Consensus statement on management in the UK: Transoral laser assisted microsurgical resection of early glottic cancer

2009 ◽  
Vol 34 (4) ◽  
pp. 367-373 ◽  
Author(s):  
P.J. Bradley ◽  
K. Mackenzie ◽  
R. Wight ◽  
P. Pracy ◽  
V. Paleri ◽  
...  
Keyword(s):  
Consensus Statement ◽  
Glottic Cancer ◽  
Early Glottic Cancer ◽  
Microsurgical Resection ◽  
The Uk

scholarly journals Our Approach for Optimizing Vocal Outcomes in Transoral Laser Microsurgical Resection of Early Glottic Carcinoma

2016 ◽  
Vol 6 (2) ◽  
pp. 68-72
Author(s):  
Shraddha Deshmukh
Keyword(s):  
Residual Disease ◽  
Critical Factor ◽  
Glottic Cancer ◽  
Type I ◽  
Glottic Carcinoma ◽  
Early Glottic Cancer ◽  
Microsurgical Resection ◽  
Moderate Change ◽  
Early Glottic Carcinoma ◽  
Vocal Outcome

ABSTRACT Objectives To assess oncologic and functional outcomes of early glottic cancer cases treated with transoral laser microsurgical resection (TLMR) and to outline the principles for optimizing vocal outcomes in these cases. Materials and methods Sixty six patients with early glottic cancer (7 CIS, 43 T1a, 15 T1b, 1 T2) underwent TLMR. Postoperatively, voice quality was assessed by Oates Russell Voice Profile. Results Local control was achieved in 95.08% of the cases and larynx was preserved in 98.3%. Residual disease developed in 3 patients. There were eight local recurrences. Single patient of T1b lesion was lost to follow-up and came back with stridor and underwent total laryngectomy. Conclusion Early glottic cancers can be effectively treated by TLMR with good oncologic outcome. Depth of infiltration of lesion is the most critical factor affecting the postoperative vocal outcome. In our study near-normal conversational voice to moderate change in voice was found after type I, II, and III cordectomies. Surprisingly, type VI cordectomy also gave a serviceable vocal outcome with moderate change in voice. In our opinion, type IV cordectomy does not give a serviceable vocal outcome even if performed unilaterally. Thus radiotherapy should be strongly considered in such cases for better vocal outcome. How to cite this article Nerurkar NK, Deshmukh S. Our Approach for Optimizing Vocal Outcomes in Transoral Laser Microsurgical Resection of Early Glottic Carcinoma. Int J Phonosurg Laryngol 2016;6(2):68-72.

Audit of transoral laser-assisted microsurgical resection of early laryngeal cancer

2015 ◽  
Vol 129 (4) ◽  
pp. 372-376
Author(s):  
I Amir ◽  
G A Vernham
Keyword(s):  
Survival Rates ◽  
Disease Free Survival ◽  
Oncological Outcome ◽  
Glottic Cancer ◽  
Transoral Laser Microsurgery ◽  
Laser Microsurgery ◽  
Free Survival ◽  
Early Glottic Cancer ◽  
Kaplan Meier ◽  
Microsurgical Resection

AbstractObjective:This study aimed to report our current practice of transoral laser microsurgery for early glottic cancer against the standards outlined by the ENT UK Head and Neck Group and assess the oncological outcome.Method:A retrospective review of case notes of patients diagnosed with early glottic cancer (tumour stages Tis, T1 and T2) who underwent transoral laser microsurgery as a primary curative treatment. The minimum follow-up period was two years.Results:Thirty-one patients had transoral laser microsurgery for early glottic cancer during the study period. Eighty-four per cent of cases were discussed by a multidisciplinary team prior to transoral laser microsurgery. Complete circumferential excision was achieved in 77 per cent of cases. Sixty-five per cent of specimens were subjected to histological analysis; they complied with standard pathology reporting for margins. Within 12 months of transoral laser microsurgery, there were 10 residual cases and 2 recurrences. Kaplan–Meier survival analysis gave disease-free survival rates of 96.8 per cent at 18 months and 93.5 per cent at 24 months. The laryngectomy-free survival rate was 96.8 per cent at two years.Conclusion:The findings of this audit are encouraging and have highlighted areas for further discussions, recommendations, training and education.

Comparison of Voice Outcomes in Early Glottic Cancer Patients after Laser Surgery or Radiotherapy

2012 ◽  
Vol 55 (11) ◽  
pp. 701 ◽  
Author(s):  
Su Hyun Ahn ◽  
Jun Hyun Kim ◽  
Su Hyun Lee ◽  
Woo Jin Kim ◽  
Dong-Hoon Kim ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Laser Surgery ◽  
Glottic Cancer ◽  
Early Glottic Cancer

scholarly journals Evolution of voice after transoral laser cordectomy for precancerous lesions and early glottic cancer

2021 ◽  
Author(s):  
Lucia Staníková ◽  
Karol Zeleník ◽  
Martin Formánek ◽  
Jana Seko ◽  
Radana Walderová ◽  
...  
Keyword(s):  
Precancerous Lesions ◽  
Voice Quality ◽  
Quality Parameters ◽  
Substantial Improvement ◽  
Glottic Cancer ◽  
Early Glottic Cancer ◽  
Post Surgery ◽  
Group I ◽  
Group Ii ◽  
Laser Cordectomy

Abstract Purpose To evaluate voice quality evolution after a transoral laser cordectomy (TLC) for precancerous lesions and early glottic cancer. Methods This prospective study enrolled 18 patients scheduled for TLC for high-grade dysplasia, Tis, T1, and T2 glottic squamous cell cancers, from May 2017 to March 2020. Patients were grouped according to the extent of TLC: Group I (n = 11, 61.1%): unilateral subepithelial or subligamental cordectomy; Group II (n = 7, 38.9%): unilateral transmuscular, total, or extended cordectomy. Voice quality parameters, including dysphonia grade (G), roughness (R), breathiness (B), maximal phonation time (MPT), jitter, and shimmer, were evaluated before, and at 6 weeks and 6 months after the TLC. Results In Group I, the degree of G and R items remained without substantial improvement 6 weeks after surgery; however, improved above the pre-surgery level up to 6 months after surgery. The MPT, jitter, and shimmer did not change significantly at 6 weeks or 6 months post-TLC. In Group II, G, R, and B remained significantly impaired even 6 months post-surgery. Jitter, and shimmer worsened at 6 weeks, but reached preoperative levels at 6 months post-surgery. MPT was significantly worse at 6 weeks and remained deteriorated at 6 months post-surgery. All measured parameters were significantly worse in Group II than in Group I at 6 weeks and 6 months post-surgery. No patient required a phonosurgical procedure. Conclusion After a TLC, voice quality evolution depended on the extent of surgery. It did not improve at 6 weeks post-surgery. Improvements in less extent cordectomies occurred between 6 weeks and 6 months post-surgery. Understanding voice development over time is important for counseling patients when considering phonosurgical procedures.

Expression and mutational analysis of Cip/Kip family in early glottic cancer

2015 ◽  
Vol 129 (2) ◽  
pp. 168-173 ◽  
Author(s):  
D-K Kim ◽  
J H Lee ◽  
O J Lee ◽  
C H Park
Keyword(s):  
Dna Methylation ◽  
Polymerase Chain Reaction ◽  
Kinase Inhibitors ◽  
Mutational Analysis ◽  
Glottic Cancer ◽  
Cyclin Dependent Kinase ◽  
Chain Reaction ◽  
Single Strand Conformational Polymorphism ◽  
Early Glottic Cancer ◽  
Polymerase Chain

AbstractBackground:Genetic alteration of cyclin-dependent kinase inhibitors has been associated with carcinogenesis mechanisms in various organs.Objective:This study aimed to evaluate the expression and mutational analysis of Cip/Kip family cyclin-dependent kinase inhibitors (p21CIP1/WAF1, p27KIP1 and p57KIP2) in early glottic cancer.Methods:Expressions of Cip/Kip family and p53 were determined by quantitative reverse transcription polymerase chain reaction and densitometry. For the analysis of p21 inactivation, sequence alteration was assessed using single-strand conformational polymorphism polymerase chain reaction. Additionally, the inactivation mechanism of p27 and p57 were investigated using DNA methylation analysis.Results:Reduced expression of p27 and p57 were detected in all samples, whereas the expression of p21 was incompletely down-regulated in 6 of 11 samples. Additionally, single-strand conformational polymorphism polymerase chain reaction analysis showed the p53 mutation at exon 6. Methylation of p27 and p57 was detected by DNA methylation assay.Conclusion:Our results suggest that the Cip/Kip family may have a role as a molecular mechanism of carcinogenesis in early glottic cancer.

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