scholarly journals Analysis of risk factors associated with renal function trajectory over time: a comparison of different statistical approaches

2014 ◽  
Vol 30 (8) ◽  
pp. 1237-1243 ◽  
Author(s):  
Karen Leffondre ◽  
Julie Boucquemont ◽  
Giovanni Tripepi ◽  
Vianda S. Stel ◽  
Georg Heinze ◽  
...  
Keyword(s):  
Risk Factors ◽  
Renal Function ◽  
Factors Associated ◽  
Statistical Approaches ◽  
Over Time

Risk Factors for Hyperlactataemia in HIV-Infected Patients, Aquitaine Cohort, 1999–2003

2005 ◽  
Vol 16 (1) ◽  
pp. 63-67 ◽  
Author(s):  
Fabrice Bonnet ◽  
Eric Balestre ◽  
Elise Bernardin ◽  
Jean-Luc Pellegrin ◽  
Didier Neau ◽  
...  
Keyword(s):  
Risk Factors ◽  
Renal Function ◽  
Multivariate Analysis ◽  
Serum Lactate ◽  
Cd4 Count ◽  
Plasma Lactate ◽  
Plasma Triglycerides ◽  
Factors Associated ◽  
Increased Risk ◽  
Over Time

The objectives of our study were to describe the characteristics of a subset of patients who had been prescribed serum lactate in clinical practice within a large cohort of HIV-infected patients and to determine the factors associated with hyperlactataemia. Hyperlactataemia (⩾T2 mmol/l) was found in 219 [29% (95% confidence interval: 25.3–31.7)] of the 768 HIV-infected participants. In multivariate analysis (logistical regression), an increased risk of hyperlactataemia was associated with increasing age, CD4 count <500/mm3, triglycerides >2.2 mmol/L, lipoatrophy and stavudine use. In a second model coding for the NRTI-based drug combinations, only those including stavudine were associated with an increased risk of hyperlactataemia. In a third model including exposure duration to NRTIs, we estimated a 20% increased risk of hyperlactataemia per year of exposure to didanosine or stavudine. The risk of hyperlactataemia could increase over time in patients treated with these drugs and is also closely associated with increased age, decreased CD4 count, lipodystrophy and increased plasma triglycerides. It could be proposed that patients having one or more of these risk factors undergo regular monitoring of plasma lactate and renal function to prevent lactic acidosis.

An Analysis of Occurrence and Prognosis Related Factors of Renal Dysfunction in Patients with Multiple Myeloma.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 4732-4732
Author(s):  
Rong Fu ◽  
Ting Wang ◽  
Zonghong Shao
Keyword(s):  
Risk Factors ◽  
Multiple Myeloma ◽  
Renal Function ◽  
Renal Dysfunction ◽  
Tumor Burden ◽  
Protection Factor ◽  
Related Factors ◽  
Factors Associated ◽  
Renal Function Recovery ◽  
Function Recovery

Abstract Objective To analysis the occurrence and prognosis related factors in renal dysfunction with multiple myeloma(MM). Methods Seventy-four cases with MM were enrolled in this study. The risk factors of occurrence and prognosis were analyzed. Results The incidence of renal dysfunction (RD) with MM was 56.8%, Age, hypertention, hemoglobin, serum ALB and GLO levels, serum β2MG, serum calcium and phosphonium level, the percentage of myeloma cells in bone marrow, types of MM, Durie-Salmon stage were the single factors associated with the incidence of RD with MM. Hypertention, serum β2MG and ALB levels were the multiple factors associated with the incidence of RD with MM. ALB was the protection factor and the other two were risk factors. The renal function recovered rapidly in the patients who received CR or received blood transfusion. The patients with renal dysfunction survived shorter (28±5months) than those with normal renal function (42±6months). Renal dysfunction caused more MM patients death(84.6%) in 3 months. Conclusion Hypertention and high tumor burden were the risk factors of renal dysfunction in MM, effective chemothemapy and support treatment help renal function recovery.

scholarly journals Clinical and metabolomic risk factors associated with rapid renal function decline in sickle cell disease

2018 ◽  
Vol 93 (12) ◽  
pp. 1451-1460 ◽  
Author(s):  
Julia Z. Xu ◽  
Melanie E. Garrett ◽  
Karen L. Soldano ◽  
Sean T. Chen ◽  
Clary B. Clish ◽  
...  
Keyword(s):  
Risk Factors ◽  
Renal Function ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Cell Disease ◽  
Renal Function Decline ◽  
Factors Associated

scholarly journals Cumulative fluid accumulation is associated with the development of acute kidney injury and non-recovery of renal function: a retrospective analysis

Critical Care ◽  
2019 ◽  
Vol 23 (1) ◽  
Author(s):  
Jing Zhang ◽  
Siobhan Crichton ◽  
Alison Dixon ◽  
Nina Seylanova ◽  
Zhiyong Y. Peng ◽  
...  
Keyword(s):  
Risk Factors ◽  
Acute Kidney Injury ◽  
Renal Function ◽  
Fluid Balance ◽  
Tertiary Care ◽  
Kidney Injury ◽  
Renal Recovery ◽  
Partial Recovery ◽  
Factors Associated ◽  
Cumulative Fluid Balance

Abstract Background Acute kidney injury (AKI) is common in patients in the intensive care unit (ICU) and may be present on admission or develop during ICU stay. Our objectives were (a) to identify factors independently associated with the development of new AKI during early stay in the ICU and (b) to determine the risk factors for non-recovery of AKI. Methods We retrospectively analysed prospectively collected data of patients admitted to a multi-disciplinary ICU in a single tertiary care centre in the UK between January 2014 and December 2016. We identified all patients without AKI or end-stage renal failure on admission to the ICU and compared the outcome and characteristics of patients who developed AKI according to KDIGO criteria after 24 h in the ICU with those who did not develop AKI in the first 7 days in the ICU. Multivariable logistic regression was applied to identify factors associated with the development of new AKI during the 24–72-h period after admission. Among the patients with new AKI, we identified those with full, partial or no renal recovery and assessed factors associated with non-recovery. Results Among 2525 patients without AKI on admission, the incidence of early ICU-acquired AKI was 33.2% (AKI I 41.2%, AKI II 35%, AKI III 23.4%). Body mass index, Sequential Organ Failure Assessment score on admission, chronic kidney disease (CKD) and cumulative fluid balance (FB) were independently associated with the new development of AKI. By day 7, 69% had fully recovered renal function, 8% had partial recovery and 23% had no renal recovery. Hospital mortality was significantly higher in those without renal recovery. Mechanical ventilation, diuretic use, AKI stage III, CKD, net FB on first day of AKI and cumulative FB 48 h later were independently associated with non-recovery with cumulative fluid balance having a U-shape association. Conclusions Early development of AKI in the ICU is common and mortality is highest in patients who do not recover renal function. Extreme negative and positive FB were strong risk factors for AKI non-recovery.

scholarly journals Long-term renal function and mortality after radical cystectomy and ileal conduit formation.

2020 ◽  
Author(s):  
Julio Chevarria ◽  
Chaudhry A. Ebad ◽  
Mairead Hamill ◽  
Catalin Constandache ◽  
Cliona Cowhig ◽  
...  
Keyword(s):  
Risk Factors ◽  
Bladder Cancer ◽  
Renal Function ◽  
Radical Cystectomy ◽  
Urinary Diversion ◽  
Beaumont Hospital ◽  
Renal Function Decline ◽  
Factors Associated ◽  
Renal Function Deterioration

Abstract Background. Treatment for bladder cancer includes radical cystectomy (RC) and urinary diversion, RC is associated with long-term morbidity, renal function deterioration and mortality. Our aim was to identify risk factors associated with postoperative long-term renal function decline and mortality. Methods. Retrospective study in patients with RC and urinary diversion in Beaumont Hospital from 1996 to 2016. We include patients who had assessment for at least two years post procedure and confirmed live status. We assessed the estimated glomerular filtration rate (eGFR) preoperatively, at first and second year, renal function decline > 10 ml/min/1.73 m2, start dialysis and mortality. Logistic regression analyses were applied to assess risk factors associated, a significant p-value < 0.05 was considered. Results. We included 264 patients, with median age 68.3 years, 73,7% males, main diagnose was bladder cancer 93.3%, TNM stages were grouped in T ≥ 2 75.9%, N ≥ 1 47.6% and M1 28%. The median eGFR preoperative was 65.8 ml/min/1.73 m2 and after 2 years 58.2 ml/min/1.73 m2 (p:0.009), 5.6% required chronic dialysis and 32.8% had a decrease > 10 ml/min/1.73 m2. Risk factors associated with ESKD included age (HR:1.13, CI95% 1.05–1.22), preoperative eGFR (HR:1.04, CI95% 1.01–1.07). Overall mortality was 43.2%, 75.9% at 5 and 10 years respectively, risk factors were age (HR:1.1, CI95% 1.04–1.18), preoperative eGFR (HR:1.03, CI95% 1.01–1.06) and male gender (HR:14.8, CI95% 1.1–192). Conclusions. Patients with RC have risk of progressive renal function deterioration and high mortality and the main risk factors associated were age, sex, and preoperative eGFR. Regular monitoring of renal function will permit early diagnosis and treatment.

scholarly journals Longitudinal Analysis of Cardiovascular Risk Factors in Active and Sedentary Kidney Transplant Recipients

Medicina ◽  
2020 ◽  
Vol 56 (4) ◽  
pp. 183
Author(s):  
Valentina Totti ◽  
Bo Fernhall ◽  
Rocco Di Michele ◽  
Paola Todeschini ◽  
Gaetano La Manna ◽  
...  
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Renal Function ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Graft Function ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Over Time ◽  
Observation Period

Background: Despite the benefits of physical activity on cardiovascular risk in kidney transplant recipients (KTRs), the long-term effects of exercise have been poorly investigated. This is a three-year observational study comparing graft function and cardiovascular risk factors in active KTRs (AKTRs) vs. sedentary KTRs (SKTRs). Methods: KTRs with stable renal function were assigned to active or sedentary group in relation to the level of daily physical activity based on World Health Organization (WHO) recommendations (<150 or >150 minutes/week, respectively). Complete blood count, renal function indices, lipid profile, blood pressure and anthropometric measures were collected yearly for an observation period of three years. The comparisons between the two groups were performed by repeated measures analyses of covariance (ANCOVAs), with age as a covariate. Results: Fifty-four subjects were included in the study. Thirty of them were identified as AKTRs (M/F 26/4, aged 45 ± 12 years) and 24 as SKTRs (M/F 18/6, aged 51 ± 14 years). Baseline characteristics were similar between the groups except body mass index (BMI) that was significantly higher in SKTRs (p = 0.043). Furthermore, over the three-year observation period, BMI decreased in AKTRs and increased in SKTRs (p = 0.006). Graft function was stable in AKTRs, while it showed a decline over time in SKTRs, as indicated by the rise in serum creatinine levels (p = 0.006) and lower eGFR (p = 0.050). Proteinuria, glucose and uric acid levels displayed a decrease in AKTRs and an increase in SKTRs during the three-year period (p = 0.015, p = 0.004 and p = 0.013, respectively). Finally, concerning lipid profiles, AKTRs had a significant reduction over time of triglycerides levels, which conversely showed a clinically relevant increase in SKTRs (p = 0.014). Conclusions: Our findings indicate that regular weekly exercise training may counteract the increased cardiovascular risks and also prevent graft function decline in KTRs.

scholarly journals Psychological Risk Factors for Childhood Nonhuman Animal Cruelty

2017 ◽  
Vol 25 (3) ◽  
pp. 280-312 ◽  
Author(s):  
Roxanne D. Hawkins ◽  
Emma L. Hawkins ◽  
Joanne M. Williams
Keyword(s):  
Risk Factors ◽  
Nonhuman Animal ◽  
Animal Cruelty ◽  
Targeted Interventions ◽  
Psychological Risk Factors ◽  
Factors Associated ◽  
Nonhuman Animals ◽  
Psychological Risk ◽  
Cruelty To Animals ◽  
Over Time

Despite growing research into human-nonhuman animal relationships, little is known about childhood cruelty to nonhuman animals. The purpose of this review was to investigate the potential psychological risk factors for childhood cruelty to animals. The aim was to assemble, synthesize, and evaluate the quality and breadth of existing empirical research and highlight areas in need of further study. The review reveals a myriad of potential psychological risk factors associated with childhood animal cruelty, but highlights the decrease in publications on this topic over time and the lack of high-quality publications. Investigating the factors underlying cruel behavior toward animals has great implications for animal welfare and child wellbeing, and is vital for designing and implementing successful universal and targeted interventions to prevent cruelty to animals.

Sign in / Sign up

Export Citation Format

Share Document