Impact of Gut Microbiota on Intestinal and Hepatic Levels of Phase 2 Xenobiotic-Metabolizing Enzymes in the Rat

2009 ◽  
Vol 37 (6) ◽  
pp. 1179-1186 ◽  
Author(s):  
Walter Meinl ◽  
Silke Sczesny ◽  
Regina Brigelius-Flohé ◽  
Michael Blaut ◽  
Hansruedi Glatt
Keyword(s):  
Gut Microbiota ◽  
Phase 2 ◽  
Metabolizing Enzymes ◽  
Xenobiotic Metabolizing Enzymes

Chemical Metabolism of Xenobiotics by Gut Microbiota

2020 ◽  
Vol 21 (4) ◽  
pp. 260-269
Author(s):  
Radislav Nakov ◽  
Tsvetelina Velikova
Keyword(s):  
Gut Microbiota ◽  
Xenobiotic Metabolism ◽  
Human Biology ◽  
Herbal Supplements ◽  
Metabolizing Enzymes ◽  
Xenobiotic Metabolizing Enzymes ◽  
Chemical Structures ◽  
Growing Body ◽  
Metabolism Of Xenobiotics

: Among the gut microbiota’s newly explored roles in human biology is the ability to modify the chemical structures of foreign compounds (xenobiotics). A growing body of evidence has now provided sufficient acumen on the role of the gut microbiota on xenobiotic metabolism, which could have an intense impact on the therapy for various diseases in the future. Gut microbial xenobiotic metabolites have altered bioavailability, bioactivity and toxicity and can intervene with the actions of human xenobiotic-metabolizing enzymes to affect the destiny of other ingested molecules. These modifications are diverse and could lead to physiologically important consequences. : In the current manuscript we aim to review the data currently available on how the gut microbiota directly modifies drugs, dietary compounds, chemicals, pollutants, pesticides and herbal supplements.

Effects of short-term saffron (Crocus sativus L.) intake on the in vivo activities of xenobiotic metabolizing enzymes in healthy volunteers

2019 ◽  
Vol 130 ◽  
pp. 32-43 ◽  
Author(s):  
Elias Begas ◽  
Maria Bounitsi ◽  
Thomas Kilindris ◽  
Evangelos Kouvaras ◽  
Konstantinos Makaritsis ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Crocus Sativus ◽  
Short Term ◽  
Metabolizing Enzymes ◽  
Xenobiotic Metabolizing Enzymes ◽  
Crocus Sativus L

scholarly journals Effects of berberine on the recovery of rat liver xenobiotic-metabolizing enzymes after partial hepatectomy

2015 ◽  
Vol 61 (3) ◽  
pp. 381-383 ◽  
Author(s):  
I.V. Zverinsky ◽  
H.G. Zverinskaya ◽  
I.P. Sutsko ◽  
P.G. Telegin ◽  
A.G. Shlyahtun
Keyword(s):  
Cytochrome P450 ◽  
Partial Hepatectomy ◽  
Rat Liver ◽  
Compensatory Growth ◽  
Metabolizing Enzymes ◽  
Xenobiotic Metabolizing Enzymes ◽  
Recovery Processes

We have studied the effect of berberine on the recovery processes of liver xenobiotic-metabolizing function during its compensatory growth after 70% partial hepatectomy. It was found the hepatic ability to metabolize foreign substances are not restored up to day 8. Administration of berberine (10 mg/kg intraperitoneally) for 6 days led to normalization of both cytochrome P450-dependent and flavin-containing monooxygenases. It is suggested that in the biotransformation of berberine involved not only cytochrome P450, but also flavin-containing monooxygenases.

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