scholarly journals Discovering candidate genes that regulate resin canal number inPinus taedastems by integrating genetic analysis across environments, ages, and populations

2014 ◽  
Vol 205 (2) ◽  
pp. 627-641 ◽  
Author(s):  
Jared W. Westbrook ◽  
Alejandro R. Walker ◽  
Leandro G. Neves ◽  
Patricio Munoz ◽  
Marcio F. R. Resende ◽  
...  
Keyword(s):  
Genetic Analysis ◽  
Candidate Genes ◽  
Resin Canal

Genetic analysis of candidate genes for the polycystic ovary syndrome

2002 ◽  
Vol 9 (6) ◽  
pp. 492-501 ◽  
Author(s):  
Margrit Urbanek ◽  
Richard S. Spielman
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Genetic Analysis ◽  
Candidate Genes ◽  
Polycystic Ovary ◽  
Ovary Syndrome

scholarly journals Exploitation of a “hockey-puck” phenotype to identify pilus and biofilm regulators in Serratia marcescens through genetic analysis

2016 ◽  
Vol 62 (1) ◽  
pp. 83-93 ◽  
Author(s):  
Robert M.Q. Shanks ◽  
Nicholas A. Stella ◽  
Kimberly M. Brothers ◽  
Denise M. Polaski
Keyword(s):  
Genetic Analysis ◽  
Serratia Marcescens ◽  
Candidate Genes ◽  
Biofilm Formation ◽  
Type I ◽  
Relative Importance ◽  
Gene Encoding ◽  
Uncharacterized Gene ◽  
Mutation Screen

Pili are essential adhesive determinants for many bacterial pathogens. A suppressor mutation screen that takes advantage of a pilus-mediated self-aggregative “hockey-puck” colony phenotype was designed to identify novel regulators of type I pili in Serratia marcescens. Mutations that decreased pilus biosynthesis mapped to the fimABCD operon; to the genes alaT, fkpA, and oxyR; upstream of the flagellar master regulator operon flhDC; and to an uncharacterized gene encoding a predicted DUF1401 domain. Biofilm formation and pilus-dependent agglutination assays were used to characterize the relative importance of the identified genes in pilus biosynthesis. Additional mutagenic or complementation analysis was used to verify the role of candidate genes in pilus biosynthesis. Presented data support a model that CRP negatively regulates pilus biosynthesis through increased expression of flhDC and decreased expression of oxyR. Further studies are warranted to determine the mechanism by which these genes mediate pilus biosynthesis or function.

scholarly journals Genetic Analysis and Related Gene Primary Mapping of Heat Stress Tolerance in Cucumber Using Bulked Segregant Analysis

HortScience ◽  
2019 ◽  
Vol 54 (3) ◽  
pp. 423-428
Author(s):  
Min Wang ◽  
Wenrui Liu ◽  
Biao Jiang ◽  
Qingwu Peng ◽  
Xiaoming He ◽  
...  
Keyword(s):  
Heat Stress ◽  
Genetic Analysis ◽  
Candidate Genes ◽  
High Temperatures ◽  
Genomic Sequence ◽  
Bulked Segregant Analysis ◽  
Recessive Gene ◽  
Chromosome 1 ◽  
Isolation And Characterization ◽  
Indel Markers

Heat stress (HS) negatively influences plant development and growth, especially production and quality. Cucumber is a widely cultivated plant in the gourd family Cucurbitaceae that is often exposed to high temperatures during summer and protected cultivation. In this study, we performed whole-genome re-sequencing of two pools, one heat-tolerant and one heat-sensitive, of the F2 population derived from L-9 (heat-resistant) and A-16 (heat-sensitive). The genetic analysis showed that the heat resistance of L-9 cucumber seedlings was controlled by a single recessive gene. By combining bulked segregant analysis (BSA) technology, the crucial gene related to HS was preliminarily mapped to a 1.08-Mb region on chromosome 1. To fine-map the locus, Indel markers were designed according to the genomic sequence. Finally, the gene was narrowed to a 550-kb region flanked by two Indel markers, namely Indel-H90 and Indel-H224, that contained 56 candidate genes. Re-sequencing results indicated that 10 candidate genes among the 56 in the candidate region showed single base pair differences in the exons. Quantitative reverse-transcription polymerase chain reaction showed that 6 genes among the 10 candidate genes were significantly decreased when exposed to high temperatures. These results not only were useful for the isolation and characterization of the key genes involved in HS but also provided a basis for understanding the mechanism of heat tolerance regulation.

scholarly journals MULTIFACTORIAL PATHOGENESIS OF OSTEOPOROSIS AND THE ROLE OF GENES OF CANONICAL WNT-SIGNALING PATHWAY

2015 ◽  
Vol 18 (2) ◽  
pp. 15-19
Author(s):  
E A Mailyan
Keyword(s):  
Genetic Analysis ◽  
Wnt Signaling ◽  
Candidate Genes ◽  
Signaling Pathway ◽  
Wnt Signaling Pathway ◽  
Scientific Research ◽  
Canonical Wnt Signaling ◽  
Canonical Wnt ◽  
Skeleton Formation

Nowadays, multifactorial nature of osteoporosis does not raise any doubts. Besides, it should be noted that about 90% disease cases are determined genetically. In 1990-s a number of candidate genes mutations were established which increase the risk of osteoporosis development. VDR, ESR1, ESR2, COLIA1, PTH, CT, CTR, BGP, AR, GCCR, TGFB1, IL-6, IGF1, IL-1ra, OPG were considered to be this kind of genes. New genetic analysis technologies (GWAS, etc.) gave the opportunity to expand our conception about multi genomic pathogenesis of osteoporosis and to point out a new group of genes candidate - a canonical Wnt-signaling pathway genes (CTNNB1, SOST, FOXC2, FOXL1, LRP4, LRP5, WNT1, WNT3, WNT16, DKK1, AXIN1, JAG1, etc.). Extreme importance of canonical Wnt-signaling pathway and genes given above in skeleton formation and its strength necessitate the need for further scientific research and opens perspective to improve osteoporosis diagnostics, treatment and prognosis.

Genetic analysis of candidate genes modifying the age-at-onset in Huntington's Disease: results of a large European association study

2005 ◽  
Vol 32 (S 4) ◽  
Author(s):  
S Metzger ◽  
P Bauer ◽  
J Tomiuk ◽  
F Laccone ◽  
S DiDonato ◽  
...  
Keyword(s):  
Genetic Analysis ◽  
Huntington's Disease ◽  
Association Study ◽  
Huntington’S Disease ◽  
Candidate Genes ◽  
European Association ◽  
Age At Onset

scholarly journals A Comprehensive Genetic Analysis of Candidate Genes Regulating Response to Trypanosoma congolense Infection in Mice

2010 ◽  
Vol 4 (11) ◽  
pp. e880 ◽  
Author(s):  
Ian Goodhead ◽  
Alan Archibald ◽  
Peris Amwayi ◽  
Andy Brass ◽  
John Gibson ◽  
...  
Keyword(s):  
Genetic Analysis ◽  
Candidate Genes ◽  
Trypanosoma Congolense

BTK genetic analysis in XLA patients: More candidate genes are to be responsible for the disease

1998 ◽  
Vol 35 (11-12) ◽  
pp. 720
Author(s):  
P ORLANDI
Keyword(s):  
Genetic Analysis ◽  
Candidate Genes

Genetic analysis of candidate genes modifying the age-at-onset in Huntington’s disease

2006 ◽  
Vol 120 (2) ◽  
pp. 285-292 ◽  
Author(s):  
Silke Metzger ◽  
Peter Bauer ◽  
Jürgen Tomiuk ◽  
Franco Laccone ◽  
Stefano DiDonato ◽  
...  
Keyword(s):  
Genetic Analysis ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Candidate Genes ◽  
Age At Onset

scholarly journals A cross-species genetic analysis identifies candidate genes for mouse anxiety and human bipolar disorder

2015 ◽  
Vol 9 ◽  
Author(s):  
David G. Ashbrook ◽  
Robert W. Williams ◽  
Lu Lu ◽  
Reinmar Hager
Keyword(s):  
Bipolar Disorder ◽  
Genetic Analysis ◽  
Candidate Genes
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