scholarly journals Improvement in glycemic control through changes in insulin regimens: findings from a Japanese cohort of children and adolescents with type 1 diabetes

2016 ◽  
Vol 18 (6) ◽  
pp. 435-442 ◽  
Author(s):  
Mie Mochizuki ◽  
Toru Kikuchi ◽  
Tatsuhiko Urakami ◽  
Nobuyuki Kikuchi ◽  
Tomoyuki Kawamura ◽  
...  
Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2625
Author(s):  
Chiara Garonzi ◽  
Gun Forsander ◽  
Claudio Maffeis

Nutrition therapy is a cornerstone of type 1 diabetes (T1D) management. Glycemic control is affected by diet composition, which can contribute to the development of diabetes complications. However, the specific role of macronutrients is still debated, particularly fat intake. This review aims at assessing the relationship between fat intake and glycemic control, cardiovascular risk factors, inflammation, and microbiota, in children and adolescents with T1D. High fat meals are followed by delayed and prolonged hyperglycemia and higher glycated hemoglobin A1c levels have been frequently reported in individuals with T1D consuming high amounts of fat. High fat intake has also been associated with increased cardiovascular risk, which is higher in people with diabetes than in healthy subjects. Finally, high fat meals lead to postprandial pro-inflammatory responses through different mechanisms, including gut microbiota modifications. Different fatty acids were proposed to have a specific role in metabolic regulation, however, further investigation is still necessary. In conclusion, available evidence suggests that a high fat intake should be avoided by children and adolescents with T1D, who should be encouraged to adhere to a healthy and balanced diet, as suggested by ISPAD and ADA recommendations. This nutritional choice might be beneficial for reducing cardiovascular risk and inflammation.


2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Mesmin Y. Dehayem ◽  
Rémy Takogue ◽  
Siméon-Pierre Choukem ◽  
Olivier T. S. Donfack ◽  
Jean-Claude Katte ◽  
...  

2018 ◽  
Vol 22 (1) ◽  
pp. 89 ◽  
Author(s):  
Bedowra Zabeen ◽  
AnaMargarida Balsa ◽  
Nasreen Islam ◽  
Mukta Parveen ◽  
Jebun Nahar ◽  
...  

2021 ◽  
Vol 69 (1) ◽  
Author(s):  
Hend Soliman ◽  
Amany Ibrahim

Abstract Background Hyperglycemia and dyslipidemia are commonly found metabolic abnormalities in diabetic children and adolescents and both increase the risk of cardiovascular disease. This study aimed to assess the prevalence and the pattern of dyslipidemia in Egyptian children and adolescents with type 1 diabetes (T1DM) and determine its relation with the glycemic control. Results This retrospective study included 806 children and adolescents with T1DM; 358 (44.42%) males and 448 (55.58%) females. Their mean age was 11.71 ± 3.6 years. Clinical and laboratory data were recruited from patients’ files. Laboratory data include the most recent fasting lipid profile (triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL) and low-density lipoprotein (LDL)), and the mean glycosylated hemoglobin (HbA1c) levels over the preceding year presented in percentage were calculated. Dyslipidemia in children and adolescents with T1DM represented 70.47% (568 patients). No statistically significant differences were detected between patients with and without dyslipidemia. As regards the pattern of dyslipidemia, high LDL and low HDL were the most frequent abnormalities in the study group; 62.16%, 60.21%, respectively. Patients with poor glycemic control (HbA1c > 7.5%) represent 73.45% and they were significantly older, with longer diabetes duration and higher TC, TG, and LDL compared to patients with good glycemic control. Significant positive correlations were found between HbA1c, TG, TC, and LDL with the age and diabetes duration. Conclusion We detected high prevalence of dyslipidemia in children and adolescents with T1DM. Therefore, dyslipidemia should be screened for in earlier ages in Egyptian children and adolescents suffering from T1DM. Programs directed to the prevention of dyslipidemia should be conducted, particularly for this group, in order to prevent/delay cardiovascular complications related to dyslipidemia. Also, parents should receive proper education targeting the prevention, control, and care of their diabetic children with dyslipidemia.


2019 ◽  
Vol 154 ◽  
pp. 138-145
Author(s):  
Roberta Ferreira Fortins ◽  
Elisa Maria de Aquino Lacerda ◽  
Raquel Nascimento Chanca Silverio ◽  
Cleber Nascimento do Carmo ◽  
Aline Alves Ferreira ◽  
...  

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