Solid lipid nanoparticles carrying Eugenia caryophyllata essential oil: the novel nanoparticulate systems with broad-spectrum antimicrobial activity

2018 ◽  
Vol 66 (6) ◽  
pp. 506-513 ◽  
Author(s):  
B.S. Fazly Bazzaz ◽  
B. Khameneh ◽  
N. Namazi ◽  
M. Iranshahi ◽  
D. Davoodi ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Essential Oil ◽  
Broad Spectrum ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
The Novel ◽  
Solid Lipid ◽  
Nanoparticulate Systems

scholarly journals Application of normal essential oil and loaded-solid lipid nanoparticles as antioxidant

2019 ◽  
Vol 44 (2) ◽  
pp. 180-186
Author(s):  
M. Taha ◽  
M. EL-Dannasoury ◽  
S. Mahmoud ◽  
M. Moghazy
Keyword(s):  
Essential Oil ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Solid Lipid

scholarly journals Enhancement of ciprofloxacin activity by incorporating it in solid lipid nanoparticles

2020 ◽  
Vol 19 (5) ◽  
pp. 909-918
Author(s):  
Saqer Alarifi ◽  
Salam Massadeh ◽  
Mohammed Al-Agamy ◽  
Manal A.l. Aamery ◽  
Abdulkareem Al Bekairy ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Pseudomonas Aeruginosa ◽  
Antimicrobial Activity ◽  
Particle Size ◽  
Solid Lipid Nanoparticles ◽  
Entrapment Efficiency ◽  
Lipid Nanoparticles ◽  
Release Profile ◽  
Drug Release Profile ◽  
Solid Lipid

Purpose: To incorporate ciprofloxacin (CIP) into solid lipid nanoparticles (SLN) in order to enhance its biopharmaceutical properties and antibacterial activity.Methods: A sonication melt-emulsification method was employed for the preparation of CIP-loaded SLN. The composition of the SLN was varied in order to investigate factors such as lipid type and combination ratio, drug to lipid ratio, and surfactant ratio. The produced SLN formulations wereevaluated for their particle size and shape, zeta potential, and entrapment efficiency. In addition, the effect of SLN formulation composition on its drug release profile and antimicrobial activity against Escherichia coli, Pseudomonas Aeruginosa, and Staphylococcus Aureus was also investigated.Results: The generated nanoparticles had particle size in the range of 165 to 320 nm. The zetapotential values were generally low within ± 5. All formulations exhibited entrapment efficiency between 50 and 90 %. CIP release exhibited a biphasic release profile with a low burst phase, followed by uniform controlled-release behavior of various rates. SLN-loaded CIP exhibited one-fold reduction in minimum inhibitory concentration (MIC) and caused significant inhibition of all the three bacterial strains tested, when compared with pure CIP.Conclusion: Loading of CIP into SLN significantly enhances its antimicrobial activity in vitro which can translate to significant enhancement of therapeutic outcomes by minimizing the dose-dependent adverse and side effects and/or enhancing the antimicrobial spectrum of activity. Keywords: Solid lipid nanoparticles, Sonication melt-emulsification, Ciprofloxacin, Escherichia coli, Pseudomonas aeruginosa

Benzothieno[3,2-e][1,2,4]triazolo[4,3-c]pyrimidines: Synthesis, Characterization, Antimicrobial Activity, and Incorporation into Solid Lipid Nanoparticles

2011 ◽  
Vol 344 (6) ◽  
pp. 358-365 ◽  
Author(s):  
Shridhar I. Panchamukhi ◽  
Jameel Ahmed S. Mulla ◽  
Nitinkumar S. Shetty ◽  
Mohammed Iqbal A. Khazi ◽  
Ashraf Y. Khan ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Solid Lipid

scholarly journals High anticancer efficacy of solid lipid nanoparticles containing Zataria multiflora essential oil against breast cancer and melanoma cell lines

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Alireza Valizadeh ◽  
Ali Asghar Khaleghi ◽  
Ghazaal Roozitalab ◽  
Mahmoud Osanloo
Keyword(s):  
Breast Cancer ◽  
Essential Oil ◽  
Solid Lipid Nanoparticles ◽  
Entrapment Efficiency ◽  
Lipid Nanoparticles ◽  
In Vivo Studies ◽  
Zataria Multiflora ◽  
Anticancer Efficacy ◽  
Solid Lipid

Abstract Background The cancer burden is rising rapidly worldwide, and it annually causes about 8.8 million deaths worldwide. Due to chemical drugs’ side effects and the emergence of resistance, the development of new green drugs has received much attention. We aimed to investigate whether solid-lipid nanoparticles containing essential oil of Zataria multiflora (ZMSLN) enhanced the anticancer efficacy of the essential oil against breast cancer (MDA-MB-468) and melanoma (A-375) cells. Results ZMSLN was prepared by the high-pressure homogenizer method; particle size 176 ± 8 nm, polydispersity index 0.22 ± 0.1, entrapment efficiency 67 ± 5%. The essential oil showed a dose-dependent antiproliferative effect on MDA-MB-468 and A-375 cells at all examined concentrations (75, 150, 300, 600, and 1200 μg/mL). Interestingly, after treating both cells with 75 μg/mL of ZMSLN, their viabilities were reduced to under 13%. Conclusion The finding showed that ZMSLN had a distinct antiproliferative efficacy; it could thus be considered a green anticancer candidate for further in vivo and in vivo studies.

scholarly journals Solid-lipid nanoparticles (SLN)s containing Zataria multiflora essential oil with no-cytotoxicity and potent repellent activity against Anopheles stephensi

2020 ◽  
Author(s):  
Hamid Reza Kelidari ◽  
Mohammad Djaefar Moemenbellah-Fard ◽  
Katayon Morteza-Semnani ◽  
Fatemeh Amoozegar ◽  
Marziae Shahriari-Namadi ◽  
...  
Keyword(s):  
Essential Oil ◽  
Solid Lipid Nanoparticles ◽  
Anopheles Stephensi ◽  
Lipid Nanoparticles ◽  
Repellent Activity ◽  
Zataria Multiflora ◽  
Solid Lipid

scholarly journals TOPICAL SOLID LIPID NANOPARTICLES BASED GEL OF LAVENDER ESSENTIAL OIL FOR ANTI‑INFLAMMATORY ACTIVITY

2019 ◽  
pp. 175-182
Author(s):  
PALLAVI M CHAUDHARI ◽  
VAISHNAVI M BIND
Keyword(s):  
Particle Size ◽  
Drug Release ◽  
Essential Oil ◽  
Solid Lipid Nanoparticles ◽  
Ex Vivo ◽  
Entrapment Efficiency ◽  
Lipid Nanoparticles ◽  
Inflammatory Activity ◽  
Solid Lipid ◽  
Anti Inflammatory

Objective: The main objective of the study was to formulate and evaluate and perform an optimization study of lavender essential oil loaded solid lipid nanoparticles (SLNs) based gel. Materials and Methods: SLNs were prepared by the hot homogenization technique. A total of eight formulations were formulated as per 23 factorial design by design expert 11 software. The formulated SLNs were further evaluated for particle size, entrapment efficiency, drug release profile. After evaluation, the optimized batch was further used for formulating gel. The formulated gel was further subjected to ex vivo studies. Results: After the evaluation of all the parameters, batch 7 was found to be optimized. Batch 7 was found to have the lowest particle size of 30.91±0.30, higher entrapment efficiency of 89.99±0.87, and higher drug release of 90.41±0.55. It was further used for formulating gel which was found to be consistent, homogenous, smooth, and spreadable. The % inhibition of the formulated SLN based gel was found to be 28±0.1%. Conclusion: The SLNs were prepared and were formulated into the gel. The gel showed anti-inflammatory activity.

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