scholarly journals Exposure to multiple mycotoxins, environmental enteric dysfunction and child growth: Results from the AflaCohort Study in Banke, Nepal

2022 ◽  
Author(s):  
Johanna Andrews‐Trevino ◽  
Patrick Webb ◽  
Robin Shrestha ◽  
Ashish Pokharel ◽  
Sudikshya Acharya ◽  
...  
Keyword(s):  
Child Growth ◽  
Environmental Enteric Dysfunction

scholarly journals Host Fecal mRNAs Predicted Environmental Enteric Dysfunction among Children with Moderate Acute Malnutrition in Sierra Leone

2021 ◽  
Author(s):  
Akriti Singh ◽  
Isabel Potani ◽  
Stacy P. Griswold ◽  
Devika Suri ◽  
Breanne Langlois ◽  
...  
Keyword(s):  
Sierra Leone ◽  
High Sensitivity ◽  
Cluster Randomized Trial ◽  
Child Growth ◽  
Acute Malnutrition ◽  
Random Forest Classification ◽  
Forest Classification ◽  
Environmental Enteric Dysfunction ◽  
Mrna Transcripts ◽  
Moderate Acute Malnutrition

Examining the role of environmental enteric dysfunction (EED) in child growth requires noninvasive, field-appropriate biomarkers. Alternatives to the traditionally used lactulose:mannitol (L:M) test have been explored, but few studies have compared the L:M test to host fecal mRNA transcripts. The objectives of this study were to examine whether 1) host fecal mRNA transcripts could predict presence and severity of EED, measured using the L:M test, and 2) EED modifies the effect of specialized nutritious foods (SNFs) on recovery from moderate acute malnutrition (MAM). This substudy was nested within a cluster randomized trial comparing four SNFs in the treatment of MAM among children 6 to 59 months in Sierra Leone. EED was assessed at enrollment using the L:M test and 15 host fecal mRNA transcripts on 522 children. Recovery from MAM was defined as achieving mid-upper arm circumference ≥ 12.5 cm within 12 weeks of supplementation. Random forest classification models were used to examine prediction of presence and severity of EED by host fecal mRNA transcripts. Logistic regression was used to test for effect modification by L:M test variables including % lactulose excreted (%L). Eight host fecal mRNA transcripts (AQP9, REG3A, IFI30, DECR1, BIRC3, SELL, PIK3AP1, DEFA6) identified EED (%L ≥ 0.2) and severe EED (%L ≥ 0.45) with high sensitivity and specificity. The L:M test variables did not modify the effect of SNFs on recovery from MAM. In this study, we found host fecal mRNA transcripts that could be biomarkers of EED but did not find EED to modify the effect of SNFs on MAM treatment.

scholarly journals Environmental enteric dysfunction, soil transmitted helminthiasis and stunting among 36- to 59-month-old children in Quezon Province, Philippines

2021 ◽  
Vol 27 (2) ◽  
Author(s):  
Angelina R. Bustos ◽  
◽  
Carmelita M. Rebancos ◽  
Corazon VC. Barba ◽  
Victorio B. Molina ◽  
...  
Keyword(s):  
Bacterial Overgrowth ◽  
The Philippines ◽  
Child Growth ◽  
High Rate ◽  
World Health ◽  
Hydrogen Breath Test ◽  
Significant Positive Association ◽  
Cross Sectional ◽  
Environmental Enteric Dysfunction ◽  
Soil Transmitted Helminthiasis

Introduction: Environmental enteric dysfunction (EED) is relevant in public health as it is a potential cause of child stunting. In the Philippines, stunting affects 33.4% of children in 2015. As of date, no local studies on EED exist. This study primarily aimed to determine the prevalence of EED, soil transmitted helminthiasis (STH) and stunting; and their relationships. Methods: A cross-sectional study was conducted among 120 children aged 36-59 months old in Quezon Province, Philippines. EED was assessed via glucose hydrogen breath test with a cut-off of >20 ppm over baseline by 90 minutes suggestive of small intestinal bacterial overgrowth (SIBO), a biomarker of EED. Kato Katz Technique was used to determine STH. Stunting was determined using the 2006 World Health Organization Child Growth Standards. Descriptive and correlation analyses of data were done at 10% level of significance. The study received approval from the National Ethics Committee of PCHRD-DOST, Philippines. Results: Data on expired hydrogen level of <20ppm were documented. The prevalence of STH among children were 38.1% for Ascaris lumbricodes, 15.3% for Trichuris trichiura, and 1.7% for hookworm infections. A high rate of stunting at 40.0% was observed. There was a significant positive association between stunting and the presence of Ascaris (p=0.01). Conclusion: There was no case of EED detected in the study. The severity of stunting was high at 40.0%. Among the STH, the prevalence of 38.1% children having Ascaris lumbricodes was alarming in terms of morbidity control. Nutrition interventions including WASH practices and the use of anthelminthic drugs need to be intensified to address stunting and STH.

Nutritional Status of Pediatric Patients in Ramathibodi Hospital Using the WHO Child Growth Standard and the Thai Growth Reference

2020 ◽  
Vol 103 (10) ◽  
pp. 1099-1106
Keyword(s):  
Nutritional Status ◽  
Pediatric Patients ◽  
Chronically Ill ◽  
Child Growth ◽  
World Health ◽  
Healthy Children ◽  
Growth Standard ◽  
Growth Reference ◽  
Child Growth Standard

Background: The appropriate assessment of nutritional status in children is an essential aspect of health supervision. Currently, there are two references used for growth assessment in Thailand. The WHO child growth standard, which has been widely used since 2007, and the Thai growth reference developed by the Ministry of Public Health, which has been used since 1998. However, there were very few studies that made a direct comparison between both tools. Objective: To compare the nutritional status of healthy pediatric patients in Ramathibodi Hospital assessed by the World Health Organization (WHO) child growth standard and the Thai growth reference. Materials and Methods: The present study was a cross-sectional study. The data were collected from all pediatric patients registered in the outpatient department (OPD) of Faculty of Medicine, Ramathibodi Hospital between January 2013 and December 2018. All healthy children (aged 0 to 15 years) were included. Exclusion criteria of possibly chronically ill children were defined by those who were 1) visiting subspecialty clinics, 2) OPD and emergency room (ER) visits more than ten times per year, 3) having ICD-10 of chronic conditions, or 4) had been admitted in the hospital during the study. The weight and height or length data were extracted from the Electronic Medical Record system. All data were analyzed by the Stata Statistical Software focusing on age and sex-specific Z-scores, which references the WHO child growth standard and the Thai growth reference. Results: Sixty-two thousand one hundred four OPD visits were divided into 31,662 OPD visits for boys and 30,442 OPD visits for girls. Percent of weight for age and height or length for age more than +2 Z-score of both boys and girls when using the Thai growth reference was greater than that using the WHO child growth standard, especially for children aged 0 to 12 months. The Thai growth reference classified as overweight were approximately 10.26% to 31.12% more than using the WHO child growth standard. There was no difference in classification of height by both standards. Conclusion: There was a difference in classification of nutritional status between the Thai growth reference and the WHO child growth standard. Keywords: Nutritional status, Pediatric growth reference, Assessment tool, Overweight

Refrigeration and Child Growth: What Is the Connection?

2019 ◽  
Author(s):  
Sebastian Martinez ◽  
Juan Manuel Murguia ◽  
Brisa Rejas ◽  
Solis Winters
Keyword(s):  
Child Growth

See How They Grow: Testing the Feasibility of a Mobile App to Support Parents' Understanding of Child Growth Charts

2020 ◽  
Author(s):  
Gayl Humphrey ◽  
Rosie Dobson ◽  
Varsha Parag ◽  
Marion Hiemstra ◽  
Stephen Howie ◽  
...  
Keyword(s):  
Child Growth ◽  
Mobile App ◽  
Growth Charts

Malnutrition pathway for the impact of in utero drought shock on child growth indicators in rural households

2021 ◽  
pp. 1-20
Author(s):  
Olukorede Abiona
Keyword(s):  
Local Level ◽  
In Utero ◽  
Child Growth ◽  
Potential Interaction ◽  
Apparent Effect ◽  
Growth Indices ◽  
Short Term ◽  
Gestational Period ◽  
The Impact ◽  
Level Reduction

Abstract This paper evaluates the short-term health effects of in utero drought shock using repeated cross-section household data on Malawi. The main finding reveals that the effects of in utero harvest variability caused by rainfall shocks on child growth indices are driven by the deleterious effects of negative rainfall deviations, namely droughts. Negative rainfall deviation during the agricultural season prior to the gestational period of a child leads to a 21.8 per cent average local level reduction in age-standardized height scores, with the counterpart positive rainfall deviation having no apparent effect. The paper also uses harvest and consumption patterns to establish an important link between early-life malnutrition and growth serving as a precursor for the fetal period programming hypothesis in the literature. The direct impact of embryonic period shocks on growth provides supportive evidence on potential interaction between nutritional and environmental pathways.

scholarly journals Relationships of Resource Strategies, Family Composition, and Child Growth in Two Rural Timor-Leste Communities

2021 ◽  
Vol 10 (7) ◽  
pp. 273 ◽  
Author(s):  
Phoebe R. Spencer ◽  
Debra S. Judge
Keyword(s):  
Cultural Practices ◽  
Principal Component ◽  
Animal Husbandry ◽  
Child Growth ◽  
Household Composition ◽  
Large Animal ◽  
Family Composition ◽  
Economic Activities ◽  
Pension Income ◽  
Timor Leste

Subsistence and economic activities undertaken by households in the context of transition from subsistence farming to cash economies are sometimes seen as substitutable with only minimal reference to the households themselves. We use data from in-depth interviews of 190 householders in Ossu (mountains) and Natarbora (coastal plains), Timor-Leste, to query relationships of family composition, resource strategies, and their relationships to children’s growth. Principal component analyses of six household composition variables reveal “grandparent and fostered-in children”, “two generational households with numerous adults and children”, and “smaller households with few adults and fostered-out children”, explaining 72% of the variance. A similar procedure with 11 resource variables produced four components explaining 56% of resource variance. Households with grandparents have a pension income and engage in large animal husbandry, and are associated with better standardized BMI for resident children. Households with numerous members (but not grandparents) are more invested in subsistence gardening and are negatively associated with child stature. Salaried income is not associated with household composition, but children in these households are taller than their peers. Consistent differences between the two communities are partially a result of differences in socioecology, but there remain unexplained differences that may relate to cultural practices.

scholarly journals Maternal Tobacco and Alcohol Use in Relation to Child Malnutrition in Gauteng, South Africa: A Retrospective Analysis

Children ◽  
2021 ◽  
Vol 8 (2) ◽  
pp. 133
Author(s):  
Perpetua Modjadji ◽  
Mpinane Pitso
Keyword(s):  
South Africa ◽  
Alcohol Use ◽  
Tobacco Use ◽  
Child Growth ◽  
Growth Patterns ◽  
World Health ◽  
Poor Growth ◽  
Growth Standards ◽  
Validated Questionnaire ◽  
Current Tobacco

Tobacco and alcohol use among mothers is associated with numerous adverse consequences for affected offspring, including poor growth and development. This study determined the association between maternal tobacco and alcohol use, and malnutrition, among infants aged ≤ 12 months (n = 300), in selected health facilities situated in Gauteng, South Africa. Data on alcohol and tobacco use were collected using a validated questionnaire, in addition to mothers’ socio-demographic characteristics and obstetric history. Stunting (low height/length-for-age), underweight (low weight-for-age) and thinness (low body mass index-for-age) were calculated using z-scores based on the World Health Organization child growth standards. The association of tobacco and alcohol use with stunting, underweight and thinness was analysed using logistic regression analysis. The results showed a mean age of 29 years (24.0; 35.0) for mothers and 7.6 ± 3 months for infants, and over half of the mothers were unemployed (63%). Approximately 18.7% of mothers had used tobacco and 3% had used alcohol during pregnancy. The prevalence of current tobacco and alcohol use among mothers were estimated at 14.3% and 49.7%, respectively, and almost three-quarters (67.3%) of them were still breastfeeding during the study period. Stunting (55%) was the most prevalent malnutrition indicator among infants, while underweight was 41.7%, and thinness was 22%. Current tobacco use was associated with increased odds of being thin [OR = 2.40, 95% CI: 1.09–5.45), and after adjusting for confounders, current alcohol use was associated with the likelihood of being underweight [AOR = 1.96, 95% CI: 1.06–3.63] among infants. Future prospective cohort studies that examine growth patterns among infants who are exposed to maternal tobacco and alcohol use from the intrauterine life to infancy are necessary to inform, partly, the public health programmes, to reduce malnutrition among children.

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