtration rate (eGFR). Among 80 T2DM patients with median eGFR of 92.4 ml/min/1.73 m2 and median urinary albumin to creatinine ratio (uACR) of 4.69 mg/g, 19 had uACR > 30 mg/g (A2). Higher serum cystatin C, serum and urine neutrophil gelatinase associated lipocalin (NGAL), urine kidney injury molecule 1 (KIM-1), detectable urine transferrin and IgG, and lower serum uromodulin significantly predicted A2 albuminuria, urine KIM-1/creatinine ratio, and IgG being the best predictors. Albuminuria, urine NGAL/creatinine, and IgG correlated with diabetes duration. Albuminuria, urine NGAL, transferrin, IgG, and uromodulin correlated with diabetes control. In a subgroup of 29 patients, retrospective data were available on changes in eGFR and uACR over one year. Decline in eGFR was observed in 17 patients and increase in uACR in 10 patients. Serum and urine NGAL correlated with eGFR changes. Higher urine NGAL, KIM-1/creatinine ratio, and detectable IgG were significantly associated with the increase in uACR. Widely available markers, serum cystatin C, urine IgG, transferrin, and NGAL, may help in early assessment of kidney disease in T2DM patients; however, large prospective studies are needed to confirm the conclusion.

scholarly journals Resistant starch alters gut microbiome and metabolomic profiles concurrent with amelioration of chronic kidney disease in rats

2016 ◽  
Vol 310 (9) ◽  
pp. F857-F871 ◽  
Author(s):  
Dorothy A. Kieffer ◽  
Brian D. Piccolo ◽  
Nosratola D. Vaziri ◽  
Shuman Liu ◽  
Wei L. Lau ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Kidney Function ◽  
Resistant Starch ◽  
Blood Levels ◽  
Microbial Composition ◽  
Urine Metabolites ◽  
Fiber Diet ◽  
Gut Microbe ◽  
Serum And Urine

Patients and animals with chronic kidney disease (CKD) exhibit profound alterations in the gut environment including shifts in microbial composition, increased fecal pH, and increased blood levels of gut microbe-derived metabolites (xenometabolites). The fermentable dietary fiber high amylose maize-resistant starch type 2 (HAMRS2) has been shown to alter the gut milieu and in CKD rat models leads to markedly improved kidney function. The aim of the present study was to identify specific cecal bacteria and cecal, blood, and urinary metabolites that associate with changes in kidney function to identify potential mechanisms involved with CKD amelioration in response to dietary resistant starch. Male Sprague-Dawley rats with adenine-induced CKD were fed a semipurified low-fiber diet or a high-fiber diet [59% (wt/wt) HAMRS2] for 3 wk ( n = 9 rats/group). The cecal microbiome was characterized, and cecal contents, serum, and urine metabolites were analyzed. HAMRS2-fed rats displayed decreased cecal pH, decreased microbial diversity, and an increased Bacteroidetes-to-Firmicutes ratio. Several uremic retention solutes were altered in the cecal contents, serum, and urine, many of which had strong correlations with specific gut bacteria abundances, i.e., serum and urine indoxyl sulfate were reduced by 36% and 66%, respectively, in HAMRS2-fed rats and urine p-cresol was reduced by 47% in HAMRS2-fed rats. Outcomes from this study were coincident with improvements in kidney function indexes and amelioration of CKD outcomes previously reported for these rats, suggesting an important role for microbial-derived factors and gut microbe metabolism in regulating host kidney function.

scholarly journals Kidney disease risk factors associate with urine biomarkers concentrations in HIV-positive persons; a cross-sectional study

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Anthony N. Muiru ◽  
Michael G. Shlipak ◽  
Rebecca Scherzer ◽  
William R. Zhang ◽  
Simon B. Ascher ◽  
...  
Keyword(s):  
Risk Factors ◽  
Kidney Disease ◽  
Disease Risk ◽  
Cross Sectional Study ◽  
Hiv Positive ◽  
Sectional Study ◽  
Cross Sectional ◽  
Urine Biomarkers

scholarly journals Role of Serum and Urine Biomarkers (PLA2R and THSD7A) in Diagnosis, Monitoring and Prognostication of Primary Membranous Glomerulonephritis

Biomolecules ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. 319 ◽  
Author(s):  
Sadiq Mu’azu Maifata ◽  
Rafidah Hod ◽  
Fadhlina Zakaria ◽  
Fauzah Abd Ghani
Keyword(s):  
Membranous Glomerulonephritis ◽  
Enzyme Linked Immunosorbent Assay ◽  
Kuala Lumpur ◽  
Non Invasive ◽  
Urine Biomarkers ◽  
Phospholipase A2 Receptor ◽  
B Virus ◽  
Elisa Technique ◽  
Effective Diagnosis ◽  
Serum And Urine

Differentiating primary and secondary membranous glomerulonephritis (MGN) using biomarkers for MGN is essential in patients’ diagnosis, treatment and follow-up. Although biopsy has been the primary tool in making the diagnosis, not all patients can withstand it due to its invasive nature, and it cannot be used to monitor treatment. Hence, there is the need for less invasive or even non-invasive biomarkers for effective diagnosis, treatment monitoring and prognostication. This study aimed at providing an alternative way of differentiating primary and secondary MGN using enzyme-linked immunosorbent assay (ELISA) technique for serum and urine biomarkers (M-type phospholipase A2 receptor (PLA2R) and thrombospondin type-1 domain-containing 7A (THSD7A)) for prompt diagnosis, treatment and prognosis. A total of 125 subjects, including 81 primary and 44 secondary MGN subjects, were diagnosed from January 2012 to October 2019 at Hospital Serdang and Hospital Kuala Lumpur from which 69 subjects consisting of 47 primary and 22 secondary MGN subjects participated in the study. Of these, 13 primary MGN subjects were positive for both serum and urine anti-PLA2R antibodies (Ab) whereas only one secondary MGN subject associated with hepatitis B virus was positive for both serum and urine anti-PLA2R Ab. At the same time, anti-THSD7A Ab was found positive in four primary MGN subjects and two secondary MGN subjects with malignancy.

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