Age-Related Changes in General and Sexual Health in Middle-Aged and Older Men: Results from the European Male Ageing Study (EMAS)

2010 ◽  
Vol 7 (4) ◽  
pp. 1362-1380 ◽  
Author(s):  
Giovanni Corona ◽  
David M. Lee ◽  
Gianni Forti ◽  
Daryl B. O'Connor ◽  
Mario Maggi ◽  
...  
Keyword(s):  
Sexual Health ◽  
Older Men ◽  
Middle Aged ◽  
Age Related ◽  
Ageing Study ◽  
Male Ageing ◽  
Age Related Changes

Perceptions of Sex Roles of Young and Middle-Aged Women and Men

1982 ◽  
Vol 55 (2) ◽  
pp. 559-562
Author(s):  
Claire Etaugh ◽  
Sharon Weber
Keyword(s):  
College Students ◽  
Sex Roles ◽  
Sex Role ◽  
Middle Aged ◽  
Age Related ◽  
Aged Woman ◽  
Male College ◽  
Middle Aged Woman ◽  
Age Related Changes ◽  
Female Subjects

48 female and 48 male college students used the Bern Sex-role Inventory to describe either a young or middle-aged woman or man. Female subjects perceived that women become increasingly feminine and less androgynous with age. No age-related changes were perceived in men's sex-role behaviors.

Correlation Between Telomere Attrition of Zona Fasciculata and Adrenal Weight Reduction in Older Men

2019 ◽  
Vol 105 (3) ◽  
pp. e200-e210
Author(s):  
K Nonaka ◽  
Junko Aida ◽  
Kaiyo Takubo ◽  
Yuto Yamazaki ◽  
Xin Gao ◽  
...  
Keyword(s):  
Sex Differences ◽  
Weight Reduction ◽  
Adrenal Glands ◽  
Older Men ◽  
Adrenal Weight ◽  
Zona Fasciculata ◽  
Biological Mechanisms ◽  
Telomere Attrition ◽  
Age Related ◽  
Age Related Changes

Abstract Context Although numerous theories are reported on sex differences in longevity, the underlying biological mechanisms remain unknown. We previously reported that telomere length in the zona reticularis cells of the human adrenal cortex was significantly longer in older than that in younger subjects. However, we could not evaluate sex differences in the telomere lengths. Objective To compare the telomere lengths of adrenocortical and adrenal medullar cells between men and women from infancy through older adulthood. Methods Adrenal glands of 30 male (aged 0 to 100 years) and 25 female (aged 0 to 104 years) autopsied subjects were retrieved from autopsy files. Using quantitative fluorescence in situ hybridization, relative telomere lengths were determined in the parenchymal cells of the 3 adrenocortical zones and medulla. Age-related changes in the weight of adrenal glands were also investigated. Main results Older male subjects (aged 65 years or older) had significantly shorter telomere lengths in zona fasciculata (ZF) cells compared to the corresponding female subjects. In men, older subjects exhibited a significant age-related reduction in adrenal weight; however, no age-related changes in adrenal weight were detected in women. Conclusion Telomere attrition of ZF cells was correlated with adrenal weight reduction in older men but not in older women, suggesting a decreased number of ZF cells in older men. This may help us understand the possible biological mechanisms of sex difference in longevity of humans.

scholarly journals The Relation of Inflammaging With Skeletal Muscle Properties in Elderly Men

2019 ◽  
Vol 13 (2) ◽  
pp. 155798831984193 ◽  
Author(s):  
Agnieszka Zembron-Lacny ◽  
Wioletta Dziubek ◽  
Edyta Wolny-Rokicka ◽  
Grazyna Dabrowska ◽  
Marek Wozniewski
Keyword(s):  
Body Composition ◽  
Growth Factors ◽  
Older Men ◽  
Knee Extension ◽  
Functional Fitness ◽  
Muscle Properties ◽  
Walking Test ◽  
Age Related ◽  
Igf I ◽  
Age Related Changes

Aging is associated with a progressive decline of muscle mass and/or the qualitative impairment of the muscle tissue. There is growing evidence of the prominent role of low-grade chronic inflammation in age-related changes in the neuromuscular system. The purpose of the study was to identify the inflammatory mediators responsible for deficit in functional fitness and to explain whether inflammation is related to changes in body composition and the decline of muscle strength in older men. Thirty-three old-aged males (73.5 ± 6.3 years) and twenty young-aged males (21.2 ± 1.3 years) participated in the study. The body composition (bioelectrical impedance analysis), functional capacity (6-min walking test) and knee extension strength (isokinetic test) were estimated. In serum, circulating inflammatory markers H2O2, IL-1β, TNFα, and hsCRP as well as growth factors IGF-I and PDGFBB concentrations were determined (immunoenzymatic methods). The concentrations of H2O2, IL-1β, TNFα, and hsCRP were significantly higher in older than young men. The growth factors IGF-I and PDGFBB were twofold lower and related to high levels of IL-1β and TNFα in the elderly. The changes in cytokines and growth factors levels were correlated with age and peak torque (TQ at 60°/s and 180°/s) in the knee extension. The result of the 6-min walking test was inversely correlated with fat mass index (FMI, r = −.983; p < .001). The generation of inflammatory mediators in older men was related to changes in body composition, maximum strength muscle, and age-related changes in skeletal muscle properties responsible for deficit in functional fitness.

A model to assess age-related changes in two-point discrimination of plantar skin

1999 ◽  
Vol 89 (8) ◽  
pp. 383-391 ◽  
Author(s):  
W Lynch ◽  
J Mooney
Keyword(s):  
Older Adults ◽  
Statistical Analysis ◽  
Linear Relationship ◽  
Middle Aged ◽  
Discrimination Accuracy ◽  
Discrimination Ability ◽  
Fixed Distance ◽  
Age Related ◽  
Older Subjects ◽  
Age Related Changes

A device was constructed to assess two-point discrimination in the plantar skin of younger, middle-aged, and older adults. The device consisted of paired filaments, each delivering a tip force of 4.56 log units (equivalent to 3.63 g), at a fixed distance apart. Statistical analysis showed significant differences in two-point discrimination accuracy between these groups of subjects. Younger subjects showed greater accuracy of plantar two-point discrimination than either middle-aged or older subjects, with an apparent inverse linear relationship between subject age and plantar two-point discrimination ability. A model to assess age-related changes in two-point discrimination is presented.

scholarly journals The Effect of Musculoskeletal Pain on Sexual Function in Middle-aged and Elderly European Men: Results from the European Male Ageing Study

2010 ◽  
Vol 38 (2) ◽  
pp. 370-377 ◽  
Author(s):  
ABDELOUAHID TAJAR ◽  
TERENCE W. O’NEILL ◽  
DAVID M. LEE ◽  
DARYL B. O’CONNOR ◽  
GIOVANNI CORONA ◽  
...  
Keyword(s):  
Sexual Function ◽  
Musculoskeletal Pain ◽  
Sexual Functioning ◽  
Population Sample ◽  
Chronic Widespread Pain ◽  
Middle Aged ◽  
Related Factors ◽  
Pain Status ◽  
Ageing Study ◽  
Male Ageing

Objective.To determine whether musculoskeletal pain was associated with impaired sexual function in a population sample of middle-aged and older men.Methods.The European Male Ageing Study (EMAS), a multicenter population-based study of men aged 40–79 years, was used to investigate this hypothesis. A questionnaire asked about the presence and duration of musculoskeletal pain, allowing subjects to be classified into 1 of 3 groups: those reporting chronic widespread pain (CWP), those reporting pain but not CWP (“some pain”), and those with no pain. Subjects completed a sexual function questionnaire from which 3 domains were considered: overall sexual functioning (OSF), sexual functioning-related distress (SFD), and change in sexual functioning compared to 1 year ago (CSF).Results.A total of 3206 men [mean age 60 (SD 11) yrs] had complete data on pain status. Of these, 8.7% had CWP and 50.34% had “some pain.” Pain was associated with lower OSF, and higher SFD and CSF scores. After adjustment for putative confounding factors, the associations became non-significant with OSF and CSF but persisted for SFD. Associations between pain status and some items within the sexual functioning domains, including frequency of sexual intercourse, frequency of morning erections, sexual desire, and orgasm were also significant, although these associations varied by pain status.Conclusion.Musculoskeletal pain is associated with several aspects of sexual functioning. These relationships differ depending on the extent of the pain (chronic or not) and are also largely confounded by other health-related factors, primarily depression.

Effect of aging on tracheal mucociliary clearance in beagle dogs

1987 ◽  
Vol 62 (3) ◽  
pp. 1331-1334 ◽  
Author(s):  
S. L. Whaley ◽  
B. A. Muggenburg ◽  
F. A. Seiler ◽  
R. K. Wolff
Keyword(s):  
Young Adult ◽  
Gamma Camera ◽  
Mucociliary Clearance ◽  
Age Groups ◽  
Beagle Dogs ◽  
Velocity Measurements ◽  
Middle Aged ◽  
Age Related ◽  
Age Related Changes ◽  
Made In

Tracheal mucous velocity measurements were made in 24 beagle dogs in five age groups, using a gamma camera to detect movement of instilled 99mTc-macroaggregated albumin. Age groups were defined as immature (9–10 mo), young adult (2.8–3.0 yr), middle aged (6.7–6.9 yr), mature (9.6–9.8 yr), and aged dogs (13.6–16.2 yr). Mean velocities were 3.6 +/- 0.4 (SE) mm/min in the immature dogs, 9.7 +/- 0.6 mm/min in the young adults, 6.9 +/- 0.5 mm/min in the middle-aged dogs, 3.5 +/- 0.8 mm/min in the mature dogs, and 2.9 +/- 0.5 mm/min in the aged dogs. Tracheal mucous velocity was significantly (P less than 0.05) greater in the young adult and middle-aged groups compared with the immature, mature, and aged dogs. This pattern of age-related changes was noted to be similar to age-related changes described for certain pulmonary function measurements.

scholarly journals Microarray analysis of aging-associated immune system alterations in the rostral ventrolateral medulla of F344 rats

2017 ◽  
Vol 49 (8) ◽  
pp. 400-415 ◽  
Author(s):  
Sivasai Balivada ◽  
Chanran K. Ganta ◽  
Yongqing Zhang ◽  
Hitesh N. Pawar ◽  
Richard J. Ortiz ◽  
...  
Keyword(s):  
Gene Expression ◽  
Immune System ◽  
Neural Substrates ◽  
Rostral Ventrolateral Medulla ◽  
Ventrolateral Medulla ◽  
Middle Aged ◽  
Transcriptomic Profile ◽  
Age Related ◽  
F344 Rats ◽  
Age Related Changes

The rostral ventrolateral medulla (RVLM) is an area of the brain stem that contains diverse neural substrates that are involved in systems critical for physiological function. There is evidence that aging affects some neural substrates within the RVLM, although age-related changes in RVLM molecular mechanisms are not well established. The goal of the present study was to characterize the transcriptomic profile of the aging RVLM and to test the hypothesis that aging is associated with altered gene expression in the RVLM, with an emphasis on immune system associated gene transcripts. RVLM tissue punches from young, middle-aged, and aged F344 rats were analyzed with Agilent’s whole rat genome microarray. The RVLM gene expression profile varied with age, and an association between chronological age and specific RVLM gene expression patterns was observed [ P < 0.05, false discovery rate (FDR) < 0.3]. Functional analysis of RVLM microarray data via gene ontology profiling and pathway analysis identified upregulation of genes associated with immune- and stress-related responses and downregulation of genes associated with lipid biosynthesis and neurotransmission in aged compared with middle-aged and young rats. Differentially expressed genes associated with the complement system and microglial cells were further validated by quantitative PCR with separate RVLM samples ( P < 0.05, FDR < 0.1). The present results have identified age-related changes in the transcriptomic profile of the RVLM, modifications that may provide the molecular backdrop for understanding age-dependent changes in physiological regulation.

scholarly journals Age-Related Changes in Gait Velocity and Leg Extension Power in Middle-Aged and Elderly People

2000 ◽  
Vol 10 (1sup) ◽  
pp. 77-81 ◽  
Author(s):  
Rumi Kozakai ◽  
Shigeki Tsuzuku ◽  
Kyonosuke Yabe ◽  
Fujiko Ando ◽  
Naoakira Niino ◽  
...  
Keyword(s):  
Elderly People ◽  
Gait Velocity ◽  
Middle Aged ◽  
Leg Extension ◽  
Age Related ◽  
Leg Extension Power ◽  
Age Related Changes

scholarly journals Age-related changes in body composition persons of middle age (letter 1)

2020 ◽  
pp. 31-41
Author(s):  
Антонина Владимировна Алексеева ◽  
Анатолий Яковлевич Рыжов ◽  
Данила Игоревич Игнатьев
Keyword(s):  
Body Composition ◽  
Middle Age ◽  
Middle Aged ◽  
Men And Women ◽  
Anthropometric Indicators ◽  
Aged People ◽  
Age Related ◽  
Positive Correlations ◽  
Age Related Changes

Исследованы антропометрические показатели и параметры состава тела у лиц среднего возраста. Установлено, что некоторые калиперометрические показатели испытывают различие у мужчин и женщин. Калиперометрические показатели величины кожных покровов спины, медиальной и латеральной поверхностей бедер характеризуются тесными положительными корреляциями. Anthropometric indicators and parameters of body composition in middle-aged people were studied. It is established that some caliperometric indicators experience a difference in men and women. Caliperometric indicators of the size of the skin of the back, medial and lateral surfaces of the thighs are characterized by close positive correlations.

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