scholarly journals Risk factors associated with the deterioration of renal function after kidney transplantation

2005 ◽  
Vol 68 ◽  
pp. S113-S117 ◽  
Author(s):  
Daniel Serón ◽  
Xavier Fulladosa ◽  
Francesc Moreso
Keyword(s):  
Risk Factors ◽  
Renal Function ◽  
Kidney Transplantation ◽  
Factors Associated

scholarly journals The risk factors associated with treatment-related mortality in 16,073 kidney transplantation—A nationwide cohort study

PLoS ONE ◽  
2020 ◽  
Vol 15 (7) ◽  
pp. e0236274 ◽  
Author(s):  
Hyunji Choi ◽  
Woonhyoung Lee ◽  
Ho Sup Lee ◽  
Seom Gim Kong ◽  
Da Jung Kim ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Kidney Transplantation ◽  
Factors Associated ◽  
Treatment Related Mortality ◽  
Related Mortality

Risk Factors Associated With Graft Loss and Patient Survival After Kidney Transplantation

2009 ◽  
Vol 41 (9) ◽  
pp. 3667-3670 ◽  
Author(s):  
K.M. Harada ◽  
E.L. Mandia-Sampaio ◽  
T.V. de Sandes-Freitas ◽  
C.R. Felipe ◽  
S.I. Park ◽  
...  
Keyword(s):  
Risk Factors ◽  
Kidney Transplantation ◽  
Patient Survival ◽  
Graft Loss ◽  
Factors Associated

scholarly journals Immunosuppression as a Risk Factor for De Novo Angiotensin II Type Receptor Antibodies Development after Kidney Transplantation

2021 ◽  
Vol 10 (22) ◽  
pp. 5390
Author(s):  
Bogdan Marian Sorohan ◽  
Ioanel Sinescu ◽  
Dorina Tacu ◽  
Cristina Bucșa ◽  
Corina Țincu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Kidney Transplantation ◽  
Angiotensin Ii ◽  
De Novo ◽  
Multivariate Logistic Regression Analysis ◽  
Study Cohort ◽  
Type I ◽  
Factors Associated ◽  
Maintenance Immunosuppression ◽  
Receptor Antibodies

(1) Background: Angiotensin II type I receptor antibodies (AT1R-Ab) represent a topic of interest in kidney transplantation (KT). Data regarding the risk factors associated with de novo AT1R-Ab development are lacking. Our goal was to identify the incidence of de novo AT1R-Ab at 1 year after KT and to evaluate the risk factors associated with their formation. (2) Methods: We conducted a prospective cohort study on 56 adult patients, transplanted between 2018 and 2019. Recipient, donor, transplant, treatment, and complications data were assessed. A threshold of >10 U/mL was used for AT1R-Ab detection. (3) Results: De novo AT1R-Ab were observed in 12 out of 56 KT recipients (21.4%). The median value AT1R-Ab in the study cohort was 8.5 U/mL (inter quartile range: 6.8–10.4) and 15.6 U/mL (10.8–19.8) in the positive group. By multivariate logistic regression analysis, induction immunosuppression with anti-thymocyte globulin (OR = 7.20, 95% CI: 1.30–39.65, p = 0.02), maintenance immunosuppression with immediate-release tacrolimus (OR = 6.20, 95% CI: 1.16–41.51, p = 0.03), and mean tacrolimus trough level (OR = 2.36, 95% CI: 1.14–4.85, p = 0.01) were independent risk factors for de novo AT1R-Ab at 1 year after KT. (4) Conclusions: De novo AT1R-Ab development at 1 year after KT is significantly influenced by the type of induction and maintenance immunosuppression.

An Analysis of Occurrence and Prognosis Related Factors of Renal Dysfunction in Patients with Multiple Myeloma.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 4732-4732
Author(s):  
Rong Fu ◽  
Ting Wang ◽  
Zonghong Shao
Keyword(s):  
Risk Factors ◽  
Multiple Myeloma ◽  
Renal Function ◽  
Renal Dysfunction ◽  
Tumor Burden ◽  
Protection Factor ◽  
Related Factors ◽  
Factors Associated ◽  
Renal Function Recovery ◽  
Function Recovery

Abstract Objective To analysis the occurrence and prognosis related factors in renal dysfunction with multiple myeloma(MM). Methods Seventy-four cases with MM were enrolled in this study. The risk factors of occurrence and prognosis were analyzed. Results The incidence of renal dysfunction (RD) with MM was 56.8%, Age, hypertention, hemoglobin, serum ALB and GLO levels, serum β2MG, serum calcium and phosphonium level, the percentage of myeloma cells in bone marrow, types of MM, Durie-Salmon stage were the single factors associated with the incidence of RD with MM. Hypertention, serum β2MG and ALB levels were the multiple factors associated with the incidence of RD with MM. ALB was the protection factor and the other two were risk factors. The renal function recovered rapidly in the patients who received CR or received blood transfusion. The patients with renal dysfunction survived shorter (28±5months) than those with normal renal function (42±6months). Renal dysfunction caused more MM patients death(84.6%) in 3 months. Conclusion Hypertention and high tumor burden were the risk factors of renal dysfunction in MM, effective chemothemapy and support treatment help renal function recovery.

scholarly journals Analysis of risk factors associated with renal function trajectory over time: a comparison of different statistical approaches

2014 ◽  
Vol 30 (8) ◽  
pp. 1237-1243 ◽  
Author(s):  
Karen Leffondre ◽  
Julie Boucquemont ◽  
Giovanni Tripepi ◽  
Vianda S. Stel ◽  
Georg Heinze ◽  
...  
Keyword(s):  
Risk Factors ◽  
Renal Function ◽  
Factors Associated ◽  
Statistical Approaches ◽  
Over Time

scholarly journals Clinical and metabolomic risk factors associated with rapid renal function decline in sickle cell disease

2018 ◽  
Vol 93 (12) ◽  
pp. 1451-1460 ◽  
Author(s):  
Julia Z. Xu ◽  
Melanie E. Garrett ◽  
Karen L. Soldano ◽  
Sean T. Chen ◽  
Clary B. Clish ◽  
...  
Keyword(s):  
Risk Factors ◽  
Renal Function ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Cell Disease ◽  
Renal Function Decline ◽  
Factors Associated

scholarly journals Cumulative fluid accumulation is associated with the development of acute kidney injury and non-recovery of renal function: a retrospective analysis

Critical Care ◽  
2019 ◽  
Vol 23 (1) ◽  
Author(s):  
Jing Zhang ◽  
Siobhan Crichton ◽  
Alison Dixon ◽  
Nina Seylanova ◽  
Zhiyong Y. Peng ◽  
...  
Keyword(s):  
Risk Factors ◽  
Acute Kidney Injury ◽  
Renal Function ◽  
Fluid Balance ◽  
Tertiary Care ◽  
Kidney Injury ◽  
Renal Recovery ◽  
Partial Recovery ◽  
Factors Associated ◽  
Cumulative Fluid Balance

Abstract Background Acute kidney injury (AKI) is common in patients in the intensive care unit (ICU) and may be present on admission or develop during ICU stay. Our objectives were (a) to identify factors independently associated with the development of new AKI during early stay in the ICU and (b) to determine the risk factors for non-recovery of AKI. Methods We retrospectively analysed prospectively collected data of patients admitted to a multi-disciplinary ICU in a single tertiary care centre in the UK between January 2014 and December 2016. We identified all patients without AKI or end-stage renal failure on admission to the ICU and compared the outcome and characteristics of patients who developed AKI according to KDIGO criteria after 24 h in the ICU with those who did not develop AKI in the first 7 days in the ICU. Multivariable logistic regression was applied to identify factors associated with the development of new AKI during the 24–72-h period after admission. Among the patients with new AKI, we identified those with full, partial or no renal recovery and assessed factors associated with non-recovery. Results Among 2525 patients without AKI on admission, the incidence of early ICU-acquired AKI was 33.2% (AKI I 41.2%, AKI II 35%, AKI III 23.4%). Body mass index, Sequential Organ Failure Assessment score on admission, chronic kidney disease (CKD) and cumulative fluid balance (FB) were independently associated with the new development of AKI. By day 7, 69% had fully recovered renal function, 8% had partial recovery and 23% had no renal recovery. Hospital mortality was significantly higher in those without renal recovery. Mechanical ventilation, diuretic use, AKI stage III, CKD, net FB on first day of AKI and cumulative FB 48 h later were independently associated with non-recovery with cumulative fluid balance having a U-shape association. Conclusions Early development of AKI in the ICU is common and mortality is highest in patients who do not recover renal function. Extreme negative and positive FB were strong risk factors for AKI non-recovery.

scholarly journals Long-term renal function and mortality after radical cystectomy and ileal conduit formation.

2020 ◽  
Author(s):  
Julio Chevarria ◽  
Chaudhry A. Ebad ◽  
Mairead Hamill ◽  
Catalin Constandache ◽  
Cliona Cowhig ◽  
...  
Keyword(s):  
Risk Factors ◽  
Bladder Cancer ◽  
Renal Function ◽  
Radical Cystectomy ◽  
Urinary Diversion ◽  
Beaumont Hospital ◽  
Renal Function Decline ◽  
Factors Associated ◽  
Renal Function Deterioration

Abstract Background. Treatment for bladder cancer includes radical cystectomy (RC) and urinary diversion, RC is associated with long-term morbidity, renal function deterioration and mortality. Our aim was to identify risk factors associated with postoperative long-term renal function decline and mortality. Methods. Retrospective study in patients with RC and urinary diversion in Beaumont Hospital from 1996 to 2016. We include patients who had assessment for at least two years post procedure and confirmed live status. We assessed the estimated glomerular filtration rate (eGFR) preoperatively, at first and second year, renal function decline > 10 ml/min/1.73 m2, start dialysis and mortality. Logistic regression analyses were applied to assess risk factors associated, a significant p-value < 0.05 was considered. Results. We included 264 patients, with median age 68.3 years, 73,7% males, main diagnose was bladder cancer 93.3%, TNM stages were grouped in T ≥ 2 75.9%, N ≥ 1 47.6% and M1 28%. The median eGFR preoperative was 65.8 ml/min/1.73 m2 and after 2 years 58.2 ml/min/1.73 m2 (p:0.009), 5.6% required chronic dialysis and 32.8% had a decrease > 10 ml/min/1.73 m2. Risk factors associated with ESKD included age (HR:1.13, CI95% 1.05–1.22), preoperative eGFR (HR:1.04, CI95% 1.01–1.07). Overall mortality was 43.2%, 75.9% at 5 and 10 years respectively, risk factors were age (HR:1.1, CI95% 1.04–1.18), preoperative eGFR (HR:1.03, CI95% 1.01–1.06) and male gender (HR:14.8, CI95% 1.1–192). Conclusions. Patients with RC have risk of progressive renal function deterioration and high mortality and the main risk factors associated were age, sex, and preoperative eGFR. Regular monitoring of renal function will permit early diagnosis and treatment.

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