scholarly journals Should Liability Play a Role in Social Control of Biobanks?

2005 ◽  
Vol 33 (1) ◽  
pp. 70-78 ◽  
Author(s):  
Larry I. Palmer
Keyword(s):  
Social Control ◽  
Cell Lines ◽  
Biomedical Research ◽  
Contract Law ◽  
Property Ownership ◽  
Blood Samples ◽  
Legal Response

Repositories of tissues, cell lines, blood samples, and other biological specimens are crucial to genomics, proteomics, and other emerging forms of biomedical research. Creation of these repositories by individual researchers and their affiliated organizations, commercial entities, and even governments has been labeled “biobanking” in the bioethics literature. Biobanking as a metaphor for the collection, transfer, and use of these specimens suggests a framework for the legal response to conflicts that may arise - one embedded in principles of contract law and property ownership with an overlay of legislatively authorized regulation of the “industry.”

scholarly journals Incidences of problematic cell lines are lower in papers that use RRIDs to identify cell lines

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Zeljana Babic ◽  
Amanda Capes-Davis ◽  
Maryann E Martone ◽  
Amos Bairoch ◽  
I Burak Ozyurt ◽  
...  
Keyword(s):  
Cell Line ◽  
Cell Lines ◽  
Biomedical Research ◽  
Cell Line Authentication ◽  
Pubmed Central ◽  
International Cell ◽  
Unique Cell

The use of misidentified and contaminated cell lines continues to be a problem in biomedical research. Research Resource Identifiers (RRIDs) should reduce the prevalence of misidentified and contaminated cell lines in the literature by alerting researchers to cell lines that are on the list of problematic cell lines, which is maintained by the International Cell Line Authentication Committee (ICLAC) and the Cellosaurus database. To test this assertion, we text-mined the methods sections of about two million papers in PubMed Central, identifying 305,161 unique cell-line names in 150,459 articles. We estimate that 8.6% of these cell lines were on the list of problematic cell lines, whereas only 3.3% of the cell lines in the 634 papers that included RRIDs were on the problematic list. This suggests that the use of RRIDs is associated with a lower reported use of problematic cell lines.

1. Introduction

2020 ◽  
pp. 1-2
Author(s):  
Robert Abbey ◽  
Mark Richards
Keyword(s):  
Contract Law ◽  
Property Law ◽  
Land Law ◽  
Property Ownership

Property Law and Practice (PLP) covers all aspects of the process that is otherwise called conveyancing. It is how practitioners arrange the transmission of property ownership from seller to buyer. This introductory chapter provides an overview of PLP. Specifically, it explains the three foundations upon which PLP rests: land law, contract law, and trusts.

1. Introduction

Property Law ◽  
2021 ◽  
pp. 1-3
Author(s):  
Mark Richards
Keyword(s):  
Contract Law ◽  
Property Law ◽  
Land Law ◽  
Property Ownership

Property Law and Practice (PLP) covers all aspects of the process that is otherwise called conveyancing. It is how practitioners arrange the transmission of property ownership from seller to buyer. This introductory chapter provides an overview of PLP. Specifically, it explains the three foundations upon which PLP rests: land law, contract law, and trusts.

1. Introduction

2019 ◽  
pp. 1-2
Author(s):  
Robert Abbey ◽  
Mark Richards
Keyword(s):  
Contract Law ◽  
Property Law ◽  
Land Law ◽  
Property Ownership

Property Law and Practice (PLP) covers all aspects of the process that is otherwise called conveyancing. It is how practitioners arrange the transmission of property ownership from seller to buyer. This introductory chapter provides an overview of PLP. Specifically, it explains the three foundations upon which PLP rests: land law, contract law, and trusts.

scholarly journals PTEN transcript variants caused by illegitimate splicing in “aged” blood samples and EBV-transformed cell lines

2010 ◽  
Vol 128 (6) ◽  
pp. 609-614 ◽  
Author(s):  
Yunying Liu ◽  
Priyangi Malaviarachchi ◽  
Marjorie Beggs ◽  
Peter D. Emanuel
Keyword(s):  
Cell Lines ◽  
Blood Samples ◽  
Transformed Cell ◽  
Transcript Variants ◽  
Transformed Cell Lines

scholarly journals Discrimination between human populations using a small number of differentially methylated CpG sites: a preliminary study using lymphoblastoid cell lines and peripheral blood samples of European and Chinese origin

BMC Genomics ◽  
2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Patrycja Daca-Roszak ◽  
Roman Jaksik ◽  
Julia Paczkowska ◽  
Michał Witt ◽  
Ewa Ziętkiewicz
Keyword(s):  
Cell Lines ◽  
Peripheral Blood ◽  
B Lymphocyte ◽  
Methylation Status ◽  
Predictive Ability ◽  
Human Populations ◽  
Lymphoblastoid Cell Lines ◽  
Blood Samples ◽  
Cpg Sites ◽  
Lymphocyte Cell

Abstract Background Epigenetics is one of the factors shaping natural variability observed among human populations. A small proportion of heritable inter-population differences are observed in the context of both the genome-wide methylation level and the methylation status of individual CpG sites. It has been demonstrated that a limited number of carefully selected differentially methylated sites may allow discrimination between main human populations. However, most of the few published results have been performed exclusively on B-lymphocyte cell lines. Results The goal of our study was to identify a set of CpG sites sufficient to discriminate between populations of European and Chinese ancestry based on the difference in the DNA methylation profile not only in cell lines but also in primary cell samples. The preliminary selection of CpG sites differentially methylated in these two populations (pop-CpGs) was based on the analysis of two groups of commercially available ethnically-specific B-lymphocyte cell lines, performed using Illumina Infinium Human Methylation 450 BeadChip Array. A subset of 10 pop-CpGs characterized by the best differentiating criteria (|Mdiff| > 1, q < 0.05; lack of the confounding genomic features), and 10 additional CpGs in their immediate vicinity, were further tested using pyrosequencing technology in both B-lymphocyte cell lines and in the primary samples of the peripheral blood representing two analyzed populations. To assess the population-discriminating potential of the selected set of CpGs (further referred to as “composite pop (CEU-CHB)-CpG marker”), three classification methods were applied. The predictive ability of the composite 8-site pop (CEU-CHB)-CpG marker was assessed using 10-fold cross-validation method on two independent sets of samples. Conclusions Our results showed that less than 10 pop-CpG sites may distinguish populations of European and Chinese ancestry; importantly, this small composite pop-CpG marker performs well in both lymphoblastoid cell lines and in non-homogenous blood samples regardless of a gender.

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