The vitamin D receptor gene variant and physical activity predicts fasting blood glucose levels in healthy young men

2004 ◽  
Vol 21 (7) ◽  
pp. 803-803 ◽  
Author(s):  
B. J. Boucher ◽  
G. A. Hitman
Keyword(s):  
Physical Activity ◽  
Vitamin D ◽  
Blood Glucose ◽  
Vitamin D Receptor ◽  
Receptor Gene ◽  
Fasting Blood Glucose ◽  
Vitamin D Receptor Gene ◽  
Gene Variant ◽  
Glucose Levels ◽  
Blood Glucose Levels

The vitamin D receptor gene variant and physical activity predicts fasting glucose levels in healthy young men

2003 ◽  
Vol 20 (6) ◽  
pp. 451-454 ◽  
Author(s):  
J. R. Ortlepp ◽  
J. Metrikat ◽  
M. Albrecht ◽  
A. von Korff ◽  
P. Hanrath ◽  
...  
Keyword(s):  
Physical Activity ◽  
Vitamin D ◽  
Vitamin D Receptor ◽  
Fasting Glucose ◽  
Receptor Gene ◽  
Young Men ◽  
Vitamin D Receptor Gene ◽  
Gene Variant ◽  
Glucose Levels

scholarly journals HUBUNGAN ASUPAN VITAMIN D DAN KALSIUM DENGAN KADAR GLUKOSA DARAH PUASA WANITA OBESITAS USIA 45-55 TAHUN

2017 ◽  
Vol 6 (4) ◽  
pp. 285
Author(s):  
Nur Rochmah ◽  
Enny Probosari ◽  
Fillah Fithra Dieny
Keyword(s):  
Physical Activity ◽  
Vitamin D ◽  
Blood Glucose ◽  
Calcium Intake ◽  
Obese Woman ◽  
Fasting Blood Glucose ◽  
Cross Sectional ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Spearman Test

Background : Vitamin D and calcium have metabolic functions in the cells and insufficient intake has been proven to increase the risk factor for many chronic diseases, such as diabetes mellitus. Vitamin D and calcium both contribute in raising insulin secretion by regulating extracelullar calcium concentration and fluxing through cell membranes facilitated by calcium-sensing receptor. This study aimed to determine correlation between vitamin D and calcium intake with blood glucose levels in obese woman aged 45-55 years.Methods : Observational study with cross sectional design. Sixty subjects were selected using consecutive sampling. Food intakes were assessed by Semi Quantitative Food Frequency Questionnaire, fasting blood glucose levels were measured by Glucose Oxidation method, and physical activities were determined by Long International Physical Activity Questionnaire. The data were analyzed using r Pearson and Rank-Spearman test. Results : Mean of fasting blood glucose levels was 90,4±37,22 mg/dL with average vitamin D was 4,1 ±2,23 μg, whereas calcium was 547,7±316,24 mg. All subjects had low vitamin D intake; 88,3% subjects had low calcium intake; 88,3% subjects had normal fasting blood glucose; and 11,7% subjects had hyperglycemia. There was no correlation between vitamin D (p = 0,295) and calcium  (p = 0,295) intake with fasting blood glucose levels. Intake of energy, carbohydrate, fat, protein, fiber  and physical activity also showed no corerelation with fasting blood glucose levels. Conclusion : There was no correlation of vitamin D and calcium intake with fasting blood glucose levels in obese woman aged 45-55 years.

scholarly journals Gambaran kadar glukosa darah puasa pada pekerja kantor

2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Louis E. Ugahari ◽  
Yanti M. Mewo ◽  
Stefana H.M. Kaligis
Keyword(s):  
Physical Activity ◽  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Sedentary Lifestyle ◽  
Fasting Blood Glucose ◽  
Office Workers ◽  
Glucose Levels ◽  
Blood Glucose Levels

Abstract: Blood glucose must be maintained in a constant concentration. Hyperglycemia, an increase of blood glucose level, can be a symptom of diabetes mellitus. One of the factors that affect the blood glucose level is physical activity. Low physical activity can be influenced by work. Sedentary lifestyle is identic with office workes. Office workers do not enough time to do physical activity. This study was aimed to describe the fasting blood glucose level among office workers. This was a descriptive study with a cross sectional design. Respondents were obtained by using total sampling method. There were 52 respondents in this study consisted of 25 males and 27 females. The results showed that 45 respondents (86.54%) had normal fasting blood glucose levels, 5 respondents (9.62%) had high fasting blood glucose levels (hyperglycemia), and 2 respondents (3.84%) had low fasting blood glucose levels (hypoglycemia). The maximum value was 243 mg/dL, the minimum value was 63 mg/dL, the median value was 83 mg/dL, the average value was 94.42 mg/dL, and standard of deviation was 37.85 mg/dL. Conclusion: Most office workers had normal blood glucose levels.Keywords: fasting blood glucose, office workers Abstrak: Glukosa darah dalam tubuh manusia harus dijaga dalam konsentrasi yang konstan. Kadar glukosa darah dalam tubuh yang meningkat (hiperglikemia) dapat menjadi gejala penyakit diabetes mellitus. Salah satu faktor yang memengaruhi kadar glukosa darah ialah aktivitas fisik. Aktivitas fisik yang kurang dapat dipengaruhi oleh pekerjaan. Pola hidup sedentary lifestyle identik dengan pekerja kantor dewasa ini. Pekerja kantor tidak memiliki waktu untuk terlibat dalam aktivitas fisik yang cukup. Penelitian ini bertujuan untuk mengetahui gambaran kadar glukosa darah puasa pada pekerja kantor. Jenis penelitian ialah deskriptif dengan desain potong lintang. Pemilihan responden dilakukan dengan metode total sampling. Responden terdiri dari 25 orang laki-laki s dan 27 orang perempuan. Hasil penelitian mendapatkan 45 responden (86,54%) memiliki kadar glukosa darah puasa normal, 5 responden (9,62%) memilki kadar glukosa darah puasa tinggi (hiperglikemia), dan 2 responden (3,84%) memilki kadar glukosa puasa rendah (hipoglikemia). Hasil pengukuran kadar glukosa darah puasa mendapatkan nilai maksimum 243 mg/dL, nilai minimum 63 mg/dL, nilai median 83 mg/dL, nilai rata-rata 94,42 mg/dL dan standar devisiasi 37,85 mg/dL. Simpulan: Sebagian besar pekerja kantor masih memiliki kadar glukosa darah puasa yang normal. Kata kunci: glukosa darah puasa, pekerja kantor

scholarly journals The Effectiveness of Vitamin D Addition to Decreasing Blood Glucose Levels of Hyperglycemic Mice Model with Glimepirid Therapy

2020 ◽  
Vol 6 (2) ◽  
pp. 71
Author(s):  
Tsintani Nur Aristiana ◽  
Cholis Abrori ◽  
Muhammad Ali Shodikin
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Negative Control ◽  
Control Group ◽  
Mice Model ◽  
Control Group Design ◽  
Glucose Levels ◽  
Blood Glucose Levels

Abstract Low 25-hydrocyvitamin D (25(OH)D3) levels are usually found in patients with type 1 and type 2 diabetes mellitus. This study aims to compare the effectiveness of fasting blood glucose levels in hyperglycemic mice model with glimepirid single therapy, hyperglycemic mice model with vitamin D, and mice model of hyperglycemic with glimepirid therapy plus vitamin D. This study used the true experimental research design with the randomized posttest only control group design. There were 25 male mice (Mus musculus) strain Balb/C with 20-30 g body weight and 2-3 months old which were grouped into 5 groups. The negative control group (K1) was injected with placebo and the positive control group (K2) was injected with STZ 150 mg/kgBW i.p. Groups P1, P2, and P3 were given STZ injection of 150 mg/kgBW i.p and given glimepirid 0.26 mg/kgBW; vitamin D 6,5 ml/kgBW; glimepirid 0,26 mg/kgBW with vitamin D supplementation 6,5 ml/kgBW. The results of the Tukey post hoc tests obtained differences in the mean of delta KGD between groups P1 and K2 = 122,55; in group P2 with K2 = 81,60; and in group P3 with K2 = 74,40. From these data, it can be concluded that in the group given glimepirid plus vitamin D there was no additional effectiveness in decreasing fasting blood glucose levels of hyperglycemic mice model compared to the group given only glimepirid therapy and the group given vitamin D alone. Keywords: diabetes mellitus, vitamin D, glimepiride, streptozotocin.

scholarly journals Association of vitamin D receptor gene polymorphism with a bone mineral density level in postmenopausal women

2019 ◽  
Vol 16 (2) ◽  
pp. 192-201 ◽  
Author(s):  
A. V. Rudenka ◽  
E. V. Rudenka ◽  
V. Yu. Samokhovec ◽  
K. V. Kobets ◽  
P. M. Marozik
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Gene Polymorphism ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Vitamin D Receptor ◽  
Receptor Gene ◽  
Vitamin D Receptor Gene ◽  
Gene Variant ◽  
Mineral Density

The analysis of association of polymorphic variants of the vitamin D receptor gene (VDR) with bone mineral density (BMD) values in menopausal women was performed. The study included 66 patients with postmenopausal osteoporosis (PMO group) and 170 postmenopausal women with normal BMD values (CON group). The statistically significant difference between the analyzed groups in the genotypes and the alleles frequency distribution for the VDR ApaI gene variant was revealed: for the carriers of C/C genotype, the risk of osteoporosis was higher compared to individuals with A/A genotype (OR = 2.7 [95 % CI: 1.5–4.7], p = 0.002). Allele A was overrepresented in the CON group and associated with the reduced risk of disease (OR = 0.6 [95 % CI: 0.4–0.8], p = 0.001). Statistically significant differences were found between the studied groups when analyzing VDR BsmI gene variant distribution. For the individuals with the unfavorable VDR BsmI G/G-genotype, the risk of PMO was significantly higher when compared to the carriers of the A/A-genotype (OR = 2.1 [95 % CI: 1.0–4.4], p = 0.02). For the bearers of A-allele, the risk of osteoporosis was significantly lower (OR = 0.6 [95 % CI: 0.4–0.9], p = 0.007). Among the carriers of the VDR ApaI C/C-genotype, the average BMD level was by 13.7 % lower compared to the carriers of the VDR ApaI A/A-genotype (0.767 and 0.872 g/cm2, respectively, p = 0.04); among individuals with the TaqI C/C-genotype, the BMD level was by 13.8 % lower compared to TaqI T/T-genotype bearers (0.803 and 0.914 g/cm2, respectively, p = 0.03). VDR gene polymorphism may play an important role in the susceptibility to osteoporosis and is significantly associated with the BMD level in postmenopausal women.

scholarly journals Association between blood glucose level with glycemic load, physical activity and compliance to medication among diabetes mellitus (DM) patients in Buleleng District General Hospital, Bali Province

2017 ◽  
Vol 5 (2) ◽  
pp. 117
Author(s):  
Ketut Adi Jaya Sutana ◽  
Komang Ayu Kartika Sari ◽  
I Wayan Weta
Keyword(s):  
Physical Activity ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Fasting Blood Glucose ◽  
Glycemic Load ◽  
Postprandial Blood Glucose ◽  
Fasting Blood Glucose Level ◽  
Glucose Levels ◽  
Blood Glucose Levels

Background and purpose: The prevalence of diabetes mellitus (DM) in Indonesia is increasing, including in Buleleng District, Bali Province. Studies regarding determinants of blood glucose control in DM patients show varied findings. This study aims to examine association between blood glucose level with physical activity, compliance to medication and glycemic load among DM patients.Methods: A cross-sectional survey was conducted in Buleleng District General Hospital from March to April 2017. A total of 73 patients were concecutively recruited to participate in our study. Data were collected through interview, observation and measurement. Data collected included socio-demographic characteristics, fasting blood glucose level, 1-hour and 2-hour postprandial blood glucose levels, carbohydrate intake, body mass index, glycemic index, glycemic load, physical activity, genetic or family history, and compliance to medication. A bivariate analysis was performed to examine association between independent variables and blood glucose levels. Multivariate analysis was also conducted to calculate adjusted odd ratio using a binary logistic regression.Results: Our study found that blood glucose levels of most respondents were relatively well managed–63% for fasting, 61.6% for 1-hour postprandial, and 63% for 2-hours postprandial. Multivariate analysis revealed that fasting blood glucose level were associated with regular physical activities (AOR=74.09; 95%CI: 7.52-729.69) and compliance to medication (AOR=11.90; 95%CI: 2.24-63.29). Furthermore, 1-hour postprandial blood glucose level were associated with breakfast glycemic load (AOR=0.63; 95%CI: 0.47-0.85) and compliance to medication (AOR=27.29; 95%CI: 2.29-323.95), while 2-hour postprandial blood glucose level were associated with breakfast glycemic load (AOR=0.69; 95%CI: 0.54-0.89) and compliance to medication (AOR=19.81; 95%CI: 2.31-170.14).Conclusions: Factors associated with fasting blood glucose level were regular physical activities and adherence to medication, while 1-hour and 2-hours postprandial blood glucose levels were both influenced by breakfast glycemic load and compliance to medication.

803: Interactions Between Ultraviolet Radiation and Polymorphisms in the Vitamin D Receptor Gene Mediate Prostate Cancer Susceptibility

2006 ◽  
Vol 175 (4S) ◽  
pp. 260-260
Author(s):  
Nicholas J. Rukin ◽  
Samuel J. Moon ◽  
Dhaval Bodiwala ◽  
Christopher J. Luscombe ◽  
Mark F. Saxby ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Vitamin D ◽  
Ultraviolet Radiation ◽  
Vitamin D Receptor ◽  
Cancer Susceptibility ◽  
Receptor Gene ◽  
Vitamin D Receptor Gene ◽  
Prostate Cancer Susceptibility
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