Neonatal bacteremia caused by emm type 80 group A Streptococcus : A case report

2020 ◽  
Vol 62 (11) ◽  
pp. 1305-1306
Author(s):  
Yu Shinoda ◽  
Tomohiro Hori ◽  
Hideo Sasai ◽  
Tadayoshi Ikebe ◽  
Hidenori Ohnishi
Keyword(s):  
Case Report ◽  
Group A Streptococcus ◽  
Group A ◽  
Streptococcus A ◽  
Emm Type

scholarly journals Effectiveness of Laparoscopic Surgery for Treating Primary Peritonitis Caused by Group A Streptococcus: A Case Report

2021 ◽  
Vol 70 (4) ◽  
pp. 407-413
Author(s):  
Ryosuke OSADA ◽  
Takashi IMAI ◽  
Sayaka YASAKI ◽  
Kota TAKANO ◽  
Masami NOIKE ◽  
...  
Keyword(s):  
Case Report ◽  
Laparoscopic Surgery ◽  
Group A Streptococcus ◽  
Primary Peritonitis ◽  
Group A ◽  
Streptococcus A

scholarly journals Early Detection of Necrotizing Fasciitis Secondary to Group A Streptococcus: A Case Report

2018 ◽  
Vol 1 (1) ◽  
Author(s):  
Joshua K. Phillips ◽  
Melanie Nukala ◽  
Vandana Grover ◽  
Peter Devito
Keyword(s):  
Case Report ◽  
Early Detection ◽  
Necrotizing Fasciitis ◽  
Group A Streptococcus ◽  
Group A ◽  
Streptococcus A

scholarly journals The most common causative bacteria in maternal sepsis-related deaths in Japan were group A Streptococcus: A nationwide survey

2019 ◽  
Vol 25 (1) ◽  
pp. 41-44 ◽  
Author(s):  
Hiroaki Tanaka ◽  
Shinji Katsuragi ◽  
Junichi Hasegawa ◽  
Kayo Tanaka ◽  
Kazuhiro Osato ◽  
...  
Keyword(s):  
Group A Streptococcus ◽  
Nationwide Survey ◽  
Group A ◽  
Maternal Sepsis ◽  
Streptococcus A

scholarly journals Unexpected relationships between frequency of antimicrobial resistance, disease phenotype and emm type in group A Streptococcus

2019 ◽  
Vol 5 (11) ◽  
Author(s):  
Misu A. Sanson ◽  
Olga R. Macias ◽  
Brittany J. Shah ◽  
Blake Hanson ◽  
Luis Alberto Vega ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Group A Streptococcus ◽  
Disease Phenotype ◽  
Group A ◽  
Emm Type

scholarly journals Biofilm formation by group A Streptococcus: a role for the streptococcal regulator of virulence (Srv) and streptococcal cysteine protease (SpeB)

Microbiology ◽  
2009 ◽  
Vol 155 (1) ◽  
pp. 46-52 ◽  
Author(s):  
Christopher D. Doern ◽  
Amity L. Roberts ◽  
Wenzhou Hong ◽  
Jessica Nelson ◽  
Slawomir Lukomski ◽  
...  
Keyword(s):  
Cysteine Protease ◽  
Biofilm Formation ◽  
Group A Streptococcus ◽  
Immunoblot Analysis ◽  
Wild Type ◽  
Flow Conditions ◽  
Group A ◽  
Streptococcus A ◽  
Insight Into ◽  
Western Immunoblot Analysis

Recently, biofilms have become a topic of interest in the study of the human pathogen group A Streptococcus (GAS). In this study, we sought to learn more about the make-up of these structures and gain insight into biofilm regulation. Enzymic studies indicated that biofilm formation by GAS strain MGAS5005 required an extracellular protein and DNA component(s). Previous results indicated that inactivation of the transcriptional regulator Srv in MGAS5005 resulted in a significant decrease in virulence. Here, inactivation of Srv also resulted in a significant decrease in biofilm formation under both static and flow conditions. Given that production of the extracellular cysteine protease SpeB is increased in the srv mutant, we tested the hypothesis that increased levels of active SpeB may be responsible for the reduction in biofilm formation. Western immunoblot analysis indicated that SpeB was absent from MGAS5005 biofilms. Complementation of MGAS5005Δsrv restored the biofilm phenotype and eliminated the overproduction of active SpeB. Inhibition of SpeB with E64 also restored the MGAS5005Δsrv biofilm to wild-type levels.

scholarly journals Distribution of emm type and antibiotic susceptibility of group A streptococci causing invasive and noninvasive disease

2008 ◽  
Vol 57 (11) ◽  
pp. 1383-1388 ◽  
Author(s):  
Takeaki Wajima ◽  
Somay Y. Murayama ◽  
Katsuhiko Sunaoshi ◽  
Eiichi Nakayama ◽  
Keisuke Sunakawa ◽  
...  
Keyword(s):  
Streptococcus Pyogenes ◽  
Macrolide Antibiotic ◽  
Group A Streptococcus ◽  
Acute Otitis Media ◽  
Toxic Shock ◽  
Medical Institutions ◽  
Invasive Infections ◽  
Group A ◽  
Resistant Strains ◽  
Emm Type

To determine the prevalence of macrolide antibiotic and levofloxacin resistance in infections with Streptococcus pyogenes (group A streptococcus or GAS), strains were collected from 45 medical institutions in various parts of Japan between October 2003 and September 2006. Four hundred and eighty-two strains from patients with GAS infections were characterized genetically. Strains were classified into four groups according to the type of infection: invasive infections (n=74) including sepsis, cellulitis and toxic-shock-like syndrome; acute otitis media (AOM; n=23); abscess (n=53); and pharyngotonsillitis (n=332). Among all strains, 32 emm types were identified; emm1 was significantly more common in invasive infections (39.2 %) and AOM (43.5 %) than in abscesses (3.8 %) or pharyngotonsillitis (10.2 %). emm12 and emm4 each accounted for 23.5 % of pharyngotonsillitis cases. Susceptibility of GAS strains to eight β-lactam agents was excellent, with MICs of 0.0005–0.063 μg ml−1. Macrolide-resistant strains accounted for 16.2 % of all strains, while the percentages of strains possessing the resistance genes erm(A), erm(B) and mef(A) were 2.5 %, 6.2 % and 7.5 %, respectively. Although no strains with high resistance to levofloxacin were found, strains with an MIC of 2–4 μg ml−1 (17.4 %) had amino acid substitutions at either Ser-79 or Asp-83 in ParC. These levofloxacin-intermediately resistant strains included 16 emm types, but macrolide-resistant strains were more likely than others to represent certain emm types.

scholarly journals 1891. Invasive Group A Streptococcus Infections Among Residents of Multiple Nursing Homes—Denver, Colorado, 2017–2018

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S55-S56
Author(s):  
Osatohamwen Idubor ◽  
Nisha B Alden ◽  
Srinivas Nanduri ◽  
Abimbola Ogundimu ◽  
Sukarma S S Tanwar ◽  
...  
Keyword(s):  
Nursing Homes ◽  
Infection Control ◽  
Group A Streptococcus ◽  
Multiple Infection ◽  
Invasive Group ◽  
Increased Risk ◽  
Group A ◽  
Sterile Site ◽  
Colorado Department ◽  
Emm Type

Abstract Background Older adults residing in nursing homes (NH) are at increased risk for invasive group A Streptococcus (GAS) infections due to advanced age, presence of wounds, and comorbidities; approximately one-third of infected patients die. Beginning in 2015, increasing numbers of GAS infections in NH residents and several NH clusters were reported from the Denver metropolitan area. Colorado Department of Public Health and Environment (CDPHE) and CDC investigated to characterize cases and assess if outbreaks resulted from interfacility transmission. Methods We reviewed data from Active Bacterial Core surveillance (ABCs) in the 5-county Denver area from January 2017 to June 2018. We defined a case as isolation of GAS from a normally sterile site in an NH resident. GAS isolates underwent whole-genome sequencing (WGS) at CDC’s Streptococcus Laboratory to determine emm types for genotyping. Among isolates with the same emm type, pairwise single-nucleotide polymorphism (SNP) distances were calculated using Nucmer software. In October 2018, a CDPHE-CDC team assessed infection control at NHs with cases of the most common emm type. Results Over 18 months, among >100 NHs in the Denver area, ≥1 GAS case was identified in 29 NHs, with 6 having ≥3 cases. During this period, 68 cases in NH residents were identified. WGS identified 17 emm types among isolates from these cases; most common was emm11.10 (34%, n = 22), a rare subtype in ABCs. All emm11.10 isolates had nearly identical genomes (average pairwise SNP distance: 3.2), and were isolated from 10 NHs, with 2 NHs having ≥ 4 cases. Multiple infection control lapses were noted during site visits to 8 NHs. Conclusion Multiple outbreaks due to GAS were noted in 5-county Denver area NHs in 2017–2018. WGS of surveillance isolates identified a rarely seen emm subtype 11.10 from multiple facilities with temporal and genomic clustering suggesting interfacility GAS transmission. Disclosures All Authors: No reported Disclosures.

scholarly journals A report on the first outbreak of a single clone group A Streptococcus (emm-type 89) tonsillopharyngitis in China

2014 ◽  
Vol 47 (6) ◽  
pp. 542-545 ◽  
Author(s):  
Ying-Mei Liu ◽  
Jian-Zhong Zhao ◽  
Bin-Bin Li ◽  
Jun-Yong Yang ◽  
Xiao-Gen Dong ◽  
...  
Keyword(s):  
Group A Streptococcus ◽  
Single Clone ◽  
Group A ◽  
Clone Group ◽  
Emm Type

scholarly journals Factors associated with Group A Streptococcus emm type diversification in a large urban setting in Brazil: a cross-sectional study

2010 ◽  
Vol 10 (1) ◽  
Author(s):  
Sara Y Tartof ◽  
Joice N Reis ◽  
Aurelio N Andrade ◽  
Regina T Ramos ◽  
Mitermayer G Reis ◽  
...  
Keyword(s):  
Group A Streptococcus ◽  
Cross Sectional Study ◽  
Urban Setting ◽  
Sectional Study ◽  
Cross Sectional ◽  
Factors Associated ◽  
Group A ◽  
Emm Type
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