The Role of an Engineering Oriented Medical Research Group in Developing Improved Methods and Devices for Achieving Ventricular Defibrillation: The University of Missouri Experience

1993 ◽  
Vol 16 (1) ◽  
pp. 95-124 ◽  
Author(s):  
JOHN C. SCHUDER
Keyword(s):  
Medical Research ◽  
Research Group ◽  
University Of Missouri ◽  
The University ◽  
Improved Methods ◽  
Ventricular Defibrillation

Role of copper in defending against bacterial infection

2015 ◽  
Author(s):  
◽  
Erik Ladomersky
Keyword(s):  
Bacterial Infection ◽  
Host Defense ◽  
Immune Defense ◽  
Copper Proteins ◽  
University Of Missouri ◽  
Susceptibility To Infection ◽  
Essential Nutrient ◽  
The University ◽  
The Relationship

[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Copper is an essential nutrient. It plays an important role in development, pigmentation, neurological function, and immune defense. Copper deficiency is known to make host's more susceptible to infection. In this work we show that two copper proteins, ATP7A and ceruloplasmin, are important for host defense against bacterial infection. Studies have shown ATP7A is responsible for increasing copper concentrations inside the phagosome. Our study sheds light on the role of Atp7a and copper in adaptive immunity, and provide a biochemical model for understanding the relationship between copper malnutrition and susceptibility to infection. Iron, another essential nutrient, is linked with copper through the actions of copper-dependent proteins which play a role in maintaining normal iron levels in the blood. One of these proteins is ceruloplasmin, a protein that is also upregulated during infection. Our study sheds light onto why this protein is necessary for host defense against Salmonella infection.

Challenge stressors, hindrance stressors, and psychological strain : the role of appraisals and goal orientations

2017 ◽  
Author(s):  
◽  
Timothy R. Moake
Keyword(s):  
Goal Orientation ◽  
Positive Relationship ◽  
Goal Orientations ◽  
Full Time ◽  
Psychological Strain ◽  
University Of Missouri ◽  
Transactional Theory ◽  
Learning Goal Orientation ◽  
The University

[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The challenge-hindrance stressor framework suggests that most workers experience challenge stressors positively and hindrance stressors negatively. However, research has shown that both types of stressors are positively related to psychological strain, a negative outcome. Using the transactional theory of stress, I examined whether and how individuals' appraisals of challenge and hindrance stressors and their goal orientations influence the positive relationships between both types of stressors and psychological strain. I surveyed 278 full-time employees from various occupations twice over a two-week span. My findings revealed that despite challenge stressors' positive conceptualization, individuals appraise them negatively as constraints. Additionally, I found that constraint appraisals are one mechanism that influences the positive relationship between challenge stressors and psychological strain. Lastly, my results also indicated that individuals with a stronger learning goal orientation are more likely to appraise both types of stressors as opportunities and individuals with a stronger performance-avoid goal orientation are more likely to appraise both types of stressors as constraints.

Determinants and consequences of private environmental regimes

2017 ◽  
Author(s):  
◽  
Krisztina A. Pusok
Keyword(s):  
Political Economy ◽  
International Relations ◽  
Environmental Governance ◽  
Environmental Politics ◽  
University Of Missouri ◽  
Political Consequences ◽  
Environmental Regimes ◽  
Global Environmental ◽  
The University

[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] While the role of firms has been acknowledged in existent research in political economy, it has played a rather peripheral role in the study of environmental politics, specifically in understanding environmental governance. In this dissertation, I seek to identify what the role of the private sector is in pushing the global environmental agenda. Specifically, I seek to offer alternative explanations for why firms choose to form these regimes, by drawing on existent comparative and international relations literatures focusing on political economy, governance, and the role of non-state actors. Additionally, I discuss the conditions determining firms to form private environmental regimes, as well as the economic and political consequences of this growing dynamic. Lastly, I investigate the mechanisms tying together different actors in terms of their environmental governance interactions.

Magical safe spaces : the role of literature in Medieval and early modern magic

2019 ◽  
Author(s):  
◽  
Emilee J. Howland-Davis
Keyword(s):  
Early Modern ◽  
Middle Ages ◽  
Early Modern Literature ◽  
Safe Space ◽  
Specific Group ◽  
University Of Missouri ◽  
Safe Spaces ◽  
Religious Behaviors ◽  
The University

[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] My dissertation argues that medieval and early modern English romances provided magic a safe space where authors and audiences engaged with the ideas of magic and superstition free from the risk of condemnation and the inquisition of medieval and early modern secular and religious authorities. The term safe space is a contemporary idea used to discuss spaces, both literal and figurative, where people who identify as LGTBQ+ are welcomed and free to express themselves. While the modern idea of a safe space has a very specific group of users and uses, it is the figurative idea of a safe space which I argue can be applied to otherworlds in medieval and early modern romances. I discuss late medieval and early modern romances as well as their interaction with and difference from historical records, trials, and treatises on magic. My methodology combines a historicist approach with Marxist and feminist theory in its exploration of magical safe spaces. The later Middle Ages were a time of increased scrutiny of non-religious behaviors, a narrowing of what constituted witchcraft and diabolism, and an upsurge in the numbers of heretical accusations and trials. Similarly, early modern England experienced an increase in accusations and investigations of magic, witchcraft, and heresy. My dissertation draws connections between historical documents and medieval and early modern literature and argues that as societal concerns about feminine heretical practice increased, literature found safe ways to explore these ideas. In doing this, medieval and early modern romance became a safe space for the exploration of magic generally and female magic users specifically.

Recovering the Midwestern Ethos of Journalism Research

2021 ◽  
pp. 17-32
Author(s):  
Jane Yeahin Pyo ◽  
Nikki Usher
Keyword(s):  
Mass Communication ◽  
The United States ◽  
Journalism Education ◽  
University Of Missouri ◽  
University Of Illinois ◽  
University Of Wisconsin ◽  
The University ◽  
Journalism Research ◽  
Back To The Land

This chapter is a reminder that practice and theory have gone hand in hand since the beginning of professional journalism. However, this history and this partnership have been lost somewhat, particularly when it comes to PhD research. By calling back to the land-grant mission at the universities home to the first schools of journalism in the United States (the University of Missouri, the University of Illinois, the University of Wisconsin), the chapter recalls how the focus on skills and on understanding mass communication was aligned with the mission of journalism education. The chapter examines the founding of the Institute of Communications Research at the University of Illinois and its PhD program that focused on applied journalism and mass communication research, explaining the role of legendary journalism scholar James Carey in recentering (and decentering) the tension between practice and research.

Investigating the role of arginine 21 in the structure and function of human [alpha]a-crystallin

2018 ◽  
Author(s):  
◽  
Ashutosh Shripad Phadte
Keyword(s):  
Functional Characterization ◽  
Lens Fiber Cell ◽  
University Of Missouri ◽  
Mutant Proteins ◽  
Plausible Mechanism ◽  
And Function ◽  
The University

[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Cataractogenesis in the eye lens occurs as a result of protein aggregation. Of the multiple mutations in [alpha]A-crystallins associated with the development of congenital hereditary cataract, three identified mutations target R21 within the N- terminal domain of the protein. On structural and functional characterization of a recently identified mutant of [alpha]A-crystallin, [alpha]A-R21Q, we revealed the contribution of R21 in dictating the interaction of [alpha]A-crystallin with other proteins. [alpha]A-R21Q showed and enhanced chaperone-like function, and increased binding to lens fiber cell membranes. Transduction of mutant proteins in ARPE-19 cells prevented their apoptosis in the presence of oxidative stress, suggesting a role for R21 in modulating the anti-apoptotic function of [alpha]A-crystallin. In addition, the R21Q point mutation rescued the chaperone-like activity of [alpha]A-G98R crystallin as well as palliated [alpha]A-G98R mediated cytotoxicity otherwise observed in transduction experiments. Although another mutation, R157Q rescued the chaperone-like activity of [alpha]A-G98R, the double mutant exhibited a loss of its cytoprotective function. The results therefore implicate an important role of R21 in regulating the functional aspect of [alpha]A-crystallin. [alpha]A-crystallin derived peptides have been shown to prevent non-specific aggregation of unfolding proteins in vitro. We show that the [alpha]A-crystallin derived mini-chaperone (mini-[alpha]A) mediated stabilization of self-aggregating [alpha]A-G98R crystallin and bovine [subscript]-crystallin occurs via compensation of lost surface charge. The observation therefore suggests a plausible mechanism of action of [alpha]A-crystallin derived peptides of therapeutic interest.

Journalism's next generation : socialization of high school journalists

2017 ◽  
Author(s):  
◽  
Marina A. Hendricks
Keyword(s):  
High School ◽  
Next Generation ◽  
University Of Missouri ◽  
Prior Review ◽  
Multimedia Environment ◽  
Time Work ◽  
Part Time ◽  
The Media ◽  
The University

[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Like their professional counterparts, high school journalists are confronting the societal and technological forces that are reshaping journalism. As members of journalism's next generation, high school journalists are charged with the responsibility of carrying journalism forward long after senior journalists exit the newsroom. This case study incorporated ethnographic observation and interviews to examine how high school journalists are socialized into journalism as an occupational ideology (Deuze, 2005). It focused on how high school journalists make meaning of public service, objectivity, autonomy, immediacy, and ethics through the intersection of their journalistic roles. It also looked at how high school journalists are socialized into journalism in the educational setting. Lastly, it considered the role of agents of socialization, such as individual educators, peers, family, part-time work, and the media. The findings suggest that high school journalists who practice free of threats from prior review and restraint are acclimating to the shared autonomy of the multimedia environment. High school journalists also are adapting to new considerations of immediacy that provide them with flexibility to act as disseminators or interpreters, as the situation warrants. Finally, high school journalists in an autonomous environment exert a strong socialization influence on their peers.

Nonlinear Models of Cable-Stayed Bridges

2006 ◽  
Vol 5-6 ◽  
pp. 425-432 ◽  
Author(s):  
C. Massow ◽  
Veronica Vidal ◽  
Alan R. Champneys ◽  
John H.G. Macdonald
Keyword(s):  
Research Group ◽  
Large Amplitude ◽  
Nonlinear Models ◽  
Vibration Data ◽  
Cable Vibrations ◽  
University Of Bristol ◽  
The University ◽  
Improved Methods ◽  
Coordinate Basis ◽  
Cable Stayed Bridges

Cable-stayed bridges frequently experience vibrations due to a variety of mechanisms, exacerbated by their very low inherent damping. A research group of the University of Bristol has focused lately on the study of cable-stayed bridges, some advances have led to the identification of vortex-induced deck vibrations occurring at the Second Severn Crossing (SSC) and improved methods of analysis of field vibration data. Based on such experience, it aims to study the autoparametric excitation which, due to very great amplitudes, can seriously damage the structure. It has been suggested that this may have been the mechanism of excitation of some large amplitude cable vibrations on real bridges, but the details of the behaviour are not very well understood and several cases of large cable vibrations on full scale bridges have not been fully explained. In this paper we examine a previously established cable-deck model and compare it to a new, more exact model in a different coordinate basis.

Social insecurity and the role of possessions : buying friends or replacing them?

2012 ◽  
Author(s):  
◽  
Alexander Gunz
Keyword(s):  
Social Anxiety ◽  
Critical Role ◽  
Emotional Awareness ◽  
Coping Behaviors ◽  
University Of Missouri ◽  
Self Monitoring ◽  
Personality Variables ◽  
Social Insecurity ◽  
The University

[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] This dissertation extends the literatures on coping and social anxiety by suggesting that people cope with social threats not just by directly trying to create (and restore) social relationships, but also by indirectly coping with the psychological fallout. It suggests that they do this by seeking hedonic product benefits that can salve emotional hurt, and by seeking product benefits that affirm unrelated aspects of the self concept. Two studies with different manipulations and outcome measures show that both manipulated and chronic forms of social anxiety can give rise to any of the above coping behaviors, and shows that the pursuit of these benefits is often moderated by relevant personality variables (e.g., entity theory and values-based transformations, emotional-awareness and hedonic transformations, and materialism and extrinsic transformations). These studies largely fail to replicate past findings that self-monitoring can moderate seeking social benefits. Finally, a new study by Lee and Shrum (2012) is discovered. A reanalysis of that paper's data suggests that there may be a critical role for implicit/explicit processing in consumers' deciding whether a given coping strategy is suitable. Applying this distinction to study 2's data generates a far more close-fitting description of its data.

Harriet Beecher Stowe and the circulation of texts

2014 ◽  
Author(s):  
◽  
Gregory David Specter
Keyword(s):  
Social Relationships ◽  
Print Culture ◽  
Harriet Beecher Stowe ◽  
University Of Missouri ◽  
Communal Relationships ◽  
The University

[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] This dissertation argues that even though Harriet Beecher Stowe participated in models of circulation throughout her career, they were shaped by drastic changes in the technology of print and transportation. Stowe witnessed changes in print culture that, in her view, detrimentally altered social relationships that print once fostered between people. This dissertation argues that Stowe saw a tightening relationship between publishers and other entities that overwhelmed readers with abundance. This profusion of print made it less personally valuable to readers and drastically altered print's ability to foster communal relationships. This dissertation examines Stowe's uneasiness and resistance to later models of print culture through her depiction of the role of letters, her use of prefaces, and through the recirculation of ideas in altered material forms echoing the scrapbook.

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