Therapeutic Aspects of Squill; An Evidence-Based Review

From ancient times, medicinal plants have been usually utilized to treat many disorders, but today, interest in these herbs is again aroused, because of their fewer side effects and low-cost. In traditional medicine, for many diseases, various medicinal herbs have been suggested so far. Drimia maritime, also named squill, is an important medicinal plant for the treatment of many diseases, especially respiratory diseases. In the current evidence-based study, we conducted a review of the general characteristics, ingredients, administration form, and side effects of squill in traditional medicine. For this purpose, traditional Persian medicine literatures and electronic databases were examined including PubMed, Scopus, and Google Scholar. Many compounds are isolated from D.maritima, including scillaren, scillirubroside, scillarenin, and bufadienolide glycosides. Oxymel is the most commonly used form of squill for various diseases, especially respiratory diseases. Besides, squill has been used in the treatment of cardiovascular, digestive, and dermatological disorders, it is also used against various cancer cells for its antioxidant and cytotoxic properties. Moreover, there is relatively reliable evidence of its benefits for bacterial and helminthic infections, rheumatism, edema, gout, abortion induction, healing of wounds and urine induction. It seems that supplementary studies are required to explore the bioactive agents and their effective mechanisms.

Download Full-text

Edukasi Dokter kepada Pengonsumsi Jamu Kemasan sebagai Obat Penghilang Lelah

10.31227/osf.io/njgdf ◽

2019 ◽

Author(s):

Milania Dwi Arwinda

Keyword(s):

Risk Factor ◽

Side Effects ◽

Traditional Medicine ◽

Mefenamic Acid ◽

Low Cost ◽

Chemical Substances ◽

Instant Form ◽

The Future

Jamu or Indonesian traditional medicine is very popular among society. The demand enhancement of jamu brought industrial world to develop jamu into modern and instant form. They can give a low-cost and society friendly. Researchers also do researches to find out if there are substances that are not allowed to be included. Researchers also have result of their research that majority of instant jamu in society have composition of chemical substances such as corticosteroid, paracetamol, and mefenamic acid. Those compounds are very dangerous to be consumed in long-term period due to the side effects which are able to deliver metabolism abnormalities. People among society, especially in village, have no awareness in consuming that instant jamu. So that, doctor has a major role to deliver education to those people in order to decrease risk factor of metabolism abnormalities in the future.

Download Full-text

An Evidence-based Study on Pharmacological Treatments of Non-Alcoholic Fatty Liver Disease Based on Traditional Persian Medicine

Current Traditional Medicine ◽

10.2174/2215083805666190902114137 ◽

2020 ◽

Vol 6 (3) ◽

pp. 188-202

Author(s):

Fatemeh Sadat Hasheminasab ◽

Haleh Tajadini ◽

Mohammad Setayesh

Keyword(s):

Liver Disease ◽

Medicinal Plants ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Current Evidence ◽

Evidence Based ◽

Alcoholic Fatty Liver ◽

Persian Medicine ◽

Traditional Persian Medicine ◽

Alcoholic Fatty Liver Disease

Background: Non-Alcoholic Fatty Liver Disease (NAFLD) is one of the most prevalent liver diseases regarded as the primary cause of chronic liver disease, which may lead to hepatic failure. Despite the recent developments in the treatment of NAFLD, the necessity to find more efficient treatments has led to investigation on medicinal plants. Traditional Persian Medicine (TPM) is one of the oldest medical schools in the world. For treatment of NAFLD, different medicinal plants have been employed in TPM. Objective: Considering the public welcome for herbal medicines, the current evidence-based review study is conducted to investigate herbal remedies for NAFLD in TPM. Methods: Medicinal plants for treating NFALD were extracted according to three famous textbooks of Persian medicine. Then anti-obesity, hypolipidemic, hypoglycemic, antioxidative and hepatoprotective effects of these medicinal plants were investigated according to modern medicine. For this purpose, databases including Scopus, web of sciences, Pubmed, Google scholar and science direct were searched. Results: Investigations of Persian medicine textbooks resulted in deriving 53 herbs, which are useful for treating NAFLD. Searching through aforesaid databases showed that most of these plants can help to treat this disease in at least 2 ways. 25 herbs are effective in all 5 mentioned effects. Conclusion: It should be considered that in Persian medicine, first-line treatment is correction of life style, then if necessary, herbs are prescribed. However, this study showed that many herbs mentioned in Persian medicine for treatment of NAFLD might have a potential to aid patient with this disease.

Download Full-text

An Evidence-Based Research on Botanical Sources for Oral Mucositis Treatment in Traditional Persian Medicine

Current Drug Discovery Technologies ◽

10.2174/1570163817666200203110803 ◽

2020 ◽

Vol 17 ◽

Author(s):

Fatemeh Sadat Hasheminasab ◽

Fariba Sharififar ◽

Seyed Mehdi Hashemi ◽

Mohammad Setayesh

Keyword(s):

Oral Mucositis ◽

Punica Granatum ◽

Economic Consequences ◽

Herbal Remedies ◽

Current Evidence ◽

Evidence Based ◽

Cancer Therapies ◽

Persian Medicine ◽

Comprehensive Survey ◽

Traditional Persian Medicine

Background: Cancer is one of the most prevalent diseases associated with heavy complications in treatment. Mucotoxic cancer therapies such as head and neck radiotherapy and some of the chemotherapy agents may lead to oral mucositis. In addition to its economic consequences, mucositis also affects patients' quality of life. In traditional Persian medicine (TPM) manuscripts, several medicaments have been suggested for treatment of mucositis. Objective: Considering the public welcome for herbal medicine, the current evidence-based review study is conducted to investigate the herbal remedies which have been proposed for oral mucositis in TPM. Methods: At first, a comprehensive survey was done on Qanon fi al-Teb which is the most important textbook of TPM; then the scientific name of the herbs was authenticated according to the botanical textbooks. At last, data banks including Scopus, Pubmed, Web of science and Science direct were investigated for possible relevant properties of each medicinal plant in the literature. Results: Totally 30 herbs are introduced in this study. According to the registered documents, 18 herbs are reported to have antioxidant, anti-inflammatory, antimicrobial, anti-nociceptive and wound healing properties of which the therapeutic effect of only a few herbs including Glycyrrhiza glabra, Malva sylvestris, Morus nigra, Punica granatum, and Solanum nigrum were directly evaluated against oral mucositis on the literature. Conclusion: Despite the lack of human studies on mucositis for the other discussed herbs, their related pharmacological properties can be considered for new natural drug discovery supported by medieval and traditional experiments.

Download Full-text

EFFICACY OF DUONG-QUY-LUC-HOANG DECOCTION IN TREATMENT OF CHRONIC URTICARIA

Journal of Medicine and Pharmacy ◽

10.34071/jmp.2019.2.1 ◽

2019 ◽

pp. 7-11

Author(s):

Thien An Tran ◽

Van Minh Doan ◽

Thi Tu Anh Nguyen

Keyword(s):

Side Effects ◽

Prospective Study ◽

Traditional Medicine ◽

Key Words ◽

Chronic Urticaria ◽

Clinical Intervention ◽

Evidence Based ◽

Central Hospital ◽

Treatment Results ◽

Before And After

Background: Chronic urticaria (CU) is characterized by repeated occurrence of wheals and itching for more than 6 weeks. Treatment of chronic urticaria with traditional medicine has been shown to relieve symptoms and prevent recurrence. In recent years, more and more evidence-based studies of CU treatment by Traditional medicine were report, including acupuncture, herbs, and food. Objective: To evaluate the efficacy of Duong-Quy-Luc-Hoang (DQLH) decoction in treatment of Chronic Urticaria. Material and Method: Including 30 patients with chronic urticaria had been treated by DQLH decoction in Faculty of Traditional Medicine, Hue Central Hospital. Prospective study, clinical intervention, comparison before and after treatment. Results: The decoction of DQLH has efficacy in 100% patient, include 56.7% of patient who became symtom-free. There is no side effects observed during the progress of this study. Key words: Chronic urticarial, Duong-quy-luc-hoang decoction, Traditional medicine

Download Full-text

An Evidence-Based Review of Antitussive Herbs Containing Essential Oils in Traditional Persian Medicine

Current Drug Discovery Technologies ◽

10.2174/1568009620666200421091245 ◽

2020 ◽

Vol 17 ◽

Cited By ~ 1

Author(s):

Ayda Hosseinkhani ◽

Bijan Ziaeian ◽

Kamran Hessami ◽

Mohammad Mehdi Zarshenas ◽

Ali Kashkooe ◽

...

Keyword(s):

Medicinal Plants ◽

Essential Oils ◽

Scientific Evidence ◽

Herbal Remedies ◽

Future Research ◽

Evidence Based ◽

Online Databases ◽

Persian Medicine ◽

Troublesome Symptom ◽

Traditional Persian Medicine

Background: Cough is one of the most common medical symptoms for which medical advice is sought. Although cough is a protective reflex responsible for clearing the airways from secretions and foreign bodies, it can be a troublesome symptom that causes discomfort to patients. Due to the increasing interest in herbal remedies in the both developed and developing countries, in the current study, we aimed to overview medicinal herbs containing essential oils used as antitussive agents according to the Traditional Persian Medicine [TPM] textbooks. We summarized the relevant scientific evidence on their possible pharmacological actions. Methods: To collect the evidence for treatment of cough or “seaal” [cough in ancient books] from TPM sources, five main medicinal Persian manuscripts were studied. The antitussive herbs were listed and their scientific names were identified and authenticated in accordance with botanical reference books. ScienceDirect and PubMed online databases were searched for related mechanisms of action of the reported medicinal plants. Results: The number of 49 herbs containing essential oils were recommended in TPM for the treatment of cough; 21 of them had at least one known mechanism of action for cough suppression in the scientific literature. According to this review, most of the cited medicinal plants were assessed for either nitric oxide inhibitory or antitussive/expectorant activities. Conclusion: In addition to advantageous effects of antitussive herbs noted by TPM, the present review highlighted some recent evidence-based data on these promising candidates that could be used as an outline for future research on their medicinal use.

Download Full-text

Calcium and Vitamin D Supplementation. Myths and Realities with Regard to Cardiovascular Risk

Current Vascular Pharmacology ◽

10.2174/1570161117666190408165805 ◽

2019 ◽

Vol 17 (6) ◽

pp. 610-617 ◽

Cited By ~ 10

Author(s):

Giovanna Muscogiuri ◽

Luigi Barrea ◽

Barbara Altieri ◽

Carolina Di Somma ◽

Harjit pal Bhattoa ◽

...

Keyword(s):

Vitamin D ◽

Side Effects ◽

Secondary Hyperparathyroidism ◽

Calcium Supplementation ◽

Physiological Role ◽

Bone Diseases ◽

Current Evidence ◽

Bone Homeostasis ◽

Mineral Density ◽

Muscle Health

Vitamin D and calcium are considered crucial for the treatment of bone diseases. Both vitamin D and calcium contribute to bone homeostasis but also preserve muscle health by reducing the risk of falls and fractures. Low vitamin D concentrations result in secondary hyperparathyroidism and contribute to bone loss, although the development of secondary hyperparathyroidism varies, even in patients with severe vitamin D deficiency. Findings from observational studies have shown controversial results regarding the association between bone mineral density and vitamin D/calcium status, thus sparking a debate regarding optimum concentrations of 25-hydroxyvitamin D and calcium for the best possible skeletal health. Although most of the intervention studies reported a positive effect of supplementation with calcium and vitamin D on bone in patients with osteoporosis, this therapeutic approach has been a matter of debate regarding potential side effects on the cardiovascular (CV) system. Thus, the aim of this review is to consider the current evidence on the physiological role of vitamin D and calcium on bone and muscle health. Moreover, we provide an overview on observational and interventional studies that investigate the effect of vitamin D and calcium supplementation on bone health, also taking into account the possible CV side-effects. We also provide molecular insights on the effect of calcium plus vitamin D on the CV system.

Download Full-text

Natural Phytochemicals and Their Therapeutic Role in Management of Several Diseases: A Review

Current Traditional Medicine ◽

10.2174/2215083805666190807111817 ◽

2020 ◽

Vol 6 (1) ◽

pp. 43-53 ◽

Cited By ~ 2

Author(s):

Nitin R. Shirsath ◽

Ajaygiri K. Goswami

Keyword(s):

Side Effects ◽

Low Cost ◽

Herbal Medicines ◽

Biological Source ◽

Natural Medicine ◽

Synthetic Chemicals ◽

Alternative Approach ◽

Health Related ◽

Activity Mechanism ◽

Natural Medicines

Introduction: These days, a lot of people face some health-related problems in day to day life. The conventional synthetic medicine is not effective enough to cure them alone. The conventional therapy for the management of these health-related issues involves the use of hazardous synthetic chemicals and surgical diagnosis, which have lots of serious side effects. It is necessary to conduct research on herbal medicines, this is an alternative approach to avoid the side effects of synthetic medicines to achieve high effectiveness, low cost and improve patient compliance. Methods: The present survey is an analysis of some of the available data on the use of plants with their biological source, active phytochemicals constituents and a probable activity/ mechanism of action of several classes of drugs. This work also focused on highlighting the advantages of natural medicines for maximum utilization. Results: This article aims to increase awareness about natural medicine and help people find a suitable herbal medicine for the treatment of specific diseases. Conclusion: This article also exhibits the scope for further process in the development of new natural substance for the management of several diseases.

Download Full-text

Ethnolichenology—The Use of Lichens in the Himalayas and Southwestern Parts of China

Diversity ◽

10.3390/d13070330 ◽

2021 ◽

Vol 13 (7) ◽

pp. 330

Author(s):

Mei-Xia Yang ◽

Shiva Devkota ◽

Li-Song Wang ◽

Christoph Scheidegger

Keyword(s):

Traditional Medicine ◽

Additional Research ◽

Lichen Species ◽

Evidence Based ◽

Modern Life ◽

The Future ◽

Ethnic Uses

Lichens are used in traditional medicine, food and various other ethnic uses by cultures across the Himalayas and southwestern parts of China. Evidence-based knowledge from historical and modern literatures and investigation of ethnic uses from 1990 proved that lichen species used as medicine in the Himalayas and southwestern parts of China totaled to 142 species; furthermore, 42 species were utilized as food. Moreover, some lichens are popularly used for lichen produce in ethnic and modern life. An understanding and clarification of the use of lichens in the Himalayas and southeastern parts of China can therefore be important for understanding uses of lichens elsewhere and a reference for additional research of lichen uses in the future.

Download Full-text

Evidence-based Research in Complementary and Alternative Medicine I: History

Evidence-based Complementary and Alternative Medicine ◽

10.1093/ecam/neh106 ◽

2005 ◽

Vol 2 (4) ◽

pp. 453-458 ◽

Cited By ~ 17

Author(s):

Francesco Chiappelli ◽

Paolo Prolo ◽

Olivia S. Cajulis

Keyword(s):

Alternative Medicine ◽

Complementary And Alternative Medicine ◽

Traditional Medicine ◽

Western Medicine ◽

Evidence Based ◽

Medical Treatments ◽

Medical Interventions ◽

Philosophical Foundations ◽

Medical Tradition ◽

Complementary And Alternative

Contemporary Western medicine has witnessed a fragmentation of our conceptualization of the medical endeavor into ‘traditional medicine’ and ‘non-traditional medicine’. The former is meant to refer to the Western medical tradition, the latter encompasses both ‘complementary’ and ‘alternative’ medical practices. Complementary medicine complements conventional medical treatments, and alternative modes of medical interventions are meant to replace traditional Western medicine. Evidence-based research must be directed at establishing the best available evidence in complementary and alternative medicine. This paper is the first of a set of four ‘lectures’ that reviews the process of evidence-based research, and discusses its implications and applications for the early decades of the 21st century. The purpose of this paper is to introduce the series by examining some of the historical and philosophical foundations of this research endeavor.

Download Full-text