Analysis of Runoff Variation Characteristics and Influencing Factors in the Wujiang River Basin in the Past 30 Years

Changes in climate and the underlying surface are the main factors affecting runoff. Quantitative assessment of runoff characteristics, and determination of the climate and underlying surface contribution to changes in runoff are critical to water resources management and protection. Based on the runoff data from the Wulong Hydrological Station, combined with the Mann-Kendall test, Indicators of Hydrologic Alteration (IHA), Budyko hypothesis, and changes in climate and the underlying surface, this study comprehensively analyzed the runoff in the Wujiang River Basin (WRB). The results showed that: (1) The annual runoff of Wujiang River showed a downward trend, and an abrupt change occurred in 2005. (2) The overall hydrological change in WRB is 46%, reaching a moderate change. (3) The contribution rates of precipitation (P), potential evaporation (ET0), and underlying surface to runoff changes are 61.5%, 11.4%, and 26.9%, respectively. (4) After 2005, the WRB has become more arid, human activities have become more active, vegetation coverage has increased, and the built-up land has increased significantly.

Regulatory Procedure of Post Approval Changes and Comparative Requirements of EU and USA Regulatory Regions

Aim: The current research paper describes the “Regulatory procedure of post approval changes and comparative regulatory requirement of EU and USA regulatory regions”. Study Design: The present study is a type of Retrospective analysis of Regulatory requirements and the reviewed data was subjected to systemic review. Understanding of the same led to several observations regarding regulatory requirements of EU and USA regulatory regions. Place and Duration of Study: The present study was carried out at Amneal Pharmaceutical Ltd., Ahmedabad, Gujarat, India from January, 2021 to April, 2021. Methodology: Several guidelines were profoundly reviewed to compare the requirements of post approval changes in EU and USA regulatory regions. Various regulatory review aspects were focused i.e. requirements for manufacturing sites addition/or Transfer, process parameters, container and closures, packaging and labelling of medicinal products. Results: The post approval changes in manufacturing sites of solid or semisolid dosage form considered as a major change for USA while considered as Moderate change for EU. The transfer of manufacturing section is major variation for USA while it is a minor but immediate inform type for EU. Change in manufacturing processes, containers, labelling section of sterile products considered as major variation for both. Semisolid and solid categories are falling under the same type of variation for EU and USA regulatory regions. Conclusion: This work demonstrated that the drug approvals in US, EU are the most demanding globally and the available guidance and procedures for the triggered changes are clear in both countries. Applicant should have scientific rationale to any change pertaining to Approved product ; Since the all change control are falling under the scope of Audit, so Applicant should maintain the all the records online.

Perinatal Exposure of Bisphenol A Differently Affects Dendritic Spines of Male and Female Grown-Up Adult Hippocampal Neurons

Perinatal exposure to Bisphenol A (BPA) at a very low dose may modulate the development of synapses of the hippocampus during growth to adulthood. Here, we demonstrate that perinatal exposure to 30 μg BPA/kg per mother’s body weight/day significantly altered the dendritic spines of the grownup rat hippocampus. The density of the spine was analyzed by imaging of Lucifer Yellow-injected CA1 glutamatergic neurons in adult hippocampal slices. In offspring 3-month male hippocampus, the total spine density was significantly decreased by BPA exposure from 2.26 spines/μm (control, no BPA exposure) to 1.96 spines/μm (BPA exposure). BPA exposure considerably changed the normal 4-day estrous cycle of offspring 3-month females, resulting in a 4∼5 day estrous cycle with 2-day estrus stages in most of the subjects. In the offspring 3-month female hippocampus, the total spine density was significantly increased by BPA exposure at estrus stage from 2.04 spines/μm (control) to 2.25 spines/μm (BPA exposure). On the other hand, the total spine density at the proestrus stage was moderately decreased from 2.33 spines/μm (control) to 2.19 spines/μm (BPA exposure). Thus, after the perinatal exposure to BPA, the total spine density in males became lower than that in females. Concerning the BPA effect on the morphology of spines, the large-head spine was significantly changed with its significant decrease in males and moderate change in females.

Geo-spatial Assessment of Land Use/Land Cover (LU/LC) Dynamics in Akoko South West Local Government, Ondo State, Nigeria

Geo-spatial assessment of land use/cover dynamics in Akoko South West Local Government was instigated to bridge the knowledge gap created by data deficiency on the nature, scope and magnitude of land use/cover change in the area. This was done through the analysis of Landsat images of three epochs from 2000 through 2010 to 2020. The processing of the satellite images was done in ArcGIS 10.8 while the analysis and 2030 projection was done in Microsoft office excel using the result from the analysis. QGIS was used to remove the scan lines error on the 2010 image. The result showed increasing built-up area, reducing vegetation and farmlands and diminishing rock outcrops. The changes vary among the different classification characteristics. The increasing change in the second epoch was higher in built up areas while rock outcrops increased in the first epoch. Farmland and vegetation were on reducing trend throughout the study period. However, the moderate change observed in the second epoch for the two land cover classes were not as significant as the first epoch. Government policies on forest reserve should strictly be adhered to in order to preserve the vegetation in the area. People of the area should be advised to diversify their economy in order to avoid total dependence on the forest reserve.

Verification of the accuracy of the SIR model in forecasting based on the improved SIR model with a constant ratio of recovery to infection rate by comparing with monitored second wave data

The temporal evolution of second and subsequent waves of epidemics such as Covid-19 is investigated. Analytic expressions for the peak time and asymptotic behaviours, early doubling time, late half decay time, and a half-early peak law, characterizing the dynamical evolution of number of cases and fatalities, are derived, where the pandemic evolution exhibiting multiple waves is described by the semi-time SIR model. The asymmetry of the epidemic wave and its exponential tail are affected by the initial conditions, a feature that has no analogue in the all-time SIR model. Our analysis reveals that the immunity is very strongly increasing in several countries during the second Covid-19 wave. Wave-specific SIR parameters describing infection and recovery rates we find to behave in a similar fashion. Still, an apparently moderate change of their ratio can have significant consequences. As we show, the probability of an additional wave is however low in several countries due to the fraction of immune inhabitants at the end of the second wave, irrespective of the ongoing vaccination efforts. We compare with alternate approaches and data available at the time of submission. Most recent data serves to demonstrate the successful forecast and high accuracy of the SIR model in predicting the evolution of pandemic outbreaks as long as the assumption underlying our analysis, an unchanged situation of the distribution of variants of concern and the fatality fraction, do not change dramatically during a wave. With the rise of the α variant at the time of submission the second wave did not terminate in some countries, giving rise to a superposition of waves that is not treated by the present contribution.

Impacts of light rail in a mid-sized city: Evidence from Olsztyn, Poland

Investments in light rail transit (LRT) have become increasingly popular solutions to promote sustainable urban transportation. However, their impacts on cities are still subject to discussion in the academic community. There is a clear need to better understand the potential impacts of LRT projects, particularly in contexts other than major cities. In this study, we focus on the Olsztyn tram project, which has been implemented in a city of 173,000 residents situated in northeastern Poland. The paper combines different perspectives and data sources, including a study of residents’ stated preferences concerning travel behavior and modelling of housing price effects using the difference-in-differences approach. Our results suggest that the Olsztyn tram project led to a moderate change in travel behavior by increasing the frequency of public transport use but did not result in a substantial shift away from car commuting. Concerning the property market, a decline in prices was observed during the construction phase, but no statistically significant effects were found after completion.

Quantification of anacardic acid, the toxic component in raw and purified samples of Semecarpus anacardium L. by Siddha purification processes

Objectives The knowledge of purification process is unique since it deals with various physical and chemical changes in the inherent toxic properties during the process and it renders a strong support in the art of medicine preparation in Siddha system of medicine. Semecarpus anacardium L. is listed under Schedule e (1) drugs and purification is mandatory before its administration in medicine preparation. The bioactive compounds present in the plant like alkaloids, terpenoids, flavonoids, saponins, glycosides, steroids enhance the medical efficacy and defense mechanisms of the plant. Hence an attempt has been made to reveal the chemical change, occurring during the purification process in Siddha system of medicine by evaluating the phytochemicals and anacardic acid which is responsible for forming blisters and dermatitis. Methods Five common methods were used to purify the Semecarpus anacardium nuts as per the Siddha classical texts. The quantification of phytochemicals and anacardic acid has been done in unpurified, intermediate and purified samples. Results Significant changes were observed in phytochemicals and anacardic acid quantity in unpurified and purified samples. The major reduction of anacardic acid from 5.62 % in S1 to below detectable limit (BDL) in S2, S3, S4, 0.24% in S5 and 3.32% in S6. There is mild to moderate change in the phytochemicals which will support the efficacy of the drug. Conclusions With the results of phytochemicals, though all the purification methods have been evidenced to reduce the toxic nature, among the above five, the process II may be recommended for further research and medicine preparation.

Differential characterization of stress sensitivity and its main control mechanism in deep pore-fracture clastic reservoirs

Stress sensitivity in reservoirs is critical during the exploitation of oil and gas fields. As a deep clastic reservoir under strong tectonic compression, the Ahe Formation in the northern tectonic zone of the Kuqa depression exhibited strong stress sensitivity effect. However, the conventional evaluation method by using permeability damage rate as a constraint restricts the mechanistic understanding of the strong stress sensitivity effect. In this study, morphology of stress sensitivity test curve, coupled with rate change of permeability and extent of irreversible damage in actual sample measurement through micro-CT in-situ scanning, is used to characterize differentially. The strong stress sensitivity effects of the studied intervals can be divided into three types: (1) rapid change in permeability–weak irreversible damage, (2) moderate change in permeability–strong irreversible damage and (3) moderate change in permeability–moderate irreversible damage. The strong stress sensitivity is caused by the micro-pores and micro-fractures, which are widely developed in the studied reservoir. The mechanisms caused by the two types of pore are different. The stress sensitivity effects in micro-fracture-rich reservoirs are characterized by rapid change in permeability and weak irreversible damage. Meanwhile, the stress sensitivity effects in micro-pore-rich reservoirs are manifested as moderate change in permeability and strong irreversible damage. The study shows that the differences in the content of micro-pores and micro-fractures and their reverse mechanisms of stress sensitivity co-create different types of stress sensitivity within the samples. Accordingly, the differences of the stress sensitivity type in macroscopic samples are caused by the competition between the microscopic differences of pore types.

Adsorption of bacteriophages on polypropylene labware affects the reproducibility of phage research

Hydrophobicity is one of the most critical factors governing the adsorption of molecules and objects, such as virions, on surfaces. Even moderate change of wetting angle of plastic surfaces causes a drastic decrease ranging from 2 to 5 logs of the viruses (e.g., T4 phage) in the suspension due to adsorption on polymer vials' walls. The effect varies immensely in seemingly identical containers but purchased from different vendors. Comparison of glass, polyethylene, polypropylene, and polystyrene containers revealed a threshold in the wetting angle of around 95°: virions adsorb on the surface of more hydrophobic containers, while in more hydrophilic vials, phage suspensions are stable. The polypropylene surface of the Eppendorf-type and Falcon-type can accommodate from around 108 PFU/ml to around 1010 PFU/ml from the suspension. The adsorption onto the container’s wall might result in complete scavenging of virions from the bulk. We developed two methods to overcome this issue. The addition of surfactant Tween20 and/or plasma treatment provides a remedy by modulating surface wettability and inhibiting virions' adsorption. Plastic containers are essential consumables in the daily use of many bio-laboratories. Thus, this is important not only for phage-related research (e.g., the use of phage therapies as an alternative for antibiotics) but also for data comparison and reproducibility in the field of biochemistry and virology.

Forecast for the second Covid-19 wave based on the improved SIR model with a constant ratio of recovery to infection rate

We start out by deriving simple analytic expressions for all measurable amounts of cases and fatalities during a pandemic evolution exhibiting multiple waves, described by the semi-time SIR model. The approximant shares all relevant features with the exact solution, including time and position of the peak of daily new infections, as well as the asymptotic behaviors at small and large times. We derive exact analytic expressions for the early doubling time, late half decay time, and a half-early peak law, characterizing the dynamical evolution. We show, in particular, how the asymmetry of the first epidemic wave and its exponential tails are affected by the initial conditions; a feature that has no analogue in the all-time SIR model. We apply the approach to available data from different continents. Our analysis reveals that the immunity is very strongly increasing during the 2nd wave, while it was still at a very moderate level of a few percent in several countries at the end of the first wave. The wave-specific SIR parameters describing the infection and recovery rates we find to behave in a similar fashion, while their ratio k was decreasing only by a about 5% for most countries. Still, an apparently moderate change of k can have significant consequences for the relevant numbers like the final amount of infected or deceased population. As we show, the probability for an additional wave is however low in several countries due to the fraction of immune inhabitants at the end of the 2nd wave, irrespective the currently ongoing vaccination efforts. We compare with alternate approaches.