Platelet‐Rich Plasma Treatment for Accelerated Androgenetic Alopecia Pattern Hair Loss After COVID‐19 Infection: A Case Series

2021 ◽  
Author(s):  
Akif İşlek ◽  
Engin Karaaslan ◽  
Sadullah Şimşek ◽  
Funda Merve Çetin
Keyword(s):  
Plasma Treatment ◽  
Hair Loss ◽  
Platelet Rich Plasma ◽  
Case Series ◽  
Androgenetic Alopecia

scholarly journals Platelet Rich Plasma Hybridized Adipose Transplant (PHAT) for the Treatment of Hair Loss: A Case Series

2021 ◽  
Author(s):  
Benjamin Talei ◽  
Orr Shauly ◽  
Daniel Gould
Keyword(s):  
Hair Loss ◽  
Platelet Rich Plasma ◽  
Case Series

Platelet‑rich plasma as a method of treatment of androgenetic alopecia in men — a case report

2020 ◽  
Vol 3 (1) ◽  
pp. 27-33
Author(s):  
Patrycja Przybylska ◽  
Teresa Matthews‑Brzozowska
Keyword(s):  
Case Report ◽  
Side Effects ◽  
Hair Loss ◽  
Platelet Rich Plasma ◽  
Nutritional Supplementation ◽  
Androgenetic Alopecia ◽  
Common Condition ◽  
Minimal Invasiveness ◽  
Photographic Documentation ◽  
Hair Transplant

Androgenetic alopecia is a common condition, accounting for about 95% of all male hair loss. Standard therapeutic solutions recommend the use of minoxidil, finasteride, spironolactone, nutritional supplementation, phototherapy and hair transplant surgery. An increasingly popular alternative method that has been used in the case report is platelet rich plasma (PRP) mesotherapy characterized by autologous character, minimal invasiveness and no serious side effects. A series of 3 treatments was performed at 3-week intervals. The effects of using medical photographic documentation after completing a series of treatments.

scholarly journals Investigating the Safety and Efficacy of Platelet-Rich Plasma (PRP) Treatment for Female Androgenetic Alopecia: Review of the Literature

Medicina ◽  
2021 ◽  
Vol 57 (4) ◽  
pp. 311
Author(s):  
Santo Raffaele Mercuri ◽  
Giovanni Paolino ◽  
Matteo Riccardo Di Nicola ◽  
Laura Vollono
Keyword(s):  
Hair Loss ◽  
Platelet Rich Plasma ◽  
Androgenetic Alopecia ◽  
Cochrane Central Register ◽  
Review Of The Literature ◽  
Psychosocial Burden ◽  
Female Pattern Hair Loss ◽  
Central Register ◽  
Topical Minoxidil

Background: female androgenetic alopecia (FAGA) is a common cause of non-scarring alopecia in women, affecting approximately 40% of women by age 50, bearing a significant psychosocial burden on affected patients. Platelet-rich plasma (PRP) has been widely investigated as a potential effective treatment for several dermatological conditions, including male androgenetic alopecia (MAGA). However, few studies have been conducted focusing on the use of PRP in FAGA. The aim of this review was to identify reports that investigated the use of PRP for the treatment of FAGA. Methods: Electronic databases of MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials (CENTRAL) from inception to September 2020 have been searched using different combinations of the following terms: “androgenetic alopecia,” “FAGA,” “female pattern hair loss,” “platelet-rich fibrin,” “platelet-rich plasma,” and “PRP”. Results and conclusions: Eight (n = 8) clinical studies consistent with our research were identified. A total of 197 subjects has been enrolled in the included studies. All of them were adult female patients (mean age: 38.9) affected by female pattern hair loss. PRP is a well-tolerated procedure which showed promising results in males-only and mixed populations of AGA patients. PRP showed to produce high levels of satisfaction and improvement in the quality of life in patients affected by FAGA. In the light of this evidence, PRP may be proposed in patients who did not respond or did not tolerate topical minoxidil, as well as in combination with topical and oral treatments.

scholarly journals Efficacy of Autologous Platelet Rich Plasma in the Treatment of Male Androgenetic Alopecia

Esculapio ◽  
2021 ◽  
Vol 16 (4 (oct 2020 - dec 2020)) ◽  
Author(s):  
Nadia Naeem ◽  
Saadiya Siddiqui ◽  
Atif Shehzad ◽  
Kehkshan Tahir ◽  
Marrium Manzoor
Keyword(s):  
Platelet Rich Plasma ◽  
Case Series ◽  
Data Entry ◽  
Stage Iv ◽  
Androgenetic Alopecia ◽  
Case Series Study ◽  
Significant Difference ◽  
Autologous Platelet Rich Plasma ◽  
Male Patients ◽  
Autologous Platelet

Objective: To assess the outcome of autologous platelet rich plasma(PRP) for the treatment of androgenetic alopecia in male patients. Methods: A total of 61 male patients from Department of Dermatology, Lahore General Hospital Lahore with ages between 18-60 years were included in the study during a period of 6 months. PRP was prepared by double spin method and CaCl2 was used to activate platelets. PRP was injected, with a 30-G needle using Nappage technique. This descriptive case series study was carefully monitored. Protocol included three treatment sessions with an interval of four weeks. Number of hairs, and hair strength was assessed by dermoscopy and hair pull test. SPSS Version-21 was used for data entry and analysis. Results: The mean age of patients was 42.67±8.63 years. Mean number of hair was 21.50±4.57 per dermatoscopic field, Post treatment number of hair was 78.10±16.24. Mean duration of disease was 10.25±3.52 months. Majority of patients were in stage iv 19(31.1%) and in stage ii 16(26.2%). There was significant difference in number of hair before and after treatment. Conclusion: PRP is an effective method to treat the patients with androgen alopecia. Key Words: Autologus platelet rich plasma, Androgen alopecia. How to Cite: Naeem N, Siddiqui S, Shehzad A, Tahir K, Manzoor M. Efficacy of autologous platelet rich plasma in the treatment of male androgenetic alopecia. Esculapio.2020;16(04):41-45.

scholarly journals Platelet-Rich Plasma for Androgenetic Alopecia in Women: A Single-Center Case Series Study in Qatar

2020 ◽  
Vol 3 (4) ◽  
pp. 228-230
Author(s):  
Mohamed Ahmed Syed ◽  
Samya Sami A.S. Abushaikha
Keyword(s):  
Platelet Rich Plasma ◽  
Case Series ◽  
Androgenetic Alopecia ◽  
Single Center ◽  
Case Series Study ◽  
Series Study

A Mechanistic Model of Platelet-Rich Plasma Treatment for Androgenetic Alopecia

2016 ◽  
Vol 42 (12) ◽  
pp. 1335-1339 ◽  
Author(s):  
Aditya K. Gupta ◽  
Jessie Carviel
Keyword(s):  
Plasma Treatment ◽  
Platelet Rich Plasma ◽  
Mechanistic Model ◽  
Androgenetic Alopecia

The Therapeutic Response of Platelet Rich Plasma (PRP) for Androgenetic Alopecia Showed No Correlation with Growth Factors and Platelet Number

Blood ◽  
2016 ◽  
Vol 128 (22) ◽  
pp. 2637-2637 ◽  
Author(s):  
Bruno Lima Rodrigues ◽  
Silmara Aparecida De Lima Montalvão ◽  
Joyce Annichinno-Bizzacchi ◽  
Rebeca Cancela ◽  
Francesca Silva ◽  
...  
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Hair Loss ◽  
Hair Growth ◽  
Therapeutic Response ◽  
Platelet Rich Plasma ◽  
Androgenetic Alopecia ◽  
Autologous Serum ◽  
Platelet Number ◽  
The Mean

Abstract Background: Androgenetic alopecia (AGA) is characterized by a pattern hair loss. Currently, treatment with platelet-rich plasma (PRP) has shown promising results due to the growth factors (GFs) released by the platelets. However, the analysis of therapeutic response according to GFs levels and platelet number in PRP has not been established. Objective: Investigate the therapeutic response to treatment of AGA using a standard method of PRP preparation, and the relation with GFs levels and platelet number. Methods: Inclusion criteria comprised diagnosis of AGA-III-vertex profile according to the Norwood-Hamilton scale, age between 18 and 50 years. Exclusion criteria comprised female gender, previous hair transplantation, any disease related to hair loss such as thyroid disease and/or iron deficiency, neoplasia present or past, kidney, liver, infectious, hematologic or rheumatoid disease, use of antiplatelet and/or anti-inflammatory drugs. All patients provided written informed consent approved by the ethic committee from the Faculty of Medical Sciences of the State University of Campinas (UNICAMP). The protocol comprised 20 subcutaneous injections of 100 µL in the scalp totaling 4 applications every fifteen days, with evaluation performed pretreatment (t0), 45 (t1) and 150 (t2) days after the start of the protocol. The endpoints for therapeutic response were hair growth and increase of percentage of anagen hairs evaluated by TrichoScan. For each patient 40 mL of peripheral blood were collected in ACD tubes. L-PRP (PRP with leukocytes) was performed, with double centrifugation (300 g for 5 minutes, and 700 g for 17 minutes). The platelets were counted in the baseline and in the PRP samples. PRP was activated with autologous serum. The platelet-derived growth factors (PDGF), vascular endothelial growth factor (VEGF), epidermal growth factor (EGF) were measured by Luminex technique (Millipore®, USA), in two different PRP samples from each patient. Results: During the period of August to December of 2014, 15 male patients were included in the study. The median of platelets in PRP was increased by 5 folds in all four PRP preparations with a minimum of 728.9 and maximum 1.901,90 x 106 cel/uL, and median values of 1.082 x 106 cel/uL (range 608 - 2.023). The baseline number of platelets and PRP preparation showed a significant correlation (r = 0.839, p < 0.0001). The variability of platelet numbers from each individual during the four applications was 19.7% with a minimum of 0.50% and a maximum 56.3%. GF quantification of two different PRP preparations showed a similar intra-individual variation, with a mean of variability coefficient of 18.4% for VEGF, 20.9% for PDGF, and 21.6% for EGF (Table 1). EGF and PDGF concentrations showed a significant correlation to PRP platelets number (r = 0.8287 and P < 0.0001, and r = 0.6925 and P=0.0014, respectively) (Figure 1). Our results showed a significant increase in hair count (P = 0.0018) and anagen hairs (P = 0.0070) in 86.6% and 53.3% of patients, respectively. However, no correlation was found between platelet counts and GFs levels with therapeutic response. The patients who presented high levels of GFs did not show better results for hair growth or anagen hair than who presented lower levels. Conclusion: Our results corroborate previous studies that showed PRP as a quite promising therapeutic option for AGA, up to 3 months after the injections. However, there was a lack of correlation between the therapeutic responses and platelet numbers or GFs levels. Although, the GFs were not considered biomarker for PRP, it may play an important role in the PRP therapeutic effect. In addition, our results suggest that the PRP effects depend on an orchestration between many mechanisms involved in the increase of number of hairs and its growth. Furthermore, local receptors might present a central role in this response. Graphs of correlation between the platelet mean in PRP and the mean of the growth factor concentrations Graphs of correlation between the platelet mean in PRP and the mean of the growth factor concentrations Figure 1 Figure 1. Disclosures No relevant conflicts of interest to declare.

scholarly journals Platelet-Rich Plasma (PRP) Effect on Androgenetic Alopecia and Female Pattern Hair Loss

2019 ◽  
Vol 6 (1) ◽  
Author(s):  
Elham Behrangi ◽  
Abbas Zamanian ◽  
Gholamhossein Ghaffarpour ◽  
Maryam Hashemi Orimi ◽  
Amir Heydarian ◽  
...  
Keyword(s):  
Hair Loss ◽  
Platelet Rich Plasma ◽  
Androgenetic Alopecia ◽  
Female Pattern Hair Loss
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