Cumulative Effect of Repeated Impacts on Lumbar Intervertebral Disc Mechanics: A Diurnal Cycle Study

2012 ◽  
Author(s):  
David Jamison ◽  
Chris J. Massey ◽  
Eric C. Pierce ◽  
Shawn K. Martin ◽  
Michele A. Marcolongo
Keyword(s):  
Back Pain ◽  
Intervertebral Disc ◽  
High Speed ◽  
Cumulative Effect ◽  
Low Back ◽  
Lumbar Intervertebral Disc ◽  
Lower Back ◽  
Vertical Accelerations ◽  
Ivd Degeneration ◽  
Lower Back Injury

In the U.S. Navy, high speed boat (HSB) crewman frequently suffer from lower back pain and accelerated intervertebral disc (IVD) degeneration. It is believed that this stems primarily from the large vertical accelerations and forces experienced while navigating on the open seas as the boats pitch and crash into the water. In a study of self-reported injuries for HSB operators, 33.6% of these subjects had suffered a lower back injury while on duty3. This is high when compared with the 15 to 20% of adults in the general population who experience low back pain.

Analysis of the Intervertebral Disc’s Mechanical Behavior Under Impact Loading Conditions

2011 ◽  
Author(s):  
David Jamison ◽  
Marco Cannella ◽  
Eric C. Pierce ◽  
Shawn K. Martin ◽  
Michele A. Marcolongo
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
General Population ◽  
High Speed ◽  
Low Back ◽  
Lower Back ◽  
Vertical Accelerations ◽  
Ivd Degeneration ◽  
Lower Back Injury ◽  
The U.S

In the U.S. Navy, high speed boat (HSB) crewman frequently suffer from lower back pain and accelerated intervertebral disc (IVD) degeneration. It is believed that this stems primarily from the large vertical accelerations and forces experienced while navigating on the open seas as the boats pitch and crash into the water. In a study of self-reported injuries for HSB operators, 33.6% of these subjects had suffered a lower back injury while on duty3. This is high when compared with the 15 to 20% of adults in the general population who experience low back pain.

scholarly journals Reactive Oxygen Species Mediate Low Back Pain by Upregulating Substance P in Intervertebral Disc Degeneration

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Jiancheng Zheng ◽  
Jian Zhang ◽  
Xingkai Zhang ◽  
Zhiping Guo ◽  
Wenjian Wu ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Low Back Pain ◽  
Back Pain ◽  
Substance P ◽  
Intervertebral Disc ◽  
Reactive Oxygen ◽  
Alternative Methods ◽  
Low Back ◽  
Oxygen Species ◽  
Ivd Degeneration

Reactive oxygen species (ROS) are thought to have a strong correlation with a number of intervertebral disc (IVD) diseases. Here, we aimed to determine whether ROS represent an etiology of low back pain (LBP) during IVD degeneration. Thirty degenerated intervertebral disc samples were obtained from patients, and ROS levels were quantified using dihydroethidium (DHE) staining. The results suggested a significant correlation between the ROS level and the severity of LBP. Subsequently, a puncture-induced LBP model was established in rats, and ROS levels significantly increased compared with those in the sham surgery group, accompanied with severe puncture-induced IVD degeneration. In addition, when ROS levels were increased by H2O2 administration or decreased by NAC treatment, the rats showed increased or decreased LBP, respectively. Based on this evidence, we further determined that stimulation with H2O2 in nucleus pulposus cells (NPCs) in vivo or in vitro resulted in upregulation of substance P (SP), a peptide thought to be involved in the synaptic transmission of pain, and that the severity of LBP decreased when SP levels were increased by exogenous SP administration or neutralized via aprepitant treatment in the IVDs of rats. In conclusion, ROS are primary inducers of LBP based on clinical and animal data, and the mechanism involves ROS stimulation of NPCs to secrete SP, which is a critical neurotransmitter peptide, to promote LBP in IVDs. Therefore, reducing the level of ROS with specific drugs and inhibiting SP may be alternative methods to treat LBP in the clinic.

Mechanical Consequence of Induced Intervertebral Disc Degeneration in the SPARC-Null Mouse

2020 ◽  
Vol 143 (2) ◽  
Author(s):  
Mitchel C. Whittal ◽  
Sara Molladavoodi ◽  
Derek P. Zwambag ◽  
Magali Millecamps ◽  
Laura S. Stone ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Intervertebral Disc ◽  
Mechanical Tests ◽  
Null Mouse ◽  
Low Back ◽  
Spine Mechanics ◽  
Tension And Compression ◽  
In Series ◽  
Ivd Degeneration

Abstract Intervertebral disc (IVD) degeneration is associated with low back pain (LBP) and accompanied by mechanical changes to the spine. Secreted protein acidic and rich in cysteine (SPARC) is a protein that contributes to the functioning and maintenance of the extracellular matrix. SPARC-null mice display accelerated IVD degeneration and pain-associated behaviors. This study examined if SPARC-null mice also display altered spine mechanics as compared to wild-type (WT) mice. Lumbar spines from SPARC-null (n = 36) and WT (n = 18) mice aged 14–25 months were subjected to cyclic axial tension and compression to determine neutral zone (NZ) length and stiffness. Three separate mechanical tests were completed for each spine to determine the effect of the number of IVDs tested in series (one versus two versus three IVDs). SPARC-null spine NZs were both stiffer (p < 0.001) and smaller in length (p < 0.001) than WT spines. There was an effect of the number of IVDs tested in series for NZ length but not NZ stiffness when collapsed across condition (SPARC-null and WT). Correlation analysis revealed a weak negative correlation (r = −0.24) between age and NZ length in SPARC-null mice and a weak positive correlation (r = 0.30) between age and NZ stiffness in WT mice. In conclusion, SPARC-null mice had stiffer and smaller NZs than WT mice, regardless of the number of IVDs in series being tested. The increased stiffness of these IVDs likely influences mobility at these spinal joints thereby potentially contributing to low back pain.

Does elite swimming accelerate lumbar intervertebral disc degeneration and increase low back pain? A cross-sectional comparison

2016 ◽  
Vol 25 (9) ◽  
pp. 2849-2855 ◽  
Author(s):  
Steffen Folkvardsen ◽  
Erland Magnussen ◽  
Jaro Karppinen ◽  
Juha Auvinen ◽  
Rasmus Hertzum Larsen ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration ◽  
Low Back ◽  
Lumbar Intervertebral Disc ◽  
Cross Sectional

Nucleus Implant Parameters Significantly Change the Compressive Stiffness of the Human Lumbar Intervertebral Disc

2005 ◽  
Vol 127 (3) ◽  
pp. 536-540 ◽  
Author(s):  
Abhijeet Joshi ◽  
Samir Mehta ◽  
Edward Vresilovic ◽  
Andrew Karduna ◽  
Michele Marcolongo
Keyword(s):  
Back Pain ◽  
Intervertebral Disc ◽  
Lower Back Pain ◽  
Recent Trend ◽  
Intervertebral Discs ◽  
Geometric Parameters ◽  
Synthetic Material ◽  
Lumbar Intervertebral Disc ◽  
Compressive Stiffness ◽  
Lower Back

Nucleus replacement by a synthetic material is a recent trend for treatment of lower back pain. Hydrogel nucleus implants were prepared with variations in implant modulus, height, and diameter. Human lumbar intervertebral discs (IVDs) were tested in compression for intact, denucleated, and implanted condition. Implantation of nucleus implants with different material and geometric parameters into a denucleated IVD significantly altered the IVD compressive stiffness. Variations in the nucleus implant parameters significantly change the compressive stiffness of the human lumbar IVD. Implant geometrical variations were more effective than those of implant modulus variations in the range examined.

scholarly journals Lumbago is different from prolapse of lumbar intervertebral disc

2018 ◽  
Vol 6 (2) ◽  
Author(s):  
Wei Zhou ◽  
Yanbo Qiu ◽  
Shaoqiu Zhou ◽  
Wei Zhao
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Intervertebral Disc ◽  
Lumbar Disc ◽  
Posterior Longitudinal Ligament ◽  
Low Back ◽  
Lumbar Intervertebral Disc ◽  
Disc Protrusion ◽  
Medical Reform ◽  
System Disease

<p>There are many errors found in the content of textbook in National Higher Education.For example:One of the errors found in the“Surgery”version no 418 is about movement system disease section.In chapter 677 Section III,the content misinterpretation of the cause of low back pain is the intervertebral disc protrusion that stimulate the outer annulus and the posterior longitudinal ligament in the sinus nerve fibers.For the past twenty years,feedbacks had been reflected repeatedly to the involved party but no one had admitted the contents of the textbook are wrong.The errors had brought great economy loss,physical and mental pain to patients.Every year,the country has to spend billions of dollars in the waste of medical reform reimbursement.This article is aimed to discuss about low back pain is not due to lumbar disc herniation.</p>

scholarly journals Transforaminal Epidural Injection of Dexamethasone vs Methylprednisolone in Reducing Low Back Pain and Disability in Prolapsed Lumbar Intervertebral Disc in Manipur, India: A RCT

2021 ◽  
Author(s):  
Kanti Rajkumari ◽  
Akoijam Joy Singh ◽  
Longjam Nilachandra Singh ◽  
Margaret Chabungbam ◽  
C Sreejith ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Intervertebral Disc ◽  
Steroid Injection ◽  
Epidural Injection ◽  
P Value ◽  
Low Back ◽  
Lumbar Intervertebral Disc ◽  
Transforaminal Epidural Injection ◽  
Epidural Steroid

Introduction: Treatment for Low Back Pain (LBP) due to Prolapsed Intervertebral Disc (PIVD) includes conservative management, Epidural Steroid Injection (ESI), and surgery. Transforaminal Epidural Steroid Injection (TFESI) is a more recently described approach. All corticosteroid preparations used for TFESI are particulate except dexamethasone and betamethasone sodium phosphate. But while comparing methylprednisolone with dexamethasone, the latter has more potent anti-inflammatory action with least likelihood of causing embolic events and is also less expensive. Aim: To compare the efficacy of transforaminal epidural injection of dexamethasone and methylprednisolone in reducing LBP and disability in prolapsed lumbar intervertebral disc amongst the indigenous population of Manipur, India. Materials and Methods: This was a randomised controlled study on 80 patients with PIVD attending Outpatient Department (OPD) at physical medicine and rehabilitation was conducted from September 2016 to August 2018. A single dose of lumbar TFESI with dexamethasone in the study group and methylprednisolone in the control were given under C-arm guidance. The outcome variables Visual Analog Scale (VAS) for pain and Oswestry Disability Index (ODI) for function were measured at one week, one month and six months. Statistical tests like t-test, Chi-square test were used for intra group and inter group analysis. Results: In the total sample of 80 patients, 40 (15 males and 25 females, mean age: 38.28±8.55 years) were categorised as Dexamethasone patients and 40 (17 males and 23 females; mean age: 39.28±7.80 years) as methylprednisolone patients, there were significant improvement in mean score of VAS and ODI in both the groups (p-value <0.05). At six months, both treatment groups maintained initial observed improvements, with no significant differences between groups on the VAS {95% Confidence Interval (CI), -0.02 to 0.4; p-value=0.07} and ODI (95% CI,-0.21 to 3.43; p-value=0.08). Conclusion: Non-particulate steroid dexamethasone was similar in efficacy to the particulate steroid methylprednisolone in lumbar TFESI. However, in view of the greater safety profile of dexamethasone, it is suggested that dexamethasone may be used as the preferred agent in lumbar TFESI.

Sign in / Sign up

Export Citation Format

Share Document