scholarly journals In vitro cytokine release profile: Predictive value for metastatic potential in head and neck squamous cell carcinomas

Head & Neck ◽  
2013 ◽  
Vol 35 (11) ◽  
pp. 1542-1550 ◽  
Author(s):  
Omar Shkeir ◽  
Maria Athanassiou-Papaefthymiou ◽  
Martian Lapadatescu ◽  
Petros Papagerakis ◽  
Michael J. Czerwinski ◽  
...  
Keyword(s):  
Head And Neck ◽  
Squamous Cell ◽  
Predictive Value ◽  
Metastatic Potential ◽  
Squamous Cell Carcinomas ◽  
Release Profile ◽  
Cytokine Release

scholarly journals Dihydroisotanshinone I as a Treatment Option for Head and Neck Squamous Cell Carcinomas

2021 ◽  
Vol 22 (16) ◽  
pp. 8881
Author(s):  
Cheng-Ming Hsu ◽  
Ming-Yu Yang ◽  
Ming-Shao Tsai ◽  
Geng-He Chang ◽  
Yao-Hsu Yang ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Mouse Model ◽  
Head And Neck ◽  
Squamous Cell ◽  
Salvia Miltiorrhiza ◽  
Chinese Herb ◽  
Squamous Cell Carcinomas ◽  
Xenograft Mouse Model ◽  
Chemotherapy Drugs

Head and neck squamous cell carcinomas (HNSCCs) are the most common cancers of the head and neck, and their prevalence is rapidly increasing. HNSCCs present a clinical challenge because of their high recurrence rate, therapeutic resistance to radiation and chemotherapy drugs, and adverse effects. Hence, traditional Chinese herbal treatment may be advantageous to therapeutic strategies for HNSCCs. Danshen (Salvia miltiorrhiza), a well-known Chinese herb, has been extensively applied in treatments for various diseases, including cancer, because of its high degree of safety and low rate of adverse effects despite its unclear mechanism. Thus, we aimed to explore the possible anticancer effects and mechanisms of dihydroisotanshinone I (DT), a compound in danshen (extract from danshen), on HNSCCs. Three HNSCCs cell lines were used for in vitro studies, and a Detroit 562 xenograft mouse model was chosen for in vivo studies. Our in vitro results showed that DT could initiate apoptosis, resulting in cell death, and the p38 signaling partially regulated DT-initiated cell apoptosis in the Detroit 562 model. In the xenograft mouse model, DT reduced tumor size with no obvious adverse effect of hepatotoxicity. The present study suggests that DT is a promising novel candidate for anti-HNSCCs therapy.

The tumor microenvironment in head and neck squamous cell carcinomas: Predictive value and clinical relevance of molecular markers

2007 ◽  
Vol 82 ◽  
pp. S27-S28
Author(s):  
I.J. Hoosteen ◽  
K.I. Wijffels ◽  
H.A.M. Marres ◽  
F.J.A. van den Hoogen ◽  
A.J. van der Kogel ◽  
...  
Keyword(s):  
Molecular Markers ◽  
Tumor Microenvironment ◽  
Head And Neck ◽  
Squamous Cell ◽  
Predictive Value ◽  
Clinical Relevance ◽  
Squamous Cell Carcinomas

Potent Antitumor Activity of a Novel Cationic Pyridinium-Ceramide Alone or in Combination with Gemcitabine against Human Head and Neck Squamous Cell Carcinomas in Vitro and in Vivo

2006 ◽  
Vol 317 (3) ◽  
pp. 1188-1199 ◽  
Author(s):  
Can E. Senkal ◽  
Suriyan Ponnusamy ◽  
Michael J. Rossi ◽  
Kamala Sundararaj ◽  
Zdzislaw Szulc ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Head And Neck ◽  
Squamous Cell ◽  
Human Head ◽  
Squamous Cell Carcinomas

scholarly journals Head and Neck Cancer Stem Cells

2011 ◽  
Vol 91 (4) ◽  
pp. 334-340 ◽  
Author(s):  
S. Krishnamurthy ◽  
J.E. Nör
Keyword(s):  
Stem Cells ◽  
Head And Neck Cancer ◽  
Cancer Stem Cells ◽  
Head And Neck ◽  
Neck Cancer ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Self Renewal ◽  
Perivascular Niche

Most cancers contain a small sub-population of cells that are endowed with self-renewal, multipotency, and a unique potential for tumor initiation. These properties are considered hallmarks of cancer stem cells. Here, we provide an overview of the field of cancer stem cells with a focus on head and neck cancers. Cancer stem cells are located in the invasive fronts of head and neck squamous cell carcinomas (HNSCC) close to blood vessels (perivascular niche). Endothelial cell-initiated signaling events are critical for the survival and self-renewal of these stem cells. Markers such as aldehyde dehydrogenase (ALDH), CD133, and CD44 have been successfully used to identify highly tumorigenic cancer stem cells in HNSCC. This review briefly describes the orosphere assay, a method for in vitro culture of undifferentiated head and neck cancer stem cells under low attachment conditions. Notably, recent evidence suggests that cancer stem cells are exquisitely resistant to conventional therapy and are the “drivers” of local recurrence and metastatic spread. The emerging understanding of the role of cancer stem cells in the pathobiology of head and neck squamous cell carcinomas might have a profound impact on the treatment paradigms for this malignancy.

Tumor microenvironment in head and neck squamous cell carcinomas: Predictive value and clinical relevance of hypoxic markers. A review

Head & Neck ◽  
2007 ◽  
Vol 29 (6) ◽  
pp. 591-604 ◽  
Author(s):  
Ilse J. Hoogsteen ◽  
Henri A. M. Marres ◽  
Johan Bussink ◽  
Albert J. van der Kogel ◽  
Johannes H. A. M. Kaanders
Keyword(s):  
Tumor Microenvironment ◽  
Head And Neck ◽  
Squamous Cell ◽  
Predictive Value ◽  
Clinical Relevance ◽  
Squamous Cell Carcinomas

Adenovirus-Mediated Gene Therapy for Head and Neck Squamous Cell Carcinomas

1996 ◽  
Vol 105 (7) ◽  
pp. 562-567 ◽  
Author(s):  
Beverly L. Davidson ◽  
Scott M. Graham ◽  
Eric A. Goebel ◽  
Joseph Zabner ◽  
Jeffrey A. Kern
Keyword(s):  
Head And Neck ◽  
Squamous Cell ◽  
Recombinant Adenovirus ◽  
Marker Gene ◽  
Squamous Cell Carcinomas ◽  
Transduction Efficiency ◽  
Gene Transduction ◽  
Novel Therapy ◽  
Simplex Virus

Advanced head and neck squamous cell carcinomas (HNSCCs) have a poor prognosis despite aggressive multimodal therapy. The goal of our study was to test the feasibility of gene transduction as a novel therapy for head and neck cancer. Three human HNSCC cell lines were transduced in vitro with a replication-deficient recombinant adenovirus containing the lacZ marker gene (Ad2/CMVßgal). Gene transduction efficiency was dependent on multiplicity of infection, duration of exposure to the virus, and viral concentration. Next, the HEp-2 cell line was transduced with an adenoviral vector (Ad.RSV tk) containing the herpes simplex virus thymidine kinase (HSV tk) gene, which, when expressed, sensitizes transduced cells to ganciclovir (GCV). Subsequent administration of GCV resulted in complete rumor cell killing. These results suggest that adenovirus-mediated transfer of KSV tk and administration of GCV has potential as a new therapy for HNSCC.

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