Evaluation of the antidiabetic activity of hydrolyzed peptides derived fromJuglans mandshuricaMaxim. fruits in insulin-resistant HepG2 cells and type 2 diabetic mice

2018 ◽  
Vol 42 (3) ◽  
pp. e12518 ◽  
Author(s):  
Ji Wang ◽  
Kaiying Du ◽  
Li Fang ◽  
Chunlei Liu ◽  
Weihong Min ◽  
...  
Keyword(s):  
Hepg2 Cells ◽  
Antidiabetic Activity ◽  
Diabetic Mice ◽  
Insulin Resistant ◽  
Type 2 Diabetic

scholarly journals Antidiabetic activity of a Flavonoid-Rich extract from flowers of Wisteria sinensis in type 2 diabetic mice via activation of the IRS-1/PI3K/Akt/GLUT4 pathway

2021 ◽  
Vol 77 ◽  
pp. 104338
Author(s):  
Yun Huang ◽  
Tongxi Zhou ◽  
Yirui Zhang ◽  
Huiqi Huang ◽  
Yuanren Ma ◽  
...  
Keyword(s):  
Antidiabetic Activity ◽  
Diabetic Mice ◽  
Wisteria Sinensis ◽  
Type 2 Diabetic

scholarly journals Reducing effect of insulin resistance on alpha-synuclein gene expression in skeletal muscle

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Amirhosein Khoshi ◽  
Golnaz Goodarzi ◽  
Rezvan Mohammadi ◽  
Roghaye Arezumand ◽  
Meysam Moghbeli ◽  
...  
Keyword(s):  
Gene Expression ◽  
Insulin Resistance ◽  
Glucose Uptake ◽  
Alpha Synuclein ◽  
C2c12 Cells ◽  
Diabetic Mice ◽  
Insulin Metabolism ◽  
Insulin Resistant ◽  
Type 2 Diabetic

Abstract Background Alpha-synuclein (SNCA) as the presynaptic protein is expressed in different tissues and prevents insulin-resistance (IR) through increasing glucose-uptake by adipocytes and muscles. However, the effect of insulin metabolism on SNCA expression has scarcely elucidated. In present study we assessed the probable effect of insulin resistance on SNCA expression in muscle C2C12 cells and also skeletal muscle tissues of type 2 diabetic mice. Materials and methods Sixteen male C57BL/6 mice were divided into two experimental groups, including control and type 2 diabetic mice with IR (induced by high-fat diet + low-dose streptozotocin). The animals of the study involved the measurements of fasting blood glucose, oral-glucose-tolerance-test, as well as fasting plasma insulin. Moreover, insulin-resistant and insulin-sensitive muscle C2C12 cells were prepared. The insulin-resistance was confirmed by the glucose-uptake assay. Comparative quantitative real time PCR was used to assess the SNCA expression. Results The obtained results have showed a significant ~ 27% decrease in SNCA expression level in muscle tissue of diabetic mice (P = 0.022). Moreover, there was a significant change of SNCA expression in insulin-resistant C2C12 cells (P < 0.001). Conclusion Type 2 diabetes due to insulin-resistance can decrease SNCA gene expression in muscles. In addition to the role of SNCA in cell susceptibility to insulin and glucose uptake, the SNCA expression can also be affected by insulin metabolism.

Preventive Effect of Geniposide on Metabolic Disease Status in Spontaneously Obese Type 2 Diabetic Mice and Free Fatty Acid-Treated HepG2 Cells

2011 ◽  
Vol 34 (10) ◽  
pp. 1613-1618 ◽  
Author(s):  
Kazuko Kojima ◽  
Tsutomu Shimada ◽  
Yasuhiro Nagareda ◽  
Michiru Watanabe ◽  
Junko Ishizaki ◽  
...  
Keyword(s):  
Metabolic Disease ◽  
Fatty Acid ◽  
Free Fatty Acid ◽  
Hepg2 Cells ◽  
Disease Status ◽  
Diabetic Mice ◽  
Preventive Effect ◽  
Type 2 Diabetic

scholarly journals Antidiabetic Activity of Green Tea (Thea sinensis L.) in Genetically Type 2 Diabetic Mice

2005 ◽  
Vol 51 (6) ◽  
pp. 708-710 ◽  
Author(s):  
Toshihiro Miura ◽  
Tomoko Koike ◽  
Torao Ishida
Keyword(s):  
Green Tea ◽  
Antidiabetic Activity ◽  
Diabetic Mice ◽  
Type 2 Diabetic

scholarly journals Antidiabetic Effect of an Active Components Group fromIlex kudingchaand Its Chemical Composition

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Chengwu Song ◽  
Chao Xie ◽  
Zhiwen Zhou ◽  
Shanggong Yu ◽  
Nianbai Fang
Keyword(s):  
Synergistic Effects ◽  
Fatty Acid Synthetase ◽  
Antidiabetic Activity ◽  
Diabetic Mice ◽  
Active Components ◽  
Triterpenoid Saponins ◽  
Antidiabetic Effect ◽  
First Time ◽  
Type 2 Diabetic

The leaves ofIlex kudingchaare used as an ethnomedicine in the treatment of symptoms related with diabetes mellitus and obesity throughout the centuries in China. The present study investigated the antidiabetic activities of an active components group (ACG) obtained fromIlex kudingchain alloxan-induced type 2 diabetic mice. ACG significantly reduced the elevated levels of serum glycaemic and lipids in type 2 diabetic mice. 3-Hydroxy-3-methylglutaryl coenzyme A reductase and glucokinase were upregulated significantly, while fatty acid synthetase, glucose-6-phosphatase catalytic enzyme was downregulated in diabetic mice after treatment of ACG. These findings clearly provided evidences regarding the antidiabetic potentials of ACG fromIlex kudingcha. Using LC-DAD/HR-ESI-TOF-MS, six major components were identified in ACG. They are three dicaffeoylquinic acids that have been reported previously, and three new triterpenoid saponins, which were the first time to be identified inIlex kudingcha. It is reasonable to assume that antidiabetic activity ofIlex kudingchaagainst hyperglycemia resulted from these six major components. Also, synergistic effects among their compounds may exist in the antidiabetic activity ofIlex kudingcha.

Orostachys japonicus A. Berger (Crassulaceae) Exerts Antidiabetic Activity by Improving Glucose and Lipid Levels in Type 2 Diabetic Mice

2019 ◽  
Vol 22 (8) ◽  
pp. 797-809 ◽  
Author(s):  
Hyuneui Jeong ◽  
Jong-Won Kim ◽  
Daram Yang ◽  
Tae-Won Jeong ◽  
Jing Zhao ◽  
...  
Keyword(s):  
Antidiabetic Activity ◽  
Diabetic Mice ◽  
Lipid Levels ◽  
Type 2 Diabetic

scholarly journals Role of Green Macroalgae Enteromorpha Prolifera Polyphenols in the Modulation of Gene Expression and Intestinal Microflora Profiles in Type 2 Diabetic Mice

2018 ◽  
Vol 20 (1) ◽  
pp. 25 ◽  
Author(s):  
Guopeng Lin ◽  
Xiaoyan Liu ◽  
Xin Yan ◽  
Dan Liu ◽  
Chengfeng Yang ◽  
...  
Keyword(s):  
Intestinal Microflora ◽  
Fasting Blood Glucose ◽  
Antidiabetic Activity ◽  
Rrna Gene ◽  
Regulation Mechanism ◽  
Diabetic Mice ◽  
Enteromorpha Prolifera ◽  
Green Macroalgae ◽  
Type 2 Diabetic

Effects of green macroalgae 55% ethanolic extract Enteromorpha prolifera through an ultrafiltration membrane of 3 kDa (EPE3k) on antidiabetic activity, gut microbiota, and regulation mechanism were investigated in high-fat/high-sucrose diet and streptozocin-induced diabetic mice. The structural characterizations of its major compounds in EPE3k were determined by ultra-performance liquid chromatography-quadrupole/time of flight mass spectrometry. Furthermore, the intestinal microflora modulation in diabetic mice was also investigated with high-throughput 16S rRNA gene sequencing. The proposed presence of polyphenols in EPE3k was confirmed. EPE3k could significantly decrease the fasting blood glucose and improve fasting glucose tolerance. The hypoglycemic effect of EPE3k was via activation of phosphatidylinositol 3-kinase and suppression of c-Jun N-terminal kinase in liver. EPE3k treatment significantly increased the relative abundance of Akkermansia and decreased the proportion of Alistipes and Turicibacter. The above results indicated that EPE3k could be provided as a new potential therapy for the treatment of type 2 diabetic mellitus.

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