scholarly journals Use of an Evidence‐Based Guideline for Management of Side Effects from Long‐Acting Reversible Contraceptives: A Quality Improvement Report

2018 ◽  
Vol 64 (2) ◽  
pp. 225-229 ◽  
Author(s):  
Julia Jacobson ◽  
Jacqueline Nasso ◽  
J. Christopher Glantz
Keyword(s):  
Quality Improvement ◽  
Side Effects ◽  
Evidence Based ◽  
Long Acting ◽  
Evidence Based Guideline ◽  
Long Acting Reversible Contraceptives

scholarly journals Plain Language Summary: Benign Paroxysmal Positional Vertigo

2017 ◽  
Vol 156 (3) ◽  
pp. 417-425
Author(s):  
Neil Bhattacharyya ◽  
Deena B. Hollingsworth ◽  
Kathryn Mahoney ◽  
Sarah O’Connor
Keyword(s):  
Quality Improvement ◽  
Clinical Practice ◽  
Clinical Practice Guideline ◽  
Benign Paroxysmal Positional Vertigo ◽  
Evidence Based ◽  
Plain Language ◽  
Positional Vertigo ◽  
Effective Diagnosis ◽  
Evidence Based Guideline ◽  
Paroxysmal Positional Vertigo

Objective. This plain language summary serves as an overview in explaining benign paroxysmal positional vertigo, abbreviated BPPV. This summary applies to patients ≥18 years old with a suspected or potential diagnosis of BPPV and is based on the 2017 “Clinical Practice Guideline: Benign Paroxysmal Positional Vertigo (Update).” The evidence-based guideline includes research to support more effective diagnosis and treatment of BPPV. The guideline was developed as a quality improvement opportunity for managing BPPV by creating clear recommendations to use in medical practice.

scholarly journals Characterizing menstrual bleeding changes occurring after SARS-CoV-2 vaccination

2021 ◽  
Author(s):  
Katharine MN Lee ◽  
Eleanor J Junkins ◽  
Urooba A Fatima ◽  
Maria L Cox ◽  
Kathryn BH Clancy
Keyword(s):  
Side Effects ◽  
Research Design ◽  
Menstrual Bleeding ◽  
Menstrual Cycles ◽  
Breakthrough Bleeding ◽  
History Of ◽  
Post Menopausal ◽  
Long Acting ◽  
Long Acting Reversible Contraceptives

Many people began sharing that they experienced unexpected menstrual bleeding after SARS-CoV-2 inoculation. This emerging phenomenon was undeniable yet understudied. We investigated menstrual bleeding patterns among currently and formerly menstruating people, with a research design based off our expectations that these bleeding changes related to changes in clotting or inflammation, affecting normal menstrual repair. In this sample, 42% of people with regular menstrual cycles bled more heavily than usual, while 44% reported no change, after being vaccinated. Among people who typically do not menstruate, 71% of people on long-acting reversible contraceptives, 39% of people on gender-affirming hormones, and 66% of post-menopausal people reported breakthrough bleeding. We found increased/breakthrough bleeding was significantly associated with age, other vaccine side effects (fever, fatigue), history of pregnancy or birth, and ethnicity. Changes to menstrual bleeding are not uncommon nor dangerous, yet attention to these experiences is necessary to build trust in medicine.

scholarly journals Pharmacological management of antipsychotic-induced akathisia: an update and treatment algorithm

2015 ◽  
Vol 21 (5) ◽  
pp. 342-344
Author(s):  
Ketan Dipak Jethwa
Keyword(s):  
Side Effects ◽  
Treatment Algorithm ◽  
Evidence Based ◽  
Acute Management ◽  
Potential Well ◽  
Review Of The Literature ◽  
Pharmacological Management ◽  
Adrenergic Antagonists ◽  
Long Acting ◽  
High Level

SummaryAkathisia is a common and distressing side-effect of antipsychotic medication. The treatment of this condition is difficult and options are limited. This review of the literature was performed to develop an evidence-based algorithm for the management of antipsychotic-induced akathisia. There is limited high-level evidence to support the use of anticholinergics. Centrally acting β-adrenergic antagonists are potential treatments, although their use is limited by troublesome side-effects. Long-acting benzodiazepines and mirtazapine are potential well-tolerated treatments for the acute management of akathisia.

scholarly journals Why indeed? Invited commentary on… Why aren't depot antipsychotics prescribed more often and what can be done about it?

2005 ◽  
Vol 11 (3) ◽  
pp. 211-213 ◽  
Author(s):  
Thomas R. E. Barnes
Keyword(s):  
Side Effects ◽  
Blood Level ◽  
Pharmacokinetic Profile ◽  
Evidence Based ◽  
Clinical Team ◽  
Burden Of Care ◽  
Long Acting ◽  
Depot Preparations ◽  
Depot Antipsychotics ◽  
Reduced Risk

A recent review concluded that replicated, evidence-based studies have demonstrated several areas of advantage for long-acting antipsychotics over oral antipsychotics. These include improved global outcome and reduced risk of rehospitalisation, psychopharmacological benefits such as more consistent bioavailabilty and more predictable dose–blood level correlations, an improved pharmacokinetic profile allowing lower dosages to be used with a consequent reduced likelihood of side-effects, and a reduced burden of care when injections are required only every 2–6 weeks (Robert & Geppert, 2004). Further, if a patient relapses despite receiving uninterrupted depot treatment, this indicates the need to consider reasons for deterioration other than poor adherence. However, perhaps the critical advantage over oral preparations is the avoidance of covert non-adherence (Barnes & Curson, 1994). With depot treatment, any decision by the patient not to continue medication will be signalled by failure to attend for, or refusal of, injection. The clinical team can therefore act to intervene appropriately, bearing in mind that non-adherence may be both a cause and consequence of worsening of illness. Lastly, with depot preparations the risk of self-poisoning is reduced.

scholarly journals Plain Language Summary for Patients: Tonsillectomy in Children

2019 ◽  
Vol 160 (2) ◽  
pp. 206-212
Author(s):  
Sandra A. Finestone ◽  
Terri Giordano ◽  
Ron B. Mitchell ◽  
Sandra A. Walsh ◽  
Sarah S. O’Connor ◽  
...  
Keyword(s):  
Quality Improvement ◽  
Clinical Practice ◽  
Medical Practice ◽  
Clinical Practice Guideline ◽  
Practice Guideline ◽  
Evidence Based ◽  
Plain Language ◽  
Management Options ◽  
Patients Âgés ◽  
Evidence Based Guideline

This plain language summary for patients serves as an overview explaining tonsillectomy in children and to help patients, caregivers, and clinicians in their discussions about the reasons that a tonsillectomy may be needed, management options, and care related to the procedure. This summary applies to patients ages 1 through 18 years and is based on the 2019 “Clinical Practice Guideline: Tonsillectomy in Children (Update).” This evidence-based guideline mainly addresses the need for tonsillectomy based on breathing problems that take place during sleep and repeated sore throats or “tonsillitis.” The guideline was developed to identify quality improvement opportunities in managing children under consideration for tonsillectomy and to create clear recommendations for clinicians to use in medical practice.

CLINICAL INVESTIGATIONS OF A LONG-ACTING OESTRIOL (POLYOESTRIOL PHOSPHATE)

1961 ◽  
Vol 38 (1) ◽  
pp. 73-87 ◽  
Author(s):  
Christian Lauritzen ◽  
Semih Velibese
Keyword(s):  
Side Effects ◽  
Phosphoric Acid ◽  
Quantitative Data ◽  
Water Soluble ◽  
Cholesterol Concentration ◽  
Experimental Investigations ◽  
Clinical Investigations ◽  
Prolonged Duration ◽  
High Doses ◽  
Long Acting

ABSTRACT A description is given of experimental investigations and preliminary clinical experience with the long-acting oestriol compound polyoestriol phosphate – a water-soluble polymere of oestriol and phosphoric acid. The compound seems to exert all the physiologically important effects of oestriol. Even with high doses the hormone causes no proliferation of the endometrium and no withdrawal bleeding. It has no untoward effect on metabolism. It decreases slightly the cholesterol concentration (to the extent of ⅓–⅕ of the effect produced by long-acting oestradiol esters). The compound has a wide therapeutic range. No side-effects have been observed. Doses of 10 mg or more have a prolonged duration. Additional prolongation of the effect is largely dependent on dosage. To ensure an effect lasting for 4 weeks 40 mg polyoestriol phosphate (corresponding with 30 mg oestriol) is required – an amount which roughly corresponds with physiological quantitative data. The compound, which involves an interesting new principle of prolongation, was most effectively used in the treatment of menopausal symptoms and genital organic disorders. For these indications it can be recommended without reservation.

Reducing Hypoglycemia through Increased Knowledge of an Evidence-Based Guideline

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 47-LB
Author(s):  
THAYER A. CLARK ◽  
LEIGH BAK
Keyword(s):  
Evidence Based ◽  
Evidence Based Guideline

Therapeutic Aspects of Squill; An Evidence-Based Review

2020 ◽  
Vol 17 (3) ◽  
pp. 318-324 ◽  
Author(s):  
Khadije Saket ◽  
Jalil T. Afshari ◽  
Ehsan Saburi ◽  
Mahdi Yousefi ◽  
Roshanak Salari
Keyword(s):  
Side Effects ◽  
Traditional Medicine ◽  
Respiratory Diseases ◽  
Low Cost ◽  
Current Evidence ◽  
Evidence Based ◽  
Helminthic Infections ◽  
Traditional Persian Medicine ◽  
Healing Of Wounds ◽  
Bioactive Agents

From ancient times, medicinal plants have been usually utilized to treat many disorders, but today, interest in these herbs is again aroused, because of their fewer side effects and low-cost. In traditional medicine, for many diseases, various medicinal herbs have been suggested so far. Drimia maritime, also named squill, is an important medicinal plant for the treatment of many diseases, especially respiratory diseases. In the current evidence-based study, we conducted a review of the general characteristics, ingredients, administration form, and side effects of squill in traditional medicine. For this purpose, traditional Persian medicine literatures and electronic databases were examined including PubMed, Scopus, and Google Scholar. Many compounds are isolated from D.maritima, including scillaren, scillirubroside, scillarenin, and bufadienolide glycosides. Oxymel is the most commonly used form of squill for various diseases, especially respiratory diseases. Besides, squill has been used in the treatment of cardiovascular, digestive, and dermatological disorders, it is also used against various cancer cells for its antioxidant and cytotoxic properties. Moreover, there is relatively reliable evidence of its benefits for bacterial and helminthic infections, rheumatism, edema, gout, abortion induction, healing of wounds and urine induction. It seems that supplementary studies are required to explore the bioactive agents and their effective mechanisms.

Access and Use of Contraception and Its Effects on Women’s Outcomes in the United States

2017 ◽  
pp. 218-258 ◽  
Author(s):  
Martha J. Bailey ◽  
Jason M. Lindo
Keyword(s):  
United States ◽  
Birth Control ◽  
The United States ◽  
Human Existence ◽  
Economic Outcomes ◽  
Birth Control Pill ◽  
American Women ◽  
Long Acting ◽  
Long Acting Reversible Contraceptives

Changes in childbearing affect almost every aspect of human existence. Over the last fifty years, American women have experienced dramatic changes in the ease and convenience of timing and limiting childbearing, ranging from the introduction of the birth control pill and the legalization of abortion to more recent availability of long-acting reversible contraceptives (LARCs). This chapter chronicles these changes, provides descriptive evidence regarding trends in the use of contraception and abortion, and reviews the literature linking them to changes in childbearing and women’s economic outcomes. It concludes by discussing the recent surge in LARC use, which seems to be one of the most pressing areas in need of further research.

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