Increased lysyl oxidase activity in fibroblasts cultured from oral submucous fibrosis associated with betel nut chewing in Taiwan

1995 ◽  
Vol 24 (9) ◽  
pp. 407-412 ◽  
Author(s):  
R. H. Ma ◽  
C. C. Tsai ◽  
T. Y. Shieh
Keyword(s):  
Oxidase Activity ◽  
Lysyl Oxidase ◽  
Oral Submucous Fibrosis ◽  
Betel Nut ◽  
Submucous Fibrosis ◽  
Betel Nut Chewing

scholarly journals A Comprehensive Review of Etiopathogenesis of Oral Submucous Fibrosis

2015 ◽  
Vol 6 (2) ◽  
pp. 76-79
Author(s):  
Sukhjinder Kaur Kalra ◽  
Alok A Lathi ◽  
Shilpa A Lathi
Keyword(s):  
Oral Submucous Fibrosis ◽  
Areca Nut ◽  
Betel Nut ◽  
Exact Role ◽  
Comprehensive Review ◽  
Submucous Fibrosis ◽  
Betel Nut Chewing ◽  
Malignant Condition ◽  
Head Neck

ABSTRACT Accepted as an Indian disease, oral submucous fibrosis, is considered not only a chronic debilitating disease but a poten tially malignant condition of oral cavity, strongly associated with the habit of betel nut chewing, that has been sporadically detected in many other western countries and various conti nents, posing a reason for concern in order to create awareness for such debilitating disease. This article provides an overview of the recent concepts and exact role of areca nut alkaloids and other etiological factors in the pathogenesis of oral submucous fibrosis (OSMF). How to cite this article Kalra SK, Lathi AA, Lathi SA. A Com prehensive Review of Etiopathogenesis of Oral Submucous Fibrosis. Int J Head Neck Surg 2015;6(2):76-79.

scholarly journals Genetic Susceptibility and Protein Expression of Extracellular Matrix Turnover-Related Genes in Oral Submucous Fibrosis

2020 ◽  
Vol 21 (21) ◽  
pp. 8104
Author(s):  
Ru-Hsiu Cheng ◽  
Yi-Ping Wang ◽  
Julia Yu-Fong Chang ◽  
Yu-Hwa Pan ◽  
Mei-Chi Chang ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Oral Cancer ◽  
Genetic Susceptibility ◽  
Molecular Mechanisms ◽  
Lysyl Oxidase ◽  
Oral Submucous Fibrosis ◽  
Tissue Inhibitors Of Metalloproteinases ◽  
Contributing Factors ◽  
Plasminogen Activator Inhibitor 1 ◽  
Submucous Fibrosis

Betel quid (BQ) chewing increased the risk of oral cancer and oral submucous fibrosis (OSMF), an oral premalignant disorder (OPMD) with malignant transformation potential. BQ components such as areca nut (AN), trauma by coarse AN fiber, catechin, copper, alkaloids, stimulated reactive oxygen species (ROS), inflammation and cytotoxicity are suggested to be the contributing factors. They may induce tissue inflammation, proliferation of fibroblasts and collagen deposition, myofibroblast differentiation and contraction, collagen cross-links and inhibit collagen phagocytosis, finally leading to the development of OSMF and oral cancer. These events are mediated by BQ components-induced changes of extracellular matrix (ECM) turnover via regulation of TGF-β1, plasminogen activator inhibitor-1 (PAI-1), cystatin, lysyl oxidase (LOX) and tissue inhibitors of metalloproteinases (TIMPs) and metalloproteinases (MMPs). Genetic susceptibility is also involved in these disease processes. Further understanding the molecular mechanisms of BQ-induced OSMF and oral cancer can be helpful for future disease prevention and treatment.

Stabilisation of collagen by betel nut polyphenols as a mechanism in oral submucous fibrosis

1987 ◽  
Vol 43 (4) ◽  
pp. 391-393 ◽  
Author(s):  
A. Scutt ◽  
S. Meghji ◽  
J. P. Canniff ◽  
W. Harvey
Keyword(s):  
Oral Submucous Fibrosis ◽  
Betel Nut ◽  
Submucous Fibrosis

The upregulation of lysyl oxidase in oral submucous fibrosis and squamous cell carcinoma

2007 ◽  
Vol 28 (6) ◽  
pp. 246-251 ◽  
Author(s):  
C. Trivedy ◽  
K. A. A. S. Warnakulasuriya ◽  
V. K. Hazarey ◽  
M. Tavassoli ◽  
P. Sommer ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Lysyl Oxidase ◽  
Oral Submucous Fibrosis ◽  
Submucous Fibrosis

scholarly journals Frequency of Oral Sub Mucous Fibrosis and Its Correlation with the Level of Education in Patients Coming to a Tertiary Care Hospital of Karachi from January 2018 to December 2018

2020 ◽  
Vol 5 (3) ◽  
pp. 157-160
Author(s):  
Hira Tariq ◽  
Sana Ahmed ◽  
Maria Naz ◽  
Ayesha Naureen
Keyword(s):  
Substance Abuse ◽  
Tertiary Care Hospital ◽  
Oral Submucous Fibrosis ◽  
Tertiary Care ◽  
Care Hospital ◽  
Betel Nut ◽  
Skilled Workers ◽  
Cross Sectional ◽  
Level Of Education ◽  
Submucous Fibrosis

Objective: To determine the frequency of oral submucous fibrosis in patients coming to dental OPD of a tertiary care hospital and to correlate the association of level of education among patients of oral submucous fibrosis.Methodology: A cross sectional study was conducted from January 2018 to December 2018 among patients coming to the dental OPD of a tertiary care hospital in Karachi. Convenience sampling was used to select patients of Oral Submucous Fibrosis and a structured questionnaire was used to collect data on level of education, age, gender and Habit. Result: A total of 4405 patients visited the OPD and 135 patients were diagnosed with OSMF based on clinical findings. Mean age of OSMF patients was 33.6 years with nearly half 47.7% having no formal education.43.2% were skilled workers followed by 34.8% housewives and 22% were professionals. Betel nut was the most common used habit 79.5% among OSMF patients. Significant association of betelnut (p-0.001) among females(94.5%) compared to males (68.8%) and significant association of gutka (p-0.004) among males(24.7%) than females (5.5%)was observed. No significant association of level of education with substance abuse was observed. Conclusion: The finding of high frequency of betel nut usage among housewives and gutka among skilled workers is alarm some. Our literacy level despite being very low is not the sole reason of increase of substance abuse rather even the educated ones are not at par with this habit.

Copper content in Areca catechu (betel nut) products and oral submucous fibrosis

The Lancet ◽  
1997 ◽  
Vol 349 (9063) ◽  
pp. 1447 ◽  
Author(s):  
Chetan Trivedy ◽  
Dianne Baldwin ◽  
Saman Warnakulasuriya ◽  
Newell Johnson ◽  
Timothy Peters
Keyword(s):  
Copper Content ◽  
Oral Submucous Fibrosis ◽  
Betel Nut ◽  
Areca Catechu ◽  
Submucous Fibrosis

Oral submucous fibrosis in a school-going Indian adolescent boy

2017 ◽  
Vol 30 (5) ◽  
Author(s):  
Vishal Khandelwal ◽  
Hallaswamy V. Kambalimath ◽  
Naveen B. Reddy ◽  
Sushma Khandelwal ◽  
Vanaja Reddy ◽  
...  
Keyword(s):  
Oral Mucosa ◽  
Oral Submucous Fibrosis ◽  
Young Patients ◽  
Chief Complaint ◽  
Burning Sensation ◽  
Areca Nut ◽  
Betel Nut ◽  
Spicy Food ◽  
Submucous Fibrosis

Abstract A 14-year-old boy presented to our hospital with a chief complaint of difficulty in opening his mouth and a burning sensation on eating spicy food. The oral mucosa showed generalized diffused blanching and he was unable to protrude his tongue. For 6 years he had habitually chewed gutkha – a mixture of betel nut and tobacco for several minutes a day. This oral submucous fibrosis condition is very rare in young patients. The case highlights the link between oral submucous fibrosis and the regular use of areca nut (gutkha) products in a young boy.

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