scholarly journals Tetradentate phenolic Schiff base ligands derived from aromatic diamine and their nickel (II) complexes: Synthesis, characterization, and in vitro anticancer screening

2019 ◽  
Vol 15 (4) ◽  
pp. 613-616
Author(s):  
Shahrul Nizam Ahmad ◽  
Hadariah Bahron ◽  
Amalina Mohd Tajuddin ◽  
Kalavathy Ramasamy
Keyword(s):  
Schiff Base ◽  
Human Colon ◽  
Aromatic Diamine ◽  
Anticancer Activities ◽  
Schiff Base Ligands ◽  
Human Colon Cancer ◽  
Colon Cancer Cell Lines ◽  
Ft Ir ◽  
Anticancer Compound

Two tetradentate phenolic Schiff base ligands namely 2,2'-((1E,1'E)-(1,2-phenylenebis(azanyl-ylidene))bis(methanylylidene))diphenol, L1H, 2,2'-((1E,1'E)-(1,2-phenylenebis(azanylylidene))bis-(methanylylidene))bis(4-fluorophenol), L1F and their new nickel(II) complexes were successfully synthesized, characterized and evaluated for their in vitro anticancer activities against human colon cancer cell lines, HCT116. The compounds were characterized using FT-IR, 1H and 13C NMR, UV-Visible, elemental analysis and melting point. The anticancer results revealed that the parent ligands were more active than their corresponding complexes with L1F being the most potent anticancer compound with IC50 of 2.8 mg/ml.

In vitro antiproliferative activity against human colon cancer cell lines of representative 4-thiazolidinones. Part I

2005 ◽  
Vol 15 (17) ◽  
pp. 3930-3933 ◽  
Author(s):  
Rosaria Ottanà ◽  
Stefania Carotti ◽  
Rosanna Maccari ◽  
Ida Landini ◽  
Giuseppa Chiricosta ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Antiproliferative Activity ◽  
Human Colon ◽  
Colon Cancer Cell ◽  
Human Colon Cancer Cell ◽  
Human Colon Cancer ◽  
Colon Cancer Cell Lines

Avenanthramides Inhibit Proliferation of Human Colon Cancer Cell Lines In Vitro

2010 ◽  
Vol 62 (8) ◽  
pp. 1007-1016 ◽  
Author(s):  
Weimin Guo ◽  
Lin Nie ◽  
Dayong Wu ◽  
Mitchell L. Wise ◽  
F. William Collins ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Colon ◽  
Cancer Cell Lines ◽  
Colon Cancer Cell ◽  
Human Colon Cancer Cell ◽  
Human Colon Cancer ◽  
Colon Cancer Cell Lines

scholarly journals Antimicrobial and Antioxidant Activities of Diorganotin(IV) Complexes Synthesized from 1,2,4-Triazole Derivatives

2020 ◽  
Vol 32 (10) ◽  
pp. 2553-2558
Author(s):  
Jyoti Yadav ◽  
Jai Devi
Keyword(s):  
Schiff Base ◽  
Antioxidant Activities ◽  
Azomethine Nitrogen ◽  
Spectroscopic Techniques ◽  
Schiff Base Ligands ◽  
Alkyl Aryl ◽  
Aryl Group ◽  
Ft Ir ◽  
Tin Metal

Novel diorganotin(IV) complexes were synthesized from 1,2,4-triazole Schiff base ligands which were synthesized by reaction between the 4-amino-5-phenyl-1,2,4-triazole-3-thiol and salicyaldehyde derivatives. The bonding and geometry of the diorganotin(IV) complexes were evaluated by using different spectroscopic techniques such as FT-IR, mass, 1H, 13C & 119Sn NMR. The different spectroscopic techniques revealed the tridentate (ONS) mode of chelation of Schiff base ligands and pentacoordinated environment around the central tin metal which was satisfied with azomethine nitrogen, phenolic oxygen, thiolic sulfur and metal-carbon bond of alkyl/aryl group. The Schiff base ligands and their organotin(IV) complexes were tested for their in vitro antimicrobial and antioxidant activities to examine the biological outline of complexes in comparison to standard drugs. The results of activities data revealed that diorganotin(IV) complexes are more active than Schiff base ligands and some diorganotin(IV) complexes are even more active than the standard drugs. In all the synthesized complexes, compound 9 (Bu2SnL2) and 10 (Ph2SnL2) were most potent and can be used in future clinical trials.

scholarly journals High Nuclearity Cu(II) and Co(II) complexes of Schiff Base Derived from o-vanillin with substituted m-phenylenediamine

2018 ◽  
Vol 7 (3.11) ◽  
pp. 72
Author(s):  
Siti Solihah Khaidir ◽  
Hadariah Bahron ◽  
Amalina Mohd Tajuddin ◽  
Kalavathy Ramasamy ◽  
Siong Meng Lim
Keyword(s):  
Schiff Base ◽  
Anticancer Agents ◽  
Condensation Reaction ◽  
Human Colon ◽  
Azomethine Nitrogen ◽  
Microwave Assisted Synthesis ◽  
Anticancer Activities ◽  
Human Colon Cancer ◽  
Tetrahedral Geometry ◽  
Tetranuclear Complexes

In the present work, a polydentate Schiff base ligand (SB) was synthesized via condensation reaction between o-vanillin and Cl-m-phenylenediamine. Dinuclear complexes of Co(II) and Cu(II) were prepared by conventional method with SB:metal ratio of 1:1 whereas tetranuclear complexes were obtained via microwave-assisted synthesis with SB:metal ratio of 1:2. Characterization was carried out through elemental analysis (C,H,N), molar conductivity, magnetic susceptibility, Fourier Transform Infrared (FTIR), and Nuclear Magnetic Resonance (NMR) spectroscopy. The experimental data indicated that the metal ions of the dinuclear and tetranuclear complexes were coordinated to the ligand through azomethine nitrogen, methoxy oxygen and deprotonated phenolic oxygen. The effective magnetic moment values of Co(II) complexes suggested tetrahedral geometry with 3 unpaired electrons. The shifting of n(C=N), n(C-O)phenolic and n(C-O)methoxy band to lower frequencies in all complexes indicated that coordination to metal centres occurred through these moieties. New weak peaks in the region 436 -559 cm-1 were assignable to n(M-N) and n(M-O). SB and its complexes were screened to be positive for anticancer activities against human colon cancer cell (HCT116). Tetranuclear Cu4SB and Co4SB metal complexes revealed IC50 values of 4.2 and 6.87, respectively; indicated to be more potent anticancer agents than the dinuclear counterparts and the parent ligand.   

scholarly journals Inhibitory Effect of CAPE and Kaempferol in Colon Cancer Cell Lines—Possible Implications in New Therapeutic Strategies

2019 ◽  
Vol 20 (5) ◽  
pp. 1199 ◽  
Author(s):  
Liviuta Budisan ◽  
Diana Gulei ◽  
Ancuta Jurj ◽  
Cornelia Braicu ◽  
Oana Zanoaga ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Proliferation ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Colon ◽  
Natural Compounds ◽  
Colon Cancer Cell ◽  
Human Colon Cancer ◽  
Colon Cancer Cell Lines

Background: Phytochemicals are natural compounds synthesized as secondary metabolites in plants and represent an important source of molecules with therapeutic applications. Attention is accorded to their potential in anti-cancer therapies as single agents or adjuvant treatment. Herby, we evaluated the in vitro effects of a panel of natural compounds with focus on caffeic acid phenethyl ester (CAPE) and Kaempferol for the treatment of human colon cancer. Methods: We exposed two human colon cancer cell lines, RKO and HCT-116, followed by functional examination of cell viability, cell proliferation and invasion, cell cycle, apoptosis, and autophagy. Modifications in gene expression were investigated through microarray and detection of existing mutations and finding of new ones was done with the help of Next Generation Sequencing (NGS). Results: Both CAPE and Kaempferol inhibit cell proliferation, motility and invasion, and stimulate apoptosis and autophagy, concomitant with modifications in coding and noncoding genes’ expression. Moreover, there are pathogenic mutations that are no longer found upon treatment with CAPE and Kaempferol. Conclusions: Our findings indicate that CAPE and Kaempferol have the ability to negatively influence the development and advancement of colon cancer in vitro by specifically altering the cells at the molecular level; this activity can be exploited in possible adjuvant therapies once the optimal dose concentration with minimal side effects but with cancer inhibitory activity is set in vivo.

Monoclonal Antibodies to αDna Polymerase as a Marker of Cell Proliferative Activity

1987 ◽  
Vol 2 (1) ◽  
pp. 25-30
Author(s):  
Angela Alama ◽  
Silvano Ferrini ◽  
Marco Gaddi ◽  
Angelo Nicolin
Keyword(s):  
Colon Cancer ◽  
Monoclonal Antibodies ◽  
Kinetic Studies ◽  
Human Colon ◽  
Peripheral Blood Lymphocytes ◽  
Growth Fraction ◽  
Human Colon Cancer ◽  
Colon Cancer Cell Lines ◽  
Cell Proliferative Activity

A hybridoma cell line (5F) secreting monoclonal antibodies directed to αDNA polymerase has been developed. Kinetic studies on peripheral blood lymphocytes stimulated with mitogen and human colon cancer cell lines established in vitro were made by the two autoradiographic techniques of Thymidine Labelling Inde and Primer-dependent αDNA polymerase Labelling Index and the immunoperoxidase assay (PAP) with monoclonal antibody to αDNA polymerase. We demonstrated the exclusively intranuclear presence of αDNA polymerase in lymphocytes induced to proliferate and actively growing colon cancer cells in contrast with the cytoplasmic distribution of the enzyme in resting stage populations. The feasibility of using monoclonal antibodies to αDNA polymerase to determine cell growth fraction was evaluated.

scholarly journals In vitro anticancer potential and GC-MS analysis of Drimia nagarjunae, an endangered medicinal plant

2015 ◽  
Vol 10 (2) ◽  
pp. 303 ◽  
Author(s):  
Narendranath Alluri ◽  
Mala Majumdar
Keyword(s):  
Ethyl Acetate ◽  
Anticancer Activity ◽  
Human Colon ◽  
Human Colon Cancer ◽  
Ms Analysis ◽  
Endangered Medicinal Plant ◽  
Colon Cancer Cell Lines ◽  
Total Growth ◽  
First Time

<p>The aim of the present study was to investigate the anticancer activity of <em>Drimia nagarjunae</em> (Liliaceae) extracts against Colo205 human colon cancer cell lines by SRB assay for the first time. The bulbs and leaves of the plant were sequentially extracted using solvents with increasing polarities (hexane&gt; chloroform&gt;ethyl acetate&gt;methanol&gt;water). Ethyl acetate and chloroform bulb extracts showed potent anticancer activity compared to standard, adriamycin. Both the extracts exhibited total growth inhibition of cell at 20.1 µg/mL and 32.1 µg/mL whereas adriamycin shown 33.1 µg/mL and 50% lethal concentration was found to be 61.5 µg/mL and &gt;80 µg/mL respectively. The active extracts were subjected to GC-MS analysis for identification of phytocompounds and it showed seven and ten major compounds respectively. Therefore, the present study demonstrated that <em>D. nagarjunae</em> can be a promising candidate as an anticancer agent.</p><p> </p>

Combination of oxaliplatin and irinotecan on human colon cancer cell lines: activity in vitro and in vivo

2001 ◽  
Vol 12 (9) ◽  
pp. 741-751 ◽  
Author(s):  
Sylvie Guichard ◽  
Stéphanie Arnould ◽  
Isabelle Hennebelle ◽  
Roland Bugat ◽  
Pierre Canal
Keyword(s):  
Colon Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Colon ◽  
Colon Cancer Cell ◽  
Human Colon Cancer Cell ◽  
Human Colon Cancer ◽  
Colon Cancer Cell Lines
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