Potent Antitumor Activity of a Novel Cationic Pyridinium-Ceramide Alone or in Combination with Gemcitabine against Human Head and Neck Squamous Cell Carcinomas in Vitro and in Vivo

2006 ◽  
Vol 317 (3) ◽  
pp. 1188-1199 ◽  
Author(s):  
Can E. Senkal ◽  
Suriyan Ponnusamy ◽  
Michael J. Rossi ◽  
Kamala Sundararaj ◽  
Zdzislaw Szulc ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Head And Neck ◽  
Squamous Cell ◽  
Human Head ◽  
Squamous Cell Carcinomas

In vitro proliferation of primary human head and neck squamous cell carcinomas evaluated by flow cytometry

1987 ◽  
Vol 36 (1) ◽  
pp. 71-81 ◽  
Author(s):  
J.Th. Bijman ◽  
D.J.Th. Wagener ◽  
J.M.C. Wessels ◽  
D. Elprana ◽  
P. van den Broek
Keyword(s):  
Flow Cytometry ◽  
Head And Neck ◽  
Squamous Cell ◽  
Human Head ◽  
Squamous Cell Carcinomas ◽  
In Vitro Proliferation

Comparison of in vivo and in vitro prostaglandin E production by squamous cell carcinoma of the head and neck

1994 ◽  
Vol 111 (3) ◽  
pp. 189-196 ◽  
Author(s):  
C SNYDERMAN ◽  
I KLAPAN ◽  
M MILANOVICH ◽  
D HEO ◽  
R WAGNER ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Prostaglandin E

scholarly journals JOSD1 promotes proliferation and chemoresistance of head and neck squamous cell carcinoma under the epigenetic regulation of BRD4

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Chao Jing ◽  
Dandan Liu ◽  
Qingchuan Lai ◽  
Linqi Li ◽  
Mengqian Zhou ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Gene Expression Omnibus ◽  
Neck Squamous Cell Carcinoma ◽  
The Cancer Genome Atlas ◽  
In Vivo Experiments

Abstract Background Deubiquitinating enzymes (DUBs) play critical roles in various cancers by modulating functional proteins post-translationally. Previous studies have demonstrated that DUB Josephin Domain Containing 1 (JOSD1) is implicated in tumor progression, however, the role and mechanism of JOSD1 in head and neck squamous cell carcinoma (HNSCC) remain to be explored. In this study, we aimed to identify the clinical significance and function of JOSD1 in HNSCC. Methods The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases were analyzed to find novel DUBs in HNSCC. Immunohistochemistry assay was performed to determine the expression of JOSD1 in our cohort of 42 patients suffered with HNSCC. Kaplan–Meier analysis was used to identify the correlation between JOSD1 and the prognosis of HNSCC patients. The regulation of BRD4 on JOSD1 was determined by using pharmacological inhibition and gene depletion. The in vitro and in vivo experiments were conducted to elucidate the role of JOSD1 in HNSCC. Results The results of IHC showed that JOSD1 was aberrantly expressed in HNSCC specimens, especially in the chemoresistant ones. The overexpression of JOSD1 indicated poor clinical outcome of HNSCC patients. Moreover, JOSD1 depletion dramatically impaired cell proliferation and colony formation, and promoted cisplatin-induced apoptosis of HNSCC cells in vitro. Additionally, JOSD1 suppression inhibited the tumor growth and improved chemosensitivity in vivo. The epigenetic regulator BRD4 contributed to the upregulation of JOSD1 in HNSCC. Conclusions These results demonstrate that JOSD1 functions as an oncogene in HNSCC progression, and provide a promising target for clinical diagnosis and therapy of HNSCC.

scholarly journals In vitro cytokine release profile: Predictive value for metastatic potential in head and neck squamous cell carcinomas

Head & Neck ◽  
2013 ◽  
Vol 35 (11) ◽  
pp. 1542-1550 ◽  
Author(s):  
Omar Shkeir ◽  
Maria Athanassiou-Papaefthymiou ◽  
Martian Lapadatescu ◽  
Petros Papagerakis ◽  
Michael J. Czerwinski ◽  
...  
Keyword(s):  
Head And Neck ◽  
Squamous Cell ◽  
Predictive Value ◽  
Metastatic Potential ◽  
Squamous Cell Carcinomas ◽  
Release Profile ◽  
Cytokine Release

scholarly journals Dihydroisotanshinone I as a Treatment Option for Head and Neck Squamous Cell Carcinomas

2021 ◽  
Vol 22 (16) ◽  
pp. 8881
Author(s):  
Cheng-Ming Hsu ◽  
Ming-Yu Yang ◽  
Ming-Shao Tsai ◽  
Geng-He Chang ◽  
Yao-Hsu Yang ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Mouse Model ◽  
Head And Neck ◽  
Squamous Cell ◽  
Salvia Miltiorrhiza ◽  
Chinese Herb ◽  
Squamous Cell Carcinomas ◽  
Xenograft Mouse Model ◽  
Chemotherapy Drugs

Head and neck squamous cell carcinomas (HNSCCs) are the most common cancers of the head and neck, and their prevalence is rapidly increasing. HNSCCs present a clinical challenge because of their high recurrence rate, therapeutic resistance to radiation and chemotherapy drugs, and adverse effects. Hence, traditional Chinese herbal treatment may be advantageous to therapeutic strategies for HNSCCs. Danshen (Salvia miltiorrhiza), a well-known Chinese herb, has been extensively applied in treatments for various diseases, including cancer, because of its high degree of safety and low rate of adverse effects despite its unclear mechanism. Thus, we aimed to explore the possible anticancer effects and mechanisms of dihydroisotanshinone I (DT), a compound in danshen (extract from danshen), on HNSCCs. Three HNSCCs cell lines were used for in vitro studies, and a Detroit 562 xenograft mouse model was chosen for in vivo studies. Our in vitro results showed that DT could initiate apoptosis, resulting in cell death, and the p38 signaling partially regulated DT-initiated cell apoptosis in the Detroit 562 model. In the xenograft mouse model, DT reduced tumor size with no obvious adverse effect of hepatotoxicity. The present study suggests that DT is a promising novel candidate for anti-HNSCCs therapy.

scholarly journals Correction: In Vitro and In Vivo Synergistic Antitumor Activity of the Combination of BKM120 and Erlotinib in Head and Neck Cancer: Mechanism of Apoptosis and Resistance

2020 ◽  
Vol 19 (9) ◽  
pp. 1955-1955
Author(s):  
Abu Syed Md Anisuzzaman ◽  
Abedul Haque ◽  
Dongsheng Wang ◽  
Mohammad Aminur Rahman ◽  
Chao Zhang ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Antitumor Activity ◽  
Head And Neck ◽  
Neck Cancer ◽  
Synergistic Antitumor Activity

Antitumor activity of protein kinase C inhibitors and cisplatin in human head and neck squamous cell carcinoma lines

2002 ◽  
Vol 13 (1) ◽  
pp. 93-100 ◽  
Author(s):  
Thomas K Hoffmann ◽  
Katrin Leenen ◽  
Dieter Hafner ◽  
Vera Balz ◽  
Claus D Gerharz ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Antitumor Activity ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Human Head ◽  
Protein Kinase C Inhibitors ◽  
Kinase C
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