Cyclic Nucleotide Gated Ion Channel 6 is involved in extracellular ATP signaling and plant immunity

2021 ◽  
Author(s):  
Ha N. Duong ◽  
Sung‐Hwan Cho ◽  
Limin Wang ◽  
An Q. Pham ◽  
Julia M. Davies ◽  
...  
Keyword(s):  
Ion Channel ◽  
Cyclic Nucleotide ◽  
Plant Immunity ◽  
Extracellular Atp ◽  
Atp Signaling

Extracellular ATP Increases NH+4 Permeability in Human Lymphocytes by Opening a P2Z Purinoceptor Operated Ion Channel

1994 ◽  
Vol 202 (3) ◽  
pp. 1511-1516 ◽  
Author(s):  
J.R. Chen ◽  
G.P. Jamieson ◽  
J.S. Wiley
Keyword(s):  
Ion Channel ◽  
Human Lymphocytes ◽  
Extracellular Atp

Extracellular ATP signaling in equine digital blood vessels

2013 ◽  
Vol 702 (1-3) ◽  
pp. 242-249 ◽  
Author(s):  
Hector Zerpa ◽  
Carol Crawford ◽  
Gillian E. Knight ◽  
Alice F. Fordham ◽  
Silvia E. Janska ◽  
...  
Keyword(s):  
Blood Vessels ◽  
Extracellular Atp ◽  
Atp Signaling

scholarly journals Genome-Wide Identification of Cyclic Nucleotide-Gated Ion Channel Gene Family in Wheat and Functional Analyses of TaCNGC14 and TaCNGC16

2018 ◽  
Vol 9 ◽  
Author(s):  
Jia Guo ◽  
Md Ashraful Islam ◽  
Haocheng Lin ◽  
Changan Ji ◽  
Yinghui Duan ◽  
...  
Keyword(s):  
Ion Channel ◽  
Gene Family ◽  
Cyclic Nucleotide ◽  
Channel Gene ◽  
Genome Wide ◽  
Functional Analyses ◽  
Ion Channel Gene

Binding orientation and specificity of calmodulin to rat olfactory cyclic nucleotide-gated ion channel

2013 ◽  
Vol 31 (4) ◽  
pp. 414-425 ◽  
Author(s):  
Deli Irene ◽  
Jian-Wen Huang ◽  
Tse-Yu Chung ◽  
Feng-Yin Li ◽  
Jason T.-C. Tzen ◽  
...  
Keyword(s):  
Ion Channel ◽  
Cyclic Nucleotide ◽  
Binding Orientation

Phosphodiesterase 3 and 5 and cyclic nucleotide-gated ion channel expression in rat trigeminovascular system

2006 ◽  
Vol 404 (1-2) ◽  
pp. 202-207 ◽  
Author(s):  
Lars S. Kruse ◽  
Nicolai T.H. Sandholdt ◽  
Steen Gammeltoft ◽  
Jes Olesen ◽  
Christina Kruuse
Keyword(s):  
Ion Channel ◽  
Cyclic Nucleotide ◽  
Trigeminovascular System ◽  
Phosphodiesterase 3 ◽  
Channel Expression

scholarly journals The Arabidopsis dnd1 "defense, no death" gene encodes a mutated cyclic nucleotide-gated ion channel

2000 ◽  
Vol 97 (16) ◽  
pp. 9323-9328 ◽  
Author(s):  
S. J. Clough ◽  
K. A. Fengler ◽  
I-c. Yu ◽  
B. Lippok ◽  
R. K. Smith ◽  
...  
Keyword(s):  
Ion Channel ◽  
Cyclic Nucleotide

scholarly journals Extracellular ATP signaling and homeostasis in plant cells

2012 ◽  
Vol 7 (5) ◽  
pp. 566-569 ◽  
Author(s):  
Jian Sun ◽  
Chunlan Zhang ◽  
Xuan Zhang ◽  
Shurong Deng ◽  
Rui Zhao ◽  
...  
Keyword(s):  
Plant Cells ◽  
Extracellular Atp ◽  
Atp Signaling

Expression of subunits for the cAMP-sensitive ‘olfactory’ cyclic nucleotide-gated ion channel in the cochlea: implications for signal transduction

2002 ◽  
Vol 98 (1-2) ◽  
pp. 1-14 ◽  
Author(s):  
Marian J Drescher ◽  
Roberto L Barretto ◽  
Deepti Chaturvedi ◽  
Kirk W Beisel ◽  
James S Hatfield ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Ion Channel ◽  
Cyclic Nucleotide

scholarly journals Chronic fructose renders pancreatic β-cells hyper-responsive to glucose-stimulated insulin secretion through extracellular ATP signaling

2019 ◽  
Vol 317 (1) ◽  
pp. E25-E41 ◽  
Author(s):  
Clarissa Bartley ◽  
Thierry Brun ◽  
Lucie Oberhauser ◽  
Mariagrazia Grimaldi ◽  
Filippo Molica ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Atp Release ◽  
Extracellular Atp ◽  
Β Cells ◽  
Pancreatic Β Cells ◽  
Cellular Mechanisms ◽  
Kinase Activation ◽  
Glucose Stimulated Insulin Secretion ◽  
Insulinoma Cells ◽  
Atp Signaling

Fructose is widely used as a sweetener in processed food and is also associated with metabolic disorders, such as obesity. However, the underlying cellular mechanisms remain unclear, in particular, regarding the pancreatic β-cell. Here, we investigated the effects of chronic exposure to fructose on the function of insulinoma cells and isolated mouse and human pancreatic islets. Although fructose per se did not acutely stimulate insulin exocytosis, our data show that chronic fructose rendered rodent and human β-cells hyper-responsive to intermediate physiological glucose concentrations. Fructose exposure reduced intracellular ATP levels without affecting mitochondrial function, induced AMP-activated protein kinase activation, and favored ATP release from the β-cells upon acute glucose stimulation. The resulting increase in extracellular ATP, mediated by pannexin1 (Panx1) channels, activated the calcium-mobilizer P2Y purinergic receptors. Immunodetection revealed the presence of both Panx1 channels and P2Y1 receptors in β-cells. Addition of an ectonucleotidase inhibitor or P2Y1 agonists to naïve β-cells potentiated insulin secretion stimulated by intermediate glucose, mimicking the fructose treatment. Conversely, the P2Y1 antagonist and Panx1 inhibitor reversed the effects of fructose, as confirmed using Panx1-null islets and by the clearance of extracellular ATP by apyrase. These results reveal an important function of ATP signaling in pancreatic β-cells mediating fructose-induced hyper-responsiveness.

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