Arterial tension time reflects subclinical atherosclerosis, arterial stiffness and stroke volume

Objective. To assess the relationship between arterial stiffness parameters in hypertensive patients with and without atherosclerotic lesions.Design and methods. We included 127 subjects who were divided into 3 groups: patients with hypertension (HTN) without atherosclerosis (n = 42); patients with HTN and subclinical atherosclerosis (SА) (n = 52) and control group which consisted of individuals without HTN, SA, or coronary artery disease (n = 33). All groups matched by age and gender. All subjects underwent following examinations: ultrasonography of extracranial segments of carotid arteries, 24-hour blood pressure monitoring with the assessment of arterial stiffness parameters.Results. In subjects with HTN compared to controls, pulse wave velocity in aorta (PWVao) was significantly higher (11,3 ± 1,5; 12,3 ± 1,8 vs 10,4 ± 1,3 m/s; p < 0,05), as well as pulse pressure (PP) (46,4 ± 9,8; 45,6 ± 10,6 vs 39,9 ± 6,5 mmHg; p < 0,05), central pulse pressure (PPао) (35,5 ± 8,5; 34,9 ± 8,5 vs 30,9 ± 5,4 mmHg; p < 0,05), and arterial stiffness index (ASI) (141 (127, 159); 139 (128,5, 160,5) vs 126 (118, 138) mmHg; p < 0,05). In subjects with HTN and SA, PWVao was significantly higher compared to other groups (p < 0,05). No significant difference in augmentation index was found (–32,5 (–45, –12); –22 (–36, –12); –37 (–50, –17); p = 0,25). Аmbulatory arterial stiffness index was higher in controls (0,5 ± 0,2) compared to HTN group (0,4 ± 0,2; p = 0,05), while HTN and SA group did not differ significantly (0,5 ± 0,2; p = 0,3). PWVao above 11,15 m/s is associated with 4,3 (2,3–8,2) times higher rate of atherosclerosis plaque detection.Conclusions. In HTN patients, arterial stiffness is changed compared to healthy individuals. PWVao above 11,15 m/s is associated with 4,3 (2,3–8,2) times higher rate of atherosclerosis plaque detection. In patients with HTN and SA arterial stiffness is higher, which might have additional predictive value in risk stratification.

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Treat to target and prevention of subclinical atherosclerosis in psoriatic arthritis—which target should we choose?

Rheumatology ◽

10.1093/rheumatology/keaa025 ◽

2020 ◽

Vol 59 (10) ◽

pp. 2881-2892

Author(s):

Isaac T Cheng ◽

Edmund K Li ◽

Priscilla C Wong ◽

Mei Yan Law ◽

Isaac C Yim ◽

...

Keyword(s):

Arterial Stiffness ◽

Protective Effect ◽

Disease Activity ◽

Disease Control ◽

Subclinical Atherosclerosis ◽

Intima Media Thickness ◽

Treat To Target ◽

Vascular Effects ◽

Treatment Targets ◽

Media Thickness

Abstract Objective PsA patients who achieved sustained minimal disease activity (sMDA) had less subclinical atherosclerosis progression. The vascular effects of achieving other potential treatment targets, including the PsA Disease Activity Score (PASDAS) and the Disease Activity in PsA (DAPSA) score, remained uncertain. This study aimed to compare the vascular effects of achieving different treatment targets in PsA patients. Method This is a post hoc analysis of a 2 year treat-to-target study aimed at MDA. A total of 101 consecutive PsA patients without overt cardiovascular disease were recruited. High-resolution carotid ultrasound and arterial stiffness markers were assessed annually. Low disease activity (LDA) was defined as MDA, DAPSA ≤14 or PASDAS ≤3.2. Sustained disease control was defined as achieving these targets at each visit from month 12 until month 24. Results Ninety patients [52 male (57.8%), age 50 years (s.d. 11)] who completed 24 months of follow-up were included in this analysis. A total of 44%, 48% and 45% of patients achieved sustained DAPSA LDA (sDAPDA-LDA), sustained PASDAS LDA (sPASDAS-LDA) and sMDA, respectively. Patients who achieved sMDA had significantly less progression of carotid intima-media thickness than those who did not (P = 0.031). Using multivariate analysis, achieving sMDA and sPASDAS-LDA had a protective effect on plaque progression, less increase in total plaque area, reduced mean intima-media thickness and reduced augmentation index after adjusting for covariates. In contrast, no significant differences in the progression of vascular parameters were demonstrated between patients who did or did not achieve sDAPSA-LDA. Conclusion Achieving sMDA/sDASPAS-LDA, but not sDAPSA-LDA, was associated with a protective effect in subclinical atherosclerosis and arterial stiffness progression. A multidimensional domain of disease control might be better in minimizing cardiovascular risk in PsA.

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SAT0162 Assessment of Subclinical Atherosclerosis (Flow Mediated Dilatation and Arterial Stiffness) after 24 Weeks of Tocilizumab Therapy in 22 Patients with Rheumatoid Arthritis

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2014-eular.4911 ◽

2014 ◽

Vol 73 (Suppl 2) ◽

pp. 649.1-649

Author(s):

M. Soubrier ◽

M.-A. Verny ◽

B. Pereira ◽

T. Frayssac ◽

M. Couderc ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Arterial Stiffness ◽

Subclinical Atherosclerosis ◽

Flow Mediated Dilatation

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The TyG Index as a Marker of Subclinical Atherosclerosis and Arterial Stiffness in Lean and Overweight Postmenopausal Women

Heart Lung and Circulation ◽

10.1016/j.hlc.2017.05.142 ◽

2018 ◽

Vol 27 (6) ◽

pp. 716-724 ◽

Cited By ~ 27

Author(s):

Irene Lambrinoudaki ◽

Maria Vasiliki Kazani ◽

Eleni Armeni ◽

Georgios Georgiopoulos ◽

Konstantinos Tampakis ◽

...

Keyword(s):

Arterial Stiffness ◽

Postmenopausal Women ◽

Subclinical Atherosclerosis ◽

Tyg Index

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The Relationship between Effective Arterial Capacitance and Pulse Wave Velocity is Dependent on Left Ventricular Stroke Volume

Angiology ◽

10.1177/0003319708315306 ◽

2008 ◽

Vol 60 (1) ◽

pp. 82-86 ◽

Cited By ~ 7

Author(s):

Oladipupo Olafiranye ◽

Ghazanfar Qureshi ◽

Louis Salciccioli ◽

Kinda Vernon-Jones ◽

Charles Philip ◽

...

Keyword(s):

Arterial Stiffness ◽

Stroke Volume ◽

Pulse Wave Velocity ◽

Wave Velocity ◽

Cardiovascular Events ◽

Pulse Wave ◽

Aortic Pressure ◽

Left Ventricular ◽

Applanation Tonometry ◽

The Relationship

Background increased arterial stiffness is a predictor of cardiovascular events. The stroke volume (SV) to pulse pressure (PP) ratio is an estimate of arterial capacitance. Pulse wave velocity (PWV) is a measure of arterial stiffness. This study evaluated the effect of left ventricular (LV) SV on the SV/PP–PWV relationship. Methods 97 patients had applanation tonometry and echocardiography to measure arterial capacitance (SV/PP), PWV, and central aortic pressure. Results 50 patients had normal SV and 47 had low SV. For all patients, PWV inversely correlated with SV/PP. PWV and SV/PP correlated more strongly in the normal SV group than in the low SV group. Aortic PP was significantly correlated with PWV in all patients, in the normal SV group, and in the low SV group. Conclusion effective arterial capacitance correlates with PWV. The presence of decreased SV weakens the relationship.

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