Novel Bio-Synthetic Graft for Tracheal Reconstruction in Pediatric Patients With Congenital Tracheal Stenosis: In Vitro Studies of Axial, and Bending Biomechanics

2019 ◽  
Author(s):  
Teja Karkhanis ◽  
Farhan Zafar ◽  
Brian Juarez ◽  
David Luis-Simon Morales ◽  
Balakrishna Haridas
Keyword(s):  
Tracheal Stenosis ◽  
Performance Testing ◽  
Congenital Tracheal Stenosis ◽  
Synthetic Graft ◽  
Current Standard ◽  
Tracheal Reconstruction ◽  
Promising Alternative ◽  
Surgical Interventions ◽  
Airway Infections

Congenital Tracheal Stenosis (CTS) is a rare birth defect requiring surgical interventions when it affects more than 30% of the trachea. Slide tracheoplasty, the current standard of care, is associated with reinterventions including the need for intraluminal stenting leading to increased airway infections. We propose a novel Bio-Synthetic Graft for long segment tracheal reconstructions in CTS patients. Preliminary bench performance testing, using lamb tracheas, shows that the Bio-Synthetic Graft reconstructed tracheas have comparable radial, axial and bending stiffness in hyperextension to healthy tracheas and resist collapse when subjected to bending in flexion. These results suggest that Bio-Synthetic Graft could be a promising alternative to existing solutions for long segment CTS.

Tracheal Reconstruction for Congenital Tracheal Stenosis: A 950-gram Neonate

2022 ◽  
Author(s):  
Rami Zibdawi ◽  
Ryaan El-Andari ◽  
Michelle Noga ◽  
Matthew Hicks ◽  
M. Muhieldin ◽  
...  
Keyword(s):  
Tracheal Stenosis ◽  
Congenital Tracheal Stenosis ◽  
Tracheal Reconstruction

Aortopexy with tracheal reconstruction for postoperative tracheomalacia in congenital tracheal stenosis

2012 ◽  
Vol 47 (6) ◽  
pp. 1080-1083 ◽  
Author(s):  
Akiko Yokoi ◽  
Hiroshi Arai ◽  
Yuko Bitoh ◽  
Makoto Nakao ◽  
Yoshihiro Oshima ◽  
...  
Keyword(s):  
Tracheal Stenosis ◽  
Congenital Tracheal Stenosis ◽  
Tracheal Reconstruction

Perioperative management of tracheal reconstruction in congenital tracheal stenosis: A case report.

1991 ◽  
Vol 11 (1) ◽  
pp. 106-111
Author(s):  
Hisashi OHORI ◽  
Takashi NAKAGAWA ◽  
Takako TSUDA ◽  
Motomi ARAKAWA ◽  
Osamu AOCHI ◽  
...  
Keyword(s):  
Case Report ◽  
Tracheal Stenosis ◽  
Perioperative Management ◽  
Congenital Tracheal Stenosis ◽  
Tracheal Reconstruction

One-stage tracheal reconstruction of congenital tracheal stenosis

1996 ◽  
Vol 34 (3) ◽  
pp. 245-252 ◽  
Author(s):  
Patrick Froehlich ◽  
Donald B. Kearns ◽  
Allan B. Seid ◽  
Seth M. Pransky ◽  
Jean-Paul Chappuis ◽  
...  
Keyword(s):  
Tracheal Stenosis ◽  
Congenital Tracheal Stenosis ◽  
Tracheal Reconstruction ◽  
One Stage

Revision Thoracic Slide Tracheoplasty for Congenital Tracheal Stenosis: Outcomes following Unsuccessful Prior Tracheal Reconstruction

2014 ◽  
Vol 151 (1_suppl) ◽  
pp. P108-P108
Author(s):  
Douglas R. Sidell ◽  
Alessandro de Alarcon ◽  
Peter B. Manning ◽  
Catherine K. Hart ◽  
Karthik Balakrishnan ◽  
...  
Keyword(s):  
Tracheal Stenosis ◽  
Congenital Tracheal Stenosis ◽  
Tracheal Reconstruction ◽  
Slide Tracheoplasty

Incidence and risk factor of vocal cord paralysis following slide tracheoplasty for congenital tracheal stenosis: a retrospective observational study

2021 ◽  
pp. 1-5
Author(s):  
Naoki Kaneko ◽  
Tomomi Hasegawa
Keyword(s):  
Risk Factor ◽  
Observational Study ◽  
Vocal Cord ◽  
Tracheal Stenosis ◽  
Vocal Cord Paralysis ◽  
Retrospective Observational Study ◽  
Congenital Tracheal Stenosis ◽  
Tracheal Reconstruction ◽  
Slide Tracheoplasty ◽  
Cardiovascular Anomalies

Abstract Background: Slide tracheoplasty for congenital tracheal stenosis (CTS) has been shown to improve post-operative outcomes, but the incidence and risk factors of vocal cord paralysis (VCP) following slide tracheoplasty remain unclear. This study aimed to review our experience of slide tracheoplasty for CTS with a focus on post-operative VCP. Methods: Twenty-eight patients, who underwent tracheal reconstruction with or without cardiovascular repair at Kobe Children’s Hospital between June, 2016 and March, 2020 were enrolled in this retrospective observational study. They were divided into two groups based on the presence of a pulmonary artery sling (PA sling). Perioperative variables were compared between the two groups. Results: Twenty-one of the 28 patients underwent concomitant repair for associated cardiovascular anomalies, including 15 patients with PA sling. The overall incidence of VCP following slide tracheoplasty was 28.6%. The incidences of VCP were 46.7% in patients with CTS and PA sling, which were 14.3% in CTS patients without cardiovascular anomalies. The only risk factor associated with VCP following slide tracheoplasty was a concomitant repair for PA sling. Post-operatively, the duration of nasogastric tube feeding in patients with VCP was significantly longer than that in patients without VCP. Conclusions: The incidence of VCP following slide tracheoplasty for CTS was high, especially in concomitant repair cases for PA sling. Routine screening and evaluation of VCP soon after post-operative extubation is required for its appropriate management.

RAPID IN VITRO PROPAGATION OF WESTERN GHATS CULTIVAR - COLOCASIA ESCULENTA FOR THE HIGH FREQUENCY OF PLANTLETS

2019 ◽  
Vol 7 (2) ◽  
Author(s):  
Jyothi R ◽  
Srinivasa Murthy K M ◽  
Hossein . ◽  
Veena .
Keyword(s):  
Tissue Culture ◽  
Wide Distribution ◽  
Colocasia Esculenta ◽  
Limiting Factor ◽  
Promising Alternative ◽  
Rapid Multiplication ◽  
Medical Plant ◽  
Total Fat ◽  
Planting Materials

Colocasia esculenta is commonly known as Taro, it is referred to as cocoyam in Nigeria. They are cherished for their rich taste, nutritional and medicinal properties. Every 100 g of taro corms possess 112 Kcal, 26.46 g carbohydrate, 1.50 g protein, 0.20 g total fat and 4.1g fiber (USDA National Nutrient Data Base). Besides its nutritional value, taro is used as a medical plant and provides bioactive compounds used as an anti-cancer drugs. Traditionally, cocoyams are vegetative propagated from tuber fragments, a practice that encourages pathogen distribution. Colocasia esculenta is a widely distributed food crop in the humid tropics and subtropics. Despite of its wide distribution, Taro plants are commonly infected with DsMV and other pathogens. This virus induces conspicuous mosaic, malformation, dwarfing or feathering on leaves in taro. As the results of infection, it reduces the quality and yield of taro production greatly. This virus is thus considered as a major limiting factor in the production of taro. Here plays the importance of  tissue culture plays a major role in producing the disease resistant plants round the year with high quality. For rapid multiplication and production of quality planting materials, tissue culture technology offers promising alternative compared to the traditional production methods. KEYWORDS: Colocasia esculenta, Virus, Pathogens, Conventional propagation, Micropropagation, Yield, Rapid multiplication, Quality

Development and Ex-vivo Evaluation of Topiramate Mucoadhesive Nanoparticles for Intranasal Delivery

2020 ◽  
Vol 13 (6) ◽  
pp. 5250-5255
Author(s):  
Ashwin Kumar Tulasi ◽  
Anil Goud Kandhula ◽  
Ravi Krishna Velupula
Keyword(s):  
Particle Size ◽  
Nasal Mucosa ◽  
Intranasal Administration ◽  
Ex Vivo ◽  
Chemical Properties ◽  
Brain Targeting ◽  
Oral Tablet ◽  
Promising Alternative ◽  
Ex Vivo Permeation

Topiramate is a second-generation antiepileptic drug used in partial, generalized seizures as an oral tablet. Oral route of administration is most convenient but shows delayed absorption. Moreover, in emergency cases, parenteral administration is not possible as it requires medical assistance. Hence, the present study was aimed to develop topiramate mucoadhesive nanoparticles for intranasal administration using ionotropic gelation method. The developed nanoparticles were evaluated for physico-chemical properties like particle size, zeta potential, surface morphology, drug content, entrapment efficiency, in vitro drug release, mucoadhesive strength, and ex vivo permeation studies in excised porcine nasal mucosa. Optimized nanoparticle formulation (T9) was composed oil mucoadhesive agent (Chitosan 1% w/w), cross linking polymer (TPP) and topiramate 275mg, 100mg and 4% respectively. It showed particle size of 350nm, high encapsulation efficacy and strong mucoadhesive strength. In vitro drug diffusion of optimized formulation showed 95.12% release of drug after 180min. Ex-vivo permeation of drug across nasal mucosa was   88.05 % after 180min. Nasocilial toxicity studies showed optimized formulation did not damage the nasal mucosa. Thus, the intranasal administration of topiramate using chitosan can be a promising alternative for brain targeting and the treatment of epilepsy.

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