Frequency Division Multiplexing of a Multi-Channel Resistive Pulse Sensor

Author(s):  
Ashish Jagtiani ◽  
Jiang Zhe ◽  
Joan Carletta

We present the design, fabrication and testing of a microfluidic multichannel resistive pulse sensor for high throughput counting of microparticles. The high throughput counting results from using multiple parallel microfluidic channels to analyze the sample. Detection is achieved by using frequency division multiplexing where a known and unique frequency is applied to modulate each microchannel and a combined measurement is made across a single pair of electrodes. Testing results using 30μm polystyrene particles demonstrate that the throughput of the multiplexed device is improved 300% over a single channel device. In addition, the AC modulation method reduces the polarization effect on the microelectrodes, and thereby allows for measurement of the actual particle sizes. The multiplexed detection principle can be extended to a larger number of channels to further improve the throughput, without increasing the external detection electronics.

2014 ◽  
Vol 548-549 ◽  
pp. 1221-1226
Author(s):  
Zeng You Sun ◽  
Fan Ming Zeng

In order to reduce the Orthogonal Frequency division Multiplexing (OFDM) Inter-Carrier Interference (ICI), Put forward a kind of modulation method that based on the orthogonal frequency division multiplexing of orthogonal wavelet, Using orthogonal wavelet instead of discrete Fourier transform, optimize the design for OFDM systems, on the premise of without protection interval to reduce the system interference, using MATLAB to simulate the OFDM system, results show that the optimization of the OFDM can reduce the power of the ICI and Inter-symbol Interference (ISI) and improve the comprehensive anti-jamming of the OFDM system.


2019 ◽  
Vol 8 (3) ◽  
pp. 2003-2008

Orthogonal Frequency Division Multiplexing (OFDM) is one of the multicarrier transmission techniques used in wireless communication system. It has many benefits such as robust in channel fading and has high spectral density. The main objective of OFDM implementation in wireless communication system is to achieve less or zero Bit Error Rate (BER). However, OFDM design complexity, requirement and selection of the suitable modulation method are among the current issues. Thus, this paper aims to investigate the performance of OFDM in wireless communication by developing two OFDM based system designs. The transmitter, channel and receiver are designed based on OFDM system principles. Forward Error Correction (FEC) method is applied to reduce the BER. Both OFDM designs produce less BER with zero BER for the second OFDM design. The investigation study shows that the performance of OFDM can be enhanced by applying Fast Fourier Transform (FFT) technique. Zero BER can be achieved if the suitable modulation scheme is applied in the system. The developed designs are not complex, suitable to be applied for IEEE 802.11 standard. The BER performance can be influenced by the types of channels, signal to noise ratio (SNR) and various modulation schemes. Thus, this study can be used as a guidance to implement the OFDM in the current or future wireless communication system.


2020 ◽  
Author(s):  
Mark Platt ◽  
Eugenie Hunsicker ◽  
Marcus Pollard

Technologies that can detect and characterise particulates in liquids have applications in health, food and environmental monitoring. Here we present a low-cost and high-throughput multiuse counter that classifies a particle’s size, concentration, porosity and shape. Using an additive manufacturing process, we have assembled a reusable flow resistive pulse sensor. The device remains stable for several days with repeat measurements. We demonstrate its use for characterising algae with spherical and rod structures as well as microplastics shed from teabags. We present a methodology that results in a specific signal for microplastics, namely a conductive pulse, in contrast to particles with smooth surfaces such as calibration particles or algae, allowing the presence of microplastics to be easily confirmed and quantified. In addition, the shape of the signal and particle are correlated, giving an extra physical property to characterise suspended particulates. The technology can rapidly screen volumes of liquid, 1 mL/ min, for the presence of microplastics and algae.<br>


Author(s):  
Ashish Jagtiani ◽  
Jiang Zhe ◽  
Bi-min Zhang Newby

We describe an all-electronic, label-free, resistive pulse sensor that utilizes multiple micropores for simultaneous detection and counting of multiple biological particles. Four particle samples were utilized for the sensor testing: 20μm and 40μm polymethacrylate (PM) particles, Juniper pollen and Eastern Cottonwood pollen. Experiments demonstrated that this sensor was able to differentiate and count multiple particle solutions simultaneously through its four micropores fabricated on polymer membranes. Thus the sensing throughput has been improved significantly. Furthermore, the experimental results also proved the feasibility of differentiating various pollens from PM microparticles with the multi-pore resistive pulse sensor, with no need for labeling of samples.


2006 ◽  
Author(s):  
Jiang Zhe ◽  
Ashish Jagtiani ◽  
Nazmul Mamun ◽  
Prashanta Dutta ◽  
Jun Hu ◽  
...  

We describe a micromachined. resistive pulse sensor with multiple sensing microchannels. A unique design placing measurement microelectrodes in the center of the microchannels is demonstrated. This design creates isolation resistances among channels and thus circumvents the crosstalk caused by automatic electrical connection among microchannels. When implemented using microscale channels, the design is appropriate for the sensing of microscale particles in deionized water or in very dilute electrolyte solution; using nanoscale channels, the design is appropriate for the sensing of nanoscale particles in electrolyte solutions of any concentration. The design has multiple channels operating in parallel, but integrated with just one sample reservoir and one power source. The results with a four-channel device show that this device is capable of differentiating and counting micro polymethacrylate particles and Juniper pollens rapidly. The throughput is improved significantly in comparison to a single channel device. The concept can be extended to a large number of sensing channels in a single chip for significant improvement in throughput.


Author(s):  
Mark Platt ◽  
Eugenie Hunsicker ◽  
Marcus Pollard

Technologies that can detect and characterise particulates in liquids have applications in health, food and environmental monitoring. Here we present a low-cost and high-throughput multiuse counter that classifies a particle’s size, concentration, porosity and shape. Using an additive manufacturing process, we have assembled a reusable flow resistive pulse sensor. The device remains stable for several days with repeat measurements. We demonstrate its use for characterising algae with spherical and rod structures as well as microplastics shed from teabags. We present a methodology that results in a specific signal for microplastics, namely a conductive pulse, in contrast to particles with smooth surfaces such as calibration particles or algae, allowing the presence of microplastics to be easily confirmed and quantified. In addition, the shape of the signal and particle are correlated, giving an extra physical property to characterise suspended particulates. The technology can rapidly screen volumes of liquid, 1 mL/ min, for the presence of microplastics and algae.<br>


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