scholarly journals Telomere dynamics in relation to experimentally increased locomotion costs and fitness in great tits

2021 ◽  
Author(s):  
Els Atema ◽  
Arie J. van Noordwijk ◽  
Simon Verhulst
Keyword(s):  
Telomere Dynamics

scholarly journals Time Lapse to Colorectal Cancer: Telomere Dynamics Define the Malignant Potential of Polyps

2017 ◽  
Vol 8 (4) ◽  
pp. e88 ◽  
Author(s):  
Brooke R Druliner ◽  
Xiaoyang Ruan ◽  
Ruth Johnson ◽  
Diane Grill ◽  
Daniel OʼBrien ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Time Lapse ◽  
Malignant Potential ◽  
Telomere Dynamics

scholarly journals Somatic growth and telomere dynamics in vertebrates: relationships, mechanisms and consequences

2018 ◽  
Vol 373 (1741) ◽  
pp. 20160446 ◽  
Author(s):  
Pat Monaghan ◽  
Susan E. Ozanne
Keyword(s):  
Cell Proliferation ◽  
Somatic Growth ◽  
Growth Strategy ◽  
Theme Issue ◽  
Confounding Variables ◽  
Telomere Loss ◽  
The Relationship ◽  
Telomere Dynamics

Much telomere loss takes place during the period of most rapid growth when cell proliferation and potentially energy expenditure are high. Fast growth is linked to reduced longevity. Therefore, the effects of somatic cell proliferation on telomere loss and cell senescence might play a significant role in driving the growth-lifespan trade-off. While different species will have evolved a growth strategy that maximizes lifetime fitness, environmental conditions encountered during periods of growth will influence individual optima. In this review, we first discuss the routes by which altered cellular conditions could influence telomere loss in vertebrates, with a focus on oxidative stress in both in vitro and in vivo studies. We discuss the relationship between body growth and telomere length, and evaluate the empirical evidence that this relationship is generally negative. We further discuss the potentially conflicting hypotheses that arise when other factors are taken into account, and the further work that needs to be undertaken to disentangle confounding variables. This article is part of the theme issue ‘Understanding diversity in telomere dynamics’.

scholarly journals Biogeography of telomere dynamics in a vertebrate

Ecography ◽  
2020 ◽  
Author(s):  
Daniele Canestrelli ◽  
Roberta Bisconti ◽  
Anita Liparoto ◽  
Frederic Angelier ◽  
Cécile Ribout ◽  
...  
Keyword(s):  
Telomere Dynamics

scholarly journals Bring It to an End: Does Telomeres Size Matter?

Cells ◽  
2019 ◽  
Vol 8 (1) ◽  
pp. 30 ◽  
Author(s):  
Camille Laberthonnière ◽  
Frédérique Magdinier ◽  
Jérôme D. Robin
Keyword(s):  
Position Effect ◽  
Critical Length ◽  
Model Organisms ◽  
Human Biology ◽  
Cell Divisions ◽  
Genome Wide ◽  
Mitotic Clock ◽  
Size Matter ◽  
Dna Ends ◽  
Telomere Dynamics

Telomeres are unique nucleoprotein structures. Found at the edge of each chromosome, their main purpose is to mask DNA ends from the DNA-repair machinery by formation of protective loops. Through life and cell divisions, telomeres shorten and bring cells closer to either cell proliferation crisis or senescence. Beyond this mitotic clock role attributed to the need for telomere to be maintained over a critical length, the very tip of our DNA has been shown to impact transcription by position effect. TPE and a long-reach counterpart, TPE-OLD, are mechanisms recently described in human biology. Still in infancy, the mechanism of action of these processes and their respective genome wide impact remain to be resolved. In this review, we will discuss recent findings on telomere dynamics, TPE, TPE-OLD, and lessons learnt from model organisms.

scholarly journals Telomere dynamics and hematopoietic differentiation of human DKC1-mutant induced pluripotent stem cells

2019 ◽  
Vol 40 ◽  
pp. 101540 ◽  
Author(s):  
Flavia S. Donaires ◽  
Raquel M. Alves-Paiva ◽  
Fernanda Gutierrez-Rodrigues ◽  
Fernanda Borges da Silva ◽  
Maria Florencia Tellechea ◽  
...  
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Hematopoietic Differentiation ◽  
Induced Pluripotent ◽  
Telomere Dynamics

scholarly journals Telomere dynamics from hatching to sexual maturity and maternal effects in the ‘multivariate egg’

2020 ◽  
Vol 223 (23) ◽  
pp. jeb232496 ◽  
Author(s):  
Francois Criscuolo ◽  
Roxanna Torres ◽  
Sandrine Zahn ◽  
Tony D. Williams
Keyword(s):  
Immune Response ◽  
Maternal Effects ◽  
Sexual Maturity ◽  
Negative Relationship ◽  
Individual Quality ◽  
Testosterone Treatment ◽  
Adult Females ◽  
Sexually Mature ◽  
Lps Treatment ◽  
Telomere Dynamics

ABSTRACTAvian eggs contain a large number of molecules deposited by the mother that provide the embryo with energy but also potentially influence its development via the effects of maternally derived hormones and antibodies: the avian egg is thus ‘multivariate’. Multivariate effects on offspring phenotype were evaluated in a study on captive zebra finches, by simultaneously manipulating maternally derived antibodies (MAb) by lipopolysaccharide (LPS) treatment of mothers and injection of testosterone into the egg yolk. LPS treatment had a positive effect on body mass growth at 30 days after hatching and immune response at sexual maturity, while egg testosterone treatment positively influenced immune response at fledging and courtship behaviour in sexually mature male offspring. Maternal effects are known to modulate offspring telomere length (TL). However, the multivariate effects of egg-derived maternal components on offspring telomere dynamics from hatching to sexual maturity are undefined. Here, we tested: (1) the effects of LPS and testosterone treatments on TL from hatching to sexual maturity (day 82); (2) how LPS treatment modulated TL over reproduction in adult females; and (3) the relationship between maternal and offspring TL. We predicted that TL would be shorter in LPS fledglings (as a cost of faster growth) and that TL would be longer in sexually mature adults after yolk testosterone treatment (as a proxy of individual quality). In adult females, there was an overall negative relationship between laying and rearing investments and TL, this relationship was weaker in LPS-treated females. In chicks, there was an overall negative effect of LPS treatment on TL measured at fledging and sexual maturity (day 25–82). In addition, at fledging, there was a Sex×LPS×Testosterone interaction, suggesting the existence of antagonistic effects of our treatments. Our data partially support the hypothesis that telomeres are proxies of individual quality and that individual differences in TL are established very early in life.

scholarly journals Interplays between pre- and post-natal environments affect early-life mortality, body mass and telomere dynamics in the wild

2020 ◽  
Vol 224 (1) ◽  
pp. jeb231290
Author(s):  
Tiia Kärkkäinen ◽  
Pauliina Teerikorpi ◽  
Wiebke Schuett ◽  
Antoine Stier ◽  
Toni Laaksonen
Keyword(s):  
Telomere Length ◽  
Early Life ◽  
Maternal Investment ◽  
Interactive Effects ◽  
Hatching Order ◽  
Hatching Synchrony ◽  
Asynchronous Hatching ◽  
In The Wild ◽  
Developmental Conditions ◽  
Telomere Dynamics

ABSTRACTEarly-life conditions are crucial determinants of phenotype and fitness. The effects of pre- and post-natal conditions on fitness prospects have been widely studied but their interactive effects have received less attention. In birds, asynchronous hatching creates challenging developmental conditions for the last-hatched chicks, but differential allocation in last-laid eggs might help to compensate this initial handicap. The relative importance and potential interaction between pre- and post-hatching developmental conditions for different fitness components remains mostly unknown. We manipulated hatching order in wild pied flycatchers (Ficedula hypoleuca), creating three groups: natural asynchrony (last-laid eggs hatching last), reversed asynchrony (last-laid eggs hatching first) and hatching synchrony (all eggs hatching at once). We examined the effects of these manipulations on early-life survival, growth and telomere length, a potential cellular biomarker of fitness prospects. Mortality was mostly affected by hatching order, with last-hatched chicks being more likely to die. Early-life telomere dynamics and growth were influenced by the interplays between laying and hatching order. Last-laid but first-hatched chicks were heavier but had shorter telomeres 5 days after hatching than their siblings, indicating rapid early growth with potential adverse consequences on telomere length. Synchronous chicks did not suffer any apparent cost of hatching synchronously. Impaired phenotypes only occurred when reversing the natural hatching order (i.e. developmental mismatch), suggesting that maternal investment in last-laid eggs might indeed counterbalance the initial handicap of last-hatched chicks. Our experimental study thus highlights that potential interplays between pre- and post-natal environments are likely to shape fitness prospects in the wild.

scholarly journals Accounting for phylogenetic relatedness in cross-species analyses of telomere shortening rates

2020 ◽  
Vol 1 ◽  
Author(s):  
Michael Le Pepke ◽  
Dan T.A. Eisenberg
Keyword(s):  
Multivariate Analysis ◽  
Body Mass ◽  
Dna Sequences ◽  
Phylogenetic Signal ◽  
Life History Strategies ◽  
Laboratory Mice ◽  
Telomere Shortening ◽  
Wild Mice ◽  
Phylogenetic Relatedness ◽  
Telomere Dynamics

AbstractTelomeres are repeating DNA sequences found on the ends of chromosomes, which shorten with age and are implicated in senescence. Cross-species analyses of telomere shortening rates (TSR) and telomere lengths are important for understanding mechanisms underlying senescence, lifespan and life-history strategies of different species. Whittemore et al. (2019) generated a new dataset on variation in TSR, lifespan and body mass. In phylogenetically uncorrected analyses they found that TSR negatively correlates with lifespan. We re-ran analyses of their dataset using appropriate phylogenetic corrections. We found a strong phylogenetic signal in the association between TSR and body mass. We were able to corroborate Whittemore et al.’s major findings, including while correcting for body mass in a multivariate analysis. Since laboratory mice have different telomere lengths and potentially different telomere dynamics than wild mice, we removed mice from the analysis, which attenuates most associations.

scholarly journals Environmental perturbations influence telomere dynamics in long-lived birds in their natural habitat

2013 ◽  
Vol 9 (5) ◽  
pp. 20130511 ◽  
Author(s):  
Yuichi Mizutani ◽  
Naoki Tomita ◽  
Yasuaki Niizuma ◽  
Ken Yoda
Keyword(s):  
Natural Habitat ◽  
Weather Conditions ◽  
Rate Of Change ◽  
Natural Setting ◽  
Stress Exposure ◽  
Free Living ◽  
Rates Of Change ◽  
Environmental Perturbations ◽  
Cellular Ageing ◽  
Telomere Dynamics

Telomeres are regarded as markers of biological or cellular ageing because they shorten with the degree of stress exposure. Accordingly, telomere lengths should show different rates of change when animals are faced with different intensities of environmental challenges. However, a relationship between telomere length and the environment has not yet been tested within a natural setting. Here, we report longitudinal telomere dynamics in free-living, black-tailed gulls ( Larus crassirostris ) through the recapture of birds of a known age over 2–5 consecutive years. The rate of change in telomere lengths differed with respect to year but not sex or age. The years when gulls showed stable telomere lengths or increases in telomere lengths (from 2009 to 2010) and decreases in telomere lengths (from 2010 to 2011) were characterized by El Niño and the Great Japan Earthquake, respectively. Both events are suspected to have had long-lasting effects on food availability and/or weather conditions. Thus, our findings that telomere dynamics in long-lived birds are influenced by dramatic changes in environmental conditions highlight the importance of environmental fluctuations in affecting stress and lifespan.

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