THEORETICAL STUDY OF COLOR CONTROL MECHANISM IN RETINAL PROTEINS.: I. ROLE OF THE TRYPTOPHAN RESIDUE, TYROSINE RESIDUE AND WATER MOLECULE

1994 ◽  
Vol 59 (6) ◽  
pp. 660-669 ◽  
Author(s):  
Yoshitaka Beppu ◽  
Toshiaki Kakitani
Keyword(s):  
Water Molecule ◽  
Theoretical Study ◽  
Control Mechanism ◽  
Tryptophan Residue ◽  
Tyrosine Residue ◽  
Retinal Proteins ◽  
Color Control

Theoretical Study of the Role of a Catalytic Water Molecule in the Hydrolysis of Thionyl Tetrafluoride (SOF4)

2020 ◽  
Vol 124 (27) ◽  
pp. 5615-5620
Author(s):  
Ming Wang ◽  
Hua Hou ◽  
Baoshan Wang ◽  
Huanjun Xu ◽  
Chaoyuan Zeng ◽  
...  
Keyword(s):  
Water Molecule ◽  
Theoretical Study ◽  
Hydrolysis Of

Role of the Cilia Membrane in Control of Microtubule Sliding

1980 ◽  
Vol 38 ◽  
pp. 612-615
Author(s):  
Edna S. Kaneshiro
Keyword(s):  
Control Mechanism ◽  
Beat Frequency ◽  
Surface Membrane ◽  
Ciliary Membrane ◽  
Ciliary Beating ◽  
Ciliary Reversal ◽  
Voltage Dependent ◽  
Reversal Mechanism ◽  
And Function

It is currently believed that ciliary beating results from microtubule sliding which is restricted in regions to cause bending. Cilia beat can be modified to bring about changes in beat frequency, cessation of beat and reversal in beat direction. In ciliated protozoans these modifications which determine swimming behavior have been shown to be related to intracellular (intraciliary) Ca2+ concentrations. The Ca2+ levels are in turn governed by the surface ciliary membrane which exhibits increased Ca2+ conductance (permeability) in response to depolarization. Mutants with altered behaviors have been isolated. Pawn mutants fail to exhibit reversal of the effective stroke of ciliary beat and therefore cannot swim backward. They lack the increased inward Ca2+ current in response to depolarizing stimuli. Both normal and pawn Paramecium made leaky to Ca2+ by Triton extrac¬tion of the surface membrane exhibit backward swimming only in reactivating solutions containing greater than IO-6 M Ca2+ Thus in pawns the ciliary reversal mechanism itself is left operational and only the control mechanism at the membrane is affected. The topographic location of voltage-dependent Ca2+ channels has been identified as a component of the ciliary mem¬brane since the inward Ca2+ conductance response is eliminated by deciliation and the return of the response occurs during cilia regeneration. Since the ciliary membrane has been impli¬cated in the control of Ca2+ levels in the cilium and therefore is the site of at least one kind of control of microtubule sliding, we have focused our attention on understanding the structure and function of the membrane.

Role of Man in Production and Social Systems Based on Digital Technologies

2020 ◽  
pp. 6-13
Author(s):  
V. K. Potemkin
Keyword(s):  
Theoretical Study ◽  
Social Systems ◽  
Digital Technologies ◽  
Changing Role ◽  
Consistent Approach ◽  
Social Improvement

The article presents the results of a theoretical study of the influence processes of the developed digital technologies and the activities of enterprises and organizations on the changing role of man in labor and their social improvement. The necessity of a balanced and consistent approach to create conditions for the use of digital technologies in practical activities and determining the con- sequences not only in enterprises and organizations, but also in the conscious behavior and social realities of all workers, without exception, is substantiated. The main directions of the development of digital technologies are determined, involving the wide participation of workers in their use in enterprises and organizations.

scholarly journals The Role of La2O3 in Enhancement the Radiation Shielding Efficiency of the Tellurite Glasses: Monte-Carlo Simulation and Theoretical Study

Materials ◽  
2021 ◽  
Vol 14 (14) ◽  
pp. 3913
Author(s):  
Aljawhara H. Almuqrin ◽  
Mohamed Hanfi ◽  
K. G. Mahmoud ◽  
M. I. Sayyed ◽  
Hanan Al-Ghamdi ◽  
...  
Keyword(s):  
Monte Carlo Simulation ◽  
Theoretical Study ◽  
Radiation Shielding ◽  
Photon Flux ◽  
Transmission Factor ◽  
Tellurite Glasses ◽  
Attenuation Coefficients ◽  
Binary Glass ◽  
Buildup Factors

The radiation shielding competence was examined for a binary glass system xLa2O3 + (1 − x) TeO2 where x = 5, 7, 10, 15, and 20 mol% using MCNP-5 code. The linear attenuation coefficients (LACs) of the glasses were evaluated, and it was found that LT20 glass has the greatest LAC, while LT5 had the least LAC. The transmission factor (TF) of the glasses was evaluated against thicknesses at various selected energies and was observed to greatly decrease with increasing thickness; for example, at 1.332 MeV, the TF of the LT5 glass decreased from 0.76 to 0.25 as the thickness increased from 1 to 5 cm. The equivalent atomic number (Zeq) of the glasses gradually increased with increasing photon energy above 0.1 MeV, with the maximum values observed at around 1 MeV. The buildup factors were determined to evaluate the accumulation of photon flux, and it was found that the maximum values for both can be seen at around 0.8 MeV. This research concluded that LT20 has the greatest potential in radiation shielding applications out of the investigated glasses due to the glass having the most desirable parameters.

scholarly journals Role of tyrosine residue 264 of RecA for the binding of cofactor and DNA.

1993 ◽  
Vol 268 (3) ◽  
pp. 1811-1816
Author(s):  
S. Eriksson ◽  
B. Nordén ◽  
K. Morimatsu ◽  
T. Horii ◽  
M. Takahashi
Keyword(s):  
Tyrosine Residue

The role of S and Mo doping on the dissociation of water molecule on FeOCl surface: Experimental and theoretical analysis

2021 ◽  
pp. 131353
Author(s):  
Xiao Liu ◽  
Wenyi Zhang ◽  
Mingguo Peng ◽  
Guangqun Zhai ◽  
Linchao Hu ◽  
...  
Keyword(s):  
Theoretical Analysis ◽  
Water Molecule ◽  
Mo Doping

scholarly journals Structural elements in the flexible tail of the co-chaperone p23 coordinate client binding and progression of the Hsp90 chaperone cycle

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Maximilian M. Biebl ◽  
Abraham Lopez ◽  
Alexandra Rehn ◽  
Lee Freiburger ◽  
Jannis Lawatscheck ◽  
...  
Keyword(s):  
Proximal Region ◽  
Tryptophan Residue ◽  
Structural Elements ◽  
Physiological Importance ◽  
In Vivo Experiments ◽  
Cellular Context ◽  
Catalytic Loop ◽  
Hsp90 Chaperone

AbstractThe co-chaperone p23 is a central part of the Hsp90 machinery. It stabilizes the closed conformation of Hsp90, inhibits its ATPase and is important for client maturation. Yet, how this is achieved has remained enigmatic. Here, we show that a tryptophan residue in the proximal region of the tail decelerates the ATPase by allosterically switching the conformation of the catalytic loop in Hsp90. We further show by NMR spectroscopy that the tail interacts with the Hsp90 client binding site via a conserved helix. This helical motif in the p23 tail also binds to the client protein glucocorticoid receptor (GR) in the free and Hsp90-bound form. In vivo experiments confirm the physiological importance of ATPase modulation and the role of the evolutionary conserved helical motif for GR activation in the cellular context.

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