Virtual Assessment of the Performance of an Inhalation Drug Delivery Device

ASME 2007 Summer Bioengineering Conference ◽

10.1115/sbc2007-176368 ◽

2007 ◽

Author(s):

Françoise Dufour ◽

Gavin Davies

Keyword(s):

Drug Delivery ◽

Nasal Delivery ◽

Pharmaceutical Aerosols ◽

Drug Delivery Device ◽

Non Invasive ◽

Optimal Drug ◽

Drug Dispersion ◽

Computational Fluid Dynamics Cfd ◽

Inhaler Devices ◽

Inhaled Medication

Inhalation therapies are gaining popularity for both respiratory and non-respiratory therapies. However the challenge remains to achieve optimal drug delivery because of the complex interaction between inhaler devices, drug formulations along with patients’ coordination and physiology. In order to lower R&D costs and efforts, and understand better the mechanics of pharmaceutical aerosols, system designers are looking for comprehensive tools enabling them to reproduce virtual inhalation processes. Computational fluid dynamics (CFD) techniques represent a non-invasive way of predicting the fate of inhaled medication from oral or nasal delivery devices. The object of this work is to apply CFD methodology to model the full inhalation mechanism, from the drug dispersion inside the device and delivery to the patient, to its journey within the respiratory tract.

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Development of a non-invasive ocular drug delivery device

10.26481/dis.20210607cb ◽

2021 ◽

Author(s):

Christian Johannes Franciscus Bertens

Keyword(s):

Drug Delivery ◽

Ocular Drug Delivery ◽

Delivery Device ◽

Drug Delivery Device ◽

Non Invasive

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Design and Analyses of a Transdermal Drug Delivery Device (TD3) †

Sensors ◽

10.3390/s19235090 ◽

2019 ◽

Vol 19 (23) ◽

pp. 5090 ◽

Cited By ~ 1

Author(s):

Jennifer García ◽

Ismael Ríos ◽

Faruk Fonthal Rico

Keyword(s):

Drug Delivery ◽

Transdermal Drug Delivery ◽

Computer Aided Design ◽

Micro Electro Mechanical System ◽

Discharge Process ◽

Microneedle Array ◽

Delivery Device ◽

Drug Delivery Device ◽

Computational Fluid Dynamics Cfd ◽

Aided Design

In this paper, we introduce a novel type of transdermal drug delivery device (TD3) with a micro-electro-mechanical system (MEMS) design using computer-aided design (CAD) techniques as well as computational fluid dynamics (CFD) simulations regarding the fluid interaction inside the device during the actuation process. For the actuation principles of the chamber and microvalve, both thermopneumatic and piezoelectric principles are employed respectively, originating that the design perfectly integrates those principles through two different components, such as a micropump with integrated microvalves and a microneedle array. The TD3 has shown to be capable of delivering a volumetric flow of 2.92 × 10−5 cm3/s with a 6.6 Hz membrane stroke frequency. The device only needs 116 Pa to complete the suction process and 2560 Pa to complete the discharge process. A 38-microneedle array with 450 µm in length fulfills the function of permeating skin, allowing that the fluid reaches the desired destination and avoiding any possible pain during the insertion.

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Innovative approach for nasal drug delivery system for brain target

GSC Advanced Research and Reviews ◽

10.30574/gscarr.2021.9.3.0296 ◽

2021 ◽

Vol 9 (3) ◽

pp. 093-106

Author(s):

Priyadarshani G Patil ◽

Sampada V Marodkar ◽

Sachin J Dighade ◽

Prajakta N Dongare ◽

Bhagyashri A Borade

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Blood Brain Barrier ◽

Delivery System ◽

Drug Transport ◽

Nasal Delivery ◽

Brain Barrier ◽

Non Invasive ◽

Brain Drug Delivery ◽

Blood Brain

The goal of brain drug targeting technology is the delivery of therapeutics across the blood brain barrier (BBB), including the human BBB. Nose to brain drug delivery has received a great deal of attention as a non- invasive, convenient and reliable drug delivery system. For the systemic and targetedadministration of drug. The various drug deliveries through some drug transport pathways, Factor influencing nasal drug absorption, formulation strategies nose to brain, colloidal carriers in nose to brain drug delivery system and nasal delivery systems. Physiological barriers (BBB) that restricts the delivery of drug to CNS. Thus intranasal route has attracted a wide attention of convenient, non-invasive, reliable, and safe route to achieve faster and higher level of drug in the brain through olfactory region by passing blood brain barrier. Intranasal administration rapid onset of action, no first –pass effect , no gastrointestinal degradation lungs toxicity and non-invasiveness application and also improves bioavailability.

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Design and fabrication of a magnetically actuated non-invasive reusable drug delivery device

Drug Development and Industrial Pharmacy ◽

10.1080/03639045.2018.1434193 ◽

2018 ◽

Vol 44 (7) ◽

pp. 1070-1077 ◽

Cited By ~ 1

Author(s):

Joyline Dsa ◽

Manish Goswami ◽

B. R. Singh ◽

Nidhi Bhatt ◽

Pankaj Sharma ◽

...

Keyword(s):

Drug Delivery ◽

Delivery Device ◽

Drug Delivery Device ◽

Non Invasive ◽

Magnetically Actuated

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Intranasal drug delivery: opportunities and toxicologic challenges during drug development

Drug Delivery and Translational Research ◽

10.1007/s13346-020-00891-5 ◽

2021 ◽

Author(s):

Lea-Adriana Keller ◽

Olivia Merkel ◽

Andreas Popp

Keyword(s):

Drug Delivery ◽

Drug Development ◽

Targeted Delivery ◽

Nasal Delivery ◽

Systemic Delivery ◽

Onset Of Action ◽

Physiological Basis ◽

Intranasal Drug Delivery ◽

Non Invasive ◽

Approved Drugs

Abstract Over the past 10 years, the interest in intranasal drug delivery in pharmaceutical R&D has increased. This review article summarises information on intranasal administration for local and systemic delivery, as well as for CNS indications. Nasal delivery offers many advantages over standard systemic delivery systems, such as its non-invasive character, a fast onset of action and in many cases reduced side effects due to a more targeted delivery. There are still formulation limitations and toxicological aspects to be optimised. Intranasal drug delivery in the field of drug development is an interesting delivery route for the treatment of neurological disorders. Systemic approaches often fail to efficiently supply the CNS with drugs. This review paper describes the anatomical, histological and physiological basis and summarises currently approved drugs for administration via intranasal delivery. Further, the review focuses on toxicological considerations of intranasally applied compounds and discusses formulation aspects that need to be considered for drug development. Graphical abstract

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Formulating SLN and NLC as Innovative Drug Delivery Systems for Non-Invasive Routes of Drug Administration

Current Medicinal Chemistry ◽

10.2174/0929867326666190624155938 ◽

2020 ◽

Vol 27 (22) ◽

pp. 3623-3656 ◽

Cited By ~ 1

Author(s):

Bruno Fonseca-Santos ◽

Patrícia Bento Silva ◽

Roberta Balansin Rigon ◽

Mariana Rillo Sato ◽

Marlus Chorilli

Keyword(s):

Drug Delivery ◽

Particle Size ◽

Drug Release ◽

Drug Loading ◽

Average Particle Size ◽

Delivery Systems ◽

Average Particle ◽

Minor Importance ◽

Routes Of Administration ◽

Non Invasive

Colloidal carriers diverge depending on their composition, ability to incorporate drugs and applicability, but the common feature is the small average particle size. Among the carriers with the potential nanostructured drug delivery application there are SLN and NLC. These nanostructured systems consist of complex lipids and highly purified mixtures of glycerides having varying particle size. Also, these systems have shown physical stability, protection capacity of unstable drugs, release control ability, excellent tolerability, possibility of vectorization, and no reported production problems related to large-scale. Several production procedures can be applied to achieve high association efficiency between the bioactive and the carrier, depending on the physicochemical properties of both, as well as on the production procedure applied. The whole set of unique advantages such as enhanced drug loading capacity, prevention of drug expulsion, leads to more flexibility for modulation of drug release and makes Lipid-based nanocarriers (LNCs) versatile delivery system for various routes of administration. The route of administration has a significant impact on the therapeutic outcome of a drug. Thus, the non-invasive routes, which were of minor importance as parts of drug delivery in the past, have assumed added importance drugs, proteins, peptides and biopharmaceuticals drug delivery and these include nasal, buccal, vaginal and transdermal routes. The objective of this paper is to present the state of the art concerning the application of the lipid nanocarriers designated for non-invasive routes of administration. In this manner, this review presents an innovative technological platform to develop nanostructured delivery systems with great versatility of application in non-invasive routes of administration and targeting drug release.

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Nanostructured Lipid Carriers (NLCs) for drug delivery: Role of Liquid lipid (oil)

Current Drug Delivery ◽

10.2174/1567201817666200423083807 ◽

2020 ◽

Vol 17 ◽

Author(s):

Anisha D’Souza ◽

Ranjita Shegokar

Keyword(s):

Drug Delivery ◽

Essential Oils ◽

Drug Carrier ◽

Drug Loading ◽

Performance Criteria ◽

Long Term Stability ◽

Natural Oils ◽

Optimal Drug

: In recent years, SLNs and NLCs are among the popular drug delivery systems studied for delivery of lipophilic drugs. Both systems have demonstrated several beneficial properties as an ideal drug-carrier, optimal drug-loading and good long-term stability. NLCs are getting popular due to their stability advantages and possibility to load various oil components either as an active or as a matrix. This review screens types of oils used till date in combination with solid lipid to form NLCs. These oils are broadly classified in two categories: Natural oils and Essential oils. NLCs offer range advantages in drug delivery due to the formation of imperfect matrix owing to the presence of oil. The type and percentage of oil used determines optimal drug loading and stability. Literature shows that variety of oils is used in NLCs mainly as matrix, which is from natural origin, triglycerides class. On the other hand, essential oils not only serve as a matrix but as an active. In short, oil is the key ingredient in formation of NLCs, hence needs to be selected wisely as per the performance criteria expected.

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