scholarly journals The Potential Value of Monocyte to Lymphocyte Ratio, Platelet to Mean Platelet Volume Ratio in the Diagnosis of Periprosthetic Joint Infections

2021 ◽  
Author(s):  
Zulipikaer Maimaiti ◽  
Chi Xu ◽  
Jun Fu ◽  
Wei Chai ◽  
Yonggang Zhou ◽  
...  
Keyword(s):  
Mean Platelet Volume ◽  
Volume Ratio ◽  
Platelet Volume ◽  
Lymphocyte Ratio ◽  
Potential Value ◽  
Joint Infections

scholarly journals Serum Inflammatory Biomarkers in the Diagnosis of Periprosthetic Joint Infections

Biomedicines ◽  
2021 ◽  
Vol 9 (9) ◽  
pp. 1128
Author(s):  
Irene K. Sigmund ◽  
Stephan E. Puchner ◽  
Reinhard Windhager
Keyword(s):  
Platelet Count ◽  
Mean Platelet Volume ◽  
Preoperative Diagnosis ◽  
Clinical Symptoms ◽  
Volume Ratio ◽  
Diagnostic Value ◽  
Inflammatory Biomarkers ◽  
Platelet Volume ◽  
Joint Infections ◽  
D Dimer

Accurate preoperative diagnosis of periprosthetic joint infections (PJIs) can be very challenging, especially in patients with chronic PJI caused by low-virulence microorganisms. Serum parameters, such as serum C-reactive protein (CRP) or the erythrocyte sedimentation rate (ESR), are—among other diagnostic test methods—widely used to distinguish septic from aseptic failure after total hip or knee arthroplasty and are recommended by the AAOS in the preoperative setting. However, they are systemic parameters, and therefore, unspecific. Nevertheless, they may be the first and occasionally the only preoperative indication, especially when clinical symptoms are lacking. They are easy to obtain, cheap, and are available worldwide. In the last decade, different novel serum biomarkers (percentage of neutrophils, neutrophils to lymphocytes ratio, platelet count to mean platelet volume ratio, fibrinogen, D-Dimer, Il-6, PCT) were investigated to find a more specific and accurate serum parameter in the diagnosis of PJI. This article reviews the diagnostic value of established (serum CRP, ESR, WBC) and ‘novel’ serum inflammatory biomarkers (fibrinogen, D-dimer, interleukin-6 (IL-6), procalcitonin, percentage of neutrophils (%N), neutrophils to lymphocytes ratio (NLR), platelet count to mean platelet volume ratio (PC/mPV)) for the preoperative diagnosis of periprosthetic joint infections.

scholarly journals Can Platelet/Mean Platelet Volume ratio, Neutrophil/lymphocyte ratio, and Procalcitonin used for Predicting Prognosis in Acute Coronary Syndrome?

2020 ◽  
Vol 1 (1) ◽  
pp. 4-10
Author(s):  
Sedat Özbay ◽  
Abuzer Coskun ◽  
Sevki Hakan Eren
Keyword(s):  
Acute Coronary Syndrome ◽  
Mean Platelet Volume ◽  
Volume Ratio ◽  
Mortality Rates ◽  
Platelet Volume ◽  
Mortality And Morbidity ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Coronary Syndrome ◽  
Vessel Disease

Objective: This study aimed to evaluate acute coronary syndrome (ACS), serum procalcitonin levels, Platelet/Mean Platelet Volume ratio (PMR) and Neutrophil/lymphocyte ratio (NLR) concerning post-myocardial infarction (MI) complications, mortality, and morbidity. Material and Method: The study included a total of 913 patients with ACS who presented to the emergency department with chest pain between January 2013 and December 2017. The patients were categorized as ST-elevated MI (STEMI), non-ST elevated MI (NSTEMI) and unstable angina (UA) according to the diagnosis. The demographic and laboratory characteristics of the patients were compared for three-vessel disease (TVD) and mortality rates. Result: Post MI complications, TVD, and mortality were significant among acute coronary syndrome groups. The three-vessel disease was mostly observed in anterior MI with a maximum rate of 58 (39.7%). Mortality was found as 23 (16.3%) in anterior MI and 18 (12.2%) in NSTEMI. Serum procalcitonin levels were highest in anterior MI. Platelet to Mean Platelet Volume ratio was higher in UA, whereas it was lower in STEMI and NSTEMI. Neutrophil to lymphocyte ratio was the lowest in UA. The cTn I values of STEMIs at 0, 6, 12 hours were higher than UA, and the 12th-hour cTnI values in anterior MI were higher than NSTEMIs. It was found that procalcitonin and NLR had a positive correlation with post-MI complications, mortality, and TVD, whereas PMR exhibited a negative correlation. Conclusion: The levels of procalcitonin, PMR, and NLR may be significant in respect of post-complications, mortality, and morbidity in acute coronary syndrome.

Pengaruh Ekstrak Daun Moringa Oleifera terhadap Mean Platelet Volume dan Neutrophil-To-Lymphocyte Ratio pada Pasien Autoimun

2021 ◽  
Vol 6 (1) ◽  
pp. 355
Author(s):  
Nurhasan Agung Prabowo ◽  
Arief Nurudhin
Keyword(s):  
Rheumatoid Arthritis ◽  
Mean Platelet Volume ◽  
Moringa Oleifera ◽  
Neutrophil To Lymphocyte Ratio ◽  
P Value ◽  
Platelet Volume ◽  
Lymphocyte Ratio

Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak MO terhadap MVP dan NLR pada pasien autoimun. Metode penelitian yang digunakan adalah eksperimental yang dilakukan pada 30 pasien autoimun yang terdiri dari 28 pasien lupus dan 2 pasien rheumatoid arthritis di Poliklinik Reumatologi RSUD Moewardi pada Januari-Juli 2020. Pasien dikelompokkan menjadi dua, yaitu kelompok perlakuan dan kontrol. Pasien kelompok perlakuan mendapat 2gram ekstrak MO per hari, sedangkan pada kelompok kontrol mendapat plasebo. Perlakuan dilakukan selama 4 minggu, Pemeriksaan MPV dan NLR menggunakan haemositometer. Analisis statistik dilakukan dengan menggunakan uji-T berpasangan dan uji-T independen. Nilai p dianggap signifikan ketika p <0,05. Hasil penelitian menunjukkan bahwa MO menurunkan MPV (delta MPV = 4.141; r = 0.656; p = 0.02) dan NLR (delta NLR = 4.1391; r 0.489; p-value = 0.04). dapat disimpulkan MO menurunkan MPV dan NLR pada pasien autoimun.

scholarly journals Preoperative Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio, and Mean Platelet Volume as Predictors of 1-Year Mortality in Patients Undergoing an Open Repair of Abdominal Aortic Aneurysms: A Retrospective Study

2021 ◽  
Vol 10 (22) ◽  
pp. 5410
Author(s):  
Da Eun Ko ◽  
Hei Jin Yoon ◽  
Sang Beom Nam ◽  
Suk Won Song ◽  
Gisong Lee ◽  
...  
Keyword(s):  
Confidence Interval ◽  
Subgroup Analysis ◽  
Mean Platelet Volume ◽  
Odds Ratio ◽  
Neutrophil To Lymphocyte Ratio ◽  
Platelet Volume ◽  
Platelet To Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Survivor Group ◽  
Abdominal Aortic

Objectives: To investigate if preoperative neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), or mean platelet volume (MPV) could be used to predict 1-year mortality in patients undergoing open abdominal aortic aneurysm (AAA) repair. Methods: We retrospectively reviewed 382 patients who underwent open AAA repair between January 2008 and July 2019. We divided the patients into two groups based on 1-year mortality and compared the preoperative NLR, PLR, and MPV. The patients were then classified into tertiles based on their preoperative NLR (first tertile: < 2.41 (n = 111); second tertile: 2.41 ≤ NLR ≤6.07 (n = 111); and third tertile: > 6.07 (n = 112)). We compared the incidence of mortality and morbidity across the aforementioned tertiles. We performed a stepwise logistic regression analysis to evaluate the predictors for mortality. An additional subgroup analysis was performed by dividing the cases into non-ruptured and ruptured cases. Results: The preoperative NLR was significantly higher in the non-survivor group than in the survivor group (10.53 ± 7.60 vs. 5.76 ± 6.44, respectively, p = 0.003). The PLR and MPV were similar between the groups (145.35 ± 91.11 vs. 154.20 ± 113.19, p = 0.626, 9.38 ± 1.20 vs. 9.11 ± 1.39, p = 0.267, respectively). The incidence of 1-year mortality was 2.7%, 9.0%, and 14.3% in the first, second, and third NLR tertiles, respectively (p = 0.009). Higher NLR (odds ratio 1.085, 95% confidence interval 1.016–1.159, p = 0.015) and ruptured AAA (odds ratio 2.706, 95% confidence interval 1.097–6.673, p = 0.031) were the independent predictors of 1-year mortality in all patients. Moreover, the preoperative NLR was significantly higher in the ruptured AAA than in the non-ruptured AAA group (11.17 ± 7.90 vs. 4.10 ± 4.75, p < 0.001). In subgroup analysis, preoperative NLR (odds ratio 1.144, 95% confidence interval 1.031–1.271, p = 0.012) and PLR (odds ratio 0.986, 95% confidence interval 16 0.975–0.998, p = 0.017) was an independent predictor for 1-year mortality in ruptured cases. Conclusions: We demonstrated an independent relationship between the preoperative NLR and 1-year mortality in patients undergoing open AAA repair, besides PLR and MPV. Furthermore, the NLR and PLR had predictive power for 1-year mortality in ruptured cases.

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