Genetic variation in the ovine uncoupling protein 1 gene: association with carcass traits in New Zealand (NZ) Romney sheep, but no association with growth traits in either NZ Romney or NZ Suffolk sheep

2014 ◽  
Vol 131 (6) ◽  
pp. 437-444 ◽  
Author(s):  
G. Yang ◽  
R. Forrest ◽  
H. Zhou ◽  
S. Hodge ◽  
J. Hickford
Keyword(s):  
Genetic Variation ◽  
New Zealand ◽  
Growth Traits ◽  
Uncoupling Protein ◽  
Carcass Traits ◽  
Uncoupling Protein 1 ◽  
Gene Association ◽  
Suffolk Sheep

scholarly journals Association of polymorphisms in the GH and GHR genes with growth and carcass traits in rabbits (Oryctolagus cuniculus)

2019 ◽  
Vol 64 (No. 6) ◽  
pp. 255-264
Author(s):  
Lukasz Migdal ◽  
Sylwia Palka ◽  
Michal Kmiecik ◽  
Olga Derewicka
Keyword(s):  
Molecular Markers ◽  
New Zealand ◽  
Oryctolagus Cuniculus ◽  
Growth Traits ◽  
Carcass Traits ◽  
Breeding Programme ◽  
Association Analyses ◽  
Meat Weight ◽  
Dressing Percentage ◽  
Intermediate Part

In rabbits, growth and carcass traits are important for the breeding programme. An increasing number of annotated polymorphisms demands validation of their influence on those traits before they can be implemented in breeding practice. Therefore, the aim of this study was to investigate GH c.-78C>T, GHR c.106G>C polymorphisms in the population of Belgian Giant Grey, Termond White, and a crossbreed between New Zealand White and Belgian Giant Grey (NZW × BGG) rabbits. In total 379 animals were genotyped and association analyses with growth traits and carcass traits were conducted. Our results demonstrated that GH c.-78C>T showed an association with growth weight in Belgian Grey and NZW × BGG rabbits. Meat weight in intermediate and hind parts for GH c.-78C>T statistically differed between Belgian Giant Grey and crossbred rabbits. GHR c.106G>C showed an association with meat weight in the intermediate part and dressing percentage in Termond White. TT/CC haplotype in Belgian Giant Grey had significantly higher meat weight in hind part, while in crossbred rabbits CC/CC haplotype was characterised by the lowest meat weight in intermediate and hind parts. Results from our study confirm that GH c.-78C>T, GHR c.106G>C polymorphisms constitute good molecular markers for growth and carcass traits.

scholarly journals Genetic variation at the uncoupling protein 1, 2 and 3 loci and the response to long-term overfeeding

2024 ◽  
Vol 55 (11) ◽  
pp. 1008-1015
Author(s):  
O Ukkola ◽  
A Tremblay ◽  
G Sun ◽  
Y C Chagnon ◽  
C Bouchard
Keyword(s):  
Genetic Variation ◽  
Uncoupling Protein ◽  
Uncoupling Protein 1

scholarly journals Genetic variation at the uncoupling protein 1, 2 and 3 loci and the response to long-term overfeeding

2001 ◽  
Vol 55 (11) ◽  
pp. 1008-1015 ◽  
Author(s):  
O Ukkola ◽  
A Tremblay ◽  
G Sun ◽  
YC Chagnon ◽  
C Bouchard
Keyword(s):  
Genetic Variation ◽  
Uncoupling Protein ◽  
Uncoupling Protein 1

Evidence of Browning of White Adipocytes in Poorly Survived Fat Grafts in Patients

2021 ◽  
Author(s):  
Tong Liu ◽  
Su Fu ◽  
Qian Wang ◽  
Hao Cheng ◽  
Dali Mu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Uncoupling Protein ◽  
Fold Increase ◽  
Fat Grafting ◽  
Electronic Microscopy ◽  
Uncoupling Protein 1 ◽  
Fat Transfer ◽  
Flap Transfer ◽  
Fat Grafts ◽  
White Adipocytes

Abstract Background Browning adipocytes induced by burn and cancer were assumed less viable and more prone to necrosis for their hypermetabolic properties. Recent studies have shown browning of white adipose after fat engraftment in mice. Objectives We tend to evaluate whether fat transfer could induce browning biogenesis in fat grafts in humans and if it is associated with graft necrosis. Methods Necrotic adipose grafts were excised from 11 patients diagnosed with fat necrosis after fat grafting or flap transfer. Non-necrotic fat grafts were from 5 patients undergoing revisionary surgeries after flap transfer. Histology and electronic microscopy, protein and gene expression of browning related marker analyses were performed. Results Fat grafts with necrosis demonstrated a higher gene expression level of uncoupling protein-1 (>5-fold increase, **p<0.01), a master beige adipocyte marker, than non-necrotic fat grafts. Electronic microscopy and histology showed that browning adipocytes were presented in necrotic adipose in patients. Conclusions Fat transfer induced browning adipocytes in patients and was evident in patients with post grafting necrosis.

Growth factor regulation of uncoupling protein-1 mRNA expression in brown adipocytes

2002 ◽  
Vol 282 (1) ◽  
pp. C105-C112 ◽  
Author(s):  
Bibian García ◽  
Maria-Jesús Obregón
Keyword(s):  
Growth Factor ◽  
Adipocyte Differentiation ◽  
Uncoupling Protein ◽  
Brown Adipocyte ◽  
Mrna Levels ◽  
Uncoupling Protein 1 ◽  
Brown Adipocytes ◽  
Proliferation And Differentiation ◽  
Epidermal Growth ◽  
Continuous Presence

To study the effect of the mitogens epidermal growth factor (EGF), acidic and basic fibroblast growth factors (aFGF and bFGF), and vasopressin on brown adipocyte differentiation, we analyzed the expression of uncoupling protein-1 (UCP-1) mRNA. Quiescent brown preadipocytes express high levels of UCP-1 mRNA in response to triiodothyronine (T3) and norepinephrine (NE). The addition of serum or the mitogenic condition aFGF + vasopressin + NE or EGF + vasopressin + NE decreases UCP-1 mRNA. A second addition of mitogens further decreases UCP-1 mRNA. Treatment with aFGF or bFGF alone increases UCP-1 mRNA, whereas the addition of EGF or vasopressin dramatically reduces UCP-1 mRNA levels. The continuous presence of T3 increases UCP-1 mRNA levels in cells treated with EGF, aFGF, or bFGF. The effect of T3 on the stimulation of DNA synthesis also was tested. T3 inhibits the mitogenic activity of aFGF and bFGF. In conclusion, mitogens like aFGF or bFGF allow brown adipocyte differentiation, whereas EGF and vasopressin inhibit the differentiation process. T3 behaves as an important hormone that regulates both brown adipocyte proliferation and differentiation.

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