Bone Turnover in Premenopausal Women with Exercise-Associated Menstrual Disorders

2007 ◽  
Vol 16 (1) ◽  
pp. 28-38
Author(s):  
Pamela S. Hinton ◽  
Laura S. Hillman ◽  
Rebecca D. Imhoff
Keyword(s):  
Bone Turnover ◽  
Premenopausal Women ◽  
Hormonal Contraceptive ◽  
Cross Sectional Study ◽  
Bone Alkaline Phosphatase ◽  
Menstrual Disorders ◽  
Mineral Density ◽  
Cross Sectional ◽  
Negative Effect ◽  
Turnover Markers

We compared bone mineral density and turnover in women with exercise-associated menstrual disorders (AMD, n=10; 0–9 cycles·y−1), hormonal contraceptive users (AHC, n=16; 12 cycles·y−1), and regularly menstruating controls (AE, n=13; 10–13 cycles·y−1). Thirty-nine active women (≥ 5 h aerobic exercise/wk) participated in this cross-sectional study. BMD was lower in AMD vs. AHC and AE . Serum hormone and bone turnover markers did not differ between AMD and AE. Cortisol was elevated (P=0.0002), progesterone suppressed (P=0.05), and bone alkaline phosphatase significantly lower (P=0.03) in AHC vs. AE. Lifetime missed menstrual cycles and body weight were significant, independent predictors of lumbar spine BMD, regardless of current menstrual status (adj R2=42.8%). Exercise-associated menstrual disorders have a negative effect on BMD.

Interrelationships between sclerostin, secondary hyperparathyroidism, and bone metabolism in patients on hemodialysis

2021 ◽  
Author(s):  
Yosuke Nakagawa ◽  
Hirotaka Komaba ◽  
Naoto Hamano ◽  
Hisae Tanaka ◽  
Takehiko Wada ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Bone Metabolism ◽  
Bone Turnover Markers ◽  
Bone Alkaline Phosphatase ◽  
Tartrate Resistant Acid Phosphatase ◽  
Mineral Density ◽  
Intact Pth ◽  
Cross Sectional ◽  
Tracp 5B ◽  
Turnover Markers

Abstract Context Sclerostin is an osteocyte-derived inhibitor of bone formation and is increased in kidney failure, but its role in the pathogenesis of renal bone disease remains unknown. Objective To explore the association of serum sclerostin with bone metabolism in patients undergoing hemodialysis, with a particular focus on parathyroid hormone (PTH)-dependent and PTH-independent pathways. Design Cross-sectional and prospective cohort study. Setting and participants 654 patients undergoing hemodialysis at 10 facilities in Japan. Main outcome measures We employed multivariable linear regression to explore whether sclerostin levels were associated with metacarpal bone mineral density (BMD), intact PTH, bone alkaline phosphatase (BAP), and tartrate-resistant acid phosphatase-5b (TRACP-5b). We employed mediation analyses to explore whether and to what extent the association of PTH with bone turnover markers is mediated by sclerostin. We also compared sclerostin levels between patients with and without previous or incident fractures. Results The median sclerostin level in hemodialysis patients was 3–4-fold higher than that in healthy individuals. Higher sclerostin levels were associated with higher metacarpal BMD and lower levels of intact PTH, BAP, and TRACP-5b. However, the relationships of sclerostin with bone turnover markers were substantially attenuated after adjustment for PTH. Mediation analysis suggested that the effects of PTH on bone turnover markers were mainly direct rather than mediated by sclerostin. Sclerostin levels were not associated with previous or incident fractures. Conclusions These findings suggest that in patients undergoing dialysis, sclerostin has only a limited role in bone metabolism and may not mediate the effect of PTH on bone turnover.

scholarly journals Bone status and aortic calcifications in chondrocalcinosis patients

2020 ◽  
Vol 28 (2) ◽  
pp. 195-204
Author(s):  
Paulina Vele ◽  
Ciprian Nicolae Silaghi ◽  
Laura Otilia Damian ◽  
Siao-Pin Simon ◽  
Alexandra Craciun ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Bone Turnover Markers ◽  
Statistical Significance ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Mineral Density ◽  
Cross Sectional ◽  
Turnover Markers

AbstractAim: We aimed to examine the association between several circulating bone turnover markers [ osteocalcin (OC), osteoprotegerin (OPG), beta-CrossLaps (β-CTx)], hip and spine bone mineral density (BMD) and abdominal aortic calcification (AAC) in patients with chondrocalcinosis (CC).Methods: Thirty-six patients with CC and thirty-seven controls were consecutively enrolled in this pilot case-control, cross-sectional study. The following parameters were assessed: serum levels of OC, OPG and β-CTx by enzyme-linked immunosorbent assay (ELISA); hip and spine BMD by dual-energy X-ray absorptiometry and AAC score by lateral radiography.Results: Patients with CC had higher levels of serum bone turnover markers and AAC score than the control group: OC [6.5 (3.5-9.9) vs 4.5 (2.6-7.2) ng/ml; p=0.05], OPG [(7.7 (6.2-9.4) vs 6.5 (5.5-8.12) pmol/ml; p=0.02], β-CTx [6078 (5870-6171) vs 5851 (5465-6109) pg/ml; p=0.02] and AAC score (3.6±6.2 vs 0.5±2; p=0.006). Conversely, even if statistical significance was not reached, hip and spine BMD was lower in patients with CC. Additionally, we found a positive correlation between OPG and AAC, but also between OPG and osteoporosis in patients with CC.Conclusion: Patients with CC are characterized by higher circulating OC, OPG and β-CTx. The presence of AAC was more common in patients with CC, being only associated with serum OPG.

A cross-sectional study of bone turnover markers in healthy premenopausal women

Bone ◽  
2007 ◽  
Vol 40 (5) ◽  
pp. 1222-1230 ◽  
Author(s):  
Anne E. de Papp ◽  
Henry G. Bone ◽  
Michael P. Caulfield ◽  
Risa Kagan ◽  
Anna Buinewicz ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Bone Turnover Markers ◽  
Premenopausal Women ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Turnover Markers

Reference intervals of bone turnover markers in healthy premenopausal women: Results from a cross-sectional European study

Bone ◽  
2012 ◽  
Vol 50 (5) ◽  
pp. 1141-1147 ◽  
Author(s):  
Richard Eastell ◽  
Patrick Garnero ◽  
Christine Audebert ◽  
David L. Cahall
Keyword(s):  
Bone Turnover ◽  
Bone Turnover Markers ◽  
Premenopausal Women ◽  
Reference Intervals ◽  
European Study ◽  
Cross Sectional ◽  
Turnover Markers
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