Human herpesvirus 6 and effectiveness of interferon beta 1b in multiple sclerosis patients

2011 ◽  
Vol 18 (8) ◽  
pp. 1027-1035 ◽  
Author(s):  
M. Garcia-Montojo ◽  
V. De Las Heras ◽  
M. Dominguez-Mozo ◽  
M. Bartolome ◽  
M. A. Garcia-Martinez ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Interferon Beta ◽  
Human Herpesvirus ◽  
Human Herpesvirus 6 ◽  
Herpesvirus 6 ◽  
Multiple Sclerosis Patients

scholarly journals MHC2TA mRNA levels and human herpesvirus 6 in multiple sclerosis patients treated with interferon beta along two-year follow-up

BMC Neurology ◽  
2012 ◽  
Vol 12 (1) ◽  
Author(s):  
Maria Inmaculada Dominguez-Mozo ◽  
Marta Garcia-Montojo ◽  
Virginia De Las Heras ◽  
Angel Garcia-Martinez ◽  
Ana Maria Arias-Leal ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Interferon Beta ◽  
Human Herpesvirus ◽  
Mrna Levels ◽  
Human Herpesvirus 6 ◽  
Herpesvirus 6 ◽  
Multiple Sclerosis Patients

scholarly journals Reactivation of Human Herpesvirus-6 in Natalizumab Treated Multiple Sclerosis Patients

PLoS ONE ◽  
2008 ◽  
Vol 3 (4) ◽  
pp. e2028 ◽  
Author(s):  
Karen Yao ◽  
Susan Gagnon ◽  
Nahid Akhyani ◽  
Elizabeth Williams ◽  
Julie Fotheringham ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Human Herpesvirus ◽  
Human Herpesvirus 6 ◽  
Herpesvirus 6 ◽  
Multiple Sclerosis Patients

Absence of human herpesvirus 6 and 7 from spinal fluid and serum of multiple sclerosis patients

Neurology ◽  
1999 ◽  
Vol 53 (6) ◽  
pp. 1367-1367 ◽  
Author(s):  
P. Mirandola ◽  
A. Stefan ◽  
E. Brambilla ◽  
G. Campadelli-Fiume ◽  
L. M. E. Grimaldi
Keyword(s):  
Multiple Sclerosis ◽  
Human Herpesvirus ◽  
Spinal Fluid ◽  
Human Herpesvirus 6 ◽  
Herpesvirus 6 ◽  
Multiple Sclerosis Patients

Human herpesvirus 6 infects the central nervous system of multiple sclerosis patients in the early stages of the disease

2004 ◽  
Vol 10 (4) ◽  
pp. 348-354 ◽  
Author(s):  
A Rotola ◽  
I Merlotti ◽  
L Caniatti ◽  
E Caselli ◽  
E Granieri ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Central Nervous System ◽  
Nervous System ◽  
Human Herpesvirus ◽  
Clinical Samples ◽  
Human Herpesvirus 6 ◽  
Early Stages ◽  
The Central Nervous System ◽  
Herpesvirus 6 ◽  
Multiple Sclerosis Patients

The presence and the replicative state of human herpesvirus 6 (HHV-6) were evaluated in clinical samples from multiple sclerosis (MS) patients at the first time of MS diagnosis. HHV-6 variant B was present in peripheral blood mononuclear cells of 5/32 (15%) patients, but persisted with a latent infection. Viral sequences were present also in cerebrospinal fluid (CSF), both free in the liquid (7/32, 22%) and latent in the cellular fraction (3/32, 9%), as shown by analysis of viral transcription. In these cases, variant A was detected. HHV-6 DNA sequences present in the CSF were associated to mature viral particles. In fact, in vitro infectious assays of CSF showed the presence of replication-competent virions. These results show that about 20% of MS patients have active foci of HHV-6 variant A infection in the early stages of the disease and suggest that viral replication takes place within the central nervous system.

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