scholarly journals Acotiamide affects antral motility, but has no effect on fundic motility, gastric emptying or symptom perception in healthy participants

2019 ◽  
Vol 31 (4) ◽  
pp. e13540 ◽  
Author(s):  
Imke Masuy ◽  
Jan Tack ◽  
Kristin Verbeke ◽  
Florencia Carbone
Keyword(s):  
Gastric Emptying ◽  
Symptom Perception ◽  
Antral Motility ◽  
Healthy Participants

46 - Acotiamide Affects Antral Motility, but has no Effect on Fundic Motility, Gastric Emptying or Symptom Perception in Healthy Participants

2018 ◽  
Vol 154 (6) ◽  
pp. S-16
Author(s):  
Imke Masuy ◽  
Jan F. Tack ◽  
Florencia Carbone
Keyword(s):  
Gastric Emptying ◽  
Symptom Perception ◽  
Antral Motility ◽  
Healthy Participants

scholarly journals Gastric emptying and antral motility in reflux esophagitis

1978 ◽  
Vol 74 (2) ◽  
pp. 253-256 ◽  
Author(s):  
Jose Behar ◽  
Gale Ramsby
Keyword(s):  
Gastric Emptying ◽  
Reflux Esophagitis ◽  
Antral Motility

The control mechanisms of gastric emptying are not overridden by motor stimulants

1986 ◽  
Vol 251 (6) ◽  
pp. G744-G751 ◽  
Author(s):  
S. Wulschke ◽  
H. J. Ehrlein ◽  
C. Tsiamitas
Keyword(s):  
Gastric Emptying ◽  
Gastrointestinal Motility ◽  
Control Mechanisms ◽  
Wall Tension ◽  
Physiological Conditions ◽  
Duodenal Motility ◽  
Antral Motility

We wanted to determine if an acceleration of the normal emptying rate by motor stimulants interfers with control mechanisms limiting gastric emptying. Therefore, we studied the effects of 5-hydroxytryptophane (5-HTP) and cisapride on canine gastrointestinal motility and gastric emptying after ingestion of viscous acaloric and nutritive meals. Prolonged contractions and relaxations that change lumen size (isotonic component) and wall tension (isometric component) are defined as “basal contractions” and “basal relaxations”, respectively. The nutrient meal emptied much slower than the acaloric meal due to several alterations of gastric, pyloric, and duodenal motility. Both drugs stimulated antral motility but failed to accelerate gastric emptying of the nutrient meal. The main causes for the failure were a basal relaxation of the proximal antrum and a basal contraction of the duodenum. In conclusion, basal contractions of the proximal antrum and duodenum play an important role in the process of gastric emptying, and under physiological conditions the control mechanisms of gastric emptying provide an optimal emptying rate that cannot be markedly accelerated by 5-HTP and cisapride.

Delayed gastric emptying rates and impaired antral motility in children fulfilling Rome III criteria for functional abdominal pain

2012 ◽  
Vol 24 (5) ◽  
pp. 420-425 ◽  
Author(s):  
N. M. Devanarayana ◽  
S. Rajindrajith ◽  
N. Rathnamalala ◽  
S. Samaraweera ◽  
M. A. Benninga
Keyword(s):  
Abdominal Pain ◽  
Gastric Emptying ◽  
Delayed Gastric Emptying ◽  
Rome Iii Criteria ◽  
Functional Abdominal Pain ◽  
Antral Motility ◽  
Rome Iii

scholarly journals Electroacupuncture at ST36 Improve the Gastric Motility by Affecting Neurotransmitters in the Enteric Nervous System in Type 2 Diabetic Rats

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Xu Han ◽  
Xiaoyan Chen ◽  
Xuan Wang ◽  
Meirong Gong ◽  
Mengjiang Lu ◽  
...  
Keyword(s):  
Nervous System ◽  
Body Weight ◽  
Blood Glucose ◽  
Gastric Emptying ◽  
Food Intake ◽  
Enteric Nervous System ◽  
The Body ◽  
Antral Motility ◽  
Excitatory Neurotransmitters

Electroacupuncture (EA) can effectively relieve hyperglycemia and gastric emptying disorders in diabetic gastroparesis (DGP). However, the effect of EA on type 2 diabetes mellitus (T2DM) gastroparesis and its mechanism in the enteric nervous system (ENS) are rarely studied. We investigated the therapeutic effect of EA at ST36 and its effect on the main inhibitory and excitatory neurotransmitters in the ENS in DGP rats. Male Sprague-Dawley (SD) rats were fed a high-fat diet for 2 weeks and injected with streptozotocin (STZ) at 35 mg/kg to induce T2DM. T2DM rats were divided into the diabetic mellitus (DM) group and the EA group. The control (CON) group comprised normal rats without any intervention. EA treatment was started 6 weeks after the induction of DM and continued for 5 weeks. The body weight and food intake of the rats were recorded every week. Blood glucose, insulin, glucose tolerance, gastric emptying, and antral motility were measured after treatment. The expression of protein gene product 9.5 (PGP9.5), neuronal nitric oxide synthase (nNOS), and choline acetyltransferase (ChAT) in gastric antrum were quantified by western blotting and quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR). The T2DM gastroparesis model was successfully established. EA treatment reduced the body weight, food intake, and blood glucose; improved glucose intolerance and insulin resistance; increased the gastric emptying rate, the mean antral pressure, and the amplitude of antral motility; and decreased the frequency of antral motility compared with those in the DM group. EA treatment increased the expression level of nNOS, ChAT, and PGP9.5 proteins, and nNOS and ChAT mRNA. The results suggested that EA at ST36 could ameliorate DGP, partly restore the damage to general neurons, and increase nNOS and ChAT in the gastric antrum. EA improved DGP partly via reducing the loss of inhibitory and excitatory neurotransmitters in the ENS.

scholarly journals Relationship of gastric emptying or accommodation with satiation, satiety, and postprandial symptoms in health

2017 ◽  
Vol 313 (5) ◽  
pp. G442-G447 ◽  
Author(s):  
Houssam Halawi ◽  
Michael Camilleri ◽  
Andres Acosta ◽  
Maria Vazquez-Roque ◽  
Ibironke Oduyebo ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Symptom Score ◽  
Correlation Coefficients ◽  
Inverse Correlation ◽  
Calorie Intake ◽  
Gastric Accommodation ◽  
Total N ◽  
Ad Libitum ◽  
Relationship Of ◽  
Healthy Participants

The contributions of gastric emptying (GE) and gastric accommodation (GA) to satiation, satiety, and postprandial symptoms remain unclear. We aimed to evaluate the relationships between GA or GE with satiation, satiety, and postprandial symptoms in healthy overweight or obese volunteers (total n = 285, 73% women, mean BMI 33.5 kg/m2): 26 prospectively studied obese, otherwise healthy participants and 259 healthy subjects with previous similar GI testing. We assessed GE of solids, gastric volumes, calorie intake at buffet meal, and satiation by measuring volume to comfortable fullness (VTF) and maximum tolerated volume (MTV) by using Ensure nutrient drink test (30 ml/min) and symptoms 30 min after MTV. Relationships between GE or GA with satiety, satiation, and symptoms were analyzed using Spearman rank ( rs) and Pearson ( R) linear correlation coefficients. We found a higher VTF during satiation test correlated with a higher calorie intake at ad libitum buffet meal ( rs = 0.535, P < 0.001). There was a significant inverse correlation between gastric half-emptying time (GE T1/2) and VTF ( rs = −0.317, P < 0.001) and the calorie intake at buffet meal ( rs = −0.329, P < 0.001), and an inverse correlation between GE Tlag and GE25% emptied with VTF ( rs = −0.273, P < 0.001 and rs = −0.248, P < 0.001, respectively). GE T1/2 was significantly associated with satiation (MTV, R = −0.234, P < 0.0001), nausea ( R = 0.145, P = 0.023), pain ( R = 0.149, P = 0.012), and higher aggregate symptom score ( R = 0.132, P = 0.026). There was no significant correlation between GA and satiation, satiety, postprandial symptoms, or GE. We concluded that GE of solids, rather than GA, is associated with postprandial symptoms, satiation, and satiety in healthy participants. NEW & NOTEWORTHY A higher volume to comfortable fullness postprandially correlated with a higher calorie intake at ad libitum buffet meal. Gastric emptying of solids is correlated to satiation (volume to fullness and maximum tolerated volume) and satiety (the calorie intake at buffet meal) and symptoms of nausea, pain, and aggregate symptom score after a fully satiating meal. There was no significant correlation between gastric accommodation and either satiation or satiety indices, postprandial symptoms, or gastric emptying.

scholarly journals Echoplanar imaging in GI clinical practice: Assessment of gastric emptying and antral motility in four patients

2000 ◽  
Vol 12 (2) ◽  
pp. 343-346 ◽  
Author(s):  
Luca Marciani ◽  
Paul Young ◽  
Jeff Wright ◽  
Rachel J. Moore ◽  
David F. Evans ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Gastric Emptying ◽  
Antral Motility ◽  
Echoplanar Imaging ◽  
Practice Assessment

scholarly journals Performance characteristics of scintigraphic measurement of gastric emptying of solids in healthy participants

2012 ◽  
Vol 24 (12) ◽  
pp. 1076-e562 ◽  
Author(s):  
M. CAMILLERI ◽  
J. ITURRINO ◽  
A. E. BHARUCHA ◽  
D. BURTON ◽  
A. SHIN ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Performance Characteristics ◽  
Healthy Participants

T1384 Effects of CP-464709, a Ghrelin Receptor Agonist, On Gastric Antral Motility and Gastric Emptying in Dogs

2008 ◽  
Vol 134 (4) ◽  
pp. A-543-A-544 ◽  
Author(s):  
Tohru Komada ◽  
Yasuo Ochi ◽  
Jeremy D. Gale
Keyword(s):  
Gastric Emptying ◽  
Receptor Agonist ◽  
Ghrelin Receptor ◽  
Antral Motility ◽  
Ghrelin Receptor Agonist
Sign in / Sign up

Export Citation Format

Share Document