Computational Fluid Dynamics Analysis of Fluid Mixing in Single Use Bioreactors

Author(s):  
Robert Spall ◽  
Nephi Jones ◽  
Clinton Staheli

CFD calculations were performed for a series of stirred, single use bioreactor vessels using both rotating reference frame and sliding mesh model approaches. Comparisons of quantities such as flow patterns, power numbers, and mixing times are presented. Calculations to predict mass transfer coefficients for a sparged 250L vessel were also performed using the rotating reference frame model. Results presented include those from a series of single, fixed bubble diameter calculations, and those which employed a population balance model consisting of 9 discrete bubble diameters.

1967 ◽  
Vol 45 (4) ◽  
pp. 1481-1495 ◽  
Author(s):  
Myer Bloom ◽  
Eric Enga ◽  
Hin Lew

A successful transverse Stern–Gerlach experiment has been performed, using a beam of neutral potassium atoms and an inhomogeneous time-dependent magnetic field of the form[Formula: see text]A classical analysis of the Stern–Gerlach experiment is given for a rotating inhomogeneous magnetic field. In general, when space quantization is achieved, the spins are quantized along the effective magnetic field in the reference frame rotating with angular velocity ω about the z axis. For ω = 0, the direction of quantization is the z axis (conventional Stern–Gerlach experiment), while at resonance (ω = −γH0) the direction of quantization is the x axis in the rotating reference frame (transverse Stern–Gerlach experiment). The experiment, which was performed at 7.2 Mc, is described in detail.


Author(s):  
Gen Fu ◽  
Alexandrina Untaroiu

Abstract Fuel efficiency becomes very important for new vehicles. Therefore, improving the aerodynamics of tires has started to receive increasing interest. While the experimental approaches are time consuming and costly, numerical methods have been employed to investigate the air flow around tires. Rotating boundary and contact patch are important challenges in the modeling of tire aerodynamics. Therefore, majority of the current modelling approaches are simplified by neglecting the tire deformation and contact patch. In this study, a baseline CFD model is created for a tire with contact patch. To generate mesh efficiently, a hybrid mesh, which combines hex elements and polyhedral elements, is used. Then, three modeling approaches (rotating wall, multiple reference frame and sliding mesh) are compared for the modeling of tire rotation. Additionally, three different tire designs are investigated, including smooth tire, grooved tire and grooved tire with open rim. The predicted results of the baseline model agree well with the measured data. Additionally, the hybrid mesh show to be efficient and to generate accurate results. The CFD model tends to over predict the drag of a rotating tire with contact patch. Sliding mesh approach generated more accurate predictions than the rotating wall and multiple reference frame approaches. For different tire designs, tire with open rim has the highest drag. It is believed that the methodology presented in this study will help in designing new tires with high aerodynamic performance.


2020 ◽  
Vol 8 (10) ◽  
pp. 744
Author(s):  
Yu-Hsien Lin ◽  
Xian-Chen Li

A computational fluid dynamics (CFD)-based simulation using a finite volume code for a full-appendage DARPA (Defense Advanced Research Projects Agency) SUBOFF model was investigated with a sliding mesh model in a multi-zone fluid domain. Unsteady Reynolds Averaged Navier–Stokes (URANS) equations were coupled with a Menter’s shear stress transport (SST) k-ω turbulence closure based on the Boussinesq approximation. In order to simulate unsteady motions and capture unsteady interactions, the sliding mesh model was employed to simulate flows in the fluid domain that contains multiple moving zones. The pressure-based solver, semi-implicit method for the pressure linked equations-consistent (SIMPLEC) algorithm was employed for incompressible flows based on the predictor-corrector approach in a segregated manner. After the grid independence test, the numerical simulation was validated by comparison with the published experimental data and other numerical results. In this study, the capability of the CFD simulation with the sliding mesh model was well demonstrated to conduct the straight-line towing tests by analyzing hydrodynamic characteristics, viz. resistance, vorticity, frictional coefficients, and pressure coefficients.


2018 ◽  
Vol 616 ◽  
pp. A14 ◽  
Author(s):  
◽  
F. Mignard ◽  
S. A. Klioner ◽  
L. Lindegren ◽  
J. Hernández ◽  
...  

Context. The second release of Gaia data (Gaia DR2) contains the astrometric parameters for more than half a million quasars. This set defines a kinematically non-rotating reference frame in the optical domain. A subset of these quasars have accurate VLBI positions that allow the axes of the reference frame to be aligned with the International Celestial Reference System (ICRF) radio frame. Aims. We describe the astrometric and photometric properties of the quasars that were selected to represent the celestial reference frame of Gaia DR2 (Gaia-CRF2), and to compare the optical and radio positions for sources with accurate VLBI positions. Methods. Descriptive statistics are used to characterise the overall properties of the quasar sample. Residual rotation and orientation errors and large-scale systematics are quantified by means of expansions in vector spherical harmonics. Positional differences are calculated relative to a prototype version of the forthcoming ICRF3. Results. Gaia-CRF2 consists of the positions of a sample of 556 869 sources in Gaia DR2, obtained from a positional cross-match with the ICRF3-prototype and AllWISE AGN catalogues. The sample constitutes a clean, dense, and homogeneous set of extragalactic point sources in the magnitude range G ≃ 16 to 21 mag with accurately known optical positions. The median positional uncertainty is 0.12 mas for G < 18 mag and 0.5 mas at G = mag. Large-scale systematics are estimated to be in the range 20 to 30 μas. The accuracy claims are supported by the parallaxes and proper motions of the quasars in Gaia DR2. The optical positions for a subset of 2820 sources in common with the ICRF3-prototype show very good overall agreement with the radio positions, but several tens of sources have significantly discrepant positions. Conclusions. Based on less than 40% of the data expected from the nominal Gaia mission, Gaia-CRF2 is the first realisation of a non-rotating global optical reference frame that meets the ICRS prescriptions, meaning that it is built only on extragalactic sources. Its accuracy matches the current radio frame of the ICRF, but the density of sources in all parts of the sky is much higher, except along the Galactic equator.


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