Laryngeal hypersensitivity and abnormal cough response during mannitol bronchoprovocation challenge

Respirology ◽  
2021 ◽  
Author(s):  
Joy Wei‐Yan Lee ◽  
Tunn Ren Tay ◽  
Brigitte M. Borg ◽  
Neha Sheriff ◽  
Anne Vertigan ◽  
...  
Keyword(s):  
Cough Response

scholarly journals Simple methods of examination in paraplegia: II. The cough response of the external anal sphincter

Spinal Cord ◽  
1966 ◽  
Vol 3 (4) ◽  
pp. 252-257 ◽  
Author(s):  
Ernest Bors
Keyword(s):  
Anal Sphincter ◽  
External Anal Sphincter ◽  
Cough Response

Comparison of the tussive effects of histamine and methacholine in humans

1983 ◽  
Vol 55 (2) ◽  
pp. 541-546 ◽  
Author(s):  
A. M. Chausow ◽  
A. S. Banner
Keyword(s):  
Chronic Cough ◽  
Volume Ratio ◽  
Forced Expiratory Volume ◽  
Additional Mechanism ◽  
Cough Response ◽  
Inhalation Challenge ◽  
The Relationship ◽  
Linear Correlations

The tussive and bronchoconstrictive effects of histamine inhalation in 7 normals, 7 asthmatics, and 24 patients with chronic cough (PCC) were measured by counting coughs during a standard histamine inhalation challenge. All PCC had a tussive response. Fifteen PCC exhibited significant linear correlations between cough count and either the change in forced expiratory volume at 1.0 (delta FEV1) or conductance-volume ratio (sGaw) (delta sGaw). Normals and asthmatics had little or no cough. Metaproterenol pretreatment in seven PCC reduced both the FEV1 and cough response to histamine without changing the relationship between cough and delta FEV1. The tussive and bronchoconstrictive effects of methacholine inhalation were also measured in 7 asthmatics and 16 PCC. One asthmatic coughed. Fifteen PCC coughed. There were significant linear correlations between cough count and delta FEV1 or delta sGaw in 10 PCC. At comparable delta FEV1 and delta sGaw, histamine produced more cough than methacholine. These data indicate that during inhalation of histamine or methacholine by PCC cough is related to, and may be caused by, bronchoconstriction. Histamine also causes cough by an additional mechanism not related to bronchoconstriction.

Adaptation of the Cough Response to Inhaled Citric Acid within One Hour

1983 ◽  
Vol 65 (3) ◽  
pp. 53P-53P
Author(s):  
J. Pounsford ◽  
K.B. Saunders
Keyword(s):  
Citric Acid ◽  
Cough Response

Effect of changes in inspiratory flow rate on cough responses to inhaled capsaicin

1991 ◽  
Vol 81 (s25) ◽  
pp. 539-542 ◽  
Author(s):  
M. J. Barros ◽  
S. L. Zammattio ◽  
P. J. Rees
Keyword(s):  
Citric Acid ◽  
Confidence Interval ◽  
Flow Rate ◽  
Negative Relationship ◽  
Random Order ◽  
Inspiratory Flow ◽  
Inspiratory Flow Rate ◽  
Flow Rates ◽  
Cough Response ◽  
The Difference

1. Twelve non-smoking subjects inhaled capsaicin at three different inspiratory flow rates: 50, 100 and 150 litres/min. Capsaicin was delivered by a breath-actuated dosimeter; inhalations consisted of 0.21–13.6 nmol of capsaicin in doubling amounts given in random order. 2. The mean number of coughs per challenge decreased with increasing inspiratory flow rate. The difference in cough numbers were significant: 7.7 (95% confidence interval 2.5–12.8) for 50 versus 100 litres/min and 10.9 (95% confidence interval 5.0–16.9) for 100 versus 150 litres/min. 3. On a separate day, a cough threshold was measured by giving increasing doses of citric acid that were inhaled at 50 litres/min. There was a positive correlation between the sensitivity to capsaicin and the cough threshold to citric acid (r = 0.69, P = 0.01), and also between the cough latencies (r = 0.67, P = 0.02). 4. The negative relationship between the cough response and the inspiratory flow rate may be caused by increased laryngeal deposition at lower inspiratory flow rates. 5. These results are compatible with a similar anatomical distribution of cough receptors for capsaicin and citric acid. 6. These results suggest that changes in inspiratory flow rate may affect the results of cough challenges.

scholarly journals Impact of Tussigenic Stimuli on Perceived Upper Airway Sensation and Motor Cough Response Following Total Laryngectomy

2020 ◽  
Vol 11 ◽  
Author(s):  
Amy Fullerton ◽  
Yuhan Mou ◽  
Natalie Silver ◽  
Neil Chheda ◽  
Donald C. Bolser ◽  
...  
Keyword(s):  
Total Laryngectomy ◽  
Upper Airway ◽  
Cough Response

Effect of inhaled and systemic opiates on responses to inhaled capsaicin in humans

1988 ◽  
Vol 65 (3) ◽  
pp. 1125-1130 ◽  
Author(s):  
R. W. Fuller ◽  
J. A. Karlsson ◽  
N. B. Choudry ◽  
N. B. Pride
Keyword(s):  
Confidence Interval ◽  
Drug Effect ◽  
Random Order ◽  
Base Line ◽  
Respiratory Resistance ◽  
Cough Reflex ◽  
Cough Response ◽  
Site Of Action ◽  
Intravenous Morphine

To determine the site of action of opiates in humans, we have studied the effect of systemic and inhaled opiates on cough and increase in respiratory resistance (Rrs) caused by inhaled capsaicin. In 13 subjects, a range of doses of capsaicin inhaled in single breaths given in random order produced a reproducible dose-cough response. Inhalation of a dose of capsaicin that caused fewer than two coughs increased Rrs by 28% (21-35, mean 95% confidence interval). Inhaled codeine (50 mg) and morphine (10 mg) did not alter the cough response. In contrast, both drugs increased base-line Rrs by 24% (16-44) and 13% (3-23), respectively, and significantly reduced the increase in Rrs after inhaled capsaicin (P less than 0.05). Oral codeine (60 mg) significantly (P less than 0.05) reduced the number of coughs at 1 and 2 h but did not alter base-line Rrs or its increase after capsaicin. Intravenous morphine (0.15 mg/kg) significantly reduced the sensitivity of the cough response (P less than 0.05), which was reversed by naloxone. However, there was no significant drug effect on either the base-line Rrs or its increase after capsaicin. Systemic dosing of opiates is therefore required to reduce the cough reflex, whereas inhaled opiates may reduce the increase in Rrs after inhaled capsaicin.

scholarly journals Effect of influenza A virus infection on acid-induced cough response in children with asthma

1997 ◽  
Vol 10 (1) ◽  
pp. 71-74 ◽  
Author(s):  
T. Shimizu ◽  
H. Mochizuki ◽  
A. Morikawa
Keyword(s):  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
Cough Response ◽  
Children With Asthma ◽  
Influenza A Virus Infection

scholarly journals Cough response to citric acid aerosol in occasional smokers.

BMJ ◽  
1986 ◽  
Vol 293 (6561) ◽  
pp. 1528-1528 ◽  
Author(s):  
J C Pounsford ◽  
K B Saunders
Keyword(s):  
Citric Acid ◽  
Cough Response

Role of Vagal Airway Reflexes in Control of Ventilation in Pulmonary Fibrosis

1981 ◽  
Vol 61 (6) ◽  
pp. 781-784 ◽  
Author(s):  
J. Savoy ◽  
S. Dhingra ◽  
N. R. Anthonisen
Keyword(s):  
Pulmonary Fibrosis ◽  
Breathing Pattern ◽  
Minute Ventilation ◽  
Arterial Oxygen ◽  
Control Subjects ◽  
Cough Response ◽  
Before And After ◽  
The Mean ◽  
Breath Cycle

1. in 10 patients with pulmonary fibrosis and in seven control subjects, we measured the pressure at the mouth 0.1 s after onset of an inspiration against occluded airway (P0.1), minute ventilation (VI), breathing frequency (fr), tidal volume (VT), inspiratory duration (Tl) and calculated the mean inspiratory flow (VT/Tl) and the fraction of the breath cycle devoted to inspiration (Tl/Ttot.). in the patients measurements were made at normal arterial oxygen saturations (Sao2), before and after lignocaine airway anaesthesia. 2. Efficacy of airway anaesthesia was tested by the cough response to citric acid inhalation. 3. in pulmonary fibrosis P0.1, f1 and VT/Tl were greater than in the control subjects, VT and Tl, were smaller and Tl/Ttot. and VI were not different. 4. Effective airway anaesthesia did not modify P0.1 and breathing pattern parameters observed in pulmonary fibrosis. 5. These results suggest that airway receptors do not contribute to a major extent to the control of breathing in pulmonary fibrosis.

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